650
Views
67
CrossRef citations to date
0
Altmetric
Review

The IL-23/IL-17 pathway in inflammatory bowel disease

&
Pages 223-237 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Marianna Lucafò, Raffaella Franca, Davide Selvestrel, Debora Curci, Letizia Pugnetti, Giuliana Decorti & Gabriele Stocco. (2018) Pharmacogenetics of treatments for inflammatory bowel disease. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1209-1223.
Read now
Bram Verstockt, Gert Van Assche, Séverine Vermeire & Marc Ferrante. (2017) Biological therapy targeting the IL-23/IL-17 axis in inflammatory bowel disease. Expert Opinion on Biological Therapy 17:1, pages 31-47.
Read now
Mats Karlsson, Ludvig Linton, Maria Lampinen, Per Karlén, Hans Glise, Ragnar Befrits, Izabella Janczewska, Marie Carlson, Ola Winqvist & Michael Eberhardson. (2013) Naïve T cells correlate with mucosal healing in patients with inflammatory bowel disease. Scandinavian Journal of Gastroenterology 49:1, pages 66-74.
Read now
Peter Norman. (2012) Selective JAK1 inhibitor and selective Tyk2 inhibitor patents. Expert Opinion on Therapeutic Patents 22:10, pages 1233-1249.
Read now

Articles from other publishers (63)

Niusha Esmaealzadeh, Mahboobe Ram, Amirhossein Abdolghaffari, André Mesquita Marques & Roodabeh Bahramsoltani. (2024) Toll-like receptors in inflammatory bowel disease: A review of the role of phytochemicals. Phytomedicine 123, pages 155178.
Crossref
Xianglu Ye, Miao Zhang, Ning Zhang, Hai Wei & Bing Wang. (2024) Gut-brain axis interacts with immunomodulation in inflammatory bowel disease. Biochemical Pharmacology 219, pages 115949.
Crossref
Jiryeon Jang & Sehoon Jeong. (2023) Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling. BioChip Journal.
Crossref
Su-yeon Kim, Kyung-Sook Chung, Seo-Yun Jang, Hee-Soo Han, So-Won Heo, Jong Kil Lee, Hyoung Ja Kim, Yu-Kyong Shin, Hye Shin Ahn, Sun Hee Lee & Kyung-Tae Lee. (2023) Hydrangenol, an active constituent of Hydrangea serrata (Thunb.) Ser., ameliorates colitis through suppression of macrophage-mediated inflammation in dextran sulfate sodium-treated mice . Food & Function 14:15, pages 6957-6968.
Crossref
Yaping Yan, Kaixiu Li, Jiang Jiang, Lihong Jiang, Xiang Ma, Fang Ai, Shuai Qiu & Wei Si. (2023) Perinatal tissue-derived exosomes ameliorate colitis in mice by regulating the Foxp3 + Treg cells and gut microbiota. Stem Cell Research & Therapy 14:1.
Crossref
Evanthia Tourkochristou, Athanasia Mouzaki & Christos Triantos. (2023) Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases. World Journal of Gastroenterology 29:1, pages 110-125.
Crossref
Gaetano Isola, Simona Santonocito, Rosalia Leonardi & Alessandro PolizziGaetano Isola, Simona Santonocito, Rosalia Leonardi & Alessandro Polizzi. 2023. Oral Lichen Planus and Lichenoid Lesions. Oral Lichen Planus and Lichenoid Lesions 15 87 .
Yan Liu, Chao Shi, Shanshan Ma, Yuelong Ma, Xinyuan Lu, Jianyu Zhu & Degang Yang. (2022) The protective role of tissue-resident interleukin 17A–producing gamma delta T cells in Mycobacterium leprae infection. Frontiers in Immunology 13.
Crossref
Xiaoqin Han, Ruifeng Luo, Naijing Ye, Yichen Hu, Chaomei Fu, Ru Gao, Shu Fu & Fei Gao. (2022) Research progress on natural β-glucan in intestinal diseases. International Journal of Biological Macromolecules 219, pages 1244-1260.
