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Expert Review of Gastroenterology & Hepatology Volume 1, 2007 - Issue 1
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Review

Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis

Bin Gao Chief, Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S-33, Bethesda, MD 20892-8115, USA. [email protected]
,
Svetlana Radaeva Program Director, Extramural Program, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, 5635 Fishers Lane, Bethesda, MD 20892-8115, USA. [email protected]
&
Won-IL Jeong Postdoctoral Fellow, Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S-12, MSC 9413, Bethesda, MD 20892, USA. [email protected]
Pages 173-180 | Published online: 10 Jan 2014

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Yi Zhang, Jun Tang, Zhiqiang Tian, Jennifer C. van Velkinburgh, Jianxun Song, Yuzhang Wu & Bing Ni. (2016) Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases. International Reviews of Immunology 35:5, pages 399-414.
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Emanuele Albano. (2008) New concepts in the pathogenesis of alcoholic liver disease. Expert Review of Gastroenterology & Hepatology 2:6, pages 749-759.
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Articles from other publishers (47)

Kirstin O. Lowe, Constantin E. Tanase, Susan Maghami, Leanne E. Fisher & Amir M. Ghaemmaghami. (2023) Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically. Immuno 3:4, pages 375-408.
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V. V. Tsukanov, M. A. Cherepnin, A. A. Savchenko, A. V. Vasyutin, E. V. Kasparov, A. G. Borisov, V. D. Belenyuk & Ju. L. Tonkikh. (2023) Subpopulation composition of blood NK cells in patients with hepatitis C with genotype 1 or 3. Meditsinskiy sovet = Medical Council:18, pages 44-51.
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Lingqi Yu, Jun Yan, Yingqi Zhan, Anyao Li, Lidan Zhu, Jingyang Qian, Fanfan Zhou, Xiaoyan Lu & Xiaohui Fan. (2023) Single-cell RNA sequencing reveals the dynamics of hepatic non-parenchymal cells in autoprotection against acetaminophen-induced hepatotoxicity. Journal of Pharmaceutical Analysis 13:8, pages 926-941.
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Ho Rim Oh, Min Kyung Ko, Daehee Son, Young Wook Ki, Shin-Il Kim, Seok-Yong Lee, Keon Wook Kang, Gi Jeong Cheon, Do Won Hwang & Hyewon Youn. (2023) Activated Natural Killer Cell Inoculation Alleviates Fibrotic Liver Pathology in a Carbon Tetrachloride-Induced Liver Cirrhosis Mouse Model. Biomedicines 11:4, pages 1090.
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Yuan Wei, Wang Bingyu, Yang Lei & Yuan Xingxing. (2022) The antifibrotic role of natural killer cells in liver fibrosis. Experimental Biology and Medicine 247:14, pages 1235-1243.
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Yang Zhang, Yuan Wu, Wenjuan Shen, Bingyu Wang & Xingxing Yuan. (2022) Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Molecular Medicine Reports 25:6.
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Anita A. Pinar & Chrishan S. Samuel. (2022) Immune Mechanisms and Related Targets for the Treatment of Fibrosis in Various Organs. Current Molecular Medicine 22:3, pages 240-249.
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Yoseph Asmelash Gebru, Haripriya Gupta, Hyeong Seop Kim, Jung A. Eom, Goo Hyun Kwon, Eunju Park, Jin-Ju Jeong, Sung-Min Won, Satya Priya Sharma, Raja Ganesan, Dong Joon Kim & Ki Tae Suk. (2021) T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences 22:22, pages 12190.
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Isabel Legaz, Jose Miguel Bolarín, Elena Navarro, Jose Antonio Campillo, Rosa Moya, María Dolores Pérez-Cárceles, Aurelio Luna, Eduardo Osuna, Manuel Miras, Manuel Muro, Alfredo Minguela & Rocio Alvarez López. (2021) KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation. Archives of Medical Science 17:3, pages 764-774.
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Ling Wang, Yinghao Wang & Jun Quan. (2020) Exosomes derived from natural killer cells inhibit hepatic stellate cell activation and liver fibrosis. Human Cell 33:3, pages 582-589.
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Frank Fasbender, Martin Obholzer, Sarah Metzler, Regina Stöber, Jan G. Hengstler & Carsten Watzl. (2020) Enhanced activation of human NK cells by drug-exposed hepatocytes. Archives of Toxicology 94:2, pages 439-448.
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Fenglei Wu, Chi Sun & Jianquan Lu. 2020. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 1 24 .
