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Review

The potential and promise of mefenamic acid

Pages 289-305 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Dounia Sid, Milad Baitiche, Zineb Elbahri, Ferhat Djerboua, Mokhtar Boutahala, Zouhair Bouaziz & Marc Le Borgne. (2021) Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 605-617.
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Qais Bashir Jarrar, Muhammad Nazrul Hakim, Zainul Amiruddin Zakaria, Manraj Singh Cheema & Said Moshawih. (2020) Renal ultrastructural alterations induced by various preparations of mefenamic acid. Ultrastructural Pathology 44:1, pages 130-140.
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Qais Bashir Jarrar, Muhammad Nazrul Hakim, Manraj Singh Cheema & Zainul Amiruddin Zakaria. (2017) Comparative ultrastructural hepatic alterations induced by free and liposome-encapsulated mefenamic acid. Ultrastructural Pathology 41:5, pages 335-345.
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Hossein Maghsoudi, Farhad Sheikhnia, Przemysław Sitarek, Nooshin Hajmalek, Sepideh Hassani, Vahid Rashidi, Sadaf Khodagholi, Seyed Mostafa Mir, Faezeh Malekinejad, Fatemeh Kheradmand, Mansour Ghorbanpour, Navid Ghasemzadeh & Tomasz Kowalczyk. (2023) The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer. Cancers 15:22, pages 5435.
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Marcus J. Gauthier, Rahimeh Rasouli, Alaa S. Abd-El-Aziz, Marya Ahmed & Amani A. Abdelghani. (2023) Synthesis and Biological Studies of Cationic Organoiron Star-Shaped Dendrimers with Attached Ketoprofen and Mefenamic Acid at the Peripheries. Journal of Inorganic and Organometallic Polymers and Materials 33:11, pages 3651-3664.
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Sahil Thakur, Irshad Mohiuddin, Raghubir Singh, Varinder Kaur, Raman Kamboj & Shaminder Singh. (2023) Biomass-Derived Core–Shell Carbon Dots with Embedded Tripodal Receptors for the Selective Recognition of Mefenamic Acid in Pharmaceutical Formulations and Urine. ACS Applied Bio Materials 6:10, pages 4403-4412.
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Wonseok Lee, Yewon Mun, Kang-Yo Lee, Jung-Min Park, Tong-Shin Chang, You-Jin Choi & Byung-Hoon Lee. (2023) Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage. Toxics 11:9, pages 735.
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Anirudh Pratap Singh Raman, Pallavi Jain, Ajay Kumar, Prashant Singh, Kamlesh Kumari, Indra Bahadur, Faruq Mohammad & Nagendra Kumar Kaushik. (2023) Eutectic Mixtures to Enhance the Solubility of Active Pharmaceutical Ingredients: Density Functional Theory and Infrared Spectroscopy Approaches. ChemistrySelect 8:25.
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Saranvignesh Alagarsamy, Ruspika Sundaresan, Shen-Ming Chen, J. Meena Devi, Narendhar Chandrasekar & Balaji Ramachandran. (2023) Fabrication of an Electrocatalyst Based on Rare Earth Manganites Incorporated with Carbon Nanofiber Hybrids: An Efficient Electrochemical Biosensor for the Detection of Anti-Inflammatory Drug Mefenamic Acid. C 9:2, pages 47.
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Maria Vitória Silva Nicolini, Wedja Timóteo Vieira, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento & Melissa Gurgel Adeodato Vieira. (2023) Mefenamic acid modified-release by encapsulation in a k-carrageenan/sericin blend. Journal of Industrial and Engineering Chemistry 121, pages 63-76.
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Shengsheng Qiang, Rong‐Bin Hu & Ying‐Yeung Yeung. (2023) Zwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acids. Asian Journal of Organic Chemistry 12:3.
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Qais Jarrar, Rami Ayoub, Said Moshawih, Yazun Jarrar & Jamal Jilani. (2023) Synthesis and Biological Evaluation of Hydroxypropyl Ester of Mefenamic Acid as a Promising Prodrug. Letters in Drug Design & Discovery 20:2, pages 144-152.
