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Immunobiology of IL-37: mechanism of action and clinical perspectives

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Xiaonan Wei, Yulan Li, Guili Zhang, Na Wang, Miaomiao Mi, Yu Xin, Huihui Jiang & Chengming Sun. (2021) IL-37 Was Involved in Progress of Acute Myeloid Leukemia Through Regulating IL-6 Expression. Cancer Management and Research 13, pages 3393-3402.
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Helena Iznardo & Lluís Puig. (2021) The interleukin-1 family cytokines in psoriasis: pathogenetic role and therapeutic perspectives. Expert Review of Clinical Immunology 17:2, pages 187-199.
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Gamal Allam, Asmaa M. Gaber, Sarah I. Othman & Adel Abdel-Moneim. (2020) The potential role of interleukin-37 in infectious diseases. International Reviews of Immunology 39:1, pages 3-10.
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Articles from other publishers (42)

Min Gu, Yuexinzi Jin, Xun Gao, Wenying Xia, Ting Xu & Shiyang Pan. (2023) Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process. Frontiers in Immunology 14.
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Shashank Shekhar, Amit K. Yadav, Ajit Khosla & Pratima R. Solanki. (2022) Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection. ECS Sensors Plus 1:4, pages 041601.
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Adel Abdel-Moneim, Rania Mahmoud, Gamal Allam & Basant Mahmoud. (2022) Relationship between Cytokines and Metabolic Syndrome Components: Role of Pancreatic-Derived Factor, Interleukin-37, and Tumor Necrosis Factor-α in Metabolic Syndrome Patients. Indian Journal of Clinical Biochemistry.
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Cuiping Ren, Fengchun Liu, Chen Xing, Ruyu Zhao, Xiaoxue Tang, Miao Liu, Wenda Gao & Jijia Shen. (2022) IL-37 alleviates liver granuloma caused by Schistosoma japonicum infection by inducing alternative macrophage activation. Parasites & Vectors 15:1.
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Ya-fei Qin, Shao-hua Ren, Bo Shao, Hong Qin, Hong-da Wang, Guang-ming Li, Yang-lin Zhu, Cheng-lu Sun, Chuan Li, Jing-yi Zhang & Hao Wang. (2022) The intellectual base and research fronts of IL-37: A bibliometric review of the literature from WoSCC. Frontiers in Immunology 13.
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Huiqiong Zeng, Kaixia Zhou & Zhizhong Ye. (2022) Biology of interleukin‑37 and its role in autoimmune diseases (Review). Experimental and Therapeutic Medicine 24:2.
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Reza Ranjbar, Mohamad Ghasemian, Mahmood Maniati, Seyyed Hossein Khatami, Navid Jamali & Mortaza Taheri-Anganeh. (2022) Gastrointestinal disorder biomarkers. Clinica Chimica Acta 530, pages 13-26.
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Zainab A. Ali, Ahmed A. Mankhi & Ali H. Ad'hiah. (2022) Interleukin-37 gene polymorphism and susceptibility to pulmonary tuberculosis among Iraqi patients. Indian Journal of Tuberculosis 69:2, pages 191-200.
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Aeshah A. Ahmed & Ali H. Ad'hiah. (2022) Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients. Meta Gene 31, pages 100989.
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Aeshah A. Ahmed & Ali H. Ad'hiah. (2021) Interleukin-37 is down-regulated in serum of patients with severe coronavirus disease 2019 (COVID-19). Cytokine 148, pages 155702.
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Ruirui Zhu, Fangyuan Zhang, Chengliang Pan, Kunwu Yu, Yucheng Zhong & Qiutang Zeng. (2021) Role of IL-37- and IL-37-Treated Dendritic Cells in Acute Coronary Syndrome. Oxidative Medicine and Cellular Longevity 2021, pages 1-9.
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Xishuang Wang, Zengtao Wei, Zhongyun Tang, Chenyue Xue, Huayun Yu, Derui Zhang, Yulan Li, Xihong Liu, Yongyu Shi, Lining Zhang, Guoling Chen, Huaiyu Zhou, Jianing Wang & Xiaoyan Wang. (2021) IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway. Laboratory Investigation 101:6, pages 760-774.
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V. Kumar. (2020) Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets. International Immunopharmacology 89, pages 107087.
