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Review

Etiological treatment of chronic Chagas disease: neglected ‘evidence’ by evidence-based medicine

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Pages 717-726 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Irene Losada Galván, Julio Alonso-Padilla, Nuria Cortés-Serra, Cristina Alonso-Vega, Joaquim Gascón & María Jesús Pinazo. (2021) Benznidazole for the treatment of Chagas disease. Expert Review of Anti-infective Therapy 19:5, pages 547-556.
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Juan M Bustamante & Rick L Tarleton. (2014) Potential new clinical therapies for Chagas disease. Expert Review of Clinical Pharmacology 7:3, pages 317-325.
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Juan M Bustamante & Rick L Tarleton. (2011) Methodological advances in drug discovery for Chagas disease. Expert Opinion on Drug Discovery 6:6, pages 653-661.
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Emmanuel Bottieau, Marc Vekemans & Alfons Van Gompel. (2011) Therapy of vector-borne protozoan infections in nonendemic settings. Expert Review of Anti-infective Therapy 9:5, pages 583-608.
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Werner Apt. (2010) Current and developing therapeutic agents in the treatment of Chagas disease. Drug Design, Development and Therapy 4, pages 243-253.
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Francisco Javier Carod-Artal. (2010) Trypanosomiasis, cardiomyopathy and the risk of ischemic stroke. Expert Review of Cardiovascular Therapy 8:5, pages 717-728.
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Jason Bowling & Elizabeth A Walter. (2009) Recognizing and meeting the challenge of Chagas disease in the USA. Expert Review of Anti-infective Therapy 7:10, pages 1223-1234.
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Rodolfo Viotti, Carlos Vigliano, Bruno Lococo, Maria Gabriela Alvarez, Marcos Petti, Graciela Bertocchi & Alejandro Armenti. (2009) Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities. Expert Review of Anti-infective Therapy 7:2, pages 157-163.
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Maria Nazaré C Soeiro & Solange L de Castro. (2009) Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opinion on Therapeutic Targets 13:1, pages 105-121.
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Articles from other publishers (53)

Iván Beltran-Hortelano, Verónica Alcolea, María Font & Silvia Pérez-Silanes. (2022) Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease. Bioorganic & Medicinal Chemistry 58, pages 116577.
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David Vizcaya, Ulrike Grossmann, Frank Kleinjung, Ruiping Zhang, Kiliana Suzart-Woischnik, Sandra Seu, Teresa Ramirez, Leylen Colmegna & Oscar Ledesma. (2021) Serological response to nifurtimox in adult patients with chronic Chagas disease: An observational comparative study in Argentina. PLOS Neglected Tropical Diseases 15:10, pages e0009801.
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Chen Chao, José L. Leone & Carlos A. Vigliano. (2020) Chagas disease: Historic perspective. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:5, pages 165689.
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Ana Cláudia Alvarenga Carneiro, G.P. Costa, Cyntia Silva Ferreira, Isalira Peroba Rezende Ramos, Mariáurea Matias Sarandy, Ana Luísa Junqueira Leite, A.P.J. Menezes, B.M. Silva, K.O.P.C. Nogueira, A.C.C. Carvalho, Reggiani Vilela Gonçalves & André Talvani. (2020) Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi. International Journal of Cardiology 299, pages 243-248.
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Julio A. Urbina. 2020. Chagas Disease. Chagas Disease 123 144 .
Samanta Moroni, Maria Elena Marson, Guillermo Moscatelli, Guido Mastrantonio, Margarita Bisio, Nicolas Gonzalez, Griselda Ballering, Jaime Altcheh & Facundo García-Bournissen. (2019) Negligible exposure to nifurtimox through breast milk during maternal treatment for Chagas Disease. PLOS Neglected Tropical Diseases 13:8, pages e0007647.
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Héctor Freilij. 2019. Chagas Disease. Chagas Disease 3 22 .
