583
Views
140
CrossRef citations to date
0
Altmetric
Review

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

, , , &
Pages 767-780 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Peng Zhao, Liping Yang, Jiansheng Li, Ya Li, Yange Tian & Suyun Li. (2016) Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 553-566.
Read now
Jian Jiang, Jarno EJ Wolters, Simone G van Breda, Jos C Kleinjans & Theo M de Kok. (2015) Development of novel tools for the in vitro investigation of drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 11:10, pages 1523-1537.
Read now
Seema Singh, Naveen Kumar Singhal, Garima Srivastava & Mahendra Pratap Singh. (2010) Omics in mechanistic and predictive toxicology. Toxicology Mechanisms and Methods 20:7, pages 355-362.
Read now
Ulf Hammerling, Annika Tallsjö, Roland Grafström & Nils-Gunnar Ilbäck. (2009) Comparative Hazard Characterization in Food Toxicology. Critical Reviews in Food Science and Nutrition 49:7, pages 626-669.
Read now
Andreu Palou, Catalina Pico & Jaap Keijer. (2009) Integration of Risk and Benefit Analysis—The Window of Benefit as a New Tool?. Critical Reviews in Food Science and Nutrition 49:7, pages 670-680.
Read now
Florian Nigsch, NJ Maximilan Macaluso, John BO Mitchell & Donatas Zmuidinavicius. (2009) Computational toxicology: an overview of the sources of data and of modelling methods. Expert Opinion on Drug Metabolism & Toxicology 5:1, pages 1-14.
Read now
Ben C Collins, Ambrose Clarke, Neil R Kitteringham, William M Gallagher & Stephen R Pennington. (2007) Use of proteomics for the discovery of early markers of drug toxicity. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 689-704.
Read now
Jan A. Miernyk & Mark L. Johnston. (2006) Chemical Cross‐Linking Immobilized Concanavalin A for use in Proteomic Analyses. Preparative Biochemistry & Biotechnology 36:3, pages 203-214.
Read now

Articles from other publishers (132)

Chi Yen Tseng, Christine M. Custer, Thomas W. Custer, Paul M. Dummer, Natalie Karouna-Renier & Cole W. Matson. (2023) Multi-omics responses in tree swallow (Tachycineta bicolor) nestlings from the Maumee Area of Concern, Maumee River, Ohio. Science of The Total Environment 856, pages 159130.
Crossref
Yaping Liu, Shuang Zhu, Zhanjun Gu & Chunying Chen. 2023. Encyclopedia of Nanomaterials. Encyclopedia of Nanomaterials 718 732 .
Jin-You Liang, Yi-Fan Cheng, Xiao-Lin Huang, Ying Xu, Yue Him Wong & Yu Zhang. (2022) Behavioral and transcriptomic changes in butenolide treated larvae of the cosmopolitan fouling bryozoan Bugulina (Bugula) neritina. Frontiers in Marine Science 9.
Crossref
Lindsay B. Wilson, Ryan S. McClure, Katrina M. Waters, Michael T. Simonich & Robyn L. Tanguay. (2022) Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene. Frontiers in Toxicology 4.
Crossref
Giorgia La Barbera, Katrine Dalmo Nommesen, Catalina Cuparencu, Jan Stanstrup & Lars Ove Dragsted. (2022) A Comprehensive Database for DNA Adductomics. Frontiers in Chemistry 10.
Crossref
Ying Zhao, Shuai Huan, Yang Yang, Weiying Gao & Jie Wang. (2022) Hippocampal proteins discovery of diabetes-induced central neuropathy based on proteomics. NeuroReport 33:8, pages 354-362.
Crossref
Yvonne Chang, Julia E. Rager & Susan C. Tilton. (2021) Linking Coregulated Gene Modules with Polycyclic Aromatic Hydrocarbon-Related Cancer Risk in the 3D Human Bronchial Epithelium. Chemical Research in Toxicology 34:6, pages 1445-1455.
Crossref
Dong Xu, Charlotte-Elisa Schaum, Bin Li, Yanan Chen, Shanying Tong, Fei-Xue Fu, David A. Hutchins, Xiaowen Zhang, Xiao Fan, Wentao Han, Yitao Wang & Naihao Ye. (2021) Acclimation and adaptation to elevated pCO2 increase arsenic resilience in marine diatoms. The ISME Journal 15:6, pages 1599-1613.
Crossref
Ragnhild Marie Mellingen, Lene Secher Myrmel, Kai Kristoffer Lie, Josef Daniel Rasinger, Lise Madsen & Ole Jakob Nøstbakken. (2021) RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice. Metallomics 13:5.
Crossref
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck & John F. Wambaugh. (2021) High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures. npj Systems Biology and Applications 7:1.
