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Expert Review of Clinical Immunology Volume 6, 2010 - Issue 6
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3,4-diaminopyridine for the treatment of Lambert–Eaton myasthenic syndrome

Paul W Wirtz Department of Neurology, Haga Hospital, The Hague, The Netherlands. [email protected]; Department of Neurology, Haga Hospital, The Hague, The Netherlands. [email protected]
,
Maarten J Titulaer Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
,
Joop MA van Gerven Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Center for Human Drug Research, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Center for Human Drug Research, Leiden, The Netherlands
&
Jan J Verschuuren Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
Pages 867-874 | Published online: 10 Jan 2014

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Kinji Ohno, Bisei Ohkawara & Mikako Ito. (2017) Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders. Expert Opinion on Therapeutic Targets 21:10, pages 949-958.
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Sabine Lindquist & Martin Stangel. (2014) 3,4-Diaminopyridine (amifampridine) for the treatment of Lambert–Eaton myasthenic syndrome. Expert Opinion on Orphan Drugs 2:3, pages 293-300.
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Agnes van Sonderen, Paul W Wirtz, Jan JGM Verschuuren & Maarten J Titulaer. (2014) Treatment options for Lambert–Eaton myasthenic syndrome. Expert Opinion on Orphan Drugs 2:2, pages 159-167.
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Sabine Lindquist & Martin Stangel. (2011) Update on treatment options for Lambert–Eaton myasthenic syndrome: focus on use of amifampridine. Neuropsychiatric Disease and Treatment 7, pages 341-349.
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Articles from other publishers (21)

Marina Mané-Damas, Peter C. Molenaar, Peter Ulrichts, Florit Marcuse, Marc H. De Baets, Pilar Martinez-Martinez & Mario Losen. (2022) Novel treatment strategies for acetylcholine receptor antibody-positive myasthenia gravis and related disorders. Autoimmunity Reviews 21:7, pages 103104.
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Marija Radosevic, Jesús Planagumà, Francesco MannaraAraceli MelladoEsther AguilarLidia Sabater, Jon Landa, Anna García-Serra, Estibaliz Maudes, Xavier Gasull, Mike LewisJosep Dalmau. (2022) Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice. Neurology Neuroimmunology & Neuroinflammation 9:1.
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Thomas Holm Pedersen, William Alexander Macdonald, Martin Broch‐Lips, Osk Halldorsdottir & Ole Bækgaard Nielsen. (2021) Chloride channel inhibition improves neuromuscular function under conditions mimicking neuromuscular disorders. Acta Physiologica 233:2.
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Maria Pia Giannoccaro, Patrizia Avoni & Rocco Liguori. (2021) Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update. Brain Sciences 11:8, pages 1035.
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Kristine S. Ojala, Scott P. Ginebaugh, Man Wu, Evan W. Miller, Gloria Ortiz, Manuel Covarrubias & Stephen D. Meriney. (2021) A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. Journal of Biological Chemistry 296, pages 100302.
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Francesco Mannara, Marija Radosevic, Jesús Planagumà, David Soto, Esther Aguilar, Anna García-Serra, Estibaliz Maudes, Marta Pedreño, Steven Paul, James Doherty, Michael Quirk, Jing Dai, Xavier Gasull, Mike Lewis & Josep Dalmau. (2020) Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis. Brain 143:9, pages 2709-2720.
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Edward A. Bittner & J.A. Jeevendra Martyn. 2019. Pharmacology and Physiology for Anesthesia. Pharmacology and Physiology for Anesthesia 412 427 .
C. Michel Harper & Vanda A. Lennon. 2018. Myasthenia Gravis and Related Disorders. Myasthenia Gravis and Related Disorders 221 237 .
Benedikt Schoser, Bruno Eymard, Joe Datt & Renato Mantegazza. (2017) Lambert–Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer. Journal of Neurology 264:9, pages 1854-1863.
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Josep Dalmau, Christian Geis & Francesc Graus. (2017) Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiological Reviews 97:2, pages 839-887.
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Peter E. Haroldsen, Marvin R. Garovoy, Donald G. Musson, Huiyu Zhou, Laurie Tsuruda, Boyd Hanson & Charles A. O'Neill. (2014) Genetic variation in aryl N ‐acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4‐diaminopyridine) phosphate . Pharmacology Research & Perspectives 3:1.
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Lydia Sharp & Jaya R. Trivedi. (2014) Treatment and Management of Neuromuscular Channelopathies. Current Treatment Options in Neurology 16:10.
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Mozaffar Asadi, Susan Torabi & Khosro Mohammadi. (2014) Synthesis, characterization, and thermodynamics of some new unsymmetrical Schiff bases of salicylaldehyde with 3,4-diaminopyridine and their cobalt(III) complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 122, pages 676-681.
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Serena Notartomaso, Cristina Zappulla, Francesca Biagioni, Milena Cannella, Domenico Bucci, Giada Mascio, Pamela Scarselli, Francesco Fazio, Filippo Weisz, Luana Lionetto, Maurizio Simmaco, Roberto Gradini, Giuseppe Battaglia, Michele Signore, Aldamaria Puliti & Ferdinando Nicoletti. (2013) Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Molecular Brain 6:1.
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Bhupinder Sandhu, Marina S. Fonari, Kayla Sawyer & Tatiana V. Timofeeva. (2013) A series of crystalline solids composed of aminopyridines and succinic, fumaric, and sebacic acids. Journal of Molecular Structure 1052, pages 125-134.
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Aurélien Viaccoz & Jérôme Honnorat. (2013) Paraneoplastic Neurological Syndromes: General Treatment Overview. Current Treatment Options in Neurology 15:2, pages 150-168.
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Agnes van Sonderen, Paul W. Wirtz, Jan J. G. M. Verschuuren & Maarten J. Titulaer. (2012) Paraneoplastic Syndromes of the Neuromuscular Junction: Therapeutic Options in Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome, and Neuromyotonia. Current Treatment Options in Neurology 15:2, pages 224-239.
Crossref
Edward A. Bittner & J.A. Jeevendra Martyn. 2013. Pharmacology and Physiology for Anesthesia. Pharmacology and Physiology for Anesthesia 309 324 .
Paul Maddison. (2012) Treatment in Lambert-Eaton myasthenic syndrome. Annals of the New York Academy of Sciences 1275:1, pages 78-84.
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Andrew J. Skalsky, Bjorn Oskarsson, Jay J. Han & David Richman. (2012) Current Pharmacologic Management in Selected Neuromuscular Diseases. Physical Medicine and Rehabilitation Clinics of North America 23:4, pages 801-820.
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James J. DowlingRomain JoubertSean E. LowAshley N. DurbanNadia MessaddeqXingli LiAshley N. Dulin-SmithAndrew D. SnyderMorgan L. MarshallJordan T. MarshallAlan H. Beggs, Anna Buj-BelloChristopher R. Pierson. (2012) Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models. Disease Models & Mechanisms.
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