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Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: a review

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Richelle C. Waldner, Gregory M. T. Guilcher, Dania A. Monagel, Josephine Ho, Sunil Desai & Elizabeth T. Rosolowsky. (2023) Gonadal health in recipients of nonmyeloablative hematopoietic stem cell transplantation in children and adolescents with sickle cell disease. Pediatric Hematology and Oncology 40:7, pages 682-687.
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Djamila L. Ghafuri, Sarah-Jo Stimpson, Melissa E. Day, Andra James, Michael R. DeBaun & Deva Sharma. (2017) Fertility challenges for women with sickle cell disease. Expert Review of Hematology 10:10, pages 891-901.
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Patrick T McGann & Russell E Ware. (2015) Hydroxyurea therapy for sickle cell anemia. Expert Opinion on Drug Safety 14:11, pages 1749-1758.
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Gift D Pule, Shaheen Mowla, Nicolas Novitzky, Charles S Wiysonge & Ambroise Wonkam. (2015) A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease. Expert Review of Hematology 8:5, pages 669-679.
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Articles from other publishers (57)

Simone Cilio, Giuseppe Fallara, Maria Teresa Lupo Stanghellini, Fabio Ciceri, Francesco Montorsi, Francesca Lunghi & Andrea Salonia. (2024) Impact of Hydroxyurea to Treat Haematological Disorders on Male Fertility: Two Case Reports and a Systematic Review. The World Journal of Men's Health 42.
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Charis J. Stanek, Jenna Reich, Charleen I. Theroux, Susan E. Creary, Gwendolyn P. Quinn & Leena Nahata. (2023) Reproductive Health Counseling among Youth with Sickle Cell Disease. Journal of Pediatric and Adolescent Gynecology 36:4, pages 393-398.
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Aude Braye, Emily Delgouffe, Jutte van der Werff ten Bosch, Inge Gies, Alina Ferster & Ellen Goossens. (2023) Gonadal development and function after immature testicular tissue banking as part of high‐risk gonadotoxic treatment. Pediatric Blood & Cancer 70:8.
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Paul Lumbala Kabuyi, Gloire Mbayabo, Mamy Ngole, Aimé Lumaka Zola, Valerie Race, Gert Matthijs, Chris Van Geet, Prosper Lukusa Tshilobo, Koenraad Devriendt & Tite Minga Mikobi. (2023) Hydroxyurea treatment for adult sickle cell anemia patients in Kinshasa. eJHaem.
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Eleanor Stevenson, Paula Tanabe, Mitchell Knisely, Rita Masese, Dominique Bulgin, Liliana Preiss, Jane S. Hankins, Allison A. King, Victor Gordeuk & Nirmish Shah. (2023) Infertility and treatment‐seeking practices among females and males with sickle cell disease in the Sickle Cell Disease Implementation Consortium registry. Pediatric Blood & Cancer 70:7.
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Ieva Masliukaite, Elissavet Ntemou, Elizabeth A M Feijen, Marianne van de Wetering, Andreas Meissner, Alexandre T Soufan, Sjoerd Repping, Leontien M C Kremer, Kirsi Jahnukainen, Ellen Goossens & Ans M M van Pelt. (2023) Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort. Human Reproduction 38:3, pages 359-370.
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Neels Lennart Aden, Matthias Bleeke, Uwe R. Kordes, Bianka Brunne, Barbara Holstermann, Ronald Biemann, Uta Ceglarek, Armin Soave, Andrea Salzbrunn, Stefan W. Schneider & Kathrein von Kopylow. (2023) Germ Cell Maintenance and Sustained Testosterone and Precursor Hormone Production in Human Prepubertal Testis Organ Culture with Tissues from Boys 7 Years+ under Conditions from Adult Testicular Tissue. Cells 12:3, pages 415.
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NisaWidya Amanda, ItaMargaretha Nainggolan, Irmanida Batubara, Uus Saepuloh & HudaShalahudin Darusman. (2023) Fetal Hemoglobin Inducer Activity of Moringa oleifera, Curcuma aueruginosa Roxb., and Artocarpus altilis Based on the Gamma Globin Expression. Journal of Applied Hematology 14:1, pages 17.
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Gideon Sartorius & David J. Handelsman. 2023. Andrologie. Andrologie 525 567 .
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Lillian R. Meacham, Lydia H. Pecker, Beatrice Gee & Adrienne Mishkin. (2022) Incorporating gonadal health counseling into pediatric care of sickle cell patients. Hematology 2022:1, pages 442-449.
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Lydia H. Pecker & Kevin H.M. Kuo. (2022) Go the Distance. Hematology/Oncology Clinics of North America 36:6, pages 1255-1270.
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Pooja Parikh, Mohamed Mohamed, Taha Bat, Alecia Nero, Angeline Wang, Sean G. Yates & Rafael L. Ufret-Vincenty. (2022) Parafoveal acute middle maculopathy (PAMM) in sickle cell disease after discontinuation of hydroxyurea. American Journal of Ophthalmology Case Reports 28, pages 101753.
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Leonard B. Weinstock, Jill B. Brook & Gerhard J. Molderings. (2022) Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series. Naunyn-Schmiedeberg's Archives of Pharmacology 395:11, pages 1441-1447.
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Margaret T. Lee & Ugochi O. Ogu. (2022) Sickle cell disease in the new era: advances in drug treatment. Transfusion and Apheresis Science 61:5, pages 103555.