Crossref
De-Kai Xiong, Xiang Shi, Miao-Miao Han, Xing-Min Zhang, Na-Na Wu, Xiu-Yue Sheng & Ji-Nian Wang. (2022) The regulatory mechanism and potential application of IL-23 in autoimmune diseases. Frontiers in Pharmacology 13.
Crossref
Lili Chen, Zhengxiang He, Bernardo S. Reis, Jesse D. Gelles, Jerry Edward Chipuk, Adrian T. Ting, Julie A. Spicer, Joseph A. Trapani, Glaucia C. Furtado & Sergio A. Lira. (2022) IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40. Cellular & Molecular Immunology 19:7, pages 777-790.
Crossref
Ting Li, Weidong Liu, Wenjia Hui, Tian Shi, Huan Liu, Yan Feng & Feng Gao. (2022) Integrated Analysis of Ulcerative Colitis Revealed an Association between PHLPP2 and Immune Infiltration. Disease Markers 2022, pages 1-15.
Crossref
Wei-Xin Cheng, Yue Ren, Miao-Miao Lu, Ling-Ling Xu, Jian-Guo Gao, Dong Chen, Farhin Shaheed Kalyani, Zi-Yan Lv, Chun-Xiao Chen, Feng Ji, He-Ning Lin & Xi Jin. (2021) Palmitoylation in Crohn’s disease: Current status and future directions. World Journal of Gastroenterology 27:48, pages 8201-8215.
Crossref
Jinke Huang, Yijun Zheng, Jinxin Ma, Jing Ma, Mengxiong Lu, Xiangxue Ma, Fengyun Wang & Xudong Tang. (2021) Exploration of the Potential Mechanisms of Wumei Pill for the Treatment of Ulcerative Colitis by Network Pharmacology. Gastroenterology Research and Practice 2021, pages 1-15.
Crossref
Zhengxiang He, Lili Chen, Jovani Catalan-Dibene, Gerold Bongers, Jeremiah J. Faith, Chalada Suebsuwong, Robert J. DeVita, Zeli Shen, James G. Fox, Juan J. Lafaille, Glaucia C. Furtado & Sergio A. Lira. (2021) Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23. Cell Metabolism 33:7, pages 1358-1371.e5.
Crossref
Kai Niu, Qifang Li, Yuan Liu, Yi Qiao, Bingbing Li, Chao Wei, Kunrui Wang, Lu’an Cui, Canlei Zheng, Rong Wang, Li Zhang, Honghua Zhang, Bing Sun & Bin Yu. (2021) Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
Crossref
Paula X. Losada, José S. Cortés, Carlos F. Narváez & Giovani Lastra. (2021) Papel de la interleuquina-17 en procesos inflamatorios y patologías pulmonares. Revista Médicas UIS 34:1.
Crossref
Ren‐Xiao Wang, Mi Zhou, Hui‐Lai Ma, Yuan‐Biao Qiao & Qing‐Shan Li. (2021) The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products. ChemMedChem 16:10, pages 1576-1592.
Crossref
Michał Sienkiewicz, Patrycja Szymańska & Jakub Fichna. (2021) Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications. Advances in Nutrition 12:2, pages 533-545.
Crossref
Beatriz Piantoni Gonçalves, Tamires Flauzino, Cláudia Junko Inoue, Jaqueline Costa Castardo de Paula, Talita Cristina Galvão, Camila Cataldi de Alcantara, Paula Kikuchi Miyazaki, Lucilene Rosa, Silva Westmore, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche & Andréa Name Colado Simão. (2020) IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease. International Journal of Colorectal Disease 36:2, pages 383-393.
Crossref
Yu‐Hsuan Lin, Cheng Li Lin & Chia‐Hung Kao. (2020) Adults with inflammatory bowel disease are at a greater risk of developing chronic rhinosinusitis: A nationwide population‐based study. Clinical Otolaryngology 46:1, pages 196-205.
Crossref
Muhammad Shahid Nadeem, Vikas Kumar, Fahad A. Al-Abbasi, Mohammad Amjad Kamal & Firoz Anwar. (2020) Risk of colorectal cancer in inflammatory bowel diseases. Seminars in Cancer Biology 64, pages 51-60.
