Advanced search
Publication Cover
Expert Review of Hematology Volume 4, 2011 - Issue 6
Submit an article Journal homepage
446
Views
66
CrossRef citations to date
0
Altmetric
Review

The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease

John J Strouse Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected]; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected]; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
,
Sophie Lanzkron Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
&
Victor Urrutia Division of Cerebrovascular Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Cerebrovascular Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Pages 597-606 | Published online: 10 Jan 2014

Citations (66)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Jennifer Light, Maria Boucher, Jacquelyn Baskin-Miller & Mike Winstead. (2023) Managing the Cerebrovascular Complications of Sickle Cell Disease: Current Perspectives. Journal of Blood Medicine 14, pages 279-293.
Read now
Foluso Joy Ogunsile, Rakhi Naik & Sophie Lanzkron. (2019) Overcoming challenges of venous thromboembolism in sickle cell disease treatment. Expert Review of Hematology 12:3, pages 173-182.
Read now

Articles from other publishers (64)

Jihee Choi, John Emmanuel Markantonis, Nicole De Simone, Alecia Nero, Jaehyup Kim & Ravi Sarode. (2023) Hemoglobin S target of <50% as compared to 30% in chronic red cell exchange for secondary stroke prevention in sickle cell disease. Journal of Clinical Apheresis.
Crossref
Ghidaa Babeer, Danah Omran, Noor Bawahab, Raghad W Mohammed Hussain, Osama Muthaffar, Fatmah Alzahrani & Jumana A Shafei. (2023) Prevalence and Risk Factors of Stroke Among Children With Sickle Cell Disease: A Retrospective Study at a Tertiary Care Center. Cureus.
Crossref
Nirupama Ramadas & Erica M. Sparkenbaugh. (2023) The APC-EPCR-PAR1 axis in sickle cell disease. Frontiers in Medicine 10.
Crossref
Kristine Matusiak, Kevin H.M. Kuo, Andrew Binding, David Barth & Christopher J. Patriquin. (2023) Characterizing the process of urgent referrals and transfers to a large tertiary care apheresis centre in Ontario: A retrospective database review. Transfusion and Apheresis Science 62:3, pages 103723.
Crossref
Vafa Alakbarzade, Chinedu Maduakor, Usman Khan, Nader Khandanpour, Elizabeth Rhodes & Anthony C Pereira. (2023) Cerebrovascular disease in sickle cell disease. Practical Neurology 23:2, pages 131-138.
Crossref
Leticia Almeida de Assunção, Ana Paula Figueiredo Barbosa, Paulo Monteiro Dos Santos Filho, Fernanda Cals de Oliveira Caraciolo, Jully Greyce Freitas de Paula Ramalho, Raquel Rodrigues De Andrade, Adriane Maria Bezerra Da Silva & Carlos Marcelo da Silva Moraes. (2023) PREDITORES GENÉTICOS DE SUSCETIBILIDADE A VASCULOPATIA CEREBRAL NA DOENÇA FALCIFORME: REVISÃO DE LITERATURA. Revista Contemporânea 3:2, pages 1086-1102.
Crossref
Taral Parikh, Ashish Goti, Kanica Yashi, Naveen Prasad Gopalakrishnan Ravikumar, Narendrasinh Parmar, Nilesh Dankhara & Vimal Satodiya. (2023) Pediatric Sickle Cell Disease and Stroke: A Literature Review. Cureus.
Crossref
Ivana Markovic, Zoran Milenkovic, Bosanka Jocic-Jakubi, Amna Al Futaisi, Kakaria Anupam Kakaria & Yasser Walli. (2022) Stroke in sickle cell disease in association with bilateral absence of the internal carotid arteries. Case report. BMC Neurology 22:1.
Crossref
Christopher P. Carroll & Amanda M. Brandow. (2022) Chronic Pain. Hematology/Oncology Clinics of North America 36:6, pages 1151-1165.
Crossref
Wyatt P. Bensken, Philip M. Alberti, Omar I. Khan, Scott M. Williams, Kurt C. Stange, Guadalupe Fernandez-Baca Vaca, Barbara C. Jobst, Martha Sajatovic & Siran M. Koroukian. (2022) A framework for health equity in people living with epilepsy. Epilepsy Research 188, pages 107038.
Crossref
Scott D. Ramsey, M. A. Bender, Li Li, Kate M. Johnson, Boshen Jiao, Beth Devine & Anirban Basu. (2022) Prevalence of comorbidities associated with sickle cell disease among non-elderly individuals with commercial insurance–A retrospective cohort study. PLOS ONE 17:11, pages e0278137.