Crossref
Naeem Sheik Abdul & Anil A. Chuturgoon. (2021) Fumonisin B1 regulates LDL receptor and ABCA1 expression in an LXR dependent mechanism in liver (HepG2) cells. Toxicon 190, pages 58-64.
Crossref
Gopala Krishna & Mayur Krishna. 2021. Nutraceuticals. Nutraceuticals 431 462 .
Yasmin M. Heikal & Nicoleta Anca Şuţan. 2021. Induced Genotoxicity and Oxidative Stress in Plants. Induced Genotoxicity and Oxidative Stress in Plants 151 197 .
David Spurgeon, Elma Lahive, Alex Robinson, Stephen Short & Peter Kille. (2020) Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications. Frontiers in Environmental Science 8.
Crossref
Yan Ren, Siva Sivaganesan, Nicholas A Clark, Lixia Zhang, Jacek Biesiada, Wen Niu, David R Plas & Mario Medvedovic. (2020) Predicting mechanism of action of cellular perturbations with pathway activity signatures. Bioinformatics 36:18, pages 4781-4788.
Crossref
Joseph A. Adeyemi, Carlos Arterio Sorgi, Ana Rita Thomazela Machado, Abayomi T. Ogunjimi, Luiz Gustavo Araujo Gardinassi, Viviani Nardini, Lucia Helena Faccioli, Lusania Maria Greggi Antunes & Fernando BarbosaJrJr. (2020) Phospholipids modifications in human hepatoma cell lines (HepG2) exposed to silver and iron oxide nanoparticles. Archives of Toxicology 94:8, pages 2625-2636.
Crossref
Richard B. Kennedy, Inna G. Ovsyannikova, Peter Palese & Gregory A. Poland. (2020) Current Challenges in Vaccinology. Frontiers in Immunology 11.
Crossref
Shane Thomas O’Donnell, R. Paul Ross & Catherine Stanton. (2020) The Progress of Multi-Omics Technologies: Determining Function in Lactic Acid Bacteria Using a Systems Level Approach. Frontiers in Microbiology 10.
Crossref
Yunlong Li, Xinhui Zhang, Jie Meng, Jieming Chen, Xinxin You, Qiong Shi & Wen-Xiong Wang. (2020) Molecular responses of an estuarine oyster to multiple metal contamination in Southern China revealed by RNA-seq. Science of The Total Environment 701, pages 134648.
Crossref
Mohammad Mehdi Banoei, Isabella Iupe, Reza Dowlatabadi Bazaz, Michael Campos, Hans J. Vogel, Brent W. Winston & Mehdi Mirsaeidi. (2019) Metabolomic and metallomic profile differences between Veterans and Civilians with Pulmonary Sarcoidosis. Scientific Reports 9:1.
Crossref
T. J. M. Kuijpers, J. E. J. Wolters, J. C. S. Kleinjans & D. G. J. Jennen. (2019) DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks. BMC Bioinformatics 20:1.
Crossref
Ethan M. McBride, Richard J. Lawrence, Kirstin McGee, Phillip M. Mach, Paul S. Demond, Michael W. Busch, John W. Ramsay, Erika K. Hussey, Trevor Glaros & Elizabeth S. Dhummakupt. (2019) Rapid liquid chromatography tandem mass spectrometry method for targeted quantitation of human performance metabolites in saliva. Journal of Chromatography A 1601, pages 205-213.
Crossref
Ceren BÖRÇEK KASURKA. (2019) Moleküler Toksikoloji ve “Omik” Teknolojileri. Nevşehir Bilim ve Teknoloji Dergisi 8:1, pages 42-55.
Crossref
Jing Xu, Tao Bo, Weibo Song & Wei Wang. (2019) Metabolomic Fingerprint of the Model Ciliate, Tetrahymena thermophila Determined by Untargeted Profiling Using Gas Chromatography-Mass Spectrometry. Journal of Ocean University of China 18:3, pages 654-662.
Crossref
Bojan Jelaković, Živka Dika, Volker M. Arlt, Marie Stiborova, Nikola M. Pavlović, Jovan Nikolić, Jean-Marie Colet, Jean-Louis Vanherweghem & Joëlle L. Nortier. (2019) Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid. Seminars in Nephrology 39:3, pages 284-296.
Crossref
Yubo Li, Yani Zhang, Yuming Wang, Yamei Li, Feifan Yang, Pengjie Zhang, Yanjun Zhang & Changxiao Liu. (2019) A strategy for the discovery and validation of toxicity quality marker of Chinese medicine based on network toxicology. Phytomedicine 54, pages 365-370.