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André Farkouh, Margit Hemetsberger, Christian R. Noe & Christoph Baumgärtel. (2022) Interpreting the Benefit and Risk Data in Between-Drug Comparisons: Illustration of the Challenges Using the Example of Mefenamic Acid versus Ibuprofen. Pharmaceutics 14:10, pages 2240.
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Lubna Al-Ameer, Kadhim K. Hashim & Dakhil Nassir Taha. (2022) Determination of mefenamic acid in aqueous solutions using merging zone – continuous flow injection. Water Practice and Technology 17:9, pages 1881-1892.
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Sandeep Kumar, Shikha Bhogal, Promila Sharma, Susheela Rani, Jatinder Singh Aulakh & Ashok Kumar Malik. (2022) Mobil catalytic material number 41 modified magnetite nano‐composites for efficient extraction of non‐steroidal anti‐inflammatory drugs from tap water and urine samples. SEPARATION SCIENCE PLUS 5:8, pages 357-367.
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Moe Yamazaki, Emi Shimamura, Takehisa Hanawa & Yayoi Kawano. (2022) Microparticulated Mefenamic Acid with High Dispersion Stability for Pediatric Dosage Form. Children 9:6, pages 861.
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Dong Zheng, Ying Yuan & Feng Wang. (2022) Fragmentation Method for Computing Quantum Mechanics and Molecular Mechanics Gradients for Force Matching: Validation with Hydration Free Energy Predictions Using Adaptive Force Matching. The Journal of Physical Chemistry A 126:16, pages 2609-2617.
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Marta S. Krawczyk & Irena Majerz. (2021) Novel Coordination Mode in the Potassium Mefenamate Trihydrate Polymeric Structure. Symmetry 13:10, pages 1761.
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Rami Ayoub, Qais Jarrar, Dalia Ali, Said Moshawih, Yazun Jarrar, Muhammad Hakim & Zainul Zakaria. (2021) Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA, Opioid and Glutamate Receptors. European Journal of Pharmaceutical Sciences 163, pages 105865.
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Jaunetta Hill & Nasser H. Zawia. (2021) Fenamates as Potential Therapeutics for Neurodegenerative Disorders. Cells 10:3, pages 702.
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Prasenjit Kar, Komal Shukla, Pratyush Jain, Govindasamy Sathiyan & Raju Kumar Gupta. (2021) Semiconductor based photocatalysts for detoxification of emerging pharmaceutical pollutants from aquatic systems: A critical review. Nano Materials Science 3:1, pages 25-46.
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Romana Smolková, Vladimír Zeleňák, Róbert Gyepes & Daniela Hudecová. (2019) Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid. Chemical Papers 74:5, pages 1525-1540.
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Ju Mi Lee, Kongara Damodar, Yeontaek Lee, Hyeong Ryeol Woo, Hong Won Suh, Sung Ho Jeon & Jeong Tae Lee. (2020) Novel Hybrid Molecules of Epinastine and Mefenamic Acid for Bioactive Assessment as Potential Anti‐inflammatory Agents. Bulletin of the Korean Chemical Society 41:4, pages 444-449.
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Athanasios Mantas & Albert Mihranyan. (2020) Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose. Molecules 25:6, pages 1277.
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Krishnaprasad Baby, Swastika Maity, Chetan H. Mehta, Akhil Suresh, Usha Y. Nayak & Yogendra Nayak. (2020) Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19. F1000Research 9, pages 1166.
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Erizal Zaini, Lili Fitriani, Risda Yulia Sari, Henni Rosaini, Ayano Horikawa & Hidehiro Uekusa. (2019) Multicomponent Crystal of Mefenamic Acid and N-Methyl-d-Glucamine: Crystal Structures and Dissolution Study. Journal of Pharmaceutical Sciences 108:7, pages 2341-2348.
