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Special Report

Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update

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Pages 543-550 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Muhammad Arif, Zhe Chi, Yong-Jun Liu & Chen-Guang Liu. (2020) Preparation, characterization, and in vitro drug release behavior of thiolated alginate nanoparticles loaded budesonide as a potential drug delivery system toward inflammatory bowel diseases. Journal of Biomaterials Science, Polymer Edition 31:18, pages 2299-2317.
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Chunhua Yang & Didier Merlin. (2019) Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives. International Journal of Nanomedicine 14, pages 8875-8889.
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Omri Wolk, Svetlana Epstein, Viktoriya Ioffe-Dahan, Shimon Ben-Shabat & Arik Dahan. (2013) New targeting strategies in drug therapy of inflammatory bowel disease: mechanistic approaches and opportunities. Expert Opinion on Drug Delivery 10:9, pages 1275-1286.
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Stephen B Hanauer & Daan W Hommes. (2010) Inflammatory bowel disease. Expert Review of Clinical Immunology 6:4, pages 499-500.
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Articles from other publishers (32)

Parikhshith Saravanan, Pooja R.Nanditaa Balachander, Kesav Ram Singh K.Silpa S.Rupachandra S.. (2023) Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides. Folia Microbiologica 68:3, pages 337-353.
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Jia Wang & Haixia Chen. 2023. Alginate Biomaterial. Alginate Biomaterial 241 265 .
Omar A. Abed, Younes Attlassy, Jin Xu, Kai Han & James J. Moon. (2022) Emerging Nanotechnologies and Microbiome Engineering for the Treatment of Inflammatory Bowel Disease. Molecular Pharmaceutics 19:12, pages 4393-4410.
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Milica Markovic, Shimon Ben-Shabat, Jagadeesh Nagendra Manda, Karina Abramov-Harpaz, Clil Regev, Yifat Miller, Aaron Aponick, Ellen M. Zimmermann & Arik Dahan. (2022) PLA2-Triggered Activation of Cyclosporine-Phospholipid Prodrug as a Drug Targeting Approach in Inflammatory Bowel Disease Therapy. Pharmaceutics 14:3, pages 675.
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Wunan Zhang, Cecilia Bohns Michalowski & Ana Beloqui. (2021) Oral Delivery of Biologics in Inflammatory Bowel Disease Treatment. Frontiers in Bioengineering and Biotechnology 9.
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Zahra Davoudi, Nathan Peroutka-Bigus, Bryan Bellaire, Albert Jergens, Michael Wannemuehler & Qun Wang. (2021) Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery. Marine Drugs 19:5, pages 282.
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María José Martínez Monteros, Carolina Maldonado Galdeano, María Florencia Balcells, Ricardo Weill, Juan Andrés De Paula, Gabriela Perdigón & Silvia Inés Cazorla. (2021) Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug. Scientific Reports 11:1.
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Sheng Zhao, Yixuan Li, Quanyi Liu, Sirong Li, Yuan Cheng, Chaoqun Cheng, Ziying Sun, Yan Du, Christopher J. Butch & Hui Wei. (2020) An Orally Administered CeO 2 @Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy . Advanced Functional Materials 30:45, pages 2004692.
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Jagadeesh Nagendra Manda, Milica Markovic, Ellen M. Zimmermann, Shimon Ben‐Shabat, Arik Dahan & Aaron Aponick. (2020) Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation. ChemMedChem 15:17, pages 1639-1644.
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Noa Fine-Shamir & Arik Dahan. (2019) Methacrylate-Copolymer Eudragit EPO as a Solubility-Enabling Excipient for Anionic Drugs: Investigation of Drug Solubility, Intestinal Permeability, and Their Interplay. Molecular Pharmaceutics 16:7, pages 2884-2891.
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Niranjan G. Kotla, Shubhasmin Rana, Gandhi Sivaraman, Omprakash Sunnapu, Praveen K. Vemula, Abhay Pandit & Yury Rochev. (2019) Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives. Advanced Drug Delivery Reviews 146, pages 248-266.
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Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2019) Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations. Pharmaceutics 11:4, pages 186.
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Milica Markovic, Shimon Ben‐Shabat, Shahar Keinan, Aaron Aponick, Ellen M. Zimmermann & Arik Dahan. (2018) Lipidic prodrug approach for improved oral drug delivery and therapy. Medicinal Research Reviews 39:2, pages 579-607.
