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Expert Review of Clinical Immunology Volume 8, 2012 - Issue 2
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Review

Filaggrin mutations and atopy: consequences for future therapeutics

Jennifer Heimall The Children’s Hospital of Philadelphia, Division of Allergy & Immunology, 550 Market Street, PA 19104, USA
&
Jonathan M Spergel[email protected]
Pages 189-197 | Published online: 10 Jan 2014

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Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, Won-Mo Yang, Hyo Sang Bae & Woo Kyung Kim. (2017) Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation. Pharmaceutical Biology 55:1, pages 1324-1329.
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Kristina Sophie Ibler & Gregor BE Jemec. (2015) Novel investigational therapies for atopic dermatitis. Expert Opinion on Investigational Drugs 24:1, pages 61-68.
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Kam Lun Hon, Clara Bik San Lau, Patrick Chi Leung Hui & Ping Chung Leung. (2013) Anti-allergic drug discovery in China for eczema: current methods and future strategies. Expert Opinion on Drug Discovery 8:7, pages 753-767.
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Emma Guttman-Yassky, Nikhil Dhingra & Donald YM Leung. (2013) New era of biologic therapeutics in atopic dermatitis. Expert Opinion on Biological Therapy 13:4, pages 549-561.
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Articles from other publishers (44)

Rajlaxmi Deolekar, Vaibhav J. Gajbe, Bilal Sufi & Vivek K. Gohane. (2023) Review on Atopic Dermatitis. International Journal of Advanced Research in Science, Communication and Technology, pages 249-257.
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Ranjit Kumar Mahato, Mohini Singh, Hemanta Pathak, Niva Rani Gogoi, Rikynjai Kharbithai, Pinky Chowrasia, Pankaj Lochan Bora, Tumpa Sarkar, Bani Kumar Jana & Bhaskar Mazumder. (2023) Emerging nanotechnology backed formulations for the management of atopic dermatitis. Therapeutic Delivery 14:9, pages 543-569.
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Lay-Hong Chuah, Hooi-Leong Loo, Choon Fu Goh, Ju-Yen Fu & Shiow-Fern Ng. (2023) Chitosan-based drug delivery systems for skin atopic dermatitis: recent advancements and patent trends. Drug Delivery and Translational Research 13:5, pages 1436-1455.
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Minje Kang, Ji-Hye Jung, Ji-Young Kim, Seok-Ho Hong & Young Her. (2023) Therapeutic and Preventive Effect of Orally Administered Prebiotics on Atopic Dermatitis in a Mouse Model. Allergy, Asthma & Immunology Research 15:3, pages 303.
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So Jeong Kim, Min Seo Kwon, Sol Ra Oh, Seon Hong Jeon, Pyeong Jae Lee, Se Keun Park, Tae Jun Kim & Yong Min Kim. (2022) Zerumbone Treatment Upregulates Hyaluronic Acid Synthesis via the MAPK, CREB, STAT3, and NF-κB Signaling Pathways in HaCaT Cells. Biotechnology and Bioprocess Engineering 27:1, pages 51-60.
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Simona Sestito, Enza D'Auria, Maria Elisabetta Baldassarre, Silvia Salvatore, Valeria Tallarico, Ettore Stefanelli, Flora Tarsitano, Daniela Concolino & Licia Pensabene. (2020) The Role of Prebiotics and Probiotics in Prevention of Allergic Diseases in Infants. Frontiers in Pediatrics 8.
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Minji KimJihyun Kim. (2020) Phenotypes and endotypes of atopic dermatitis: Clinical implications. Allergy, Asthma & Respiratory Disease 8:1, pages 9.
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Ivana Čepelak, Slavica Dodig & Ivan Pavić. (2019) Filaggrin and atopic march. Biochemia medica 29:2, pages 214-227.
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Galina I. Smirnova, D. B. Munblit, A. I. Kolotilina & D. M. Levina. (2019) SKIN MICROBIOTA AND ATOPIC DERMATITIS IN CHILDREN: NEW TREATMENT OPTIONS. Russian Pediatric Journal 21:2, pages 106-113.
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Kayoko Kawashima, Takahiro Sasaki, Yuri Takaoka, Yukinori Yoshida & Makoto Kameda. (2019) Examination of inhaled antigen sensitization in children with food allergy食物アレルギー患児における吸入抗原感作の検討. Journal of Japan Society of Immunology & Allergology in Otolaryngology 37:1, pages 3-9.
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Bita Hassani, Anna Isaian, Mansoureh Shariat, Hasan Mollanoori, Soheila Sotoudeh, Vahid Babaei, Arghavan Ziaali & Shahram Teimourian. (2018) Filaggrin gene polymorphisms in Iranian ichthyosis vulgaris and atopic dermatitis patients. International Journal of Dermatology 57:12, pages 1485-1491.
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Takashi Nomura, Tetsuya Honda & Kenji Kabashima. (2018) Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers. International Immunology 30:9, pages 419-428.
