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Review

Delivery of drugs applied topically to the skin

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Pages 383-397 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Qing An, Xinjiong Ni, Dong Liu, Yun Zhang & Yuhua Cao. (2021) Preparation and evaluation of polymer-encapsulated UV filter nanocapsules with miniemulsion polymerization. Journal of Dispersion Science and Technology 42:11, pages 1593-1600.
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Hanumanth Srikanth Cheruvu, Xin Liu, Jeffrey E. Grice & Michael S. Roberts. (2020) Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery 15:10, pages 1181-1198.
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Thiago de Farias Pires, Ana Paula Azambuja, Andrea Roseli Vançan Russo Horimoto, Mary Sanae Nakamura, Rafael de Oliveira Alvim, José Eduardo Krieger & Alexandre Costa Pereira. (2016) A population-based study of the stratum corneum moisture. Clinical, Cosmetic and Investigational Dermatology 9, pages 79-87.
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Joseph A. Laszlo, Kervin O. Evans & David L. Compton. (2014) Stability of a liposomal formulation containing lipoyl or dihydrolipoyl acylglycerides. Journal of Liposome Research 24:4, pages 304-312.
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Armin Ariaei & Fatemeh Ramezani. The promising impact of Bemcentinib and Repotrectinib on sleep impairment in Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
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Gulengul Duman, Ecem Gucu, Feride Sermin Utku, Burcu Uner, Meltem Macit, Sevval Sarialtin & Mustafa Ozilgen. (2023) Kinetic assessment of iontophoretic delivery efficiency of niosomal tetracycline hydrochloride incorporated in electroconductive gel. Drug Delivery and Translational Research.
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Maria Dul, Mohammed Alali, Mahmoud Ameri, Matthew Douglas Burke, Christine M. Craig, Benjamin Paul Creelman, Lisa Dick, Ryan F. Donnelly, Michael N. Eakins, Collrane Frivold, Angus Harry Forster, Philippe-Alexandre Gilbert, Stefan Henke, Sebastien Henry, Desmond Hunt, Hayley Lewis, Howard I. Maibach, Jessica Joyce Mistilis, Jung-Hwan Park, Mark R. Prausnitz, David Kenneth Robinson, Carmen Amelia Rodriguez Hernandez, Charles Ross, Juyeop Shin, Tycho Joseph Speaker, Kevin Michael Taylor, Darin Zehrung, James C. Birchall, Courtney Jarrahian & Sion A. Coulman. (2023) Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361, pages 236-245.
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Anukrati Goel, Dimitrios Tsikritsis, Natalie A. Belsey, Ruth Pendlington, Stephen Glavin & Tao Chen. (2023) Measurement of chemical penetration in skin using Stimulated Raman scattering microscopy and multivariate curve resolution - alternating least squares. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 296, pages 122639.
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Delly Ramadon, Lissa Florencia Putri Sutrisna, Yahdiana Harahap, Kurnia Sari Setio Putri, Fathin Ulayya, Pietradewi Hartrianti, Qonita Kurnia Anjani & Ryan F. Donnelly. (2023) Enhancing Intradermal Delivery of Lidocaine by Dissolving Microneedles: Comparison between Hyaluronic Acid and Poly(Vinyl Pyrrolidone) Backbone Polymers. Pharmaceutics 15:1, pages 289.
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Parijat Pandey, Neha Minocha, Neelam Vashist, Rashmi Shah, Sapna Saini, Manish Makhija, Deepika Purohit & Dhirender Kaushik. (2022) Emulgel: An Emerging Approach towards Effective Topical Drug Delivery. Drug Delivery Letters 12:4, pages 227-242.
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Angie Jefferson & Clarice Borges. (2022) Evaluation of the safety, tolerability and plasma vitamin D response to long-term use of patented transdermal vitamin D patches in healthy adults: a randomised parallel pilot study. BMJ Nutrition, Prevention & Health 5:2, pages 217-226.
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A.A. Amarah, J. Hadgraft, M.S. Roberts & Y.G. Anissimov. (2022) Compartmental modeling of skin absorption and desorption kinetics: Donor solvent evaporation, variable diffusion/partition coefficients, and slow equilibration process within stratum corneum. International Journal of Pharmaceutics 623, pages 121902.
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Moetaz El‐Domyati, Tag S. Anbar, Maysa Yehia & Rasha T. A. Abdel‐Aziz. (2021) The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation. International Journal of Dermatology 61:5, pages 582-590.
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Joanna Hummer, Thomas Birngruber, Frank Sinner, Leanne Page, Frank Toner, Clive S. Roper, David J. Moore, Mark B. Baker & Mila Boncheva Bettex. (2022) Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs. International Journal of Pharmaceutics 620, pages 121737.