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Françoise Bernaudin, Cécile Arnaud, Annie Kamdem, Isabelle Hau, Fouad Madhi, Camille Jung, Ralph Epaud & Suzanne Verlhac. (2022) Incidence, kinetics, and risk factors for intra- and extracranial cerebral arteriopathies in a newborn sickle cell disease cohort early assessed by transcranial and cervical color Doppler ultrasound. Frontiers in Neurology 13.
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Elrazi A Ali, Mohammad Abu-Tineh, Waail Rozi, Bashir Ali, Anas Babiker, Yousef Hailan, Qusai Al-Maharmeh, Zakaria Maat, Abdellatif Ismail & Mohamed A Yassin. (2022) The Outcome of Fatherhood in Patients With Philadelphia-Negative Myeloproliferative Neoplasms: A Single-Institution Experience. Cureus.
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Oladeji John Alabi, Fikayo Noah Adegboyega, Dolapo Samuel Olawoyin & Oluwakemi Arinola Babatunde. (2022) Functional foods: promising therapeutics for Nigerian Children with sickle cell diseases. Heliyon 8:6, pages e09630.
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Emily Delgouffe, Aude Braye & Ellen Goossens. (2022) Testicular Tissue Banking for Fertility Preservation in Young Boys: Which Patients Should Be Included?. Frontiers in Endocrinology 13.
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Klara M. Benninghoven-Frey, Nina Neuhaus, Atte K. Lahtinen, Claudia Krallmann, Joana M.D. Portela, Andrea Jarisch, Verena Nordhoff, Armin Soave, Hajar A.M. Ba Omar, Mikael Sundin, Cecilia Langenskiöld, Sabine Kliesch, Jan-Bernd Stukenborg & Kirsi Jahnukainen. (2021) Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease. Haematologica 107:4, pages 975-979.
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Nirmani Yasara, Anuja Premawardhena & Sachith Mettananda. (2021) A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic. Orphanet Journal of Rare Diseases 16:1.
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Anderson Reis de Sousa, Adriana Castro de Jesus, Rúbia Cássia Souza de Andrade, Thallys Fabricio de Almeida Lopes, Coretta Melissa Jenerette, Evanilda Souza de Santana Carvalho & Álvaro Pereira. (2021) Ser homem com doença falciforme: discursos sobre adoecer e cuidar de si. Acta Paulista de Enfermagem 34.
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Mariane Montalembert, Ersi Voskaridou, Lena Oevermann, Giovanna Cannas, Anoosha Habibi, Gylna Loko, Laure Joseph, Raffaella Colombatti, Pablo Bartolucci, Valentine Brousse & Frédéric Galactéros. (2021) Real‐Life experience with hydroxyurea in patients with sickle cell disease: Results from the prospective ESCORT‐HU cohort study . American Journal of Hematology 96:10, pages 1223-1231.
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Lydia H. Pecker, Deva Sharma, Alecia Nero, Michael J. Paidas, Russell E. Ware, Andra H. James & Kim Smith‐Whitley. (2021) Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease. British Journal of Haematology 194:6, pages 970-979.
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Claudio Mussolino & John Strouboulis. (2021) Recent Approaches for Manipulating Globin Gene Expression in Treating Hemoglobinopathies. Frontiers in Genome Editing 3.
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Dito Anurogo, Nova Yuli Prasetyo Budi, Mai-Huong Thi Ngo, Yen-Hua Huang & Jeanne Adiwinata Pawitan. (2021) Cell and Gene Therapy for Anemia: Hematopoietic Stem Cells and Gene Editing. International Journal of Molecular Sciences 22:12, pages 6275.
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Maria Domenica Cappellini, Alessia Marcon, Bruno Fattizzo & Irene Motta. (2021) Innovative Treatments for Rare Anemias. HemaSphere 5:6, pages e576.
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L. JosephC. JeanS. ManceauC. ChalasC. Arnaud, A. KamdemC. PondarréA. HabibiF. BernaudinS. Allali, M. de Montalembert, B. Boutonnat-FaucherJ.-B. ArletB. KoehlM. Cavazzana, J.-A. Ribeil, F. LionnetI. Berthaut & V. Brousse. (2021) Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease. Blood 137:6, pages 826-829.
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Gideon Sartorius & David J. Handelsman. 2020. Andrologie. Andrologie 1 43 .
Swati V. Elchuri, Rebecca Williamson Lewis, Maa-Ohui Quarmyne, Ann E. Haight, Hanh N. Cottrell & Lillian R. Meacham. (2020) Longitudinal Description of Gonadal Function in Sickle-cell Patients Treated With Hematopoietic Stem Cell Transplant Using Alkylator-based Conditioning Regimens. Journal of Pediatric Hematology/Oncology 42:7, pages e575-e582.
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Adrienne D. Mishkin, Markus Y. Mapara, Michelle Barhaghi & Ran Reshef. (2020) Fertility Concerns and Access to Care for Stem Cell Transplantation Candidates with Sickle Cell Disease. Biology of Blood and Marrow Transplantation 26:8, pages e192-e197.
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Ibrahim M. Idris, Akib AbbaJamil A. GaladanciSharfuddeen A. MashiNafiu Hussaini, Sagir Ahmed GumelArthur L. Burnett & Michael R. DeBaun. (2020) Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease. Blood Advances 4:14, pages 3277-3283.
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Françoise Bernaudin. (2019) Why, Who, When, and How? Rationale for Considering Allogeneic Stem Cell Transplantation in Children with Sickle Cell Disease. Journal of Clinical Medicine 8:10, pages 1523.
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Alison Wakoff Loren & Suneeta Senapati. (2019) Fertility preservation in patients with hematologic malignancies and recipients of hematopoietic cell transplants. Blood 134:9, pages 746-760.
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