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Review

An update on the use of NOD mice to study autoimmune (Type 1) diabetes

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Pages 939-955 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Christine S. Haddad, Palash Bhattacharya, Khaled Alharshawi, Alejandra Marinelarena, Prabhakaran Kumar, Osama El-Sayed, Hatem A. Elshabrawy, Alan L. Epstein & Bellur S. Prabhakar. (2016) Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice. Autoimmunity 49:5, pages 298-311.
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David R Powell, Deon Doree, Sabrina Jeter-Jones, Zhi-Ming Ding, Brian Zambrowicz & Arthur Sands. (2015) Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes. Diabetes, Metabolic Syndrome and Obesity 8, pages 121-127.
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Anita Kondrashova & Heikki Hyöty. (2014) Role of Viruses and Other Microbes in the Pathogenesis of Type 1 Diabetes. International Reviews of Immunology 33:4, pages 284-295.
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Articles from other publishers (41)

Evangelia Kalaitzoglou, John L. Fowlkes & Kathryn M. Thrailkill. (2022) Mouse models of type 1 diabetes and their use in skeletal research. Current Opinion in Endocrinology, Diabetes & Obesity 29:4, pages 318-325.
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Annie R. Piñeros, Abhishek Kulkarni, Hongyu Gao, Kara S. Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Cara M. Anderson, Carmella Evans-Molina, Marcia McDuffie, Jerry L. Nadler, Margaret A. Morris, Raghavendra G. Mirmira & Sarah A. Tersey. (2022) Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes. Cell Reports 39:13, pages 111011.
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Jeng-Rong Lin, Shing-Hwa Huang, Chih-Hsiung Wu, Yuan-Wu Chen, Zhi-Jie Hong, Chia-Pi Cheng, Huey-Kang Sytwu & Gu-Jiun Lin. (2021) Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes. Pharmaceuticals 14:5, pages 475.
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Bernard Vialettes. (2021) « Des souris et des hommes » en quête de la pathogénie du diabète de type 1 : hommage aux souris NOD et à leurs inventeurs. Médecine des Maladies Métaboliques 15:3, pages 347-352.
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Stefania BianchiVerónica C. Martínez AlloMilena MassiminoMaría del R. Lavignolle HeguyFrancisco R. BorzoneSofía Gomez BustilloNorma A. ChasseingCarlos LibertunAlejandro D. MontanerGabriel A. RabinovichMarta A. ToscanoVictoria A. Lux-LantosMaría S. Bianchi. (2021) Oligonucleotide IMT504 Improves Glucose Metabolism and Controls Immune Cell Mediators in Female Diabetic NOD Mice. Nucleic Acid Therapeutics 31:2, pages 155-171.
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Ygor Schleier, Oscar Moreno-Loaiza, Maria Micaela López Alarcón, Eduarda Gabrielle Lopes Martins, Bruno Cabral Braga, Isalira Peroba Ramos, Antonio Galina & Emiliano Horacio Medei. (2020) NOD Mice Recapitulate the Cardiac Disturbances Observed in Type 1 Diabetes. Journal of Cardiovascular Translational Research 14:2, pages 271-282.
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Marie-Christine Simon, Anna Lena Reinbeck, Corinna Wessel, Julia Heindirk, Tomas Jelenik, Kirti Kaul, Juan Arreguin-Cano, Alexander Strom, Michael Blaut, Fredrik Bäckhed, Volker Burkart & Michael Roden. (2020) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice. Journal of Biological Chemistry 295:4, pages 969-980.
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Ken Coppieters, Matthias von Herrath & Dirk Homann. 2020. The Autoimmune Diseases. The Autoimmune Diseases 493 511 .
Terri C. Thayer, Dimitri Kakabadse, Joanne Boldison & F. Susan Wong. 2020. Animal Models of Diabetes. Animal Models of Diabetes 269 289 .
Blerta Shtylla, Marissa Gee, An Do, Shahrokh Shabahang, Leif Eldevik & Lisette de Pillis. (2019) A Mathematical Model for DC Vaccine Treatment of Type I Diabetes. Frontiers in Physiology 10.
