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Editorials

Milk thistle to treat non-alcoholic fatty liver disease: dream or reality?

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Pages 677-679 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

A. Z. Mahmoud, H. A. Ibrahim, M. R. El-Sawi & M. N. Habza. (2020) Effects of silymarin and mesenchymal stem cells on hematological and some biochemical changes induced by gamma radiation in albino rats. International Journal of Radiation Biology 96:2, pages 220-227.
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Ludovico Abenavoli, Marta Greco, Immacolata Nazionale, Valentina Peta, Natasa Milic, Francesca Accattato, Daniela Foti, Elio Gulletta & Francesco Luzza. (2015) Effects of Mediterranean diet supplemented with silybin–vitamin E–phospholipid complex in overweight patients with non-alcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology 9:4, pages 519-527.
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Samir Rouabhia, Natasa Milic & Ludovico Abenavoli. (2014) Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism. Expert Review of Gastroenterology & Hepatology 8:4, pages 343-349.
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Articles from other publishers (21)

Aqsa Qurban, Hamid Khan, Fizza Ali, Saba Abbas, Syeda Amber Hameed & Nousheen Hussain. (2023) Determine the Curing Effects of Silybum marianum (milk thistle) Administered Orally to Non-Alcoholic Fatty Liver Disease (NAFLD) Patients for Six Months. Pakistan BioMedical Journal, pages 27-30.
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Oluyemi Komolafe, Elena Buzzetti, Audrey Linden, Lawrence MJ Best, Angela M Madden, Danielle Roberts, Thomas JG Chase, Dominic Fritche, Suzanne C Freeman, Nicola J Cooper, Alex J Sutton, Elisabeth Jane Milne, Kathy Wright, Chavdar S Pavlov, Brian R Davidson, Emmanuel Tsochatzis & Kurinchi Selvan Gurusamy. (2021) Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis. Cochrane Database of Systematic Reviews 2021:7.
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Karla MacDonald-Ramos, Layla Michán, Alejandra Martínez-Ibarra & Marco Cerbón. (2021) Silymarin is an ally against insulin resistance: A review. Annals of Hepatology 23, pages 100255.
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Aleksandra Kołota & Dominika Głąbska. (2021) Dietary Intake of Milk Thistle Seeds as a Source of Silymarin and Its Influence on the Lipid Parameters in Nonalcoholic Fatty Liver Disease Patients. Applied Sciences 11:13, pages 5836.
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Jung-Hyo Cho, Jong-Suk Lee, Hyeong-Geug Kim, Hye Won Lee, Zhigang Fang, Hyeok-Hee Kwon, Dong Woon Kim, Chang-Min Lee & Jin-Woo Jeong. (2021) Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants 10:7, pages 998.
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Elena Buzzetti, Audrey Linden, Lawrence MJ Best, Angela M Madden, Danielle Roberts, Thomas J G Chase, Suzanne C Freeman, Nicola J Cooper, Alex J Sutton, Dominic Fritche, Elisabeth Jane Milne, Kathy Wright, Chavdar S Pavlov, Brian R Davidson, Emmanuel Tsochatzis & Kurinchi Selvan Gurusamy. (2021) Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis. Cochrane Database of Systematic Reviews 2021:6.
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Seul Lee, Dong-Cheol Woo, Jeeheon Kang, Moonjin Ra, Ki Hyun Kim, Seoung Rak Lee, Dong Kyu Choi, Heejin Lee, Ki Bum Hong, Sang-Hyun Min, Yongjun Lee & Ji Hoon Yu. (2020) The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice. Biology 9:5, pages 93.
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Runbin Sun, Dan Xu, Qingli Wei, Bangling Zhang, Jiye Aa, Guangji Wang & Yuan Xie. (2020) Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomedicine & Pharmacotherapy 123, pages 109721.
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Michelle L. Montonye, Dan-Dan Tian, Tarana Arman, Katherine D. Lynch, Bruno Hagenbuch, Mary F. Paine & John D. Clarke. (2019) A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model. Journal of Pharmacology and Experimental Therapeutics 371:2, pages 385-393.
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Sarah A. Middleton, Neetu Rajpal, Leanne Cutler, Palwinder Mander, Inmaculada Rioja, Rab K. Prinjha, Deepak Rajpal, Pankaj Agarwal & Vinod Kumar. (2018) BET Inhibition Improves NASH and Liver Fibrosis. Scientific Reports 8:1.
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Ludovico Abenavoli, Angelo A. Izzo, Natasa Milić, Carla Cicala, Antonello Santini & Raffaele Capasso. (2018) Milk thistle ( Silybum marianum ): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases . Phytotherapy Research 32:11, pages 2202-2213.
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Kurinchi Selvan Gurusamy, Emmanuel Tsochatzis & Angela M Madden. (2018) Nutritional supplementation for non-alcohol-related fatty liver disease: a network meta-analysis. Cochrane Database of Systematic Reviews.
Crossref
Kurinchi Selvan Gurusamy, Emmanuel Tsochatzis & Angela M Madden. (2018) Lifestyle modifications for non-alcohol related fatty liver disease: a network meta-analysis. Cochrane Database of Systematic Reviews.
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Joaquim Bosch-Barrera, Bernardo Queralt & Javier A. Menendez. (2017) Targeting STAT3 with silibinin to improve cancer therapeutics. Cancer Treatment Reviews 58, pages 61-69.
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Rosa Lombardi, Simona Onali, Douglas Thorburn, Brian R Davidson, Kurinchi Selvan Gurusamy & Emmanuel Tsochatzis. (2017) Pharmacological interventions for non-alcohol related fatty liver disease (NAFLD). Cochrane Database of Systematic Reviews 2017:4.
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Wen-Yi Hu, Xiao-Hui Ma, Wang-Yi Zhou, Xin-Xin Li, Ting-Ting Sun & He Sun. (2017) Preventive effect of Silibinin in combination with Pu-erh tea extract on non-alcoholic fatty liver disease in ob/ob mice. Food & Function 8:3, pages 1105-1115.
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L. Abenavoli & N. Milic. 2017. Liver Pathophysiology. Liver Pathophysiology 621 631 .
Ludovico Abenavoli, Natasa Milic, Laura Di Renzo, Tomislav Preveden, Milica Medić-Stojanoska & Antonino De Lorenzo. (2016) Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World Journal of Gastroenterology 22:31, pages 7006.
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Kurinchi Selvan Gurusamy, Douglas Thorburn, Brian R Davidson & Emmanuel Tsochatzis. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Min Suk Seo, Sung-Woon Hong, Sung Hum Yeon, Young-Mok Kim, Key An Um, Jung Hwan Kim, Hye Jung Kim, Ki Churl Chang & Sang Won Park. (2014) Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes. Journal of Ethnopharmacology 157, pages 140-148.
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Ludovico Abenavoli. (2014) Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet. World Journal of Gastroenterology 20:45, pages 16831.
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