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Romana Smolková, Lukáš Smolko, Vladimír Zeleňák, Juraj Kuchár, Róbert Gyepes, Ivan Talian, Ján Sabo, Zuzana Biščáková & Miroslava Rabajdová. (2019) Impact of the central atom on human genomic DNA and human serum albumin binding properties in analogous Zn(II) and Cd(II) complexes with mefenamic acid. Journal of Molecular Structure 1188, pages 42-50.
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Eloi M. Lago, Marcos P. Silva, Talita G. Queiroz, Susana F. Mazloum, Vinícius C. Rodrigues, Paulo U. Carnaúba, Pedro L. Pinto, Jefferson A. Rocha, Leonardo L.G. Ferreira, Adriano D. Andricopulo & Josué de Moraes. (2019) Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis. EBioMedicine 43, pages 370-379.
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Nurettin Özgür Doğan, Sevinç Taş Çaylak & Serkan Yılmaz. (2019) Central nervous system toxicity due to mefenamic acid. The American Journal of Emergency Medicine 37:3, pages 561.e1-561.e2.
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Parto S. Khansari & Robert F. Halliwell. (2019) Mechanisms Underlying Neuroprotection by the NSAID Mefenamic Acid in an Experimental Model of Stroke. Frontiers in Neuroscience 13.
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Qais Bashir Jarrar, Muhammad Nazrul Hakim, Manraj Singh Cheema & Zainul Amiruddin Zakaria. (2019) In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes. Brazilian Journal of Pharmaceutical Sciences 55.
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Doris Weiss & Tamar Kinaciyan. (2019) Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) induced by mefenamic acid. JAAD Case Reports 5:1, pages 89-90.
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Manali Rathod, Pareshkumar G. Moradeeya, Soumya Haldar & Shaik Basha. (2020) Nanocellulose/TiO2 composites: preparation, characterization and application in the photocatalytic degradation of a potential endocrine disruptor, mefenamic acid, in aqueous media. Photochemical & Photobiological Sciences 17:10, pages 1301-1309.
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Karolina Kafarska, Michał Gacki & Wojciech M. Wolf. (2017) Synthesis, Spectroscopic, and Thermal Investigations of Metal Complexes with Mefenamic Acid. Journal of Chemistry 2017, pages 1-7.
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Grazielle C. Aguiar, Celso M. Queiroz-Junior, Giovana L. Sitta, Flávio A. Amaral, Mauro M. Teixeira, Marcelo V. Caliari & Anderson J. Ferreira. (2016) Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. International Journal of Experimental Pathology 97:6, pages 438-446.
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Siok Yean Tan, Mei Mei Wong, Angela Lu Wun Tiew, Yai Wen Choo, Suat Hun Lim, Ing Hong Ooi, Pilar Modamio, Cecilia Fernández, Eduardo L. Mariño & Ignacio Segarra. (2016) Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice. Cancer Chemotherapy and Pharmacology 78:4, pages 709-718.
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Ann Arens & Craig Smollin. (2016) Case Files of the University of California, San Francisco Medical Toxicology Fellowship: Seizures and a Persistent Anion Gap Metabolic Acidosis. Journal of Medical Toxicology 12:3, pages 309-314.
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Pari Rahi, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh-Charandabi, Yousef Javadzadeh & Simin Seidi. (2016) Comparison of the effect of mefenamic acid and quince on the level of menstrual bleeding and hemoglobin: A randomized controlled clinical trial. European Journal of Integrative Medicine 8:1, pages 67-72.
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Sophia Yui Kau Fong, Yufeng Zhang, Yin Cheong Wong, Limin Zhou, Quanbin Han & Zhong Zuo. (2015) Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo . Biopharmaceutics & Drug Disposition 36:8, pages 529-551.
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Sophia Yui Kau Fong, Yin Cheong Wong, Chen Xie & Zhong Zuo. (2015) Herb–drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats. Journal of Ethnopharmacology 170, pages 106-116.
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