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Drug Profile

Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients

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Pages 569-579 | Published online: 10 Jan 2014

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Shasha Lu, Yu Xu, Qitian Mu, Lihong Cao, Jian Chen, Zhijuan Zhu, Yinjun Lou, Haitao Meng, Wenbin Qian, Hongyan Tong, Wenyuan Mai, Jian Huang, Wenjuan Yu, Xiaoying Zhao & Jie Jin. (2015) The risk of hepatitis B virus reactivation and the role of antiviral prophylaxis in hepatitis B surface antigen negative/hepatitis B core antibody positive patients with diffuse large B-cell lymphoma receiving rituximab-based chemotherapy. Leukemia & Lymphoma 56:4, pages 1027-1032.
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Ying Liu, Wai I. Ho, Feiwen Deng, Siwei Peng, Wan Yee Lau & Huanwei Chen. (2021) Entecavir Monotherapy Prevents Hepatitis B Virus Recurrence After Liver Transplant for Chronic Hepatitis B Patients: A Long-Term Retrospective Study. Transplantation Proceedings 53:5, pages 1700-1706.
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Jun Chen, Shu-Shan Zhao, Xiao-xiao Liu, Ze-Bing Huang & Yan Huang. (2017) Comparison of the Efficacy of Tenofovir Versus Tenofovir plus Entecavir in the Treatment of Chronic Hepatitis B in Patients With Poor Efficacy of Entecavir: A Systematic Review and Meta-analysis. Clinical Therapeutics 39:9, pages 1870-1880.
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Xi Yang, Zhiyuan Ma, Sisi Zhou, Yayun Weng, Hongmei Lei, Su Zeng, Liping Li & Huidi Jiang. (2016) Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir. Antimicrobial Agents and Chemotherapy 60:10, pages 6260-6270.
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Ma Min, Jiang Xingjun, Wang Xueding, Zou Hao, Yang Weiqing, Zhang Yuanyuan, Peng Changrong, Li Zicheng, Yang Jing, Du Quan & Ma Menglin. (2016) Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication. Chemical Biology & Drug Design 88:3, pages 451-459.
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Jing Yang, Min Ma, Xue-Ding Wang, Xing-Jun Jiang, Yuan-Yuan Zhang, Wei-Qing Yang, Zi-Cheng Li, Xi-Hong Wang, Bin Yang & Meng-Lin Ma. (2015) Synthesis and quantitative structure–activity relationships study for phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. European Journal of Medicinal Chemistry 99, pages 82-91.
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Zhi-Feng Xi & Qiang Xia. (2015) Recent advances in prevention of hepatitis B recurrence after liver transplantation. World Journal of Gastroenterology 21:3, pages 829.
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Maria Buti, Rosa M. Morillas, Juan Pérez, Martín Prieto, Ricard Solà, Antonio Palau, Moisés Diago, Lucía Bonet, Adolfo Gallego, Javier García-Samaniego, Milagros Testillano, Manuel Rodríguez, Gregorio Castellano, María L. Gutiérrez, Manuel Delgado, Antoni Mas, Manuel Romero-Gómez, José L. Calleja, Agustina González-Guirado, Juan I. Arenas, Luisa García-Buey, Raúl Andrade & Ana Gila. (2015) Entecavir has high efficacy and safety in white patients with chronic hepatitis B and comorbidities. European Journal of Gastroenterology & Hepatology 27:1, pages 46-54.
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Ze-Bing Huang, Shu-Shan Zhao, Yan Huang, Xia-Hong Dai, Rong-Rong Zhou, Pan-Pan Yi, Ruo-Chan Chen, Wen-Ting Li, Bao-Xin Zhang, Ning Li & Xue-Gong Fan. (2013) Comparison of the Efficacy of Lamivudine Plus Adefovir Versus Entecavir in the Treatment of Lamivudine-Resistant Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Clinical Therapeutics 35:12, pages 1997-2006.
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S. Amini-Bavil-Olyaee, U. Herbers, T. Luedde, C. Trautwein & F. Tacke. (2011) Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains. Journal of Viral Hepatitis 18:11, pages 804-814.
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Yu Xuan Koo, Matthew Tay, Yii Ean Teh, David Teng, Daniel S. W. Tan, Iain B. H. Tan, David W. M. Tai, Richard Quek, Miriam Tao & Soon Thye Lim. (2011) Risk of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen negative/hepatitis B core antibody positive patients receiving rituximab-containing combination chemotherapy without routine antiviral prophylaxis. Annals of Hematology 90:10, pages 1219-1223.
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Peiyuan Wang, Devan Naduthambi, Ralph T. Mosley, Congrong Niu, Phillip A. Furman, Michael J. Otto & Michael J. Sofia. (2011) Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs. Bioorganic & Medicinal Chemistry Letters 21:15, pages 4642-4647.
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Li-Chun Wang, En-Qiang Chen, Jing Cao, Li Liu, Li Zheng, Da-Jiang Li, Lu Xu, Xue-Zhong Lei, Cong liu & Hong Tang. (2011) De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naïve HBeAg-negative chronic hepatitis B patients. Hepatology International 5:2, pages 671-676.
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Zhiliang Lv, Chunquan Sheng, Tiantian Wang, Yikai Zhang, Jia Liu, Jilu Feng, Hailing Sun, Hanyu Zhong, Chunjuan Niu & Ke Li. (2009) Design, Synthesis, and Antihepatitis B Virus Activities of Novel 2-Pyridone Derivatives. Journal of Medicinal Chemistry 53:2, pages 660-668.
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Raymond Liang. (2009) How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation. Blood 113:14, pages 3147-3153.
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