Crossref
Mahdi Bedrouni, Lahoud Touma, Caroline Sauvé, Stephan Botez, Denis Soulières & Stéphanie Forté. (2022) Numb Chin Syndrome in Sickle Cell Disease: A Systematic Review and Recommendations for Investigation and Management. Diagnostics 12:12, pages 2933.
Crossref
Caterina Minniti, Carlo Brugnara & Martin H. Steinberg. (2022) HbSC disease: A time for progress . American Journal of Hematology 97:11, pages 1390-1393.
Crossref
Chinedu Maduakor, Vafa Alakbarzade, Yezen Sammaraiee, Angeliki Vakrinou, Alina Corobana, Julia Sikorska, Elizabeth Rhodes & Anthony C. Pereira. (2021) The Epidemiology of Neurological Complications in Adults With Sickle Cell Disease: A Retrospective Cohort Study. Frontiers in Neurology 12.
Crossref
Rufus O. Akinyemi, Bruce Ovbiagele, Olaleye A. Adeniji, Fred S. Sarfo, Foad Abd-Allah, Thierry Adoukonou, Okechukwu S. Ogah, Pamela Naidoo, Albertino Damasceno, Richard W. Walker, Adesola Ogunniyi, Rajesh N. Kalaria & Mayowa O. Owolabi. (2021) Stroke in Africa: profile, progress, prospects and priorities. Nature Reviews Neurology 17:10, pages 634-656.
Crossref
Fenella Jane Kirkham & Ikeoluwa A. Lagunju. (2021) Epidemiology of Stroke in Sickle Cell Disease. Journal of Clinical Medicine 10:18, pages 4232.
Crossref
Pallab Bhattacharya, Deepaneeta Sarmah, Kunjan R. Dave, Avirag Goswami, Mitsuyoshi Watanabe, Xin Wang, Kiran Kalia, Nikolaus Plesnila, Dileep R. Yavagal & Ofelia Alvarez. (2021) Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries. Journal of the Neurological Sciences 427, pages 117510.
Crossref
Frédéric B. Piel, Minesh Jobanputra, Meghan Gallagher, Jon Weber, Sandra G. Laird & Michael McGahan. (2021) Co-morbidities and mortality in patients with sickle cell disease in England: A 10-year cohort analysis using hospital episodes statistics (HES) data. Blood Cells, Molecules, and Diseases 89, pages 102567.
Crossref
Sandip Kuikel, Robin Rauniyar, Sanjeev Kharel, Anil Bist, Subarna Giri, Sahil Thapaliya & Sunanda Paudel. (2021) Prevalence of Stroke in Asian Patients with Sickle Cell Anemia: A Systematic Review and Meta-Analysis. Neurology Research International 2021, pages 1-7.
Crossref
SangitaD Kamath & ManishGanesh Pai. (2021) A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!. Asian Journal of Transfusion Science 15:2, pages 241.
Crossref
Babawale Arabambi, Olajumoke Oshinaike, OluwakemiOluwabunmi Akilo, Yakub Yusuf & ShamsideenAbayomi Ogun. (2021) Pattern, risk factors, and outcome of acute stroke in a Nigerian university teaching hospital: A 1-year review. Nigerian Journal of Medicine 30:3, pages 252.
Crossref
Dermot Mallon, David Doig, Luke Dixon, Anastasia Gontsarova, Wajanat Jan & Francesca Tona. (2020) Neuroimaging in Sickle Cell Disease: A Review. Journal of Neuroimaging 30:6, pages 725-735.
Crossref
Amal Al Hashmi & Sanjith Aaron. (2020) Acute Ischemic Stroke in Sickle Cell Disease Challenges for Thrombolysis. Dubai Medical Journal 3:4, pages 173-177.
Crossref
Jessica Venugopal, Jintao Wang, Jalal Mawri, Chiao Guo & Daniel Eitzman. (2020) Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease. Haematologica 106:9, pages 2469-2477.
Crossref
Sandra L. Samarron, Joshua W. Miller, Anthony T. Cheung, Peter C. Chen, Xin Lin, Theodore Zwerdling, Ted Wun & Ralph Green. (2020) Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients. British Journal of Haematology 190:3, pages 450-457.
Crossref
L. Distelmaier, U. Dührsen & R. Dickerhoff. (2020) SichelzellkrankheitSickle cell disease. Der Internist 61:7, pages 754-758.
Crossref
Andrew Srisuwananukorn, Rasha RaslanXu ZhangBinal N. Shah, Jin Han, Michel GowhariRobert E. Molokie, Victor R. Gordeuk & Santosh L. Saraf. (2020) Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease. Blood Advances 4:9, pages 1978-1986.