Crossref
Ana Margarida Araújo, Maria de Lourdes Bastos, Eduarda Fernandes, Félix Carvalho, Márcia Carvalho & Paula Guedes de Pinho. (2018) GC–MS metabolomics reveals disturbed metabolic pathways in primary mouse hepatocytes exposed to subtoxic levels of 3,4-methylenedioxymethamphetamine (MDMA). Archives of Toxicology 92:11, pages 3307-3323.
Crossref
Enitome E. Bafor, Edward G. Rowan & RuAngelie Edrada-Ebel. (2018) Metabolomics-Coupled Functional Pharmacology of Chlorophyll Compounds Isolated From the Leaves of Ficus Exasperata Vahl (Moraceae) Provides Novel Pathways on Myometrial Activity. Reproductive Sciences 25:6, pages 923-937.
Crossref
Yanpeng Tian, Feng Jiang, Yunlun Li, Haiqiang Jiang, Yanjun Chu, Lijuan Zhu & Weixing Guo. (2018) Evaluation of the anti-hypertensive effect of Tengfu Jiangya tablet by combination of UPLC-Q-exactive-MS-based metabolomics and iTRAQ-based proteomics technology. Biomedicine & Pharmacotherapy 100, pages 324-334.
Crossref
Chandrabose Selvaraj, Sugunadevi Sakkiah, Weida Tong & Huixiao Hong. (2018) Molecular dynamics simulations and applications in computational toxicology and nanotoxicology. Food and Chemical Toxicology 112, pages 495-506.
Crossref
Goran Gajski, Marko Gerić, Višnja Oreščanin & Vera Garaj-Vrhovac. (2018) Cytokinesis-block micronucleus cytome assay parameters in peripheral blood lymphocytes of the general population: Contribution of age, sex, seasonal variations and lifestyle factors. Ecotoxicology and Environmental Safety 148, pages 561-570.
Crossref
Benjamin Alexander-Dann, Lavinia Lorena Pruteanu, Erin Oerton, Nitin Sharma, Ioana Berindan-Neagoe, Dezső Módos & Andreas Bender. (2018) Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data. Molecular Omics 14:4, pages 218-236.
Crossref
Benjamin Piña, Demetrio Raldúa, Carlos Barata, José Portugal, Laia Navarro-Martín, Rubén Martínez, Inmaculada Fuertes & Marta Casado. 2018. Data Analysis for Omic Sciences: Methods and Applications. Data Analysis for Omic Sciences: Methods and Applications 583 611 .
Annalaura Mancia. 2018. Marine Mammal Ecotoxicology. Marine Mammal Ecotoxicology 291 320 .
Benjamin Piña, Laia Navarro, Carlos Barata, Demetrio Raldúa, Rubén Martínez & Marta Casado. 2018. Teratogenicity Testing. Teratogenicity Testing 421 441 .
Ping-Pin Zheng, Jin Li & Johan M Kros. (2018) Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights. Medicinal Research Reviews 38:1, pages 325-376.
Crossref
Michael Waters & Claude HughesMichael D. Waters. 2017. Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer. Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer 61 110 .
J.M. Zaldívar Comenges, E. Joossens, J.V. Sala Benito, A. Worth & A. Paini. (2017) Theoretical and mathematical foundation of the Virtual Cell Based Assay – A review. Toxicology in Vitro 45, pages 209-221.
Crossref
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian & Yajun Zhao. (2017) Spermine and spermidine reversed age-related cardiac deterioration in rats. Oncotarget 8:39, pages 64793-64808.
Crossref
Xuedong Wang, Yan Ma, Jinfeng Liu, Xiaohan Yin, Zhiheng Zhang, Caihong Wang, Yanyan Li & Huili Wang. (2017) Reproductive toxicity of β-diketone antibiotic mixtures to zebrafish ( Danio rerio ). Ecotoxicology and Environmental Safety 141, pages 160-170.
Crossref
Weijie Peng, Pallab Datta, Bugra Ayan, Veli Ozbolat, Donna Sosnoski & Ibrahim T. Ozbolat. (2017) 3D bioprinting for drug discovery and development in pharmaceutics. Acta Biomaterialia 57, pages 26-46.
Crossref
Jiansheng Li, Peng Zhao, Liping Yang, Ya Li, Yange Tian, Suyun Li & Yunping Bai. (2017) Integrating 3-omics data analyze rat lung tissue of COPD states and medical intervention by delineation of molecular and pathway alterations. Bioscience Reports 37:3.
Crossref
Enitome E. Bafor, Edward G. Rowan & RuAngelie Edrada-Ebel. (2017) Toward Understanding Myometrial Regulation: Metabolomic Investigation Reveals New Pathways of Oxytocin and Ritodrine Activity on the Myometrium. Reproductive Sciences 24:5, pages 691-705.
