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Expert Review of Cardiovascular Therapy Volume 9, 2011 - Issue 5
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Clinical Trial Report

Efficacy and safety of pitavastatin in Japanese patients with hypercholesterolemia: LIVES study and subanalysis

Koutaro Yokote Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. [email protected]; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. [email protected]
,
Hitoshi Shimano Department of Internal Medicine, Metabolism and Endocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Internal Medicine, Metabolism and Endocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Mitsuyoshi Urashima Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan; Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
&
Tamio Teramoto Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan; Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Pages 555-562 | Published online: 10 Jan 2014

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Steven G. Chrysant. (2017) New onset diabetes mellitus induced by statins: current evidence. Postgraduate Medicine 129:4, pages 430-435.
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Vivencio Barrios, Carlos Escobar & José L Zamorano. (2013) Searching the place of pitavastatin in the current treatment of patients with dyslipidemia. Expert Review of Cardiovascular Therapy 11:12, pages 1597-1612.
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Articles from other publishers (29)

Seung-Jun Lee, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Bum-Kee Hong, Yangsoo Jang, Myeong-Ki Hong, Myeong-Ki Hong, Donghoon Choi, Young-Guk Ko, Byeong-Keuk Kim, Jung-Sun Kim, Chul-Min Ahn, Sung-Jin Hong, Seung-Jun Lee, Yong-Joon Lee, Bum-Kee Hong, Hyuck Moon Kwon, Jong-Youn Kim, Pil Ki Min, Young Won Yoon, Byoung Kwon Lee, Se-Joong Rim, Eui-Young Choi, Woong CholKang, Pyung Chun Oh, Jong-Young Lee, Jin-Bae Lee, Kee Sik Kim, Ji Yong Choi, Jae Kean Ryu, Seung Pyo Hong, Chang Yeon Kim, Tae-Hyun Yang, Hyung-Jin Cho, Junghan Yoon, Min-Soo Ahn, Sung Gyun Ahn, Jun-Won Lee, Jung-Woo Son, Yangsoo Jang, Hyuck-Jun Yoon, Cheol Hyun Lee, Jongmin Hwang, Yun-Kyeong Cho, Seung-Ho Hur, Seongwook Han, Chang-Wook Nam, Hyoungseop Kim, Hyoung-Seob Park, In-Cheol Kim, Yun-Hyeong Cho, Hyeon-Ju Jeong, Jin-Ho Kim, Chewan Lim, Yongsung Suh, Eui Seok Hwang, Ji Hyun Lee, Sung Yun Lee, Sung Uk Kwon, Song-Yi Kim, Keun-Ho Park & Hyun Kuk Ki. (2023) Treat-to-target versus high-intensity statin treatment in patients with or without diabetes mellitus: a pre-specified analysis from the LODESTAR trial. eClinicalMedicine 64, pages 102227.
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A. A. Nekrasov, E. S. Timoshchenko, D. V. Cherneva, I. N. Volovatova & T. A. Nekrasova. (2023) Indicators of carbohydrate metabolism in a patient with dyslipidemia and impaired fasting glycemia receiving pitavastatin: a case report. Cardiovascular Therapy and Prevention 21:12, pages 3496.
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Ming-Ting Chou, Anthony McGirr, Gwo-Ping Jong, Ting-Hsing Chao, I-Te Lee, Chun-Yao Huang, Ching-Pei Chen, Chang-Hsun Hsieh, Chieh-Hsiang Lu & Wayne Huey-Herng Sheu. (2022) Effect of 1PC111, a Fixed-dose Combination of Pitavastatin and Ezetimibe, Versus Pitavastatin or Ezetimibe Monotherapy on Lipid Profiles in Patients With Hypercholesterolemia or Mixed Dyslipidemia: A Randomized, Double-blind, Multicenter, Phase III Study. Clinical Therapeutics 44:10, pages 1272-1281.