María Elena Villagran-Herrera, José Alejandro Martínez-Ibarra, Manuel Sánchez-Moreno, Hebert Luis Hernández-Montiel, Ricardo Francisco Mercado-Curiel, Nicolás Camacho-Calderón & José Antonio de Diego-Cabrera. 2018. Chagas Disease - Basic Investigations and Challenges. Chagas Disease - Basic Investigations and Challenges.
Julio A Urbina. (2018) The long road towards a safe and effective treatment of chronic Chagas disease. The Lancet Infectious Diseases 18:4, pages 363-365.
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Jaime Franco, Laura Scarone & Marcelo A. Comini. 2018. Neglected Diseases: Extensive Space for Modern Drug Discovery. Neglected Diseases: Extensive Space for Modern Drug Discovery 97 133 .
Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Lostracco-Johnson, Liliane Batista de Mesquita, Alanderson Nogueira, Marcelo Meuser-Batista, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R. Roush, Mirian Claudia de Souza Pereira, James H. McKerrow & Larissa M. Podust. (2017) 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLOS Neglected Tropical Diseases 11:12, pages e0006132.
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María G. Álvarez, Carlos Vigliano, Bruno Lococo, Graciela Bertocchi & Rodolfo Viotti. (2017) Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study. Acta Tropica 174, pages 149-152.
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Glaucia Vilar-Pereira, Isabela Resende Pereira, Leonardo Alexandre de Souza Ruivo, Otacilio Cruz Moreira, Andrea Alice da Silva, Constança Britto & Joseli Lannes-Vieira. (2016) Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease. Antimicrobial Agents and Chemotherapy 60:7, pages 4297-4309.
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. (2016) Benznidazole for Chronic Chagas’ Cardiomyopathy. New England Journal of Medicine 374:2, pages 188-190.
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Francisco Cordeiro-Barbosa, Fernando Oréfice & Daniel Vítor Vasconcelos-Santos. 2016. Intraocular Inflammation. Intraocular Inflammation 1413 1417 .
Julio A. Urbina & James H. McKerrow. (2015) Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrobial Agents and Chemotherapy 59:12, pages 7923-7924.
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Deena Shrestha, Arlete Rita Penitente, Aline Luciano Horta, Ana Luísa Junqueira Leite, Clóvis A. Neves, Antônio J. Natali, Guilherme de Paula Costa & Andre Talvani. (2015) Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi. The American Journal of Tropical Medicine and Hygiene 93:5, pages 976-982.
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M. Silvina Lo Presti, P. Carolina Bazán, Mariana Strauss, Alejandra L. Báez, H. Walter Rivarola & Patricia A. Paglini-Oliva. (2015) Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease. Acta Tropica 145, pages 79-87.
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Maria Jose Morilla & Eder Lilia Romero. (2015) Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis. Nanomedicine 10:3, pages 465-481.
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Facundo García-Bournissen, Samanta Moroni, Maria Elena Marson, Guillermo Moscatelli, Guido Mastrantonio, Margarita Bisio, Laura Cornou, Griselda Ballering & Jaime Altcheh. (2015) Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease. Archives of Disease in Childhood 100:1, pages 90-94.
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Julio A. Urbina. (2015) Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives. Journal of Eukaryotic Microbiology 62:1, pages 149-156.
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Jaime Altcheh, Guillermo Moscatelli, Guido Mastrantonio, Samanta Moroni, Norberto Giglio, Maria Elena Marson, Griselda Ballering, Margarita Bisio, Gideon Koren & Facundo García-Bournissen. (2014) Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults. PLoS Neglected Tropical Diseases 8:5, pages e2907.
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R. Viotti, B. Alarcón de Noya, T. Araujo-Jorge, M. J. Grijalva, F. Guhl, M. C. López, J. M. Ramsey, I. Ribeiro, A. G. Schijman, S. Sosa-Estani, F. Torrico & J. Gascon. (2014) Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease. Antimicrobial Agents and Chemotherapy 58:2, pages 635-639.