Crossref
Christoph Thiel, Henrik Cordes, Isabel Conde, José Vicente Castell, Lars Mathias Blank & Lars Kuepfer. (2016) Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients. Archives of Toxicology 91:2, pages 865-883.
Crossref
Peng Zhao, Jiansheng Li, Ya Li, Yange Tian, Liping Yang & Suyun Li. (2017) Integrating Transcriptomics, Proteomics, and Metabolomics Profiling with System Pharmacology for the Delineation of Long-Term Therapeutic Mechanisms of Bufei Jianpi Formula in Treating COPD. BioMed Research International 2017, pages 1-17.
Crossref
U. Christians, J. Klawitter, J. Klepacki & J. Klawitter. 2017. Biomarkers of Kidney Disease. Biomarkers of Kidney Disease 33 118 .
Huili Wang, Xiaohan Yin, Fanghui Li, Randy A. Dahlgren, Yuna Zhang, Hongqin Zhang & Xuedong Wang. (2016) Chronic toxicological effects of β-diketone antibiotics on Zebrafish ( D anio rerio ) using transcriptome profiling of deep sequencing . Environmental Toxicology 31:11, pages 1357-1371.
Crossref
Alessandro Allegra, Vanessa Innao, Demetrio Gerace, Oriana Bianco & Caterina Musolino. (2016) The metabolomic signature of hematologic malignancies. Leukemia Research 49, pages 22-35.
Crossref
Michael D. Waters. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 1 38 .
Yuna Zhang, Xuedong Wang, Xiaohan Yin, Mengru Shi, Randy Alan Dahlgren & Huili Wang. (2016) Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish ( D anio rerio ) . Environmental Toxicology 31:6, pages 736-750.
Crossref
Jiansheng Li, Peng Zhao, Liping Yang, Ya Li, Yange Tian & Suyun Li. (2016) System biology analysis of long-term effect and mechanism of Bufei Yishen on COPD revealed by system pharmacology and 3-omics profiling. Scientific Reports 6:1.
Crossref
Bas J. Blaauboer, Alan R. Boobis, Bobbie Bradford, Andrew Cockburn, Anne Constable, Mardas Daneshian, Gareth Edwards, Jossie A. Garthoff, Brett Jeffery, Cyrille Krul & Jeroen Schuermans. (2016) Considering new methodologies in strategies for safety assessment of foods and food ingredients. Food and Chemical Toxicology 91, pages 19-35.
Crossref
Weng-Keong Chan, Loh Tan, Kok-Gan Chan, Learn-Han Lee & Bey-Hing Goh. (2016) Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules 21:5, pages 529.
Crossref
Gopala Krishna & Gopa Gopalakrishnan. 2016. Nutraceuticals. Nutraceuticals 355 385 .
Isidro Cortés-Ciriano & Andreas Bender. (2016) How Consistent are Publicly Reported Cytotoxicity Data? Large-Scale Statistical Analysis of the Concordance of Public Independent Cytotoxicity Measurements. ChemMedChem 11:1, pages 57-71.
Crossref
Linda Rieswijk, Karen J. J. Brauers, Maarten L. J. Coonen, Simone G. J. van Breda, Danyel G. J. Jennen & Jos C. S. Kleinjans. (2015) Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes. Mutagenesis 30:6, pages 771-784.
Crossref
Yan-Hong Li, William Chi-Shing Tai, Jun-Yi Xue, Wing-Yan Wong, Cheng Lu, Jian-Qing Ruan, Na Li, Tai-Fung Wan, Wood-Yee Chan, Wen-Luan Wendy Hsiao & Ge Lin. (2015) Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats. Chemical Research in Toxicology 28:9, pages 1715-1727.
Crossref
Mehdi Mirsaeidi, Mohammad Mehdi Banoei, Brent W. Winston & Dean E. Schraufnagel. (2015) Metabolomics: Applications and Promise in Mycobacterial Disease. Annals of the American Thoracic Society 12:9, pages 1278-1287.
Crossref
Mengying Lv, Wanqiu Huang, Zhipeng Chen, Hulin Jiang, Jiaqing Chen, Yuan Tian, Zunjian Zhang & Fengguo Xu. (2015) Metabolomics techniques for nanotoxicity investigations. Bioanalysis 7:12, pages 1527-1544.
Crossref
Mark T. Mc Auley, Hyunok Choi, Kathleen Mooney, Emily Paul & Veronica M. Miller. (2015) Systems Biology and Synthetic Biology: A New Epoch for Toxicology Research. Advances in Toxicology 2015, pages 1-14.