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Célia Luiza Petersen Vitello Kalil, Clarissa Prieto Herman Reinehr & Renato Marchiori Bakos. (2022) Short-Term Follow-Up of a Randomized Controlled Trial of 0.5% and 5% 5-Fluorouracil After Microneedling for Treatment of Facial Actinic Keratoses. Dermatologic Surgery 48:3, pages 293-298.
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Desak Gede Budi Krisnamurti, Erni H. Purwaningsih, Radiana Dhewayani Antarianto & Melva Louisa. Glucose-responsive pectin insulin patch for diabetes mellitus: A review. Glucose-responsive pectin insulin patch for diabetes mellitus: A review.
Lavinia Vlaia, Ioana Olariu, Ana Maria Muţ, Georgeta Coneac, Vicenţiu Vlaia, Dan Florin Anghel, Monica Elisabeta Maxim, Gabriela Stângă, Amadeus Dobrescu, Maria Suciu, Zoltan Szabadai & Dumitru Lupuleasa. (2021) New, Biocompatible, Chitosan-Gelled Microemulsions Based on Essential Oils and Sucrose Esters as Nanocarriers for Topical Delivery of Fluconazole. Pharmaceutics 14:1, pages 75.
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Johnny Bullón, Laura Márquez, José Alejandro Fernández, César Scorzza, José Vicente Scorza, Jimmy Rodríguez, Atilio Cordero, Francia Véjar, Sonia Koteich-Khatib & Ana Forgiarini. (2021) A Promising Cutaneous Leishmaniasis Treatment with a Nanoemulsion-Based Cream with a Generic Pentavalent Antimony (Ulamina) as the Active Ingredient. Cosmetics 8:4, pages 115.
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Rafaela Santos de Oliveira, Stephani Silva Fantaus, Antonio José Guillot, Ana Melero & Ruy Carlos Ruver Beck. (2021) 3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery. Pharmaceutics 13:11, pages 1946.
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Ana R. Caldas, Maria J. Faria, Artur Ribeiro, Raul Machado, Hugo Gonçalves, Andreia C. Gomes, Graça M.B. Soares, Carla M. Lopes & Marlene Lúcio. (2021) Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textiles. Journal of Molecular Liquids 342, pages 116965.
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Srividya Gorantla, Neha Dabholkar, Sudhanshu Sharma, Vamshi Krishna Rapalli, Amit Alexander & Gautam Singhvi. (2021) Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects. International Journal of Biological Macromolecules 184, pages 438-453.
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Jörg Täubel, Alessandro Mazzetti, Georg Ferber, William Burch, Sara Fernandes, Avani Patel, Christopher S. Spencer, Anne Freier, Claus Graff, Jørgen K. Kanters & John Camm. (2021) A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity. Clinical Pharmacology in Drug Development 10:6, pages 572-581.
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Shibani Supe & Pooja Takudage. (2020) Methods for evaluating penetration of drug into the skin: A review. Skin Research and Technology 27:3, pages 299-308.
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Vamshi Krishna Rapalli, Saswata Banerjee, Shahid Khan, Prabhat Nath Jha, Gaurav Gupta, Kamal Dua, Md Saquib Hasnain, Amit Kumar Nayak, Sunil Kumar Dubey & Gautam Singhvi. (2021) QbD-driven formulation development and evaluation of topical hydrogel containing ketoconazole loaded cubosomes. Materials Science and Engineering: C 119, pages 111548.
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Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Andre Boon Hwa Choo, Ellen Birgit Lane & Sai Kiang Lim. (2021) Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation. International Journal of Molecular Sciences 22:2, pages 720.
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Purnima D. Amin, Bahijja Tolulope Raimi-Abraham, Devanshi S. Shah & Sharda Gurram. 2021. Remington. Remington 381 393 .
Clarissa Prieto Herman Reinehr, Laura de Mattos Milman & Valéria Campos. 2021. Drug Delivery in Dermatology. Drug Delivery in Dermatology 1 10 .
Dilesh Jagdish Singhavi & Shagufta Khan. 2020. Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment. Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment 113 128 .
Gabriela Pereira Parchen, Joslaine Jacumazo, Heidegrid Siebert Koop, Stellee Marcela Petris Biscaia, Edvaldo S. Trindade, Joana Léa Meira Silveira & Rilton Alves de Freitas. (2020) Modulation of Epidermal Growth Factor Release by Biopolymer-Coated Liposomes. Journal of Pharmaceutical Sciences 109:7, pages 2294-2301.