Crossref
Esther Boot, Merel Sanne Ekker, Jukka Putaala, Steven Kittner, Frank-Erik De Leeuw & Anil M Tuladhar. (2020) Ischaemic stroke in young adults: a global perspective. Journal of Neurology, Neurosurgery & Psychiatry 91:4, pages 411-417.
Crossref
Fenella J Kirkham. 2020. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 595 609 .
Robyn Westmacott & Ida Sue Baron. 2020. Neurovascular Neuropsychology. Neurovascular Neuropsychology 359 398 .
Purim Cesar, Anamika Dhyani, Luiz Augusto Schwade, Pollyana Acordi, Cinthia Xerez Albuquerque, Rejane Nina, Erich V. De Paula & Nelson Fraiji. (2019) Epidemiological, clinical, and severity characterization of sickle cell disease in a population from the Brazilian Amazon. Hematology/Oncology and Stem Cell Therapy 12:4, pages 204-210.
Crossref
M.E. Houwing, P.J. de Pagter, E.J. van Beers, B.J. Biemond, E. Rettenbacher, A.W. Rijneveld, E.M. Schols, J.N.J. Philipsen, R.Y.J. Tamminga, K. Fijn van Draat, E. Nur & M.H. Cnossen. (2019) Sickle cell disease: Clinical presentation and management of a global health challenge. Blood Reviews 37, pages 100580.
Crossref
Ann Brunson, Theresa Keegan, Anjlee Mahajan, Richard White & Ted Wun. (2019) High incidence of venous thromboembolism recurrence in patients with sickle cell disease. American Journal of Hematology 94:8, pages 862-870.
Crossref
Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Tarek Mostafa Kamal, Deena Samir Eissa, Eman Abdel Rahman Ismail & Samar Hassan Mohamed. (2019) Angiotensinogen M235T Gene Polymorphism is a Genetic Determinant of Cerebrovascular and Cardiopulmonary Morbidity in Adolescents with Sickle Cell Disease. Journal of Stroke and Cerebrovascular Diseases 28:2, pages 441-449.
Crossref
Meher R. Juttukonda, Chelsea A. Lee, Niral J. Patel, Larry T. Davis, Spencer L. Waddle, Melissa C. Gindville, Sumit Pruthi, Adetola A. Kassim, Michael R. DeBaun, Manus J. Donahue & Lori C. Jordan. (2019) Differential cerebral hemometabolic responses to blood transfusions in adults and children with sickle cell anemia. Journal of Magnetic Resonance Imaging 49:2, pages 466-477.
Crossref
Sneha JacobAmelia AdcockAnn MurrayJoanna Kolodney. (2018) More Than Meets the Eye. Stroke 49:6.
Crossref
Jeanne E. Hendrickson & Ross M. Fasano. 2018. Sickle Cell Disease and Hematopoietic Stem Cell Transplantation. Sickle Cell Disease and Hematopoietic Stem Cell Transplantation 111 136 .
Elliott Vichinsky. (2017) Chronic organ failure in adult sickle cell disease. Hematology 2017:1, pages 435-439.
Crossref
Susan Zamani, Afshin Borhan Haghighi, Sezaneh Haghpanah, Mehran Karimi & Mohammad R. Bordbar. (2017) Transcranial Doppler Screening in 50 Patients With Sickle Cell Hemoglobinopathies in Iran. Journal of Pediatric Hematology/Oncology 39:7, pages 506-512.
Crossref
Sara Mazzucco, Marina Diomedi, Amrana Qureshi, Laura Sainati & Soundrie T Padayachee. (2017) Transcranial Doppler screening for stroke risk in children with sickle cell disease: a systematic review. International Journal of Stroke 12:6, pages 580-588.
Crossref
Loubna Majhadi, David Calvet, Charlotte Rosso & Pablo Bartolucci. (2017) Thrombolytic therapy for the treatment of acute ischaemic stroke in adults with homozygous sickle cell disease. BMJ Case Reports, pages bcr-2017-220011.
Crossref
Abhishek Dattani & Ava Jackson. (2017) The cause of the stroke: a diagnostic uncertainty. BMJ Case Reports, pages bcr-2016-218358.
Crossref
A. Kyle Mack & Alexis A. Thompson. (2017) Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease. Journal of Pediatric Health Care 31:2, pages 145-154.
Crossref
Erica Simon, Brit Long & Alex Koyfman. (2016) Emergency Medicine Management of Sickle Cell Disease Complications: An Evidence-Based Update. The Journal of Emergency Medicine 51:4, pages 370-381.