Crossref
Nick J. Plant. (2015) An introduction to systems toxicology. Toxicology Research 4:1, pages 9-22.
Crossref
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen & Andreas Bender. (2015) Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects. MedChemComm 6:1, pages 24-50.
Crossref
Dragana Mitic Potkrajac, Branka Rakic, Gordana Apic & Robert B. Russell. 2015. Computational Systems Toxicology. Computational Systems Toxicology 95 108 .
Jie Zhang, Heqing Shen, Weipan Xu, Yankai Xia, Dana Boyd Barr, Xiaoli Mu, Xiaoxue Wang, Liangpo Liu, Qingyu Huang & Meiping Tian. (2014) Urinary Metabolomics Revealed Arsenic Internal Dose-Related Metabolic Alterations: A Proof-of-Concept Study in a Chinese Male Cohort. Environmental Science & Technology 48:20, pages 12265-12274.
Crossref
Ayako Shiraki, Fumiyo Saito, Hirotoshi Akane, Masahiro Takeyoshi, Nobuya Imatanaka, Megu Itahashi, Toshinori Yoshida & Makoto Shibutani. (2014) Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil. Toxicology Letters 228:3, pages 225-234.
Crossref
J D Zhang, N Berntenis, A Roth & M Ebeling. (2013) Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity. The Pharmacogenomics Journal 14:3, pages 208-216.
Crossref
Adrian Roth & Thomas Singer. (2014) The application of 3D cell models to support drug safety assessment: Opportunities & challenges. Advanced Drug Delivery Reviews 69-70, pages 179-189.
Crossref
Silvia Balbo, Robert J. Turesky & Peter W. Villalta. (2014) DNA Adductomics. Chemical Research in Toxicology 27:3, pages 356-366.
Crossref
Jean-de-Dieu Tamokou & Victor Kuete. 2014. Toxicological Survey of African Medicinal Plants. Toxicological Survey of African Medicinal Plants 277 322 .
Barae Jomaa. 2014. Toxicogenomics-Based Cellular Models. Toxicogenomics-Based Cellular Models 159 189 .
S.V. Vulimiri, B.R. Sonawane & D.T. Szabo. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 454 458 .
Ana Cauerhff, Yanina N. Martinez, German A. Islan & Guillermo R. Castro. 2014. Nanotoxicology. Nanotoxicology 57 95 .
Tien-Chueh Kuo, Tze-Feng Tian & Yufeng Jane Tseng. (2013) 3Omics: a web-based systems biology tool for analysis, integration and visualization of human transcriptomic, proteomic and metabolomic data. BMC Systems Biology 7:1.
Crossref
Mounir Bouhifd, Thomas Hartung, Helena T. Hogberg, Andre Kleensang & Liang Zhao. (2013) Review: Toxicometabolomics. Journal of Applied Toxicology 33:12, pages 1365-1383.
Crossref
Kalaimathi Murugesan, Sven Baumann, Dirk K. Wissenbach, Stefanie Kliemt, Stefan Kalkhof, Wolfgang Otto, Iljana Mögel, Tibor Kohajda, Martin von Bergen & Janina M. Tomm. (2013) Subtoxic and toxic concentrations of benzene and toluene induce Nrf2-mediated antioxidative stress response and affect the central carbon metabolism in lung epithelial cells A549. PROTEOMICS 13:21, pages 3211-3221.
Crossref
Hyobin Jeong, Sang Rho & Daehee Hwang. 2013. Kidney. Kidney 121 139 .
Peng WangZhen Chen. (2013) Traditional Chinese Medicine ZHENG and OMICS Convergence: A Systems Approach to Post-Genomics Medicine in a Global World. OMICS: A Journal of Integrative Biology 17:9, pages 451-459.
Crossref
Ariane Vettorazzi, Joost van Delft & Adela López de Cerain. (2013) A review on ochratoxin A transcriptomic studies. Food and Chemical Toxicology 59, pages 766-783.
Crossref
Jan van der Greef, Herman van Wietmarschen, Ben van Ommen & Elwin Verheij. (2013) Looking back into the future: 30 years of metabolomics at TNO. Mass Spectrometry Reviews 32:5, pages 399-415.
Crossref
Ewa Szalowska, Geert Stoopen, Jeroen C.W. Rijk, Si Wang, Peter J.M. Hendriksen, Maria J. Groot, Jan Ossenkoppele & Ad A.C.M. Peijnenburg. (2013) Effect of oxygen concentration and selected protocol factors on viability and gene expression of mouse liver slices. Toxicology in Vitro 27:5, pages 1513-1524.