İbrahim KÖKER & Belkıs ÜNSAL. (2019) Increased ascites natural killer cells in patients with chronic hepatitis B cirrhosis using lamivudine: A pilot studyKronik hepatit B’ye bağlı sirozda lamivudin kullanımı ile artan asit natural killer hücreleri: Pilot çalışma. Akademik Gastroenteroloji Dergisi 18:3, pages 80-86.
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Kritika Ramani & Partha S. Biswas. (2019) Interleukin-17: Friend or foe in organ fibrosis. Cytokine 120, pages 282-288.
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David Fernández-Ramos, Pablo Fernández-Tussy, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de-Juan, Nicolás Navasa, Lucía Barbier-Torres, Imanol Zubiete-Franco, Jorge Simón, Agustín F. Fernández, Ander Arbelaiz, Ana M. Aransay, José Luis Lavín, Naiara Beraza, María J. Perugorria, Jesus M. Banales, Erica Villa, Mario F. Fraga, Juan Anguita, Matias A. Avila, Carmen Berasain, Paula Iruzibieta, Javier Crespo, Shelly C. Lu, Marta Varela-Rey, José M. Mato, Teresa C. Delgado & María L. Martínez-Chantar. (2018) MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. Cell Death & Disease 9:10.
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Yue Shen, Jing Li, Si-Qi Wang & Wei Jiang. (2018) Ambiguous roles of innate lymphoid cells in chronic development of liver diseases. World Journal of Gastroenterology 24:18, pages 1962-1977.
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Steven Horsburgh, Stephen Todryk, Andreas Ramming, Jörg H.W. Distler & Steven O’Reilly. (2018) Innate lymphoid cells and fibrotic regulation. Immunology Letters 195, pages 38-44.
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Gyongyi Szabo, Banishree Saha & Aditya Ambade. 2018. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 66 76.e5 .
Ali Saeed, Mark Hoekstra, Martijn Oscar Hoeke, Janette Heegsma & Klaas Nico Faber. (2017) The interrelationship between bile acid and vitamin A homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862:5, pages 496-512.
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Jijing Shi, Juanjuan Zhao, Xin Zhang, Yongqian Cheng, Jinhua Hu, Yuanyuan Li, Xin Zhao, Qinghua Shang, Yanling Sun, Bo Tu, Lei Shi, Bin Gao, Fu-Sheng Wang & Zheng Zhang. (2017) Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients. Scientific Reports 7:1.
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Pia Svendsen, Jonas H. Graversen, Anders Etzerodt, Henrik Hager, Rasmus Røge, Henning Grønbæk, Erik I. Christensen, Holger J. Møller, Hendrik Vilstrup & Søren K. Moestrup. (2017) Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes. Molecular Therapy - Methods & Clinical Development 4, pages 50-61.
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SuFey Ong, Noel R Rose & Daniela Čiháková. (2017) Natural killer cells in inflammatory heart disease. Clinical Immunology 175, pages 26-33.
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Frank Fasbender, Agata Widera, Jan G. Hengstler & Carsten Watzl. (2016) Natural Killer Cells and Liver Fibrosis. Frontiers in Immunology 7.
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Prakash Baligar, Snehasish Mukherjee, Veena Kochat, Archana Rastogi & Asok Mukhopadhyay. (2016) Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of Bone Marrow CD45 Cells Over Mesenchymal Stem Cells in Liver Cirrhosis. Stem Cells 34:1, pages 135-147.
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Franziska Wolter, Andreas Glässner, Benjamin Krämer, Pavlos Kokordelis, Claudia Finnemann, Dominik J. Kaczmarek, Felix Goeser, Philipp Lutz, Hans Dieter Nischalke, Christian P. Strassburg, Ulrich Spengler & Jacob Nattermann. (2015) Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection. Journal of Hepatology 63:6, pages 1334-1344.
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Don C Rockey. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 2070 2086 .
Florent Duval, Jorge E. Moreno-Cuevas, María Teresa González-Garza, Carmen Maldonado-Bernal & Delia Elva Cruz-Vega. (2015) Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response. International Journal of Inflammation 2015, pages 1-14.
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Liying Hou, Haijin Zhang, Peixiang Xu, Lijia Zhang, Xuguang Zhang, Yanpei Sun, Xiaoli Huang & Kun Wu. (2015) Effect of vitamin E succinate on the expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor in gastric cancer cells and CD4 + T cells . Molecular BioSystems 11:11, pages 3119-3128.
