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Review

Decitabine: a promising epi-immunotherapeutic agent in solid tumors

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Pages 363-375 | Published online: 12 Jan 2015

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Lucia Lisi, Marta Chiavari, Gabriella Maria Pia Ciotti, Pedro M. Lacal, Pierluigi Navarra & Grazia Graziani. (2020) DNA inhibitors for the treatment of brain tumors. Expert Opinion on Drug Metabolism & Toxicology 16:3, pages 195-207.
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Abdallah Abou Zahr, Ehab Saad Aldin, Lisa Barbarotta, Nikolai Podoltsev & Amer M Zeidan. (2015) The clinical use of DNA methyltransferase inhibitors in myelodysplastic syndromes. Expert Review of Anticancer Therapy 15:9, pages 1019-1036.
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Yu-Hsin Chu, Yi-Chen Huang, Pei-Yun Chiu, Wen-Hung Kuo, Yan-Ru Pan, Yuan-Ting Kuo, Rong-Hsuan Wang, Yu-Chin Kao, Yi-Hsiang Wang, Yi-Fan Lin & Kai-Ti Lin. (2023) Combating breast cancer progression through combination therapy with hypomethylating agent and glucocorticoid. iScience 26:5, pages 106597.
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Joana Alpoim-Moreira, Anna Szóstek-Mioduchowska, Magda Słyszewska, Maria Rosa Rebordão, Dariusz J. Skarzynski & Graça Ferreira-Dias. (2023) 5-Aza-2′-Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III Expression in TGF-β1-Treated Equine Endometrial Fibroblasts. Animals 13:7, pages 1212.
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Ganjun Yu, Wenying Wang, Xiaobo He, Jia Xu, Rongrong Xu, Tao Wan & Yanfeng Wu. (2022) Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability. Frontiers in Oncology 12.
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Amr El-Sayed, Lotfi Aleya & Mohamed Kamel. (2021) Microbiota and epigenetics: promising therapeutic approaches?. Environmental Science and Pollution Research 28:36, pages 49343-49361.
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Thoria Donia, Sherien Khedr, Elsayed I. Salim & Mohamed Hessien. (2021) Trichostatin A sensitizes hepatoma cells to Taxol more than 5-Aza-dC and dexamethasone. Drug Metabolism and Personalized Therapy 0:0.
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Xiang Li, Liang Dong, Jiejie Liu, Chunmeng Wang, Yan Zhang, Qian Mei, Weidong Han, Ping Xie & Jing Nie. (2021) Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ+ CD4+ T Cells Through Enhancing IκBα Degradation and NF-κB Activation. Frontiers in Cell and Developmental Biology 9.
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Kah Keng Wong. (2020) DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications. Cellular Oncology 43:5, pages 779-792.
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Xiaojuan Shi, Xinfeng Chen, Baijun Fang, Yu Ping, Guohui Qin, Dongli Yue, Feng Li, Shengli Yang & Yi Zhang. (2019) Decitabine enhances tumor recognition by T cells through upregulating the MAGE-A3 expression in esophageal carcinoma. Biomedicine & Pharmacotherapy 112, pages 108632.
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Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák & Marián Hajdúch. (2018) Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs. Stem Cells International 2018, pages 1-11.
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Zhong‑Tian Bai, Bing Bai, Jun Zhu, Cui‑Xia Di, Xun Li & Wen‑Ce Zhou. (2017) Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncology Letters.
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Jihao Zhou, Yushi Yao, Qi Shen, Guoqiang Li, Lina Hu & Xinyou Zhang. (2017) Demethylating agent decitabine disrupts tumor-induced immune tolerance by depleting myeloid-derived suppressor cells. Journal of Cancer Research and Clinical Oncology 143:8, pages 1371-1380.
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Michael KlutsteinJoshua Moss, Tommy Kaplan & Howard Cedar. (2017) Contribution of epigenetic mechanisms to variation in cancer risk among tissues. Proceedings of the National Academy of Sciences 114:9, pages 2230-2234.
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Valeria Lucarini, Carla Buccione, Giovanna Ziccheddu, Francesca Peschiaroli, Paola Sestili, Rossella Puglisi, Gianfranco Mattia, Cristiana Zanetti, Isabella Parolini, Laura Bracci, Iole Macchia, Alessandra Rossi, Maria Teresa D'Urso, Daniele Macchia, Massimo Spada, Adele De Ninno, Annamaria Gerardino, Pamela Mozetic, Marcella Trombetta, Alberto Rainer, Luca Businaro, Giovanna Schiavoni & Fabrizio Mattei. (2017) Combining Type I Interferons and 5-Aza-2′-Deoxycitidine to Improve Anti-Tumor Response against Melanoma. Journal of Investigative Dermatology 137:1, pages 159-169.
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Chunchao Zhang, Jinfeng Suo, Hiroyuki Katayama, Yue Wei, Guillermo Garcia-Manero & Samir Hanash. (2016) Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines. Clinical Proteomics 13:1.
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Ana Carolina Morandini, Carlos F. Santos & Özlem Yilmaz. (2016) Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling. Pathogens and Disease 74:7, pages ftw082.
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Lin Liu, Lin Chen, Xuan Wu, Xiang Li, Yang Song, Qian Mei, Jing Nie & Weidong Han. (2016) Low-dose DNA-demethylating agent enhances the chemosensitivity of cancer cells by targeting cancer stem cells via the upregulation of microRNA-497. Journal of Cancer Research and Clinical Oncology 142:7, pages 1431-1439.
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Jing Nie, Yan Zhang, Xiang Li, Meixia Chen, Chuanjie Liu & Weidong Han. (2016) DNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire. Oncotarget 7:25, pages 37882-37892.
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Lei Wang, Zohreh Amoozgar, Jing Huang, Mohammad H. Saleh, Deyin Xing, Sandra Orsulic & Michael S. Goldberg. (2015) Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model. Cancer Immunology Research 3:9, pages 1030-1041.
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