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Interferon-free therapies for chronic hepatitis C: toward a hepatitis C virus-free world?

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Riccardo Scotto, Antonio Riccardo Buonomo, Stefania De Pascalis, Mariagiovanna Nerilli, Biagio Pinchera, Laura Staiano, Simona Mercinelli, Letizia Cattaneo, Maria Stanzione, Gianfranca Stornaiuolo, Salvatore Martini, Vincenzo Messina, Carmine Coppola, Nicola Coppola & Ivan Gentile. (2021) Changing epidemiology of patients treated with direct acting antivirals for HCV and persistently high SVR12 in an endemic area for HCV infection in Italy: real-life ‘LIver Network Activity’ (LINA) cohort update results. Expert Review of Gastroenterology & Hepatology 15:9, pages 1057-1063.
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Carol Stanciu, Anca Trifan, Cristina Muzica & Catalin Sfarti. (2019) Efficacy and safety of alisporivir for the treatment of hepatitis C infection. Expert Opinion on Pharmacotherapy 20:4, pages 379-384.
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Isabella Esposito, Sebastián Marciano & Julieta Trinks. (2018) Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 649-657.
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Allister Sebastian Lee, Mieke L van Driel & Darrell HG Crawford. (2017) The cost of successful antiviral therapy in hepatitis C patients: a comparison of IFN-free versus IFN-based regimens at an individual patient level in Australia. ClinicoEconomics and Outcomes Research 9, pages 595-607.
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Ivan Gentile, Alberto E. Maraolo, Massimo Niola, Vincenzo Graziano, Guglielmo Borgia & Mariano Paternoster. (2016) Limiting the access to direct-acting antivirals against HCV: an ethical dilemma. Expert Review of Gastroenterology & Hepatology 10:11, pages 1227-1234.
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Guglielmo Borgia, Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Riccardo Scotto & Ivan Gentile. (2016) The therapeutic potential of new investigational hepatitis C virus translation inhibitors. Expert Opinion on Investigational Drugs 25:10, pages 1209-1214.
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Laura Benítez-Gutiérrez, Pablo Barreiro, Pablo Labarga, Carmen de Mendoza, José V. Fernandez-Montero, Ana Arias, José M. Peña & Vicente Soriano. (2016) Prevention and management of treatment failure to new oral hepatitis C drugs. Expert Opinion on Pharmacotherapy 17:9, pages 1215-1223.
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Ivan Gentile, Riccardo Scotto, Emanuela Zappulo, Antonio Riccardo Buonomo, Biagio Pinchera & Guglielmo Borgia. (2016) Investigational direct-acting antivirals in hepatitis C treatment: the latest drugs in clinical development. Expert Opinion on Investigational Drugs 25:5, pages 557-572.
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José-R. Blanco & Antonio Rivero-Juarez. (2016) HCV genotype 3: a wolf in sheep’s clothing. Expert Review of Anti-infective Therapy 14:2, pages 149-152.
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Vincent Soriano, Pablo Labarga, Carmen de Mendoza, José V Fernández-Montero, Isabella Esposito, Laura Benítez-Gutiérrez, José M Peña & Pablo Barreiro. (2016) New hepatitis C therapies for special patient populations. Expert Opinion on Pharmacotherapy 17:2, pages 217-229.
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Ivan Gentile, Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Emanuela Zappulo & Guglielmo Borgia. (2015) The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C. Expert Opinion on Drug Discovery 10:12, pages 1363-1377.
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Ivan Gentile, Emanuela Zappulo, Antonio Riccardo Buonomo, Riccardo Scotto & Guglielmo Borgia. (2015) Asunaprevir for hepatitis C: a safety evaluation. Expert Opinion on Drug Safety 14:10, pages 1631-1646.
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Isabella Esposito, Pablo Labarga, Pablo Barreiro, José V Fernandez-Montero, Carmen de Mendoza, Laura Benítez-Gutiérrez, José M Peña & Vicente Soriano. (2015) Dual antiviral therapy for HIV and hepatitis C – drug interactions and side effects. Expert Opinion on Drug Safety 14:9, pages 1421-1434.
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Jerzy Jaroszewicz, Marta Flisiak-Jackiewicz, Dariusz Lebensztejn & Robert Flisiak. (2015) Current drugs in early development for treating hepatitis C virus-related hepatic fibrosis. Expert Opinion on Investigational Drugs 24:9, pages 1229-1239.
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Ivan Gentile, Emanuela Zappulo, Antonio Riccardo Buonomo, Alberto Enrico Maraolo & Guglielmo Borgia. (2015) Beclabuvir for the treatment of hepatitis C. Expert Opinion on Investigational Drugs 24:8, pages 1111-1121.
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Adriaan J van der Meer. (2015) Achieving sustained virological response: what’s the impact on further hepatitis C virus-related disease?. Expert Review of Gastroenterology & Hepatology 9:5, pages 559-566.
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Ashley Arezou Minaei & Kris V Kowdley. (2015) ABT-450/ritonavir and ABT-267 in combination with ABT-333 for the treatment of hepatitis C virus. Expert Opinion on Pharmacotherapy 16:6, pages 929-937.
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Vincent Soriano, Pablo Labarga, Pablo Barreiro, José V Fernandez-Montero, Carmen de Mendoza, Isabella Esposito, Laura Benítez-Gutiérrez & José M Peña. (2015) Drug interactions with new hepatitis C oral drugs. Expert Opinion on Drug Metabolism & Toxicology 11:3, pages 333-341.
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Ivan Gentile, Antonio Riccardo Buonomo, Emanuela Zappulo & Guglielmo Borgia. (2015) Discontinued drugs in 2012 – 2013: hepatitis C virus infection. Expert Opinion on Investigational Drugs 24:2, pages 239-251.