Crossref
Anthony A. O’Kane, Olivier P. Chevallier, Stewart F. Graham, Christopher T. Elliott & Mark H. Mooney. (2013) Metabolomic Profiling of In Vivo Plasma Responses to Dioxin-Associated Dietary Contaminant Exposure in Rats: Implications for Identification of Sources of Animal and Human Exposure. Environmental Science & Technology 47:10, pages 5409-5418.
Crossref
Xiaoyan Lu, Tingting Jin, Yachao Jin, Leihong Wu, Bin Hu, Yu Tian & Xiaohui Fan. (2013) Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice. Nanotechnology 24:1, pages 015106.
Crossref
Hirotoshi Akane, Fumiyo Saito, Hidenori Yamanaka, Ayako Shiraki, Nobuya Imatanaka, Yumi Akahori, Reiko Morita, Kunitoshi Mitsumori & Makoto Shibutani. (2013) Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats. The Journal of Toxicological Sciences 38:3, pages 431-443.
Crossref
Goran Gajski, Marko Gerić, Višnja Oreščanin & Vera Garaj-Vrhovac. (2013) Cytogenetic status of healthy children assessed with the alkaline comet assay and the cytokinesis-block micronucleus cytome assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 750:1-2, pages 55-62.
Crossref
Uwe Christians, Volker Schmitz, Jost Klawitter & Jelena Klawitter. 2012. Analytical Techniques for Clinical Chemistry. Analytical Techniques for Clinical Chemistry 691 774 .
Moustapha Ouedraogo, Thomas Baudoux, Caroline Stévigny, Joëlle Nortier, Jean-Marie Colet, Thomas Efferth, Fan Qu, Jue Zhou, Kelvin Chan, Debbie Shaw, Olavi Pelkonen & Pierre Duez. (2012) Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms. Journal of Ethnopharmacology 140:3, pages 492-512.
Crossref
Aurel CamiAlana ArnoldShannon ManziBen Reis. (2011) Predicting Adverse Drug Events Using Pharmacological Network Models. Science Translational Medicine 3:114.
Crossref
Tessa E. Pronk, Jochem W. van der Veen, Janine Ezendam, Henk Van Loveren & Jeroen L.A. Pennings. (2011) Effects of pooling RNA from samples treated with different compounds for determining class specific biomarkers and processes in toxicogenomics. Toxicology in Vitro 25:8, pages 1841-1847.
Crossref
Jianshe Wang, Jun Jiang, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng & Jiayin Dai. (2011) Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes. Molecular & Cellular Proteomics 10:9, pages M111.008748.
Crossref
Kimberly J. Ralston‐Hooper, Jiri Adamec, Amber Jannash, Robert Mollenhauer, Hugo Ochoa‐Acuña & Maria S. Sepúlveda. (2010) Use of GC × GC/TOF‐MS and LC/TOF‐MS for metabolomic analysis of Hyalella azteca chronically exposed to atrazine and its primary metabolite, desethylatrazine . Journal of Applied Toxicology 31:5, pages 399-410.
Crossref
Suryanarayana V. Vulimiri, Alvin Berger & Babasaheb Sonawane. (2011) The potential of metabolomic approaches for investigating mode(s) of action of xenobiotics: Case study with carbon tetrachloride. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 722:2, pages 147-153.
Crossref
Hai-bin Chen & He-qing Huang. (2011) Proteomic analysis of methyl parathion-responsive proteins in Sparus latus liver. Fish & Shellfish Immunology 30:3, pages 800-806.
Crossref
António Marques, Helena Maria Lourenço, Maria Leonor Nunes, Cristina Roseiro, Carlos Santos, Alejandro Barranco, Sandra Rainieri, Tomaž Langerholc & Avrelija Cencic. (2011) New tools to assess toxicity, bioaccessibility and uptake of chemical contaminants in meat and seafood. Food Research International 44:2, pages 510-522.
Crossref
Fernando García-Alcalde, Federico García-López, Joaquín Dopazo & Ana Conesa. (2011) Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data. Bioinformatics 27:1, pages 137-139.
Crossref
Uwe Christians, Jeska Albuisson, Jost Klawitter & Jelena Klawitter. 2011. Biomarkers of Kidney Disease. Biomarkers of Kidney Disease 39 100 .
Balam Muñoz & Arnulfo Albores. (2010) The Role of Molecular Biology in the Biomonitoring of Human Exposure to Chemicals. International Journal of Molecular Sciences 11:11, pages 4511-4525.
Crossref
Jonathan BarrMercedes Vázquez-ChantadaCristina AlonsoMiriam Pérez-CormenzanaRebeca MayoAsier GalánJuan CaballeríaAntonio Martín-DuceAlbert TranConrad WagnerZigmund LukaShelly C. LuAzucena CastroYannick Le Marchand-BrustelM. Luz Martínez-ChantarNicolas VeyrieKarine ClémentJoan TordjmanPhilippe GualJosé M. Mato. (2010) Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease. Journal of Proteome Research 9:9, pages 4501-4512.