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Francisco Javier Carod Artal. 2014. Meningitis, encefalitis y otras infecciones del SNC. Meningitis, encefalitis y otras infecciones del SNC 253 288 .
Graciela L. Bertocchi, Carlos A. Vigliano, Bruno G. Lococo, Marcos A. Petti & Rodolfo J. Viotti. (2013) Clinical characteristics and outcome of 107 adult patients with chronic Chagas disease and parasitological cure criteria. Transactions of The Royal Society of Tropical Medicine and Hygiene 107:6, pages 372-376.
Crossref
Julio A. Urbina. 2013. Trypanosomatid Diseases. Trypanosomatid Diseases 489 514 .
D. E. Perez-Mazliah, M. G. Alvarez, G. Cooley, B. E. Lococo, G. Bertocchi, M. Petti, M. C. Albareda, A. H. Armenti, R. L. Tarleton, S. A. Laucella & R. Viotti. (2012) Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study. Journal of Antimicrobial Chemotherapy 68:2, pages 424-437.
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Francisco Javier Carod-Artal. 2013. Neuroparasitology and Tropical Neurology. Neuroparasitology and Tropical Neurology 103 123 .
Roberta Lattes, Laura Linares & Marcelo Radisic. (2012) Emerging Parasitic Infections in Transplantation. Current Infectious Disease Reports 14:6, pages 642-649.
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Rick L. Tarleton & James W. Curran. (2012) Is Chagas Disease Really the “New HIV/AIDS of the Americas”?. PLoS Neglected Tropical Diseases 6:10, pages e1861.
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Antonio L. Ribeiro, Maria P. Nunes, Mauro M. Teixeira & Manoel O. C. Rocha. (2012) Diagnosis and management of Chagas disease and cardiomyopathy. Nature Reviews Cardiology 9:10, pages 576-589.
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Samar N. El-Beshbishi, Nairmen N. Ahmed, Samar H. Mostafa & Goman A. El-Ganainy. (2011) Parasitic infections and myositis. Parasitology Research 110:1, pages 1-18.
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Rodolfo Viotti, Carlos Vigliano, María Gabriela Álvarez, Bruno Lococo, Marcos Petti, Graciela Bertocchi, Alejandro Armenti, Ana María De Rissio, Gretchen Cooley, Rick Tarleton & Susana Laucella. (2011) Impact of Aetiological Treatment on Conventional and Multiplex Serology in Chronic Chagas Disease. PLoS Neglected Tropical Diseases 5:9, pages e1314.
Crossref
Cristiane Menezes, Germano Carneiro Costa, Kenneth J. Gollob & Walderez O. Dutra. (2011) Clinical aspects of Chagas disease and implications for novel therapies. Drug Development Research 72:6, pages 471-479.
Crossref
Solange L. de Castro, Denise G. J. Batista, Marcos M. Batista, Wanderson Batista, Anissa Daliry, Elen M. de Souza, Rubem F. S. Menna-Barreto, Gabriel M. Oliveira, Kelly Salomão, Cristiane F. Silva, Patricia B. Silva & Maria de Nazaré C. Soeiro. (2011) Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones . Molecular Biology International 2011, pages 1-13.
Crossref
Michal Svoboda, Myrna Virreira, Carine Truyens, Faustino Torrico & Yves Carlier. 2011. Molecular Microbiology. Molecular Microbiology 713 725 .
Jaime Altcheh, Guillermo Moscatelli, Samanta Moroni, Facundo Garcia-Bournissen & Hector Freilij. (2011) Adverse Events After the Use of Benznidazole in Infants and Children With Chagas Disease. Pediatrics 127:1, pages e212-e218.
Crossref
. (2010) Chagas' Disease and Solid Organ Transplantation. Transplantation Proceedings 42:9, pages 3354-3359.