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Sebastian Wawrocki, Grzegorz Kielnierowski, Wieslawa Rudnicka, Michal Seweryn & Magdalena Druszczynska. (2020) Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis. Pathogens 9:6, pages 451.
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Jin-Xin Liu, Bo Liao, Qi-Hong Yu, Hai Wang, Yi-Bo Liu, Cui-Lian Guo, Zhi-Chao Wang, Zhi-Yong Li, Zhe-Zheng Wang, Jian-Wen Ruan, Li Pan, Yin Yao, Cai-Ling Chen, Heng Wang, Yuxia Liang, Guohua Zhen & Zheng Liu. (2020) The IL-37–Mex3B–Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology 145:1, pages 160-172.
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Eugenio Cavalli, Emanuela Mazzon, Maria Sofia Basile, Santa Mammana, Manuela Pennisi, Paolo Fagone, Reni Kalfin, Vanja Martinovic, Jovana Ivanovic, Marko Andabaka, Sarlota Mesaros, Tatjana Pekmezovic, Jelena Drulovic, Ferdinando Nicoletti & Maria Cristina Petralia. (2019) In Silico and In Vivo Analysis of IL37 in Multiple Sclerosis Reveals Its Probable Homeostatic Role on the Clinical Activity, Disability, and Treatment with Fingolimod. Molecules 25:1, pages 20.
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Mi So Kim, Ae Rin Baek, June Hyuk Lee, An Soo Jang, Do Jin Kim, Su Sie Chin & Sung Woo Park. (2019) IL-37 Attenuates Lung Fibrosis by Inducing Autophagy and Regulating TGF-β1 Production in Mice. The Journal of Immunology 203:8, pages 2265-2275.
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Elham Mahabadi-Ashtiyani, Vida Sheikh, Shiva Borzouei, Iraj Salehi & Mahdi Alahgholi-Hajibehzad. (2019) The increased T helper cells proliferation and inflammatory responses in patients with type 2 diabetes mellitus is suppressed by sitagliptin and vitamin D3 in vitro. Inflammation Research 68:10, pages 857-866.
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Ziyi Yang, Lin Kang, Yan Wang, Jiaqing Xiang, Qianying Wu, Cong Xu, Yanqing Zhou, Shaoyuan Chen, Hongcheng Fang, Jie Liu & Ming Dong. (2019) Role of IL-37 in Cardiovascular Disease Inflammation. Canadian Journal of Cardiology 35:7, pages 923-930.
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Erin Fahey & Sarah L. Doyle. (2019) IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis. Frontiers in Immunology 10.
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Rachel Freire, Laura Ingano, Gloria Serena, Murat Cetinbas, Anthony Anselmo, Anna Sapone, Ruslan I. Sadreyev, Alessio Fasano & Stefania Senger. (2019) Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease. Scientific Reports 9:1.
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Shenpeng R. Zhang, Marcel F. Nold, Sung-Chun Tang, Christine B. Bui, Claudia A. Nold, Thiruma V. Arumugam, Grant R. Drummond, Christopher G. Sobey & Hyun Ah Kim. (2019) IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice. Scientific Reports 9:1.
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Ruohui Tang, Jin Yi, Jing Yang, Yueqi Chen, Wei Luo, Shiwu Dong & Jun Fei. (2018) Interleukin‐37 inhibits osteoclastogenesis and alleviates inflammatory bone destruction. Journal of Cellular Physiology 234:5, pages 7645-7658.
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Vinicius L. Ferreira, Helena H.L. Borba, Aline de F. Bonetti, Leticia P. Leonart & Roberto Pontarolo. 2019. Autoantibodies and Cytokines. Autoantibodies and Cytokines.
Pio Conti, Gianpaolo Ronconi, Spyridon K. Kritas, Alessandro Caraffa & Theoharis C. Theoharides. (2018) Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: Interleukin-37 Could Be Beneficial. Canadian Journal of Diabetes 42:5, pages 568-573.
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Gamal Allam, Adel Abdel-Moneim & Asmaa M. Gaber. (2018) The pleiotropic role of interleukin-17 in atherosclerosis. Biomedicine & Pharmacotherapy 106, pages 1412-1418.