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Marina G. Bubnova. (2022) Optimizing therapy for cardiovascular diseases: proven organ-protective and preventive effects of pitavastatin and lercanidipine: A review. CardioSomatics 13:1, pages 31-42.
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Won-Woo Seo, Seung In Seo, Yerim Kim, Jong Jin Yoo, Woon Geon Shin, Jinseob Kim, Seng Chan You, Rae Woong Park, Young Min Park, Kyung-Jin Kim, Sang Youl Rhee, Meeyoung Park, Eun-Sun Jin & Sung Eun Kim. (2022) Impact of pitavastatin on new-onset diabetes mellitus compared to atorvastatin and rosuvastatin: a distributed network analysis of 10 real-world databases. Cardiovascular Diabetology 21:1.
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Kush K. Patel, Viren S. Sehgal & Khosrow Kashfi. (2022) Molecular targets of statins and their potential side effects: Not all the glitter is gold. European Journal of Pharmacology 922, pages 174906.
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In-Kyung Jeong & Sung-Rae Kim. (2020) Efficacy and Safety of Pitavastatin in a Real-World Setting: Observational Study Evaluating SaFety in Patient Treated with Pitavastatin in Korea (PROOF Study). Endocrinology and Metabolism 35:4, pages 882-891.
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Woong Chol Kang, Minsu Kim, Sang Min Park, Byeong-Keuk Kim, Byoung-Kwon Lee & Hyuck Moon Kwon. (2020) Preventive Effect of Pretreatment with Pitavastatin on Contrast-Induced Nephropathy in Patients with Renal Dysfunction Undergoing Coronary Procedure: PRINCIPLE-II Randomized Clinical Trial. Journal of Clinical Medicine 9:11, pages 3689.
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Hae-Young Lee, Ki-Hoon Han, Woo-Baek Chung, Sung-Ho Her, Tae-Ho Park, Seung-Woon Rha, So-Yeon Choi, Kyung-Tae Jung, Jong-Seon Park, Pum-Joon Kim, Jong-Min Lee, Myung-Ho Jeong, Eun-Seok Shin, Hyeon-Cheol Gwon, Kyoo-Rok Han, Jei-Keon Chae, Woo-Shik Kim, Dong-Ju Choi, Bum-Kee Hong, Si-Wan Choi & Namsik Chung. (2020) Safety and Efficacy of Pitavastatin in Patients With Impaired Fasting Glucose and Hyperlipidemia: A Randomized, Open-labeled, Multicentered, Phase IV Study. Clinical Therapeutics 42:10, pages 2036-2048.
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Georgios A. Christou, Spyridon G Mprikos, Konstantinos A. Christou, Maria A. Christou, Evangelos A. Christou, Dimitrios N. Nikas & Dimitrios N. Kiortsis. (2020) High Tolerability of Pitavastatin Therapy: A Case Report of Comparison with other Statins. Cardiology 145:7, pages 421-424.
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Maryam Paseban, Alexandra E. Butler & Amirhossein Sahebkar. (2019) Mechanisms of statin‐induced new‐onset diabetes. Journal of Cellular Physiology 234:8, pages 12551-12561.
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Jianning Zhang, Yijia Shao, Yin Liu & Jun Tao. (2018) A Multi-Center, Open-Label, Two-Arm Parallel Group Non-inferiority Randomized Controlled Trial Evaluating the Effect of Pitavastatin, Compared to Atorvastatin, on Glucose Metabolism in Prediabetics with Hypertension and Dyslipidemia: Rationale and Design for the China Hemoglobin A1c Metabolism Protection Union Study (CAMPUS). Cardiovascular Drugs and Therapy 32:6, pages 581-589.
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Mayumi Wake, Yoshie Onishi, Florent Guelfucci, Akinori Oh, Shinzo Hiroi, Yukio Shimasaki & Tamio Teramoto. (2018) Treatment patterns in hyperlipidaemia patients based on administrative claim databases in Japan. Atherosclerosis 272, pages 145-152.