Crossref
William J. Griffiths, Therese Koal, Yuqin Wang, Matthias Kohl, David P. Enot & Hans‐Peter Deigner. (2010) Targeted Metabolomics for Biomarker Discovery. Angewandte Chemie International Edition 49:32, pages 5426-5445.
Crossref
William J. Griffiths, Therese Koal, Yuqin Wang, Matthias Kohl, David P. Enot & Hans‐Peter Deigner. (2010) “Targeted Metabolomics” in der Biomarkerforschung. Angewandte Chemie 122:32, pages 5554-5575.
Crossref
Peter L. Bullock. 2010. Early Drug Development. Early Drug Development 89 130 .
Yuxia Cui & Richard S Paules. (2010) Use of transcriptomics in understanding mechanisms of drug-induced toxicity. Pharmacogenomics 11:4, pages 573-585.
Crossref
Jin Zhou, Zhong-Hua Cai, Lei Li, Yun-Feng Gao & Thomas H. Hutchinson. (2010) A proteomics based approach to assessing the toxicity of bisphenol A and diallyl phthalate to the abalone (Haliotis diversicolor supertexta). Chemosphere 79:5, pages 595-604.
Crossref
Ben C. Collins, Alexandra Sposny, Diane McCarthy, Arnd Brandenburg, Ronald Woodbury, Stephen R. Pennington, Jean-Charles Gautier, Phillip Hewitt & William M. Gallagher. (2010) Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: A multi-site, multi-compound study. PROTEOMICS 10:8, pages 1592-1608.
Crossref
Shayne Cox GadMary Jane Cunningham & Mrinal Shah. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Marco F. L. Lemos, Amadeu M. V. M. Soares, António C. Correia & Ana C. Esteves. (2010) Proteins in ecotoxicology - How, why and why not?. PROTEOMICS 10:4, pages 873-887.
Crossref
Shuzhao Li, Alexander Pozhitkov, Rachel A Ryan, Charles S Manning, Nancy Brown-Peterson & Marius Brouwer. (2010) Constructing a fish metabolic network model. Genome Biology 11:11, pages R115.
Crossref
M. Leonor Cancela, Luca Bargelloni, Pierre Boudry, Viviane Boulo, Jorge Dias, Arnaud Huvet, Vincent Laizé, Sylvie Lapègue, Ricardo Leite, Sara Mira, Einar E. Nielsen, Josep V. Planas, Nerea Roher, Elena Sarropoulou & Filip A.M. Volckaert. 2010. Introduction to Marine Genomics. Introduction to Marine Genomics 213 286 .
Bensu Karahalil. 2009. Advances in Food Biochemistry. Advances in Food Biochemistry 477 496 .
Michael D. Waters & B. Alex Merrick. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Lixin Yang, Nga Yu Ho, Rüdiger Alshut, Jessica Legradi, Carsten Weiss, Markus Reischl, Ralf Mikut, Urban Liebel, Ferenc Müller & Uwe Strähle. (2009) Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive Toxicology 28:2, pages 245-253.
Crossref
Alexandra Kroll, Mike H. Pillukat, Daniela Hahn & Jürgen Schnekenburger. (2009) Current in vitro methods in nanoparticle risk assessment: Limitations and challenges. European Journal of Pharmaceutics and Biopharmaceutics 72:2, pages 370-377.
Crossref
Annick Lesne & Arndt Benecke. (2008) Probability landscapes for integrative genomics. Theoretical Biology and Medical Modelling 5:1.
Crossref
Jacob G Bundy, Jasmin K Sidhu, Faisal Rana, David J Spurgeon, Claus Svendsen, Jodie F Wren, Stephen R Stürzenbaum, A John Morgan & Peter Kille. (2008) 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus. BMC Biology 6:1.
Crossref
Sabine ClassenAndrea Staratschek-JoxJoachim L Schultze. (2008) Use of genome-wide high-throughput technologies in biomarker development. Biomarkers in Medicine 2:5, pages 509-524.
Crossref
Pim W.J. de Waard, Ad A.C.M. Peijnenburg, Hakan Baykus, Jac M.M.J.G. Aarts, Ron L.A.P. Hoogenboom, Frederik J. van Schooten & Theo M.C.M. de Kok. (2008) A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. Chemico-Biological Interactions 176:1, pages 19-29.
Crossref
Mark P. Kühnel, Bojana Cosovic, Goran Medic, Robert B. Russell & Gordana Apic. 2008. Pathway Analysis for Drug Discovery. Pathway Analysis for Drug Discovery 195 217 .