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Gyongyi Szabo, Banishree Saha & Terence N. Bukong. 2015. Biological Basis of Alcohol-Induced Cancer. Biological Basis of Alcohol-Induced Cancer 197 216 .
Ziba Shabani, Masomeh Bagheri, Mohammad Zare-Bidaki, Gholamhossein Hassanshahi, Mohammad Kazemi Arababadi, Mozafar Mohammadi Nejad & Derek Kennedy. (2014) NK cells in hepatitis B virus infection: a potent target for immunotherapy. Archives of Virology 159:7, pages 1555-1565.
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Jessica Howell & Kumar Visvanathan. (2013) The Role of Natural Killer Cells in Hepatitis C Infection. Antiviral Therapy 18:7, pages 853-865.
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Andreas Glässner, Marianne Eisenhardt, Pavlos Kokordelis, Benjamin Krämer, Franziska Wolter, Hans Dieter Nischalke, Christoph Boesecke, Tilman Sauerbruch, Jürgen K. Rockstroh, Ulrich Spengler & Jacob Nattermann. (2013) Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients. Journal of Hepatology 59:3, pages 427-433.
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Bin Gao & Svetlana Radaeva. (2013) Natural killer and natural killer T cells in liver fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832:7, pages 1061-1069.
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Georg WickCecilia GrundtmanChristina MayerlThomas-Florian WimpissingerJohann Feichtinger, Bettina ZelgerRoswitha SgoncDolores Wolfram. (2013) The Immunology of Fibrosis. Annual Review of Immunology 31:1, pages 107-135.
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Hajime Tanaka, Patrick S. C. Leung, Tom P. Kenny, M. Eric Gershwin & Christopher L. Bowlus. (2012) Immunological Orchestration of Liver Fibrosis. Clinical Reviews in Allergy & Immunology 43:3, pages 220-229.
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Marianne Eisenhardt, Andreas Glässner, Benjamin Krämer, Christian Körner, Bernhard Sibbing, Pavlos Kokordelis, Hans Dieter Nischalke, Tilman Sauerbruch, Ulrich Spengler & Jacob Nattermann. (2012) The CXCR3(+)CD56Bright Phenotype Characterizes a Distinct NK Cell Subset with Anti-Fibrotic Potential That Shows Dys-Regulated Activity in Hepatitis C. PLoS ONE 7:7, pages e38846.
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Andreas Glässner, Marianne Eisenhardt, Benjamin Krämer, Christian Körner, Martin Coenen, Tilman Sauerbruch, Ulrich Spengler & Jacob Nattermann. (2012) NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. Laboratory Investigation 92:7, pages 967-977.
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Don C. Rockey & Scott L. Friedman. 2012. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 64 85 .
Edith Hintermann, Monika Bayer, Josef M. Pfeilschifter, Andrew D. Luster & Urs Christen. (2010) CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. Journal of Autoimmunity 35:4, pages 424-435.
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Emanuele Albano & Matteo Vidali. (2009) Immune mechanisms in alcoholic liver disease. Genes & Nutrition 5:2, pages 141-147.
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Jin-Kyu Park, Mi-Ran Ki, Hye-Rim Lee, Il-Hwa Hong, Ae-Ri Ji, Akihito Ishigami, Se-Il Park, Ji-Min Kim, Hae-Young Chung, Sung-Eun Yoo & Kyu-Shik Jeong. (2010) Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology 51:5, pages 1766-1777.
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Georg Wick, Aleksandar Backovic, Evelyn Rabensteiner, Nadine Plank, Christian Schwentner & Roswitha Sgonc. (2010) The immunology of fibrosis: innate and adaptive responses. Trends in Immunology 31:3, pages 110-119.
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Costica Aloman & Frank Tacke. (2010) Dendritic cells in liver fibrosis: conductor of the inflammatory orchestra?. Hepatology 51:3, pages 1070-1072.
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Emanuele Albano. 2009. Endogenous Toxins. Endogenous Toxins 449 483 .
Kyu-Shik Jeong. (2008) Therapeutic target for chronic liver fibrosis by regulation of transforming growth factor-beta. Basic and Applied Pathology 1:2, pages 56-60.
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Won‐Il Jeong & Bin Gao. (2008) Innate immunity and alcoholic liver fibrosis. Journal of Gastroenterology and Hepatology 23:s1.
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Bin Gao, Won-Il Jeong & Zhigang Tian. (2007) Liver: An organ with predominant innate immunity. Hepatology 47:2, pages 729-736.
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