Crossref
Sheila Razdan, John J. Strouse, Anusha Reddy, Danielle F. Resar, Rani K. Hasan, Jon R. Resar, Rakhi P. Naik, Victor C. Urrutia, Sophie Lanzkron & Linda M.S. Resar. (2016) Patent foramen ovale in adults with sickle cell disease and stroke. American Journal of Hematology 91:9, pages E358-E360.
Crossref
Stella T. Chou & Ross M. Fasano. (2016) Management of Patients with Sickle Cell Disease Using Transfusion Therapy. Hematology/Oncology Clinics of North America 30:3, pages 591-608.
Crossref
Lynne Neumayr & Elliott Vichinsky. (2016) Stroke recurrence in adult sickle cell patients: it is time for action!. Transfusion 56:5, pages 1001-1004.
Crossref
Sarah Mattioni, Katia Stankovic Stojanovic, Robert Girot & François Lionnet. (2016) La drépanocytose en France. Revue Francophone des Laboratoires 2016:481, pages 61-66.
Crossref
Lori C. Jordan, Melissa C. Gindville, Allison O. Scott, Meher R. Juttukonda, Megan K. Strother, Adetola A. Kassim, Sheau-Chiann Chen, Hanzhang Lu, Sumit Pruthi, Yu Shyr & Manus J. Donahue. (2016) Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain 139:3, pages 738-750.
Crossref
Michael R. DeBaun & Fenella J. Kirkham. (2016) Central nervous system complications and management in sickle cell disease. Blood 127:7, pages 829-838.
Crossref
J. Strouse. 2016. Neuroepidemiology. Neuroepidemiology 311 324 .
Akifumi Fujita, Chie Asai, Yu-Ming Chang, Nadja Kadom, Martin H. Steinberg, Naoko Saito & Osamu Sakai. 2016. Neurovascular Imaging. Neurovascular Imaging 439 467 .
Shruti Chaturvedi & Michael R. DeBaun. (2016) Evolution of sickle cell disease from a life-threatening disease of children to a chronic disease of adults: The last 40 years. American Journal of Hematology 91:1, pages 5-14.
Crossref
Adnan I. Qureshi, Ahmed A. Malik, Malik M. Adil & M. Fareed K. Suri. (2015) Oral contraceptive use and incident stroke in women with sickle cell disease. Thrombosis Research 136:2, pages 315-318.
Crossref
Matthew Lyon, Justin Jeter & Richard Lottenberg. (2015) Approach to the diagnosis and treatment of acute subarachnoid hemorrhage in a patient with sickle cell disease. The American Journal of Emergency Medicine 33:3, pages 481.e3-481.e4.
Crossref
Ademola Samson Adewoyin. (2015) Management of Sickle Cell Disease: A Review for Physician Education in Nigeria (Sub-Saharan Africa). Anemia 2015, pages 1-21.
Crossref
Ross M. Fasano, Emily R. Meier & Monica L. Hulbert. (2015) Cerebral vasculopathy in children with sickle cell anemia. Blood Cells, Molecules, and Diseases 54:1, pages 17-25.
Crossref
Melissa C. CaugheyLaura R. LoehrNigel S. KeyVimal K. DerebailRebecca F. GottesmanAbhijit V. KshirsagarMegan L. GroveGerardo Heiss. (2014) Sickle Cell Trait and Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study. Stroke 45:10, pages 2863-2867.
Crossref
Murad TalahmaDaniel StrbianSophia Sundararajan. (2014) Sickle Cell Disease and Stroke. Stroke 45:6.
Crossref
Oluseyi Oniyangi, AO Akano, TT Wakama & AB Oyesakin. (2014) Transcranial Doppler ultrasound studies for the primary prevention of strokes among children with sickle cell disease in Nigeria – a single tertiary center experience. Research 1.
Crossref
Akifumi Fujita, Chie Asai, Yu-Ming Chang, Nadja Kadom, Martin H. Steinberg, Naoko Saito & Osamu Sakai. 2014. Neurovascular Imaging. Neurovascular Imaging 1 35 .
Julie Kanter & Rebecca Kruse-Jarres. (2013) Management of sickle cell disease from childhood through adulthood. Blood Reviews 27:6, pages 279-287.
Crossref
Philippe Connes, Suzanne Verlhac & Françoise Bernaudin. (2013) Advances in understanding the pathogenesis of cerebrovascular vasculopathy in sickle cell anaemia. British Journal of Haematology 161:4, pages 484-498.
Crossref
Sheila Razdan, John J. Strouse, Rakhi Naik, Sophie Lanzkron, Victor Urrutia, Jon R. Resar & Linda M. S. Resar. (2013) Patent Foramen Ovale in Patients with Sickle Cell Disease and Stroke: Case Presentations and Review of the Literature. Case Reports in Hematology 2013, pages 1-5.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.