Crossref
François-Xavier Lescure, Guillaume Le Loup, Hector Freilij, Michel Develoux, Luc Paris, Laurent Brutus & Gilles Pialoux. (2010) Chagas disease: changes in knowledge and management. The Lancet Infectious Diseases 10:8, pages 556-570.
Crossref
Julio A. Urbina. (2010) Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches. Acta Tropica 115:1-2, pages 55-68.
Crossref
Alexander J. McADam & Arlene H. Sharpe. 2010. Robbins and Cotran Pathologic Basis of Disease. Robbins and Cotran Pathologic Basis of Disease 331 398 .
C.N. Kotton & R. Lattes. (2009) Parasitic Infections in Solid Organ Transplant Recipients. American Journal of Transplantation 9, pages S234-S251.
Crossref
Guillaume Le Loup, Francois-Xavier Lescure, Michel Develoux & Gilles Pialoux. (2009) Maladie de Chagas : formes cliniques et prise en charge en zone non endémique. La Presse Médicale 38:11, pages 1654-1666.
Crossref
Rodolfo Viotti, Carlos Vigliano & Alejandro Armenti. (2009) Nothing Goes on Forever...Chagas Disease. Revista Española de Cardiología (English Edition) 62:11, pages 1332-1333.
Crossref
Rodolfo Viotti, Carlos A. Vigliano, María G. Álvarez, Bruno E. Lococo, Marcos A. Petti, Graciela L. Bertocchi & Alejandro H. Armenti. (2009) The Impact of Socioeconomic Conditions on Chronic Chagas Disease Progression. Revista Española de Cardiología (English Edition) 62:11, pages 1224-1232.
Crossref
Rodolfo Viotti, Carlos Vigliano & Alejandro Armenti. (2009) No hay mal que cien años dure… el mal de Chagas. Revista Española de Cardiología 62:11, pages 1332-1333.
Crossref
Rodolfo Viotti, Carlos A. Vigliano, María G. Álvarez, Bruno E. Lococo, Marcos A. Petti, Graciela L. Bertocchi & Alejandro H. Armenti. (2009) El impacto de las condiciones socioeconómicas en la evolución de la enfermedad de Chagas crónica. Revista Española de Cardiología 62:11, pages 1224-1232.
Crossref
Michele Gabriele de Oliveira Pacheco, Cristiane França da Silva, Elen Mello de Souza, Marcos Meuser Batista, Patrícia Bernardino da Silva, Arvind Kumar, Chad E. Stephens, David W. Boykin & Maria de Nazaré C. Soeiro. (2009) Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro. Experimental Parasitology 123:1, pages 73-80.
Crossref
Julio A Urbina. (2009) Ergosterol biosynthesis and drug development for Chagas disease. Memórias do Instituto Oswaldo Cruz 104:suppl 1, pages 311-318.
Crossref
Mario Fernández-Ruiz & Francisco López-Medrano. (2009) Implicaciones diagnósticas y terapéuticas de la enfermedad de Chagas en España. Medicina Clínica 133:3, pages 117-118.
Crossref
Caryn Bern, Susan P Montgomery, Louis Katz, Sally Caglioti & Susan L Stramer. (2008) Chagas disease and the US blood supply. Current Opinion in Infectious Diseases 21:5, pages 476-482.
Crossref
Johannes A Blum, Michael J Zellweger, Christian Burri & Christoph Hatz. (2008) Cardiac involvement in African and American trypanosomiasis. The Lancet Infectious Diseases 8:10, pages 631-641.
Crossref
Paola Carolina Bazán, María Silvina Lo Presti, Héctor Walter Rivarola, María Fernanda Triquell, Ricardo Fretes, Alicia Ruth Fernández, Julio Enders & Patricia Paglini-Oliva. (2008) Chemotherapy of chronic indeterminate Chagas disease: a novel approach to treatment. Parasitology Research 103:3, pages 663-669.
Crossref

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