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Hamid-Reza Ahmadi-Ashtiani, Parisa Bishe, Anna Baldisserotto, Piergiacomo Buso, Stefano Manfredini & Silvia Vertuani. (2020) Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration. International Journal of Molecular Sciences 21:6, pages 2251.
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Robert Tungadi & Prisca Wicita. (2020) Formulation, optimization, and characterization of snakehead fish (Ophiocephalus Striatus) powder nanoemulgel. Brazilian Journal of Pharmaceutical Sciences 56.
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Xiaoxiang He, Jingyao Sun, Jian Zhuang, Hong Xu, Ying Liu & Daming Wu. (2019) Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects. Dose-Response 17:4, pages 155932581987858.
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Hatem Abo‐El‐Wafa Zohdy & Mohamed Saber Hussein. (2018) Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment. Journal of Cosmetic Dermatology 18:5, pages 1430-1434.
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Lisa Binder, Julia Mazál, Romana Petz, Victoria Klang & Claudia Valenta. (2019) The role of viscosity on skin penetration from cellulose ether‐based hydrogels. Skin Research and Technology 25:5, pages 725-734.
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Stefano Colombo, Necati Harmankaya, Jorrit J. Water & Adam Bohr. (2019) Exploring the potential for rosacea therapeutics of siRNA dispersion in topical emulsions. Experimental Dermatology 28:3, pages 261-269.
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María Rincón, Ana Calpena, María-José Fabrega, María Garduño-Ramírez, Marta Espina, María Rodríguez-Lagunas, María García & Guadalupe Abrego. (2018) Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders. Nanomaterials 8:12, pages 1022.
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Peter Sjövall, Lisa Skedung, Sébastien Gregoire, Olga Biganska, Franck Clément & Gustavo S. Luengo. (2018) Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry. Scientific Reports 8:1.
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Gabriela Maria D’Angelo Costa, Claudinéia Aparecida Sales de Oliveira Pinto, Vânia Rodrigues Leite-Silva, André Rolim Baby & Maria Valéria Robles Velasco. (2018) Is Vitamin D3 Transdermal Formulation Feasible? An Ex Vivo Skin Retention and Permeation. AAPS PharmSciTech 19:5, pages 2418-2425.
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Hamideh Parhiz, Makan Khoshnejad, Jacob W. Myerson, Elizabeth Hood, Priyal N. Patel, Jacob S. Brenner & Vladimir R. Muzykantov. (2018) Unintended effects of drug carriers: Big issues of small particles. Advanced Drug Delivery Reviews 130, pages 90-112.
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David Bonnel, Raphaël Legouffe, André H. Eriksson, Rasmus W. Mortensen, Fabien Pamelard, Jonathan Stauber & Kim T. Nielsen. (2018) MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles. Analytical and Bioanalytical Chemistry 410:11, pages 2815-2828.
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Barbora Amélie Čuříková, Kamila Procházková, Barbora Filková, Petra Diblíková, Jan Svoboda, Andrej Kováčik, Kateřina Vávrová & Jarmila Zbytovská. (2017) Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International Journal of Pharmaceutics 534:1-2, pages 287-296.
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Isabella S. Sørensen, Christian Janfelt, Mette Marie B. Nielsen, Rasmus W. Mortensen, Nina Ø. Knudsen, André H. Eriksson, Anders J. Pedersen & Kim T. Nielsen. (2017) Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant. Analytical and Bioanalytical Chemistry 409:21, pages 4993-5005.
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A.C.H.R. Machado, P.S. Lopes, C.P. Raffier, I.N. Haridass, M. Roberts, J. Grice & V.R. Leite-Silva. 2017. Cosmetic Science and Technology. Cosmetic Science and Technology 741 755 .
Marcio Adriano Andréo, Iasmin Mimoto Rufino, Daniela Cecilia Ortiz de Orue Ubaldo, Estela Boaro Herbst, Heron Dominguez Torres da Silva, Pedro Gonçalves de Oliveira, Marcio Ferrari, Paulo Cesar Pires Rosa, Patrícia Santos Lopes & Vânia Rodrigues Leite-Silva. (2016) Performance evaluation of Cryo Laser Phoresis technique as biophysical method to promote diclofenac sodium cutaneous perfusion. Brazilian Journal of Pharmaceutical Sciences 52:1, pages 69-76.
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Peter Sjövall, Tanja M. Greve, Susanne K. Clausen, Kristian Moller, Stefan Eirefelt, Björn Johansson & Kim T. Nielsen. (2014) Imaging of Distribution of Topically Applied Drug Molecules in Mouse Skin by Combination of Time-of-Flight Secondary Ion Mass Spectrometry and Scanning Electron Microscopy. Analytical Chemistry 86:7, pages 3443-3452.
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