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Drug Profile

Laquinimod, a once-daily oral drug in development for the treatment of relapsing–remitting multiple sclerosis

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Pages 245-256 | Published online: 10 Jan 2014

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Massimo Radin, Irene Cecchi, Karen Schreiber, Simone Baldovino, Daniela Rossi, Elisa Menegatti, Dario Roccatello & Savino Sciascia. (2017) Immunotherapies in phase II and III trials for the treatment of systemic lupus erythematosus. Expert Opinion on Orphan Drugs 5:1, pages 55-69.
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Huza Zhang, William Chambers, Savino Sciascia & Maria J. Cuadrado. (2016) Emerging therapies in systemic lupus erythematous: from clinical trial to the real life. Expert Review of Clinical Pharmacology 9:5, pages 681-694.
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Chi Chiu Mok. (2014) Emerging biological therapies for systemic lupus erythematosus. Expert Opinion on Emerging Drugs 19:2, pages 303-322.
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Radu Tanasescu, Nikos Evangelou & Cris S Constantinescu. (2013) Role of oral teriflunomide in the management of multiple sclerosis. Neuropsychiatric Disease and Treatment 9, pages 539-553.
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Jan Thöne & Gisa Ellrichmann. (2013) Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits. Drug, Healthcare and Patient Safety 5, pages 37-47.
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Jan Thöne & Ralf Gold. (2013) Review of laquinimod and its therapeutic potential in multiple sclerosis. Expert Opinion on Pharmacotherapy 14:18, pages 2545-2552.
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Articles from other publishers (19)

Chao Ma, Mohammed S. Taghour, Amany Belal, Ahmed B. M. Mehany, Naglaa Mostafa, Ahmed Nabeeh, Ibrahim H. Eissa & Ahmed A. Al-Karmalawy. (2021) Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies. Frontiers in Chemistry 9.
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Anna Elgart, David J. Greenblatt, Pippa S. Loupe, Arik A. Zur, Sivan Weiss, Dorit Mimrod & Ofer Spiegelstein. (2020) The Effect of CYP3A Induction and Inhibition on the Pharmacokinetics of Laquinimod, a Novel Neuroimmunomodulator. Clinical Pharmacology in Drug Development 9:8, pages 1015-1024.
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Anna Elgart, Arik A. Zur, Dorit Mimrod, Vered Dror, Oren Bar-Ilan, Tjeerd Korver & Ofer Spiegelstein. (2018) The effect of laquinimod, a novel immuno-modulator in development to treat Huntington disease, on the pharmacokinetics of ethinylestradiol and levonorgestrel in healthy young women. European Journal of Clinical Pharmacology 75:1, pages 41-49.
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Ofer Spiegelstein, Dorit Mimrod, Laura Rabinovich, Eli Eyal, Craig Sprenger, Anna Elgart, Emil Samara & Joel Morganroth. (2019) A Thorough QT/QTc Study With Laquinimod, a Novel Immunomodulator in Development for Multiple Sclerosis and Huntington Disease. Clinical Pharmacology in Drug Development 8:1, pages 49-59.
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Savino Sciascia, Massimo Radin, Dario Roccatello, Giovanni Sanna & Maria Laura Bertolaccini. (2018) Recent advances in the management of systemic lupus erythematosus. F1000Research 7, pages 970.
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R. Marignier, A. Ruiz, S. Cavagna, A. Nicole, C. Watrin, M. Touret, S. Parrot, G. Malleret, C. Peyron, C. Benetollo, N. Auvergnon, S. Vukusic & P. Giraudon. (2016) Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid. Journal of Neuroinflammation 13:1.
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Michel Varrin-DoyerKara L. PekarekCollin M. SpencerClaude C.A. BernardRaymond A. SobelBruce A.C. CreeUlf Schulze-TopphoffScott S. Zamvil. (2016) Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression. Neurology Neuroimmunology & Neuroinflammation 3:5.
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Dagmar E. Ehrnhoefer, Nicholas S. Caron, Yu Deng, Xiaofan Qiu, Michelle Tsang & Michael R. Hayden. (2016) Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons. Experimental Neurology 283, pages 121-128.
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C. C. Mok. (2016) Towards new avenues in the management of lupus glomerulonephritis. Nature Reviews Rheumatology 12:4, pages 221-234.
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Benedikt Kretzschmar, Hannah Pellkofer & Martin S. Weber. (2016) The Use of Oral Disease-Modifying Therapies in Multiple Sclerosis. Current Neurology and Neuroscience Reports 16:4.
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Savino Sciascia, Eva Talavera-Garcia, Dario Roccatello, Simone Baldovino, Elisa Mengatti & Maria Jose Cuadrado. (2015) Upcoming biological therapies in systemic lupus erythematosus. International Immunopharmacology 27:2, pages 189-193.
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Michel Varrin-Doyer, Scott S. Zamvil & Ulf Schulze-Topphoff. (2014) Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis. Experimental Neurology 262, pages 66-71.
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Alireza Minagar. (2014) Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 6:4, pages 1-117.
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Alan M. Palmer. (2014) New and emerging immune-targeted drugs for the treatment of multiple sclerosis. British Journal of Clinical Pharmacology 78:1, pages 33-43.
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Renaud A. Du Pasquier, Daniel D. Pinschewer & Doron Merkler. (2014) Immunological Mechanism of Action and Clinical Profile of Disease-Modifying Treatments in Multiple Sclerosis. CNS Drugs 28:6, pages 535-558.
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Manoj Kumar Mishra, Janet Wang, Michael B. Keough, Yan Fan, Claudia Silva, Scott Sloka, Liat Hayardeny, Wolfgang Brück & V. Wee Yong. (2014) Laquinimod reduces neuroaxonal injury through inhibiting microglial activation. Annals of Clinical and Translational Neurology 1:6, pages 409-422.
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Wolfgang Brück & Timothy Vollmer. (2013) Oral laquinimod for MS—bringing the brain into focus. Nature Reviews Neurology 9:12, pages 664-665.
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Alireza Minagar. (2013) Current and Future Therapies for Multiple Sclerosis. Scientifica 2013, pages 1-11.
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Wolfgang Brück, Ramona Pförtner, Trinh Pham, Jingya Zhang, Liat Hayardeny, Victor Piryatinsky, Uwe-Karsten Hanisch, Tommy Regen, Denise van Rossum, Lars Brakelmann, Karin Hagemeier, Tanja Kuhlmann, Christine Stadelmann, Gareth R. John, Nadine Kramann & Christiane Wegner. (2012) Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathologica 124:3, pages 411-424.
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