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Adrian Chan, William Terry, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, John W. Holloway, Graham Roberts, Ramesh Kurukulaaratchy & Syed Hasan Arshad. (2018) Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization. Clinical & Experimental Allergy 48:2, pages 147-155.
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Antonella Cianferoni, Melanie A. Ruffner, Ryan Guzek, Shaobo Guan, Terri Brown-Whitehorn, Amanda Muir & Jonathan M. Spergel. (2018) Elevated expression of activated T H 2 cells and milk-specific T H 2 cells in milk-induced eosinophilic esophagitis. Annals of Allergy, Asthma & Immunology 120:2, pages 177-183.e2.
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E. V. Matushevskaya & E. V. Svirshchevskaya. (2018) Antihistamines in dermatology. Klinicheskaya dermatologiya i venerologiya 17:1, pages 14.
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G I Smirnova. (2017) CURRENT CONCEPTS OF ATOPIC DERMATITIS IN CHILDREN: PROBLEMS AND PROSPECTS. Russian Journal of Allergy 14:4-5, pages 30-39.
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Julia N. Mayba & Melinda J. Gooderham. (2016) Review of Atopic Dermatitis and Topical Therapies. Journal of Cutaneous Medicine and Surgery 21:3, pages 227-236.
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Özge Uluçkan & Erwin F. Wagner. (2017) Chronic systemic inflammation originating from epithelial tissues. The FEBS Journal 284:4, pages 505-516.
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T. V. Sokolova & L. A. Safonova. (2016) The course and treatment of atopic erythroderma Hill (case study). Vestnik dermatologii i venerologii 92:3, pages 128-138.
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Kenji Kabashima. 2016. Immunology of the Skin. Immunology of the Skin 1 11 .
Lucie Mondoulet, Vincent Dioszeghy, Claude Thébault, Pierre-Henri Benhamou & Christophe Dupont. (2015) Epicutaneous immunotherapy for food allergy as a novel pathway for oral tolerance induction. Immunotherapy 7:12, pages 1293-1305.
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Wataru Amano, Saeko Nakajima, Hayato Kunugi, Yasuharu Numata, Akihiko Kitoh, Gyohei Egawa, Teruki Dainichi, Tetsuya Honda, Atsushi Otsuka, Yukari Kimoto, Yasuo Yamamoto, Atsuo Tanimoto, Mutsuyoshi Matsushita, Yoshiki Miyachi & Kenji Kabashima. (2015) The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling. Journal of Allergy and Clinical Immunology 136:3, pages 667-677.e7.
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Kristina Rueter, Aveni Haynes & Susan L. Prescott. (2015) Developing Primary Intervention Strategies to Prevent Allergic Disease. Current Allergy and Asthma Reports 15:7.
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Dana Malajian & Emma Guttman-Yassky. (2015) New pathogenic and therapeutic paradigms in atopic dermatitis. Cytokine 73:2, pages 311-318.
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M. Armengot-Carbo, Á. Hernández-Martín & A. Torrelo. (2015) The Role of Filaggrin in the Skin Barrier and Disease Development. Actas Dermo-Sifiliográficas (English Edition) 106:2, pages 86-95.
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M. Armengot-Carbo, Á. Hernández-Martín & A. Torrelo. (2015) Filagrina: papel en la barrera cutánea y en el desarrollo de patología. Actas Dermo-Sifiliográficas 106:2, pages 86-95.
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M. A. Portelli, E. Hodge & I. Sayers. (2014) Genetic risk factors for the development of allergic disease identified by genome‐wide association. Clinical & Experimental Allergy 45:1, pages 21-31.
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Thomas Bieber. 2015. Personalized Treatment Options in Dermatology. Personalized Treatment Options in Dermatology 61 76 .
Susanne Stemmler, Qumar Parwez, Elisabeth Petrasch-Parwez, Joerg T Epplen & Sabine Hoffjan. (2014) Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case–control cohort. BMC Dermatology 14:1.
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Zhanglei Mu, Yan Zhao, Xiaojing Liu, Christopher Chang & Jianzhong Zhang. (2014) Molecular Biology of Atopic Dermatitis. Clinical Reviews in Allergy & Immunology 47:2, pages 193-218.
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Ali H. Ziyab, Wilfried Karmaus, Hongmei Zhang, John W. Holloway, Susan E. Steck, Susan Ewart & Syed Hasan Arshad. (2014) Association of Filaggrin Variants with Asthma and Rhinitis: Is Eczema or Allergic Sensitization Status an Effect Modifier?. International Archives of Allergy and Immunology 164:4, pages 308-318.
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