Crossref
Ke Ke, Tim (Hung‐Po) Chen, Manoj Arra, Gabriel Mbalaviele, Gaurav Swarnkar & Yousef Abu‐Amer. (2019) Attenuation of NF‐κB in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis. Journal of Bone and Mineral Research 34:10, pages 1880-1893.
Crossref
Yu Long, Yuqing He, Fengming Jie, Sixin Li, Yanli Wu, Yanwu Li & Qun Du. (2019) Kuijieling-Containing Serum Regulates Th17 and Treg Cell Differentiation by Inhibiting STAT3 Signaling In Vitro . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-9.
Crossref
Santosh K. Panda & Marco Colonna. (2019) Innate Lymphoid Cells in Mucosal Immunity. Frontiers in Immunology 10.
Crossref
Alessandro Poggi, Roberto Benelli, Roberta Venè, Delfina Costa, Nicoletta Ferrari, Francesca Tosetti & Maria Raffaella Zocchi. (2019) Human Gut-Associated Natural Killer Cells in Health and Disease. Frontiers in Immunology 10.
Crossref
Arash Assadsangabi, Caroline A. Evans, Bernard M. Corfe & Alan Lobo. (2019) Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives. Gastroenterology Research and Practice 2019, pages 1-24.
Crossref
Xin‐Pu Miao, Xiao‐Ning Sun, Qiong‐Si Li, Lu‐Jia Cui, Xuan‐Yu Wang, Gui‐Feng Zhuang & Tao‐Zhi Deng. (2018) Pectic polysaccharides extracted from Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang ameliorate ulcerative colitis via regulating the MAPK s and NF ‐κB pathways in dendritic cells . Clinical and Experimental Pharmacology and Physiology 46:1, pages 48-55.
Crossref
Lizhi Zhang & Tsung-Teh Wu. 2019. Surgical Pathology of Non-neoplastic Gastrointestinal Diseases. Surgical Pathology of Non-neoplastic Gastrointestinal Diseases 373 424 .
Youssra Haouami, Tarak Dhaouadi, Imen Sfar, Mongi Bacha, Tahar Gargah, Rafika Bardi, Ezzeddine Abderrahim, Rym Goucha, Taïeb Ben Abdallah & Yousr Gorgi. (2018) The role of IL-23/IL-17 axis in human kidney allograft rejection. Journal of Leukocyte Biology 104:6, pages 1229-1239.
Crossref
I. Luzardo-Ocampo, R. Campos-Vega, M.L. Cuellar-Nuñez, P.A. Vázquez-Landaverde, L. Mojica, J.A. Acosta-Gallegos & G. Loarca-Piña. (2018) Fermented non-digestible fraction from combined nixtamalized corn (Zea mays L.)/cooked common bean (Phaseolus vulgaris L.) chips modulate anti-inflammatory markers on RAW 264.7 macrophages. Food Chemistry 259, pages 7-17.
Crossref
Yu Long, Sixin Li, Jingchun Qin, Liwei Xie, Liping Gan, Fengming Jie, Yanli Wu, Yanwu Li & Qun Du. (2018) Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats. Biomedicine & Pharmacotherapy 105, pages 781-788.
Crossref
Nicole Cash. (2018) Psoriasis: From Gene to Clinic. EMJ Dermatology, pages 10-16.
Crossref
Ulas Emre AKBULUT, Safak ERSOZ, Gokhan TUMGOR, Mehmet AGİN, Fatih UNAL, Erhun KASİRGA & Murat CAKİR. (2018) FOXP3+ Treg cells and interleukin-23 expression in the intestinal mucosa of children with ulcerative colitisÜlseratif kolitli çocukların intestinal mukozasında FOXP3+ Treg hücreleri ve interlökin-23 ekspresyonu. Mucosa 1:1, pages 10-17.
Crossref
Tarak Dhaouadi, Mayssa Chahbi, Youssra Haouami, Imen Sfar, Leila Abdelmoula, Taieb Ben Abdallah & Yousr Gorgi. (2018) IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis. PLOS ONE 13:3, pages e0194883.
Crossref
Mariangela Allocca, Federica Furfaro, Gionata Fiorino, Daniela Gilardi, Silvia D'Alessio & Silvio Danese. (2018) Can IL-23 be a good target for ulcerative colitis?. Best Practice & Research Clinical Gastroenterology 32-33, pages 95-102.