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A.E. Alagbe, A.S. Justo Junior, L.P. Ruas, W.V. Tonassé, R.M. Santana, T.H.C. Batista, I.F. Domingos, A.S. Araujo, M.A.C. Bezerra, M.N.N. Santos & M.H.S.L. Blotta. (2018) Interleukin-27 and interleukin-37 are elevated in sickle cell anemia patients and inhibit in vitro secretion of interleukin-8 in neutrophils and monocytes. Cytokine 107, pages 85-92.
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Jorge Rodrigues de Sousa, Renata Lima Prudente, Leonidas Braga Dias Junior, Francisca Regina Oliveira Carneiro, Mirian Nacagami Sotto & Juarez Antonio Simões Quaresma. (2018) IL-37 and leprosy: A novel cytokine involved in the host response to Mycobacterium leprae infection. Cytokine 106, pages 89-94.
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Ramatu Bello, Voon Chin, Mohammad Abd Rachman Isnadi, Roslaini Abd Majid, Maizaton Atmadini Abdullah, Tze Lee, Zainul Amiruddin Zakaria, Mohd Hussain & Rusliza Basir. (2018) The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis. International Journal of Molecular Sciences 19:4, pages 1149.
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Y Li, M Zhao, C Guo, H Chu, W Li, X Chen, X Wang, Y Li, Y Jia, S Koussatidjoa, F Zhu, J Wang, X Wang, Q Wang, W Zhao, Y Shi, W Chen & L Zhang. (2017) Intracellular mature IL-37 suppresses tumor metastasis via inhibiting Rac1 activation. Oncogene 37:8, pages 1095-1106.
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R.A. Prell & J.M. Tarrant. 2018. Comprehensive Toxicology. Comprehensive Toxicology 428 466 .
Lina Zhang, Jie Zhang & Peng Gao. (2017) The potential of interleukin-37 as an effective therapeutic agent in asthma. Respiratory Research 18:1.
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Jingjing Yan, Yuling Zhang, Shimeng Cheng, Bin Kang, Jinbiao Peng, Xiaodan Zhang, Meichun Yuan, Wenqi Chu, Wen Zhang, Jiayin Shen & Shuye Zhang. (2016) Common genetic heterogeneity of human interleukin-37 leads to functional variance. Cellular & Molecular Immunology 14:9, pages 783-791.
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Vivi A. Ding, Ziwen Zhu, Alyse A. Mantz, Huaping Xiao, Mark R. Wakefield, Qian Bai & Yujiang Fang. (2016) The Role of IL-37 in Non-Cancerous Diseases. Pathology & Oncology Research 23:3, pages 463-470.
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Kun Liu, Qiang Tang, Xinyuan Zhu & Xinchun Yang. (2017) IL-37 increased in patients with acute coronary syndrome and associated with a worse clinical outcome after ST-segment elevation acute myocardial infarction. Clinica Chimica Acta 468, pages 140-144.
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Ayoub Abulkhir, Suzanne Samarani, Devendra Amre, Michel Duval, Elie Haddad, Daniel Sinnett, Jean-Marie Leclerc, Caroline Diorio & Ali Ahmad. (2017) A protective role of IL-37 in cancer: a new hope for cancer patients. Journal of Leukocyte Biology 101:2, pages 395-406.
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Vivi A. Ding, Ziwen Zhu, Huaping Xiao, Mark R. Wakefield, Qian Bai & Yujiang Fang. (2016) The role of IL-37 in cancer. Medical Oncology 33:7.
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L. A. Borthwick. (2016) The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Seminars in Immunopathology 38:4, pages 517-534.
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Marina Coll-MiróIsaac Francos-QuijornaEva Santos-NogueiraAbel Torres-EspinPhilip BuflerCharles A. Dinarello & Rubèn López-Vales. (2016) Beneficial effects of IL-37 after spinal cord injury in mice. Proceedings of the National Academy of Sciences 113:5, pages 1411-1416.
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Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda & Jesús K. Yamamoto-Furusho. (2015) Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease. Cytokine 75:2, pages 389-402.
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Xu Shuai, Li Wei-min, Ya-lin Tong, Ning Dong, Zhi-yong Sheng & Yong-ming Yao. (2015) Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells. Scientific Reports 5:1.
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Gabriela Fonseca-Camarillo & Jesús K. Yamamoto-Furusho. (2015) Immunoregulatory Pathways Involved in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 21:9, pages 2188-2193.
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