484
Views
29
CrossRef citations to date
0
Altmetric
Review

Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays

, &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Andreas Thomas, Wilhelm Schänzer & Mario Thevis. (2017) Immunoaffinity techniques coupled to mass spectrometry for the analysis of human peptide hormones: advances and applications. Expert Review of Proteomics 14:9, pages 799-807.
Read now
Boris Y. Zaslavsky, Vladimir N. Uversky & Arnon Chait. (2016) Solvent interaction analysis as a proteomic approach to structure-based biomarker discovery and clinical diagnostics. Expert Review of Proteomics 13:1, pages 9-17.
Read now

Articles from other publishers (27)

Bas Sleumer, Jordan Zwerwer, Martijn van Faassen, Michel J. Vos, Rainer Bischoff, Ido P. Kema & Nico C. van de Merbel. (2023) An antibody-free LC-MS/MS method for the quantification of sex hormone binding globulin in human serum and plasma. Clinical Chemistry and Laboratory Medicine (CCLM) 61:7, pages 1266-1274.
Crossref
Nico C van de Merbel, Oladapo Olaleye, Baubek Spanov & Rainer Bischoff. (2022) Large molecule bioanalysis by LC–MS: beyond simply quantifying. Bioanalysis 14:7, pages 397-400.
Crossref
Mohsin El Amrani, Laszlo Gerencser, Alwin D.R. Huitema, C. Erik Hack, Matthijs van Luin & Kim C.M. van der Elst. (2021) A generic sample preparation method for the multiplex analysis of seven therapeutic monoclonal antibodies in human plasma or serum with liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1655, pages 462489.
Crossref
Shiqi Dong, Aijie Zhang, Yuan Gu, Shuixiu Lu, Lingyan Teng, Rui Wang, Jianfeng Liu, Huirong Fan & Duanyun Si. (2020) Direct quantification of intact FIM in monkey plasma using a selective chromatography–tandem mass spectrometry method: Application in a pharmacokinetic study. Biomedical Chromatography 34:2.
Crossref
Qi Qiao, Freek G. Bouwman, Marleen A. van Baak, Johan Renes & Edwin C.M. Mariman. (2019) Glucose Restriction Plus Refeeding in Vitro Induce Changes of the Human Adipocyte Secretome with an Impact on Complement Factors and Cathepsins. International Journal of Molecular Sciences 20:16, pages 4055.
Crossref
Peter Bults, Baubek Spanov, Oladapo Olaleye, Nico C. van de Merbel & Rainer Bischoff. (2019) Intact protein bioanalysis by liquid chromatography – High-resolution mass spectrometry. Journal of Chromatography B 1110-1111, pages 155-167.
Crossref
Nico Merbel. 2019. Sample Preparation in LC‐MS Bioanalysis. Sample Preparation in LC‐MS Bioanalysis 304 318 .
Peter Bults, Marcel Meints, Anders Sonesson, Magnus Knutsson, Rainer Bischoff & Nico C van de Merbel. (2018) Improving selectivity and sensitivity of protein quantitation by LC–HR–MS/MS: determination of somatropin in rat plasma. Bioanalysis 10:13, pages 1009-1021.
Crossref
Sonya VanPatten & Yousef Al-Abed. (2017) High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target. Journal of Medicinal Chemistry 61:12, pages 5093-5107.
Crossref
Kenichiro Todoroki, Tomohiro Yamada, Hajime Mizuno & Toshimasa Toyo'oka. (2018) Current Mass Spectrometric Tools for the Bioanalyses of Therapeutic Monoclonal Antibodies and Antibody-Drug Conjugates. Analytical Sciences 34:4, pages 397-406.
Crossref
Coşkun Güzel, Natalia I. Govorukhina, Christoph Stingl, Lennard J. M. Dekker, Alexander Boichenko, Ate G. J. van der Zee, Rainer P.H. Bischoff & Theo M. Luider. (2018) Comparison of Targeted Mass Spectrometry Techniques with an Immunoassay: A Case Study for HSP90α. PROTEOMICS - Clinical Applications 12:1, pages 1700107.
Crossref
Huai-Hsuan Chiu, I-Lin Tsai, Yen-Shen Lu, Ching-Hung Lin & Ching-Hua Kuo. (2017) Development of an LC-MS/MS method with protein G purification strategy for quantifying bevacizumab in human plasma. Analytical and Bioanalytical Chemistry 409:28, pages 6583-6593.