Crossref
Xiaoshi Ma, Zhaolai Dai, Kaiji Sun, Yunchang Zhang, Jingqing Chen, Ying Yang, Patrick Tso, Guoyao Wu & Zhenlong Wu. (2017) Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review. Frontiers in Immunology 8.
Crossref
Alessandra Geremia & Carolina V. Arancibia-Cárcamo. (2017) Innate Lymphoid Cells in Intestinal Inflammation. Frontiers in Immunology 8.
Crossref
Haihua Lin, Renpin Chen, Xuepei Jiang, Xiaoli Wu, Xielin Huang, Xiuli Dong, Xu Yang, Xiuqing Lin, Xin Chen, Xiangrong Chen & Zhiming Huang. (2017) Elevated fibrinogen-like protein 2 in TNBS-induced colitis mice: Association with Th17 and regulatory T cells. Molecular Medicine Reports 16:3, pages 3445-3454.
Crossref
Fangli Yang, Danan Wang, Yan Li, Lixuan Sang, Junfeng Zhu, Jinyan Wang, Bing Wei, Changlong Lu & Xun Sun. (2017) Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis. Journal of Immunology Research 2017, pages 1-11.
Crossref
Y. Darbaky, B. Evrard, S. Patrier, J. Falenta, S. Garcin, A. Tridon, M. Dapoigny, C. Silberberg, A. Nivoliez & L. Diop. (2017) Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 ® prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress . Journal of Applied Microbiology 122:1, pages 188-200.
Crossref
Jennifer Lee, Pedro M. Moraes-Vieira, Angela Castoldi, Pratik Aryal, Eric U. Yee, Christopher Vickers, Oren Parnas, Cynthia J. Donaldson, Alan Saghatelian & Barbara B. Kahn. (2016) Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. Journal of Biological Chemistry 291:42, pages 22207-22217.
Crossref
Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Krystyna Stec-Michalska, Jakub Fichna & Maria Wiśniewska-Jarosińska. (2016) The influence of family pattern abnormalities in the early stages of life on the course of inflammatory bowel diseases. Pharmacological Reports 68:4, pages 852-858.
Crossref
Xuelian Hu, Peng Wang, Junfeng Du, Fan Yang, Yuan Tian, Xiaofei Shen, Tao Yang, Lianfeng Zhang & Yong Zhao. (2016) Phosphatase Wip1 Masters IL-17–producing Neutrophil-mediated Colitis in Mice. Inflammatory Bowel Diseases 22:6, pages 1316-1325.
Crossref
Anthony W. Segal. (2016) Making sense of the cause of Crohn’s – a new look at an old disease. F1000Research 5, pages 2510.
Crossref
M. Kave, M. Shadman, A. Alizadeh & M. Samadi. (2015) Analysis of the association between IL-23R rs11209026 polymorphism and incidence of atherosclerosis. International Journal of Immunogenetics 42:5, pages 341-345.
Crossref
Cristina-Sorina Cătană, Ioana Berindan Neagoe, Vasile Cozma, Cristian Magdaş, Flaviu Tăbăran & Dan Lucian Dumitraşcu. (2015) Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology 21:19, pages 5823-5830.
Crossref
Xin-Pu Miao, Xiao-Ning Sun, Lu-Jia Cui, Qin-Fang Cao, Gui-Feng Zhuang, Tao-Zhi Deng & Dong-Yan Zhang. (2015) Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF– κ B pathway and interleukin–17 in mice with dextran sulphatesodium–induced ulcerative colitis. Asian Pacific Journal of Tropical Medicine 8:2, pages 147-152.
Crossref
Tilman Schmidt, Hans‐Joachim Paust, Christian F. Krebs, Jan‐Eric Turner, Anna Kaffke, Sabrina B. Bennstein, Tobias Koyro, Anett Peters, Joachim Velden, Stefanie Hünemörder, Friedrich Haag, Oliver M. Steinmetz, Hans‐Willi Mittrücker, Rolf A. K. Stahl & Ulf Panzer. (2015) Function of the Th17/Interleukin‐17A Immune Response in Murine Lupus Nephritis. Arthritis & Rheumatology 67:2, pages 475-487.
