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Aerosol therapy in children: challenges and solutions

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Pages 665-672 | Published online: 09 Jan 2014

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Read on this site (3)

Arzu Ari, Karen Blain, Said Soubra & Nicola A Hanania. (2021) Treating COPD Patients with Inhaled Medications in the Era of COVID-19 and Beyond: Options and Rationales for Patients at Home. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2687-2695.
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Joy H. Samuels-Reid & Judith U. Cope. (2019) Medical devices and the pediatric population – a head-to-toe approach. Expert Review of Medical Devices 16:8, pages 647-652.
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Awni M. Al-Subu, Scott Hagen, Marlowe Eldridge & Juan Boriosi. (2017) Aerosol therapy through high flow nasal cannula in pediatric patients. Expert Review of Respiratory Medicine 11:12, pages 945-953.
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Articles from other publishers (25)

Arzu Ari & Bshayer Ramadan Alhamad. (2023) Evaluating dry powder inhalers: From in vitro studies to mobile health technologies. Respiratory Medicine 215, pages 107281.
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Arzu Ari, Namita Raghavan, Martha Diaz, Bruce K. Rubin & James B. Fink. (2023) Individualized aerosol medicine: Integrating device into the patient. Paediatric Respiratory Reviews.
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Penghui Li, Weiqi Guo, Jinbo Fan, Chen Su, Xiuguo Zhao & Xinxi Xu. (2023) Fluid-structure interaction analysis of airflow, structural mechanics and aerosol dynamics in a four-generation acinar model. Journal of Aerosol Science 171, pages 106166.
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Penghui Li, Weiqi Guo, Jinbo Fan, Chen Su, Xiuguo Zhao & Xinxi Xu. (2023) Aerosol deposition in the pulmonary acinar region: Influence of wall motion and interparticle collisions. Journal of Aerosol Science 167, pages 106077.
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Arzu Ari, Bruce K. Rubin & James B. Fink. (2022) Mesh nebulizers enabling transnasal pulmonary delivery of medical aerosols to infants and toddlers: Roles, challenges, and opportunities. Frontiers in Drug Delivery 2.
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Arbel Artzy-Schnirman, Sivan Arber Raviv, Ofri Doppelt Flikshtain, Jeny Shklover, Netanel Korin, Adi Gross, Boaz Mizrahi, Avi Schroeder & Josué Sznitman. (2021) Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics. Advanced Drug Delivery Reviews 176, pages 113901.
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Laura C. Brennan, Andrew O’Sullivan & Ronan MacLoughlin. (2021) Cellular Therapy for the Treatment of Paediatric Respiratory Disease. International Journal of Molecular Sciences 22:16, pages 8906.
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Arzu Ari & James B. Fink. (2021) Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity. Pharmaceutics 13:8, pages 1179.
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Kamran Poorbahrami, Irene E. Vignon-Clementel, Shawn C. Shadden & Jessica M. Oakes. (2021) A whole lung in silico model to estimate age dependent particle dosimetry. Scientific Reports 11:1.
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Gerald B. Moody & Arzu Ari. (2020) Quantifying continuous nebulization via high flow nasal cannula and large volume nebulizer in a pediatric model. Pediatric Pulmonology 55:10, pages 2596-2602.
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Mahmood A. Alalwan, James B. Fink & Arzu Ari. (2019) In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children. Pediatric Pulmonology 54:12, pages 1968-1973.
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Sajith Kesavan & Israel Amirav. (2019) Is aerosol delivery by high‐flow nasal cannula in children an effective alternative to face mask aerosol nebulization?. Pediatric Pulmonology 54:12, pages 1873-1874.
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Arzu Ari. (2019) Effect of nebulizer type, delivery interface, and flow rate on aerosol drug delivery to spontaneously breathing pediatric and infant lung models. Pediatric Pulmonology 54:11, pages 1735-1741.
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Estefanía Grotz, Nancy L. Tateosian, Jimena Salgueiro, Ezequiel Bernabeu, Lorena Gonzalez, Maria Letizia Manca, Nicolas Amiano, Donatella Valenti, Maria Manconi, Verónica García, Marcela A. Moretton & Diego A. Chiappetta. (2019) Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis. Journal of Drug Delivery Science and Technology 53, pages 101170.
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Jie Li, Lingyue Gong, Arzu Ari & James B. Fink. (2019) Decrease the flow setting to improve trans‐nasal pulmonary aerosol delivery via “high‐flow nasal cannula” to infants and toddlers. Pediatric Pulmonology 54:6, pages 914-921.
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Dominique N. Price, Nitesh K. Kunda & Pavan Muttil. (2019) Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing. KONA Powder and Particle Journal 36:0, pages 129-144.
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Prashant Das, Eliram Nof, Israel Amirav, Stavros C. Kassinos & Josué Sznitman. (2018) Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD). PLOS ONE 13:11, pages e0207711.
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François Réminiac, Laurent Vecellio, Ronan Mac Loughlin, Deborah Le Pennec, Maria Cabrera, Nathalie Heuzé Vourc'h, James B. Fink & Stephan Ehrmann. (2017) Nasal high flow nebulization in infants and toddlers: An in vitro and in vivo scintigraphic study. Pediatric Pulmonology 52:3, pages 337-344.
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Yvonne J. Rosenberg & James B. Fink. (2016) Creation of a protective pulmonary bioshield against inhaled organophosphates using an aerosolized bioscavenger. Annals of the New York Academy of Sciences 1374:1, pages 151-158.
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Janna Tenenbaum KatanPhilipp HofemeierJosué Sznitman. (2016) Computational Models of Inhalation Therapy in Early Childhood: Therapeutic Aerosols in the Developing Acinus. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:3, pages 288-298.
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Ronan J. MacLoughlin, Geert van AmerongenJames B. FinkHettie M. JanssensW. Paul DuprexRik L. de Swart. (2016) Optimization and Dose Estimation of Aerosol Delivery to Non-Human Primates. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:3, pages 281-287.
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Arzu Ari. (2016) Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children. World Journal of Clinical Pediatrics 5:3, pages 281.
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Marcela A. Moretton, Maximiliano Cagel, Ezequiel Bernabeu, Lorena Gonzalez & Diego A. Chiappetta. (2015) Nanopolymersomes as potential carriers for rifampicin pulmonary delivery. Colloids and Surfaces B: Biointerfaces 136, pages 1017-1025.
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Marie‐Pierre Flament. 2015. Pulmonary Drug Delivery. Pulmonary Drug Delivery 63 86 .
Arzu AriArmele Dornelas de AndradeMeryl SheardBshayer AlHamadJames B. Fink. (2015) Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:4, pages 281-289.
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