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Expert Review of Clinical Immunology Volume 6, 2010 - Issue 6
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Canakinumab: a human anti-IL-1β monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes

Leigh D Church Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, B15 2TT, UK; Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, B15 2TT, UK
&
Michael F McDermott NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James’s University Hospital, Beckett Street, Leeds, LS9 7TF, UK. [email protected]; NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James’s University Hospital, Beckett Street, Leeds, LS9 7TF, UK. [email protected]
Pages 831-841 | Published online: 10 Jan 2014

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Roberto Ippoliti, Giovanni B. Ramello & Frederic M. Scherer. (2021) Partnership and innovation in the pharmaceutical industry: the case of clinical research. Economics of Innovation and New Technology 30:3, pages 317-334.
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Na Li, Ruijia Zhang, Minghai Tang, Min Zhao, Xueqin Jiang, Xiaoying Cai, Neng Ye, Kaiyue Su, Jing Peng, Xinlu Zhang, Wenshuang Wu & Haoyu Ye. (2023) Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition. Journal of Medicinal Chemistry 66:21, pages 14447-14473.
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Simon Bossart, S. Morteza Seyed Jafari, Kristine Heidemeyer, Kexiang Yan, Laurence Feldmeyer, Luca Borradori & Nikhil Yawalkar. (2023) Canakinumab leads to rapid reduction of neutrophilic inflammation and long-lasting response in Schnitzler syndrome. Frontiers in Medicine 10.
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Bo-Zong Shao, Hai-Yan Xu, Yi-Cheng Zhao, Xiao-Rui Zheng, Fang Wang & Guan-Ren Zhao. (2022) NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation. Inflammation 46:1, pages 35-46.
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Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee & Joo Young Lee. (2021) Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases. Archives of Pharmacal Research 44:1, pages 16-35.
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Xu Cao, Lei Cao, Wencan Zhang, Rongzhu Lu, Jin-Song Bian & Xiaowei Nie. (2020) Therapeutic potential of sulfur-containing natural products in inflammatory diseases. Pharmacology & Therapeutics 216, pages 107687.
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Monica L. Fernández‐Quintero, Valentin J. Hoerschinger, Leonida M. Lamp, Alexander Bujotzek, Guy Georges & Klaus R. Liedl. (2020) V H ‐V L interdomain dynamics observed by computer simulations and NMR . Proteins: Structure, Function, and Bioinformatics 88:7, pages 830-839.
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Arinna Bertoni, Sonia Carta, Chiara Baldovini, Federica Penco, Enrica Balza, Silvia Borghini, Marco Di Duca, Emanuela Ognio, Alessio Signori, Paolo Nozza, Francesca Schena, Patrizia Castellani, Claudia Pastorino, Carola Perrone, Laura Obici, Alberto Martini, Isabella Ceccherini, Marco Gattorno, Anna Rubartelli & Sabrina Chiesa. (2020) A novel knock-in mouse model of cryopyrin-associated periodic syndromes with development of amyloidosis: Therapeutic efficacy of proton pump inhibitors. Journal of Allergy and Clinical Immunology 145:1, pages 368-378.e13.
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Baris Afsar, Adrian Covic, Alberto Ortiz, Rengin Elsurer Afsar & Mehmet Kanbay. (2018) The Future of IL-1 Targeting in Kidney Disease. Drugs 78:11, pages 1073-1083.
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Kelli P.A. MacDonald, Brian C. Betts & Daniel Couriel. (2018) Reprint of: Emerging Therapeutics for the Control of Chronic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 24:3, pages S7-S14.
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Kelli P.A. MacDonald, Brian C. Betts & Daniel Couriel. (2018) Emerging Therapeutics for the Control of Chronic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 24:1, pages 19-26.
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Lisa M. Sedger, Charani Ranasinghe, Michael F. McDermott & Parisa Asvadi. 2017. Immunotherapy - Myths, Reality, Ideas, Future. Immunotherapy - Myths, Reality, Ideas, Future.
Kenneth R. Cooke, Leo Luznik, Stefanie Sarantopoulos, Frances T. Hakim, Madan Jagasia, Daniel H. Fowler, Marcel R.M. van den Brink, John A. Hansen, Robertson Parkman, David B. Miklos, Paul J. Martin, Sophie Paczesny, Georgia Vogelsang, Steven Pavletic, Jerome Ritz, Kirk R. Schultz & Bruce R. Blazar. (2017) The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 23:2, pages 211-234.
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Marco Gattorno, Laura Obici, Marco Cattalini, Vincent Tormey, Ken Abrams, Nicole Davis, Antonio Speziale, Suraj G Bhansali, Alberto Martini & Helen J Lachmann. (2017) Canakinumab treatment for patients with active recurrent or chronic TNF receptor-associated periodic syndrome (TRAPS): an open-label, phase II study. Annals of the Rheumatic Diseases 76:1, pages 173-178.
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Zuhre Tutuncu & Arthur Kavanaugh. 2017. Kelley and Firestein's Textbook of Rheumatology. Kelley and Firestein's Textbook of Rheumatology 999 1019 .
Thomas Gicquel, Sacha Robert, Tatiana Victoni & Vincent Lagente. (2016) L’inflammasome NLRP3 : physiopathologie et application thérapeutique. La Presse Médicale 45:4, pages 438-446.
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Tatiana V. Cohen, Gina M. Many, Bryan D. Fleming, Viola F. Gnocchi, Svetlana Ghimbovschi, David M. Mosser, Eric P. Hoffman & Terence A. Partridge. (2015) Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages. Skeletal Muscle 5:1.
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Katie N. Murray, Adrian R. Parry-Jones & Stuart M. Allan. (2015) Interleukin-1 and acute brain injury. Frontiers in Cellular Neuroscience 9.
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Stephanie McCarty & William Frishman. (2014) Interleukin 1β. Cardiology in Review 22:4, pages 176-181.
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Jasmin B. Kuemmerle-Deschner & Iris Haug. (2013) Canakinumab in patients with cryopyrin-associated periodic syndrome: an update for clinicians. Therapeutic Advances in Musculoskeletal Disease 5:6, pages 315-329.
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Monique P. Curran. (2012) Canakinumab. BioDrugs 26:1, pages 53-59.
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Keith A. Sikora & Alexei A. Grom. (2011) Update on the pathogenesis and treatment of systemic idiopathic arthritis. Current Opinion in Pediatrics 23:6, pages 640-646.
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Jaklien C. Leemans, Suzanne L. Cassel & Fayyaz S. Sutterwala. (2011) Sensing damage by the NLRP3 inflammasome. Immunological Reviews 243:1, pages 152-162.
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Thomas Schirrmann, Torsten Meyer, Mark Schütte, André Frenzel & Michael Hust. (2011) Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy. Molecules 16:1, pages 412-426.
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