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Kristin R. Peterson, Dario A. Gutierrez, Takuya Kikuchi, Emily K. Anderson-Baucum, Nathan C. Winn, Megan M. Shuey, William R. Bolus, Owen P. McGuinness & Alyssa H. Hasty. (2019) Impaired insulin signaling in the B10.D2- Hc 0 H2 d H2 - T18 c /oSnJ mouse model of complement factor 5 deficiency . American Journal of Physiology-Endocrinology and Metabolism 317:2, pages E200-E211.
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Anthony W. Purcell, Salvatore Sechi & Teresa P. DiLorenzo. (2019) The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes. Diabetes 68:5, pages 879-886.
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Maki Nakayama & Aaron W. Michels. (2019) Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes. Frontiers in Immunology 10.
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Hiroka Katsube, Yukiko Hinami, Tatsuki Yamazoe & Yoshihiro H. Inoue. (2019) Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila . Biology Open.
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Rajeev K. Tyagi, Nikunj Tandel, Richa Deshpande, Robert W. Engelman, Satish D. Patel & Priyanka Tyagi. (2018) Humanized Mice Are Instrumental to the Study of Plasmodium falciparum Infection. Frontiers in Immunology 9.
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Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite & Alberto Pugliese. (2018) MicroRNAs. Current Opinion in Endocrinology & Diabetes and Obesity 25:4, pages 237-245.
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Sahar Tahvili, Marie Törngren, Dan Holmberg, Tomas Leanderson & Fredrik Ivars. (2018) Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLOS ONE 13:5, pages e0196598.
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Jeremy J. Racine, Isabel Stewart, Jeremy Ratiu, Greg Christianson, Emily Lowell, Kelsay Helm, Jennifer Allocco, Richard S. Maser, Yi-Guang Chen, Cathleen M. Lutz, Derry Roopenian, Jennifer Schloss, Teresa P. DiLorenzo & David V. Serreze. (2018) Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes 67:5, pages 923-935.
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David A. Ostrov, Aimon Alkanani, Kristen A. McDaniel, Stephanie Case, Erin E. Baschal, Laura Pyle, Sam Ellis, Bernadette Pöllinger, Katherine J. Seidl, Viral N. Shah, Satish K. Garg, Mark A. Atkinson, Peter A. Gottlieb & Aaron W. Michels. (2018) Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. Journal of Clinical Investigation 128:5, pages 1888-1902.
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Sally C. Kent, Stuart I. Mannering, Aaron W. Michels & Jenny Aurielle B. Babon. (2017) Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the “Scene of the Crime”. Current Diabetes Reports 17:10.
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Barry McGuiness, Sinead M. Gibney, Wouter Beumer, Marjan A. Versnel, Inge Sillaber, Andrew Harkin & Hemmo A. Drexhage. (2016) Exaggerated Increases in Microglia Proliferation, Brain Inflammatory Response and Sickness Behaviour upon Lipopolysaccharide Stimulation in Non-Obese Diabetic Mice. Neuroimmunomodulation 23:3, pages 137-150.
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Yi Lin & Zhongjie Sun. (2015) Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes . Diabetes 64:12, pages 4298-4311.
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James C. Reed & Kevan C. Herold. (2015) Thinking bedside at the bench: the NOD mouse model of T1DM. Nature Reviews Endocrinology 11:5, pages 308-314.
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I Gómez-Touriño, R Simón-Vázquez, J Alonso-Lorenzo, S Arif, C Calviño-Sampedro, Á González-Fernández, E Pena-González, J Rodríguez, J Viñuela-Roldán, J Verdaguer, O J Cordero, M Peakman & R Varela-Calvino. (2015) Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes. Clinical and Experimental Immunology 180:2, pages 207-217.
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Gayatri Mukherjee, Rodolfo J. Chaparro, Jennifer Schloss, Carla Smith, Christopher D. Bando & Teresa P. DiLorenzo. (2015) Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice. Immunology 144:4, pages 631-640.
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J Babad, G Mukherjee, A Follenzi, R Ali, B O Roep, L D Shultz, P Santamaria, O O Yang, H Goldstein, D L Greiner & T P DiLorenzo. (2015) Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clinical and Experimental Immunology 179:3, pages 398-413.