Alberto Mantovani, Francesca Maranghi, Cinzia La Rocca, Gian Mario Tiboni & Maurizio Clementi. (2008) The role of toxicology to characterize biomarkers for agrochemicals with potential endocrine activities. Reproductive Toxicology 26:1, pages 1-7.
Crossref
Jacob T Bjerrum, Ole H Nielsen, Yulan L Wang & Jørgen Olsen. (2008) Technology Insight: metabonomics in gastroenterology—basic principles and potential clinical applications. Nature Clinical Practice Gastroenterology & Hepatology 5:6, pages 332-343.
Crossref
Kimberly Ralston-Hooper, Amber Hopf, Cheolhwan Oh, Xiang Zhang, Jiri Adamec & Maria S. Sepúlveda. (2008) Development of GCxGC/TOF-MS metabolomics for use in ecotoxicological studies with invertebrates. Aquatic Toxicology 88:1, pages 48-52.
Crossref
Aram Adourian, Ezra Jennings, Raji Balasubramanian, Wade M. Hines, Doris Damian, Thomas N. Plasterer, Clary B. Clish, Paul Stroobant, Robert McBurney, Elwin R. Verheij, Ivana Bobeldijk, Jan van der Greef, Johan Lindberg, Kerstin Kenne, Ulf Andersson, Heike Hellmold, Kerstin Nilsson, Hugh Salter & Ina Schuppe-Koistinen. (2008) Correlation network analysis for data integration and biomarker selection. Molecular BioSystems 4:3, pages 249.
Crossref
Richard D. Handy. 2008. Comparative Toxicogenomics. Comparative Toxicogenomics 249 281 .
Grazia Saturno, Manuela Pesenti, Cristiano Cavazzoli, Anna Rossi, Anna M. Giusti, Berthold Gierke, Michael Pawlak & Miro Venturi. (2016) Expression of Serine/Threonine Protein-Kinases and Related Factors in Normal Monkey and Human Retinas: The Mechanistic Understanding of a CDK2 Inhibitor Induced Retinal Toxicity. Toxicologic Pathology 35:7, pages 972-983.
Crossref
Jeffrey A. Kramer, John E. Sagartz & Dale L. Morris. (2007) The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery 6:8, pages 636-649.
Crossref
Tiphaine Monsinjon & Thomas Knigge. (2007) Proteomic applications in ecotoxicology. PROTEOMICS 7:16, pages 2997-3009.
Crossref
Jing-Xian Zhang, Wei-Juan Huang, Jing-Hua Zeng, Wen-Hui Huang, Yi Wang, Rui Zhao, Bu-Cong Han, Qing-Feng Liu, Yu-Zong Chen & Zhi-Liang Ji. (2007) DITOP: drug-induced toxicity related protein database. Bioinformatics 23:13, pages 1710-1712.
Crossref
Louise Brown & Frans van der Ouderaa. (2007) Nutritional genomics: food industry applications from farm to fork. British Journal of Nutrition 97:6, pages 1027-1035.
Crossref
Saghir Akhtar & Ibrahim Benter. (2007) Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity. Advanced Drug Delivery Reviews 59:2-3, pages 164-182.
Crossref
Mark A. Ator, John P. Mallamo & Michael Williams. (2006) Overview of Drug Discovery and Development. Current Protocols in Pharmacology 35:1.
Crossref
Olga Teufelhofer, Wolfram Parzefall, Leonilla Elbling, Eveline Kainzbauer, Bettina Grasl‐Kraupp, Christoph Zielinski, Rolf Schulte‐Hermann & Christopher Gerner. (2006) Divide and conquer: Rat liver tissue proteomics based on the analysis of purified constituents. ELECTROPHORESIS 27:20, pages 4112-4120.
Crossref
Pilar Prieto, Alan W. Baird, Bas J. Blaauboer, Jose Vicente Castell Ripoll, Raffaella Corvi, Wolfgang Dekant, Paul Dietl, Alessandra Gennari, Laura Gribaldo, Julian L. Griffin, Thomas Hartung, Jerry J. Heindel, Peter Hoet, Paul Jennings, Luciana Marocchio, Jens Noraberg, Patricia Pazos, Carl Westmoreland, Armin Wolf, Jayne Wright & Walter Pfaller. (2019) The Assessment of Repeated Dose Toxicity In Vitro : A Proposed Approach . Alternatives to Laboratory Animals 34:3, pages 315-341.
Crossref
Gabriela Gebrin Cezar. (2006) Embryonic Stem Cells. International Journal of Pharmaceutical Medicine 20:2, pages 107-114.
Crossref
M. Drent & J.A. Jacobs. 2006. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 275 284 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.