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Editorial

G-quadruplexes: selective DNA targeting for cancer therapeutics?

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Pages 139-142 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Suganthi Soundarapandian, Aleyamma Alexander, Archana Sumohan Pillai, Israel V. M. V. Enoch & Sameena Yousuf. (2022) G-Quadruplex binding of cavity-containing anthraquinonesulfonyl-β-cyclodextrin conjugate. Effect of encapsulation of ethidium bromide and berberine. Journal of Biomolecular Structure and Dynamics 40:18, pages 8301-8311.
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Sebastian Müller & Raphaël Rodriguez. (2014) G-quadruplex interacting small molecules and drugs: from bench toward bedside. Expert Review of Clinical Pharmacology 7:5, pages 663-679.
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Articles from other publishers (29)

Hikaru Fukuda, Tingting Zou, Satoshi Fujii, Shinobu Sato, Daiki Wakahara, Sen Higashi, Ting-Yuan Tseng, Ta-Chau Chang, Naomi Yada, Kou Matsuo, Manabu Habu, Kazuhiro Tominaga, Hiroshi Takeuchi & Shigeori Takenaka. (2023) Cyclic anthraquinone derivatives, unique G-quadruplex binders, selectively induce cancer cell apoptosis and inhibit tumor growth. PNAS Nexus 2:7.
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Tingting Zou, Yuka Sato, Shuma Kaneyoshi, Kota Mano, Rui Yasukawa, Yoshifumi Nakano, Satoshi Fujii, Shinobu Sato & Shigeori Takenaka. (2022) Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition. Molecules 27:13, pages 4053.
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Xue‐Wen Liu, Ning‐Yi Liu, Yuan‐Qing Deng, Shan Wang, Ting Liu, Yu‐Cai Tang, Yuan‐Dao Chen & Ji‐Lin Lu. (2021) A luminescence probe for c‐myc G‐quadruplex by a triphenylamine‐appended ruthenium complex. Applied Organometallic Chemistry 35:4.
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Nirali Pandya, Eshan Khan, Neha Jain, Lakshminarayana Satham, Rahul Singh, Ravindra D. Makde, Amit Mishra & Amit Kumar. (2021) Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence. Biochimie 180, pages 205-221.
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Rongxin Zhang, Ke Xiao, Yu Gu, Hongde Liu & Xiao Sun. (2020) Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2. Frontiers in Genetics 11.
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Zhiguo Wang, Guo Li, Zhou Tian, Xiaoqin Lou, Yining Huang, Lihui Wang, Jianfeng Li, Tingjun Hou & Jun-Ping Liu. (2020) Insight Derived from Molecular Dynamics Simulation into the Selectivity Mechanism Targeting c-MYC G-Quadruplex . The Journal of Physical Chemistry B 124:44, pages 9773-9784.
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Xue-Wen Liu, Ning-Yi Liu, Yuan-Qing Deng, Shan Wang & Ting Liu. (2020) Topoisomerase I Inhibition, DNA Photocleavage Activity, and G-Quadruplex DNA ‘Light Switch’ Based on Nitro-Substituted Ruthenium Complexes. Russian Journal of Inorganic Chemistry 65:8, pages 1186-1195.
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Xue‐Wen Liu, Ning‐Yi Liu, Yuan‐Qing Deng, Shan Wang, Ting Liu, Yu‐Cai Tang, Yuan‐Dao Chen & Ji‐Lin Lu. (2020) An unexpected fluorescent probe for G‐quadruplex DNA based on a nitro‐substituted ruthenium (II) complex. Applied Organometallic Chemistry 34:8.
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Susanna Stroik, Kevin Kurtz, Kevin Lin, Sergey Karachenets, Chad L Myers, Anja-Katrin Bielinsky & Eric A Hendrickson. (2020) EXO1 resection at G-quadruplex structures facilitates resolution and replication. Nucleic Acids Research 48:9, pages 4960-4975.
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Xue-Wen Liu, Ning-Yi Liu, Yuan-Qing Deng, Shan Wang, Ting Liu, Yu-Cai Tang, Yuan-Dao Chen & Ji-Lin Lu. (2019) Nitro-Substituted Ruthenium(II) Complex: A New Strategy for a G-Quadruplex DNA Fluorescent Probe. Inorganic Chemistry 58:24, pages 16326-16329.
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Clinton G. Mikek, Savannah J. West, J. Cole Gwin, Neetu Dayal, Herman O. Sintim & Edwin A. Lewis. (2018) Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures. ACS Omega 3:9, pages 11582-11591.
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Rafael del Villar-Guerra, Robert D Gray, John O Trent & Jonathan B Chaires. (2018) A rapid fluorescent indicator displacement assay and principal component/cluster data analysis for determination of ligand–nucleic acid structural selectivity. Nucleic Acids Research 46:7, pages e41-e41.
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Fengmin Yang, Xin Sun, Lixia Wang, Qian Li, Aijiao Guan, Gang Shen & Yalin Tang. (2017) Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8 a -disubstituted indolizinone . RSC Advances 7:82, pages 51965-51969.