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Dieter Rondas, Inne Crèvecoeur, Wannes D’Hertog, Gabriela Bomfim Ferreira, An Staes, Abhishek D. Garg, Decio L. Eizirik, Patrizia Agostinis, Kris Gevaert, Lut Overbergh & Chantal Mathieu. (2015) Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes. Diabetes 64:2, pages 573-586.
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Joanna Kern, Robert Drutel, Silvia Leanhart, Marek Bogacz & Rafal Pacholczyk. (2014) Reduction of T Cell Receptor Diversity in NOD Mice Prevents Development of Type 1 Diabetes but Not Sjögren’s Syndrome. PLoS ONE 9:11, pages e112467.
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Valentina Di Caro, Brett Phillips, Carl Engman, Jo Harnaha, Massimo Trucco & Nick Giannoukakis. (2014) Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice. PLoS ONE 9:1, pages e83575.
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Tina Märker, Jennifer Kriebel, Ulrike Wohlrab, Volker Burkart & Christiane Habich. (2014) Adipocytes from New Zealand Obese Mice Exhibit Aberrant Proinflammatory Reactivity to the Stress Signal Heat Shock Protein 60. Journal of Diabetes Research 2014, pages 1-13.
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Abhirup Jayasimhan, Kristy P. Mansour & Robyn M. Slattery. (2013) Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse. Clinical Science 126:1, pages 1-18.
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Paul McGonigle & Bruce Ruggeri. (2014) Animal models of human disease: Challenges in enabling translation. Biochemical Pharmacology 87:1, pages 162-171.
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L C da Rosa, F Chiuso-Minicucci, S F G Zorzella-Pezavento, T G D França, L L W Ishikawa, P M Colavite, B Balbino, L C B Tavares, C L Silva, C Marques, M R V Ikoma & A Sartori. (2013) Bacille Calmette–Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetes. Clinical and Experimental Immunology 173:3, pages 430-437.
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Irma Pujol-Autonell, Rosa M. Ampudia, Pau Monge, Anna M. Lucas, Jorge Carrascal, Joan Verdaguer & Marta Vives-Pi. (2013) Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice. ISRN Endocrinology 2013, pages 1-5.
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A. Giocanti-Auregan, R. Tadayoni, L. Ahn, J.T. Pena & D.J. D’Amico. (2013) Revue systématique de la littérature des modèles murins de rétinopathie diabétique. Journal Français d'Ophtalmologie 36:3, pages 268-276.
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Charles A. Steward, Jose M. Gonzalez, Steve Trevanion, Dan Sheppard, Giselle Kerry, James G. R. Gilbert, Linda S. Wicker, Jane Rogers & Jennifer L. Harrow. (2013) The non-obese diabetic mouse sequence, annotation and variation resource: an aid for investigating type 1 diabetes. Database 2013.
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Preeti Chhabra, Kailo Schlegel, Mark D. Okusa, Peter I. Lobo & Kenneth L. Brayman. (2012) Naturally Occurring Immunoglobulin M (nIgM) Autoantibodies Prevent Autoimmune Diabetes and Mitigate Inflammation After Transplantation. Annals of Surgery 256:4, pages 634-641.
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Elodie Roggli, Sonia Gattesco, Dorothée Caille, Claire Briet, Christian Boitard, Paolo Meda & Romano Regazzi. (2012) Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice. Diabetes 61:7, pages 1742-1751.
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Teresa P. DiLorenzo. (2011) Multiple antigens versus single major antigen in type 1 diabetes: arguing for multiple antigens. Diabetes/Metabolism Research and Reviews 27:8, pages 778-783.
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Dibyendu SamantaGayatri MukherjeeUdupi A. RamagopalRodolfo J. ChaparroStanley G. NathensonTeresa P. DiLorenzo & Steven C. Almo. (2011) Structural and functional characterization of a single-chain peptide–MHC molecule that modulates both naive and activated CD8 + T cells . Proceedings of the National Academy of Sciences 108:33, pages 13682-13687.
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D. A. Melton. (2011) Using stem cells to study and possibly treat type 1 diabetes. Philosophical Transactions of the Royal Society B: Biological Sciences 366:1575, pages 2307-2311.
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