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Diviya Santhanes, Loo Yee Teng, Foo Siang Sheng & Allan G.A. Coombes. (2018) Exploiting the versatility of oral capsule formulations based on high M-alginate for targeted delivery of poorly water soluble drugs to the upper and lower GI tract. Journal of Drug Delivery Science and Technology 46, pages 384-391.
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Yilin Guo, Shiyu Zong, Yiqiong Pu, Benliang Xu, Tong Zhang & Bing Wang. (2018) Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease. Molecules 23:7, pages 1622.
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Guiping Guan & Shile Lan. (2018) Implications of Antioxidant Systems in Inflammatory Bowel Disease. BioMed Research International 2018, pages 1-7.
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Arik Dahan, Milica Markovic, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2017) Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease. Journal of Computer-Aided Molecular Design 31:11, pages 1021-1028.
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Arik Dahan, Milica Markovic, Svetlana Epstein, Noa Cohen, Ellen M. Zimmermann, Aaron Aponick & Shimon Ben-Shabat. (2017) Phospholipid-drug conjugates as a novel oral drug targeting approach for the treatment of inflammatory bowel disease. European Journal of Pharmaceutical Sciences 108, pages 78-85.
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Isabel Lozoya-Agullo, Moran Zur, Noa Fine-Shamir, Milica Markovic, Yael Cohen, Daniel Porat, Isabel González-Álvarez, Marta González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo & Arik Dahan. (2017) Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion. International Journal of Pharmaceutics 527:1-2, pages 135-141.
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Tian Tian, Ziling Wang & Jinhua Zhang. (2017) Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity 2017, pages 1-18.
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Nir Debotton & Arik Dahan. (2017) Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms. Medicinal Research Reviews 37:1, pages 52-97.
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Sufeng ZhangJoerg ErmannMarc D. SucciAllen ZhouMatthew J. HamiltonBonnie CaoJoshua R. KorzenikJonathan N. GlickmanPraveen K. VemulaLaurie H. GlimcherGiovanni TraversoRobert LangerJeffrey M. Karp. (2015) An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Science Translational Medicine 7:300.
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Stewart S. Cao. (2015) Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 21:3, pages 636-644.
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Katherine Luo & Stewart Siyan Cao. (2015) Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease. Gastroenterology Research and Practice 2015, pages 1-6.
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Haisheng Peng, Chao Wang, Xiaoyang Xu, Chenxu Yu & Qun Wang. (2015) An intestinal Trojan horse for gene delivery. Nanoscale 7:10, pages 4354-4360.
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Arik Dahan, Ellen Zimmermann & Shimon Ben-Shabat. (2014) Modern Prodrug Design for Targeted Oral Drug Delivery. Molecules 19:10, pages 16489-16505.
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Omri Wolk & Arik Dahan. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 343 357 .
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Stewart Siyan Cao, Ellen M. Zimmermann, Brandy–Mengchieh Chuang, Benbo Song, Anosike Nwokoye, J. Erby Wilkinson, Kathryn A. Eaton & Randal J. Kaufman. (2013) The Unfolded Protein Response and Chemical Chaperones Reduce Protein Misfolding and Colitis in Mice. Gastroenterology 144:5, pages 989-1000.e6.
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Dan Chang, Jing Lei, Huiran Cui, Na Lu, Yanjuan Sun, Xiaohua Zhang, Cheng Gao, Hua Zheng & Yihua Yin. (2012) Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior. Carbohydrate Polymers 88:2, pages 663-669.
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Jiajie Chen, Lin Xie, Sayaka Toyama, Thomas Hünig, Shiro Takahara, Xiao-Kang Li & Liang Zhong. (2011) The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis. International Immunopharmacology 11:5, pages 610-617.
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Chaobo Huang, Stefaan J. Soenen, Joanna Rejman, Bart Lucas, Kevin Braeckmans, Jo Demeester & Stefaan C. De Smedt. (2011) Stimuli-responsive electrospun fibers and their applications. Chemical Society Reviews 40:5, pages 2417.
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