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Clinical trials involving the oncolytic virus, reovirus: ready for prime time?

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Pages 517-520 | Published online: 10 Jan 2014

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Maria Eugenia Davola & Karen Louise Mossman. (2019) Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?. OncoImmunology 8:6.
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Francisca Cristi, Maiah Walters, Nashae Narayan, Kate Agopsowicz, Mary M. Hitt & Maya Shmulevitz. (2023) Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment. Molecular Therapy - Oncolytics 31, pages 100743.
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Zhen Yun SiewAlson LohSharrada SegeranPooi Pooi LeongKenny Voon. (2023) Oncolytic Reoviruses: Can These Emerging Zoonotic Reoviruses Be Tamed and Utilized?. DNA and Cell Biology 42:6, pages 289-304.
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Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li & Funan Liu. (2023) Oncolytic Virus‐Driven Biotherapies from Bench to Bedside. Small 19:23.
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Ramazan Rezaei, Hadi Esmaeili Gouvarchin Ghaleh, Mahdieh Farzanehpour, Ruhollah Dorostkar, Reza Ranjbar, Masoumeh Bolandian, Majid Mirzaei Nodooshan & Akbar Ghorbani Alvanegh. (2021) Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy. Cancer Gene Therapy 29:6, pages 647-660.
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Delphine Lanoie, Stéphanie Côté, Emmanuelle Degeorges & Guy Lemay. (2019) A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells. Virology 528, pages 73-79.
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Delphine Lanoie & Guy Lemay. (2018) Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection. Virus Research 247, pages 40-46.
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Adel Rezaei Moghadam, Elham Patrad, Elham Tafsiri, Warner Peng, Benjamin Fangman, Timothy J Pluard, Anthony Accurso, Michael Salacz, Kushal Shah, Brandon Ricke, Danse Bi, Kyle Kimura, Leland Graves, Marzieh Khajoie Najad, Roya Dolatkhah, Zohreh Sanaat, Mina Yazdi, Naeimeh Tavakolinia, Mohammad Mazani, Mojtaba Amani, Saeid Ghavami, Robyn Gartell, Colleen Reilly, Zaid Naima, Tuba Esfandyari & Faris Farassati. (2017) Ral signaling pathway in health and cancer. Cancer Medicine 6:12, pages 2998-3013.
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Alena C. Jaime-Ramirez, Jun-Ge Yu, Enrico Caserta, Ji Young Yoo, Jianying Zhang, Tae Jin Lee, Craig Hofmeister, John H. Lee, Bhavna Kumar, Quintin Pan, Pawan Kumar, Robert Baiocchi, Theodoros Teknos, Flavia Pichiorri, Balveen Kaur & Matthew Old. (2017) Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma. Molecular Therapy - Oncolytics 5, pages 87-96.
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Zahid Delwar, Kaixin Zhang, Paul S. Rennie & William Jia. (2016) Oncolytic virotherapy for urological cancers. Nature Reviews Urology 13:6, pages 334-352.
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Timothy Cooper, Vincent L Biron, David Fast, Raymond Tam, Thomas Carey, Maya Shmulevitz & Hadi Seikaly. (2015) Oncolytic activity of reovirus in HPV positive and negative head and neck squamous cell carcinoma. Journal of Otolaryngology - Head & Neck Surgery 44:1.
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Véronique Sandekian & Guy Lemay. (2015) A single amino acid substitution in the mRNA capping enzyme λ2 of a mammalian orthoreovirus mutant increases interferon sensitivity. Virology 483, pages 229-235.
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Romit Chakrabarty, Hue Tran, Giovanni Selvaggi, Allison Hagerman, Brad Thompson & Matt Coffey. (2015) The oncolytic virus, pelareorep, as a novel anticancer agent: a review. Investigational New Drugs 33:3, pages 761-774.
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E . Anders Kolb, Valerie Sampson, Deborah Stabley, Alexa Walter, Katia Sol-Church, Timothy Cripe, Pooja Hingorani, Charlotte Hsieh Ahern, Brenda J. Weigel, James Zwiebel & Susan M. Blaney. (2015) A phase I trial and viral clearance study of reovirus (Reolysin) in children with relapsed or refractory extra-cranial solid tumors: A Children's Oncology Group Phase I Consortium report. Pediatric Blood & Cancer 62:5, pages 751-758.
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V?ronique Sandekian & Guy Lemay. (2015) Amino acids substitutions in ?1 and ?1 outer capsid proteins of a Vero cell-adapted mammalian orthoreovirus are required for optimal virus binding and disassembly. Virus Research 196, pages 20-29.
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Roberta L. DeBiasi & Kenneth L. Tyler. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 1848 1850.e1 .
Mingxu Guan, Gaetano Romano, Roberta Coroniti & Earl E Henderson. (2014) Progress in oncolytic virotherapy for the treatment of thyroid malignant neoplasm. Journal of Experimental & Clinical Cancer Research 33:1.
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Romit Chakrabarty, Hue Tran, Yves Fortin, Zhenbao Yu, Shi-Hsiang Shen, John Kolman, David Onions, Robert Voyer, Allison Hagerman, Sarah Serl, Amine Kamen, Brad Thompson & Matt Coffey. (2014) Evaluation of homogeneity and genetic stability of REOLYSIN? (pelareorep) by complete genome sequencing of reovirus after large scale production. Applied Microbiology and Biotechnology 98:4, pages 1763-1770.
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Ella Fremder & Yuval Shaked. 2014. Metronomic Chemotherapy. Metronomic Chemotherapy 23 38 .
Romit Chakrabarty, Hue Tran, Iohann Boulay, Tanya Moran, Audrey Parenteau, Robert Tavcar, Maude Bigras, Allison Hagerman, Sarah Serl, Brad Thompson & Matt Coffey. (2013) Bio-distribution study of Reolysin® (pelareorep) through a single intravenous infusion in Sprague-Dawley rats. Investigational New Drugs 31:6, pages 1476-1486.
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Roland Jabre, V?ronique Sandekian & Guy Lemay. (2013) Amino acid substitutions in ?1 and ?1 outer capsid proteins are selected during mammalian reovirus adaptation to Vero cells. Virus Research 176:1-2, pages 188-198.
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V?ronique Sandekian, Debbie Lim, Patrick Prud?homme & Guy Lemay. (2013) Transient high level mammalian reovirus replication in a bat epithelial cell line occurs without cytopathic effect. Virus Research 173:2, pages 327-335.
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