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Sheng-Shun Yang & Jia-Horng Kao. (2015) Asunaprevir-containing regimens for the treatment of hepatitis C virus infection. Expert Review of Gastroenterology & Hepatology 9:1, pages 9-20.
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Ivan Gentile, Antonio Riccardo Buonomo, Emanuela Zappulo, Giuseppina Minei, Filomena Morisco, Francesco Borrelli, Nicola Coppola & Guglielmo Borgia. (2014) Asunaprevir, a protease inhibitor for the treatment of hepatitis C infection. Therapeutics and Clinical Risk Management 10, pages 493-504.
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Ivan Gentile, Antonio Riccardo Buonomo, Emanuela Zappulo, Nicola Coppola & Guglielmo Borgia. (2014) GS-9669: a novel non-nucleoside inhibitor of viral polymerase for the treatment of hepatitis C virus infection. Expert Review of Anti-infective Therapy 12:10, pages 1179-1186.
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Ivan Gentile, Antonio Riccardo Buonomo & Guglielmo Borgia. (2014) Ombitasvir: a potent pan-genotypic inhibitor of NS5A for the treatment of hepatitis C virus infection. Expert Review of Anti-infective Therapy 12:9, pages 1033-1043.
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Articles from other publishers (17)

Vasilios Papastergiou, Hariklia Kranidioti & Spilios Manolakopoulos. 2021. Hepatitis C: Care and Treatment. Hepatitis C: Care and Treatment 97 117 .
Waleed Ismail, Amr Hanafy & Mohammed Abdelsattar. (2019) The outcome of the sofosbuvir Based Therapy in the treatment of Hepatitis C Virus Genotype 4 in Egyptian patients. african journal of gastroenterology and hepatology 2:1, pages 10-27.
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Ivan Gentile, Antonio Riccardo Buonomo, Riccardo Scotto, Emanuela Zappulo & Guglielmo Borgia. (2017) Infections worsen prognosis of patients with cirrhosis irrespective of the liver disease stage. European Journal of Internal Medicine 46, pages e45-e47.
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Wikrom Karnsakul & Kathleen B. Schwarz. (2017) Hepatitis B and C. Pediatric Clinics of North America 64:3, pages 641-658.
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L. Benítez-Gutiérrez, C. de Mendoza, I. Baños, A. Duca, A. Arias, A. Treviño, S. Requena, M.J. Citores & V. Cuervas-Mons. (2016) Drug-Induced Lung Injury in a Liver Transplant Patient Treated With Sofosbuvir. Transplantation Proceedings 48:7, pages 2515-2518.
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Jia-Wu Zhu, Feng-Liang Liu, Dan Mu, De-Yao Deng & Yong-Tang Zheng. (2016) Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients. Journal of Medical Virology 88:6, pages 987-995.
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Sheng-Shun Yang & Jia-Horng Kao. (2015) Daclatasvir-containing all-oral regimens for the treatment of hepatitis C virus infection. Hepatology International 10:2, pages 258-266.
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Mona Abdelmonem Esmail, Noha A. Hassuna, Khalda Sayed Amr, Eman Ramadan Ghazawy & Mohamed Abdel-Hamid. (2016) Polymorphisms at IL28B gene as predictors of viral relapse in genotype 4 Egyptian hepatitis C patients. Journal of Medical Virology 88:3, pages 481-486.
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Vincent Soriano, Pablo Labarga, José V Fernandez-Montero, Carmen de Mendoza, Isabella Esposito, Laura Benítez-Gutiérrez & Pablo Barreiro. (2016) Hepatitis C Cure with Antiviral Therapy – Benefits beyond the Liver. Antiviral Therapy 21:1, pages 1-8.
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Christoph R Werner, Carolin Franz, Daniel P Egetemeyr, Robert Beck, Nisar P Malek, Ulrich M Lauer & Christoph P Berg. (2015) First-generation protease inhibitor-triple therapy: SVR 24, safety, and predictors of response in a large single center cohort. Virology Journal 12:1.
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Mohammad Saeid Rezaee-Zavareh, Reza Hadi, Hamidreza Karimi-Sari, Mohammad Hossein Khosravi, Reza Ajudani, Fardin Dolatimehr, Mahdi Ramezani-Binabaj, Seyyed Mohammad Miri & Seyed Moayed Alavian. (2015) Occult HCV Infection: The Current State of Knowledge. Iranian Red Crescent Medical Journal 17:11.
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Amy B. Dounay. 2015. Innovative Drug Synthesis. Innovative Drug Synthesis 15 42 .
Andrew J. Muir. (2015) Understanding the Complexities of Cirrhosis. Clinical Therapeutics 37:8, pages 1822-1836.
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Ivan Gentile & Guglielmo Borgia. (2015) A pill a day keeps HCV away. The Lancet Infectious Diseases 15:6, pages 616-617.
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Ming-Zhi Zhang, Qiong Chen & Guang-Fu Yang. (2015) A review on recent developments of indole-containing antiviral agents. European Journal of Medicinal Chemistry 89, pages 421-441.
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Ivan Gentile & Guglielmo Borgia. (2014) Ledipasvir/Sofosbuvir administration achieves very high rate of viral clearance in patients with HCV genotype 1 infection without cirrhosis, regardless of ribavirin co-administration or length of treatment. Evidence Based Medicine 19:6, pages 223-224.
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C. Brauner, T.O. Lankisch, P. Fytili, J. Jaroszewicz, F. Lehner, H. Barg‐Hock, J. Klempnauer, E. Jaeckel, M.P. Manns, H. Wedemeyer & A.A. Negm. (2014) Clinical value and safety of liver biopsies in patients transplanted for hepatitis C virus‐related end‐stage liver disease. Transplant Infectious Disease 16:6, pages 958-967.
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