Crossref
Miao Qu, Bo An, Shichen Shen, Ming Zhang, Xiaomeng Shen, Xiaotao Duan, Joseph P. Balthasar & Jun Qu. (2017) Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry. Mass Spectrometry Reviews 36:6, pages 734-754.
Crossref
QingQing Wang, Lili Guo & Ian A. Blair. 2017. Targeted Biomarker Quantitation by LC–MS. Targeted Biomarker Quantitation by LC–MS 65 78 .
Michael T. Furlong. 2017. Protein Analysis using Mass Spectrometry. Protein Analysis using Mass Spectrometry 161 181 .
Kevin Buckley & Alan G. Ryder. (2017) Applications of Raman Spectroscopy in Biopharmaceutical Manufacturing: A Short Review. Applied Spectroscopy 71:6, pages 1085-1116.
Crossref
Jean-Francois Jourdil, Dorothée Lebert, Elodie Gautier-Veyret, Florian Lemaitre, Bruno Bonaz, Guillaume Picard, Julia Tonini & Françoise Stanke-Labesque. (2016) Infliximab quantitation in human plasma by liquid chromatography-tandem mass spectrometry: towards a standardization of the methods?. Analytical and Bioanalytical Chemistry 409:5, pages 1195-1205.
Crossref
Stefan K.G. Grebe & Ravinder J. Singh. (2016) Clinical peptide and protein quantification by mass spectrometry (MS). TrAC Trends in Analytical Chemistry 84, pages 131-143.
Crossref
Christian Lanshoeft, Thierry Wolf, Markus Walles, Samuel Barteau, Franck Picard, Olivier Kretz, Sarah Cianférani & Olivier Heudi. (2016) The flexibility of a generic LC–MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies. Journal of Pharmaceutical and Biomedical Analysis 131, pages 214-222.
Crossref
Yannick Van Wanseele, An De Prins, Dimitri De Bundel, Ilse Smolders & Ann Van Eeckhaut. (2016) Challenges for the in vivo quantification of brain neuropeptides using microdialysis sampling and LC–MS . Bioanalysis 8:18, pages 1965-1985.
Crossref
Thorsten Verch, Christopher Roselle & Mary Shank-Retzlaff. (2016) Reduction of dilution error in ELISAs using an internal standard. Bioanalysis 8:14, pages 1451-1464.
Crossref
Daniel Wilffert, Angela Asselman, Riccardo Donzelli, Jos Hermans, Natalia Govorukhina, Wim J Quax, Nico C van de Merbel & Rainer Bischoff. (2016) Highly sensitive antibody-free μLC–MS/MS quantification of rhTRAIL in serum. Bioanalysis 8:9, pages 881-890.
Crossref
Boris Y. Zaslavsky, Vladimir N. Uversky & Arnon Chait. (2016) Analytical applications of partitioning in aqueous two-phase systems: Exploring protein structural changes and protein–partner interactions in vitro and in vivo by solvent interaction analysis method. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:5, pages 622-644.
Crossref
Christian Lanshoeft, Olivier Heudi & Sarah Cianférani. (2016) SMART Digest™ compared with pellet digestion for analysis of human immunoglobulin G1 in rat serum by liquid chromatography tandem mass spectrometry. Analytical Biochemistry 501, pages 23-25.
Crossref
Peter Bults, Rainer Bischoff, Hilde Bakker, Jourik A. Gietema & Nico C. van de Merbel. (2016) LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma . Analytical Chemistry 88:3, pages 1871-1877.
Crossref
Christian Lanshoeft, Thierry Wolf, Olivier Heudi, Sarah Cianférani, Samuel Barteau, Markus Walles, Franck Picard & Olivier Kretz. (2016) The use of generic surrogate peptides for the quantitative analysis of human immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry. Analytical and Bioanalytical Chemistry 408:6, pages 1687-1699.
Crossref
Feng Zhou, Shu Liu, Junpeng Xing, Fengrui Song, Zhiqiang Liu & Shuying Liu. (2016) Thermal-assisted gasification injector for analyzing high-salt solution samples: a novel device developed for online coupling of liquid chromatography with direct analysis in real time mass spectrometry. RSC Advances 6:101, pages 98927-98934.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.