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Laura A Cox, Michael Olivier, Kimberly Spradling-Reeves, Genesio M Karere, Anthony G Comuzzie & John L VandeBerg. (2017) Nonhuman Primates and Translational Research—Cardiovascular Disease. ILAR Journal 58:2, pages 235-250.
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M. G Bubnova. (2017) Modern opportunities for lifestyle changes and statin therapy in the prevention of cardiovascular diseases. CardioSomatics 8:3, pages 39-4.
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Angela Pirillo & Alberico L. Catapano. (2017) Pitavastatin and HDL: Effects on plasma levels and function(s). Atherosclerosis Supplements 27, pages e1-e9.
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Sheridan M. Hoy. (2017) Pitavastatin: A Review in Hypercholesterolemia. American Journal of Cardiovascular Drugs 17:2, pages 157-168.
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Vivencio Barrios & Carlos Escobar. (2016) Clinical benefits of pitavastatin: focus on patients with diabetes or at risk of developing diabetes. Future Cardiology 12:4, pages 449-466.
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Marjet J.A.M. Braamskamp, Claudia Stefanutti, Gisle Langslet, Euridiki Drogari, Albert Wiegman, Neil Hounslow & John J.P. Kastelein. (2015) Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk. The Journal of Pediatrics 167:2, pages 338-343.e5.
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Niki Katsiki, Manfredi Rizzo, Dimitri P. Mikhailidis & Christos S. Mantzoros. (2015) New-Onset Diabetes and Statins: Throw the Bath Water Out, But, Please, Keep the Baby!. Metabolism 64:4, pages 471-475.
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Lorenzo Arnaboldi & Alberto Corsini. (2015) Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin. Atherosclerosis Supplements 16, pages 1-27.
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Antonio M. Gotto & Jennifer E. Moon. 2015. Dyslipidemias. Dyslipidemias 403 421 .
Tomohiro Yamasaki, Yoshio Iwashima, Subrina Jesmin, Yuko Ohta, Hiroshi Kusunoki, Shin-ichiro Hayashi, Takeshi Horio & Yuhei Kawano. (2014) Comparison of Efficacy of Intensive versus Mild Pitavastatin Therapy on Lipid and Inflammation Biomarkers in Hypertensive Patients with Dyslipidemia. PLoS ONE 9:2, pages e89057.
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Peter J. Little, Alan Chait, Andrzej S. Januszewski, Alex Bobik, David O’Neal & Alicia J. Jenkins. 2014. Lipoproteins in Diabetes Mellitus. Lipoproteins in Diabetes Mellitus 435 453 .
Kazumasa Kurogi, Seigo Sugiyama, Kenji Sakamoto, Shinji Tayama, Shinichi Nakamura, Takeshi Biwa, Kunihiko Matsui & Hisao Ogawa. (2013) Comparison of pitavastatin with atorvastatin in increasing HDL-cholesterol and adiponectin in patients with dyslipidemia and coronary artery disease: The COMPACT-CAD study. Journal of Cardiology 62:2, pages 87-94.
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Stefania Lamon-Fava. (2013) Statins and lipid metabolism. Current Opinion in Lipidology 24:3, pages 221-226.
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Steen StenderDragos BudinskiNeil Hounslow. (2012) Pitavastatin demonstrates long-term efficacy, safety and tolerability in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia. European Journal of Preventive Cardiology 20:1, pages 29-39.
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Hangyuan Guo, Haitao Lv, Weiliang Tang, Jufang Chi, Longbin Liu, Fukang Xu, Zheng Ji, Xiaoya Zhai & Fang Peng. (2012) Rosuvastatin may Modulate Insulin Signaling and Inhibit Atherogenesis Beyond its Plasma Cholesterol-Lowering Effect in Insulin-Resistant Mice. Cardiovascular Drugs and Therapy 26:5, pages 375-382.
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Jean Davignon. (2012) Pleiotropic effects of pitavastatin. British Journal of Clinical Pharmacology 73:4, pages 518-535.
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