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Geneviève Pratviel. (2016) Porphyrins in complex with DNA: Modes of interaction and oxidation reactions. Coordination Chemistry Reviews 308, pages 460-477.
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Laurent Sabater, Pei-Ju Fang, Chi-Fon Chang, Aurore De Rache, Enora Prado, Jérôme Dejeu, Antonio Garofalo, Jung-Hsin Lin, Jean-Louis Mergny, Eric Defrancq & Geneviève Pratviel. (2015) Cobalt( iii )porphyrin to target G-quadruplex DNA . Dalton Transactions 44:8, pages 3701-3707.
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Raphaël Rodriguez & Kyle M. Miller. (2014) Unravelling the genomic targets of small molecules using high-throughput sequencing. Nature Reviews Genetics 15:12, pages 783-796.
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Sebastian Müller, Katta Laxmi-Reddy, Prakrit V. Jena, Benoit Baptiste, Zeyuan Dong, Frédéric Godde, Taekjip Ha, Raphaël Rodriguez, Shankar Balasubramanian & Ivan Huc. (2014) Targeting DNA G-Quadruplexes with Helical Small Molecules. ChemBioChem 15:17, pages 2563-2570.
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Asmae Zanzoul, Youssef Ramli, El Mokhtar Essassi & Geneviève Pratviel. (2014) A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting. Medicinal Chemistry Research 23:9, pages 4042-4049.
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Vishal Sharma & Richard Sheardy. (2014) The Human Telomere Sequence, (TTAGGG)4, in the Absence and Presence of Cosolutes: A Spectroscopic Investigation. Molecules 19:1, pages 595-608.
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Claudia Percivalle, Claudia Sissi, Maria Laura Greco, Caterina Musetti, Angelica Mariani, Anna Artese, Giosuè Costa, Maria Lucia Perrore, Stefano Alcaro & Mauro Freccero. (2014) Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures. Org. Biomol. Chem. 12:22, pages 3744-3754.
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Vincent Pradines & Geneviève Pratviel. (2013) Interaction of Cationic Manganese Porphyrin with G-Quadruplex Nucleic Acids Probed by Differential Labeling of the Two Faces of the Porphyrin. Angewandte Chemie International Edition 52:8, pages 2185-2188.
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Vincent Pradines & Geneviève Pratviel. (2013) Interaction of Cationic Manganese Porphyrin with G‐Quadruplex Nucleic Acids Probed by Differential Labeling of the Two Faces of the Porphyrin. Angewandte Chemie 125:8, pages 2241-2244.
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Zhe Xu, Jared B. Shaw & Jennifer S. Brodbelt. (2012) Comparison of MS/MS Methods for Characterization of DNA/Cisplatin Adducts. Journal of the American Society for Mass Spectrometry 24:2, pages 265-273.
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Kogularamanan Suntharalingam, Anna Łęczkowska, Mona A. Furrer, Yilei Wu, Marina K. Kuimova, Bruno Therrien, Andrew J. P. White & Ramon Vilar. (2012) A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA. Chemistry – A European Journal 18:51, pages 16277-16282.
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Hoi-Ling Seng, Wai-San Wang, Siew-Ming Kong, Han-Kiat Alan Ong, Yip-Foo Win, Raja Noor Zaliha Raja Abd. Rahman, Makoto Chikira, Weng-Kee Leong, Munirah Ahmad, Alan Soo-Beng Khoo & Chew-Hee Ng. (2012) Biological and cytoselective anticancer properties of copper(II)-polypyridyl complexes modulated by auxiliary methylated glycine ligand. BioMetals 25:5, pages 1061-1081.
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Marco Di Antonio, Raphaël Rodriguez & Shankar Balasubramanian. (2012) Experimental approaches to identify cellular G-quadruplex structures and functions. Methods 57:1, pages 84-92.
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Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan, Sébastien Britton, Tobias Oelschlaegel, Blerta Xhemalce, Shankar Balasubramanian & Stephen P Jackson. (2012) Small-molecule–induced DNA damage identifies alternative DNA structures in human genes. Nature Chemical Biology 8:3, pages 301-310.
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Guo-Liang Liao, Xiang Chen, Liang-Nian Ji & Hui Chao. (2012) Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex. Chemical Communications 48:87, pages 10781.
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Akash K. Jain & Santanu Bhattacharya. (2011) Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands. Bioconjugate Chemistry 22:12, pages 2355-2368.
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