Crossref
Tomoo Nakagawa, Tatsuro Katsuno, Yoshiko Noguchi, Yasushi Mandai, Sayuri Yoshihama, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai & Osamu Yokosuka. (2015) Irsogladine Maleate Prevents Colitis in Interleukin-10 Gene-Deficient Mice by Reducing Interleukin-12 and -23 Production. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 38:11, pages 1681-1688.
Crossref
Bruno Rafael Ramos de Mattos, Maellin Pereira Gracindo Garcia, Julia Bier Nogueira, Lisiery Negrini Paiatto, Cassia Galdino Albuquerque, Caique Lopes Souza, Luís Gustavo Romani Fernandes, Wirla Maria da Silva Cunha Tamashiro & Patricia Ucelli Simioni. (2015) Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments. Mediators of Inflammation 2015, pages 1-11.
Crossref
Hirotada Akiho, Yohei Tokita, Kazuhiko Nakamura, Kazuko Satoh, Mitsue Nishiyama, Naoko Tsuchiya, Kazuaki Tsuchiya, Katsuya Ohbuchi, Yoichiro Iwakura, Eikichi Ihara, Ryoichi Takayanagi & Masahiro Yamamoto. (2014) Involvement of Interleukin-17A-Induced Hypercontractility of Intestinal Smooth Muscle Cells in Persistent Gut Motor Dysfunction. PLoS ONE 9:5, pages e92960.
Crossref
Agnieszka Karczmarczyk, Marta Karp & Krzysztof Giannopoulos. (2014) The role of Th17 cells in tumor immunity. Acta Haematologica Polonica 45:2, pages 155-160.
Crossref
Antonietta RizzoCaterina Romano CarratelliAntonio LosaccoMaria Rosaria Iovene. (2014) Antimicrobial Effect of Natural Polyphenols With or Without Antibiotics on Chlamydia pneumoniae Infection In Vitro . Microbial Drug Resistance 20:1, pages 1-10.
Crossref
Rui Lu, Xin Zeng, Qi Han, Mu Lin, Long Long, Hongxia Dan, Gang Zhou & Qianming Chen. (2014) Overexpression and Selectively Regulatory Roles of IL-23/IL-17 Axis in the Lesions of Oral Lichen Planus. Mediators of Inflammation 2014, pages 1-12.
Crossref
Alessandra Geremia, Paolo Biancheri, Philip Allan, Gino R. Corazza & Antonio Di Sabatino. (2014) Innate and adaptive immunity in inflammatory bowel disease. Autoimmunity Reviews 13:1, pages 3-10.
Crossref
Crispian Scully. 2014. Scully's Medical Problems in Dentistry. Scully's Medical Problems in Dentistry 199 211 .
Kevan Jacobson & Philip C. Calder. 2014. Pharma-Nutrition. Pharma-Nutrition 75 89 .
Sang Doo Kim, Soonil Kwon, Sung Kyun Lee, Minsoo Kook, Ha Young Lee, Ki-Duk Song, Hak-Kyo Lee, Suk-Hwan Baek, Chan Bae Park & Yoe-Sik Bae. (2013) The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Experimental & Molecular Medicine 45:9, pages e40-e40.
Crossref
Jing Zhang, Bing Wang, Wen Zhang, Yao Wei, Zhen Bian, Chen-Yu Zhang, Limin Li & Ke Zen. (2013) Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells. PLoS ONE 8:8, pages e70828.
Crossref
Severine Navarro, Ivana Ferreira & Alex Loukas. (2013) The hookworm pharmacopoeia for inflammatory diseases. International Journal for Parasitology 43:3-4, pages 225-231.
Crossref
Daniel S Straus. (2013) TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Molecular Cancer 12:1, pages 78.
Crossref
Daniela Fenoglio, Francesca Bernuzzi, Florinda Battaglia, Alessia Parodi, Francesca Kalli, Simone Negrini, Raffaele De Palma, Pietro Invernizzi & Gilberto Filaci. (2012) Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases. Autoimmunity Reviews 12:2, pages 300-304.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.