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Review

DC Bead™: a major development in the toolbox for the interventional oncologist

Pages 389-400 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Seong Ik Jeon, Moo Song Kim, Hyung Jun Kim, Young Il Kim, Hwan Jun Jae & Cheol-Hee Ahn. (2022) Biodegradable poly(lactide-co-glycolide) microspheres encapsulating hydrophobic contrast agents for transarterial chemoembolization. Journal of Biomaterials Science, Polymer Edition 33:4, pages 409-425.
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Andrew S. Mikhail, Ayele H. Negussie, Michal Mauda-Havakuk, Joshua W. Owen, William F. Pritchard, Andrew L. Lewis & Bradford J. Wood. (2021) Drug-eluting embolic microspheres: State-of-the-art and emerging clinical applications. Expert Opinion on Drug Delivery 18:3, pages 383-398.
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Qin Shi, Yongning Lu, Songjiang Huang, Chen Zhou, Chongtu Yang, Jiacheng Liu, Jinqiang Ma & Bin Xiong. (2020) Apatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo. Drug Delivery 27:1, pages 1301-1307.
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Shuisheng Zhang, Can Huang, Zhengzheng Li, Yongjie Yang, Tingting Bao, Haibo Chen, Yinghua Zou & Li Song. (2017) Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers. Drug Delivery 24:1, pages 1011-1017.
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Yujing Wang, Abderazak Benzina, Daniel G.M. Molin, Nynke van den Akker, Mick Gagliardi & Leo H. Koole. (2015) Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy. Journal of Biomaterials Science, Polymer Edition 26:2, pages 77-91.
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Andrew L Lewis & Rachel R Holden. (2011) DC Bead embolic drug-eluting bead: clinical application in the locoregional treatment of tumours. Expert Opinion on Drug Delivery 8:2, pages 153-169.
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Articles from other publishers (46)

Enhao LuJun TieLingxiao LiuDong LuWeifu LvXianyi Sha. (2023) An In Vitro Comparative Study of Three Drug-Eluting Beads Loaded with Raltitrexed . Cancer Biotherapy and Radiopharmaceuticals 38:9, pages 641-649.
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Xiyu Zhu, Minghui Duan, Lin Zhang, Jiasheng Zhao, Sheng Yang, Rui Shen, Sen Chen, Linlin Fan & Jing Liu. (2023) Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization. Advanced Functional Materials 33:18.
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Xiaoya Liu, Xueying Wang, Yucheng Luo, Meijuan Wang, Zijian Chen, Xiaoyu Han, Sijia Zhou, Jiahao Wang, Jian Kong, Hanry Yu, Xiaobo Wang, Xiaoying Tang & Qiongyu Guo. (2023) A 3D Tumor‐Mimicking In Vitro Drug Release Model of Locoregional Chemoembolization Using Deep Learning‐Based Quantitative Analyses. Advanced Science 10:11.
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Ayele H. Negussie, Andrew S. Mikhail, Joshua W. Owen, Natalie Hong, Camella J. Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L. Lewis, John W. Karanian, William F. Pritchard & Bradford J. Wood. (2022) In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer. Scientific Reports 12:1.
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Andrew S. Mikhail, Michal Mauda-Havakuk, Ayele H. Negussie, Natalie Hong, Natalie M. Hawken, Camella J. Carlson, Joshua W. Owen, Olga Franco-Mahecha, Paul G. Wakim, Andrew L. Lewis, William F. Pritchard, John W. Karanian & Bradford J. Wood. (2022) Evaluation of immune-modulating drugs for use in drug-eluting microsphere transarterial embolization. International Journal of Pharmaceutics 616, pages 121466.
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Guorong Jia, Juno Van Valkenburgh, Austin Z. Chen, Quan Chen, Jindian Li, Changjing Zuo & Kai Chen. (2021) Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma. WIREs Nanomedicine and Nanobiotechnology 14:2.
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Yanqiao Ren, Yusheng Guo, Lei Chen, Tao Sun, Weihua Zhang, Bo Sun, Licheng Zhu, Fu Xiong & Chuansheng Zheng. (2022) Efficacy of Drug-Eluting Beads Transarterial Chemoembolization Plus Camrelizumab Compared With Conventional Transarterial Chemoembolization Plus Camrelizumab for Unresectable Hepatocellular Carcinoma. Cancer Control 29, pages 107327482210768.
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Shamsuddeen A. Ahmad, A.L. Lewis, G. Parkes, Y. Tang & L.J. Waters. (2021) Quantification and characterization of water within drug-eluting beads. Polymer 235, pages 124287.
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Cheng-Tang Pan, Ruei-Siang Yu, Chih-Jung Yang, Lih-Ren Chen, Zhi-Hong Wen, Nai-Yu Chen, Hsin-You Ou, Chun-Yen Yu & Yow-Ling Shiue. (2021) Sustained-Release and pH-Adjusted Alginate Microspheres-Encapsulated Doxorubicin Inhibit the Viabilities in Hepatocellular Carcinoma-Derived Cells. Pharmaceutics 13:9, pages 1417.
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Enhao Lu, Guoliang Shao, Jingqin Ma, Yiwei He, Yuanchuan Gong, Zhiping Yan & Xianyi Sha. (2021) Optimized Loading of Idarubicin in CalliSpheres® Drug-Eluting Beads and Characterization of Release Profiles and Morphological Properties. Pharmaceutics 13:6, pages 799.
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Aigerim Karina, Abderazak Benzina, Samal Tazhibayeva, Haiyan Fan & Levinus H. Koole. (2020) Polymer microparticles with a cavity designed for transarterial chemo‐embolization with crystalline drug formulations. Journal of Biomedical Materials Research Part B: Applied Biomaterials 109:3, pages 401-409.
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Monica S. Pearl, Nalin Gupta & Steven W. Hetts. 2021. Interventional Neuroradiology. Interventional Neuroradiology 361 378 .
Jun Zhao, Yan-shu Li, Zhi-Xing Liu, Mu-Hua Huang, Yu-hua Xu, Qing-rong Liang, Li Chen, Rong-guang Luo & Qun Tang. (2020) Nanosized drug-eluting bead for transcatheter arterial chemoembolization (ND-TACE). Journal of Materials Chemistry B 8:37, pages 8684-8694.
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A.L. Lewis. 2020. Biocompatibility and Performance of Medical Devices. Biocompatibility and Performance of Medical Devices 269 301 .
Alice Hagan, Marcus Caine, Cara Press, Wendy M. Macfarlane, Gary Phillips, Andrew W. Lloyd, Peter Czuczman, Hugh Kilpatrick, Zainab Bascal, Yiqing Tang, Pedro Garcia & Andrew L. Lewis. (2019) Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods. European Journal of Pharmaceutical Sciences 136, pages 104943.
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Andrew L Lewis & Brenda Hall. (2019) Toward a better understanding of the mechanism of action for intra-arterial delivery of irinotecan from DC Bead (TM) (DEBIRI) . Future Oncology 15:17, pages 2053-2068.
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Jean-Luc Raoul, Alejandro Forner, Luigi Bolondi, Tan To Cheung, Roman Kloeckner & Thierry de Baere. (2019) Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence. Cancer Treatment Reviews 72, pages 28-36.
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Baolin Wu, Jun Zhou, Gonghao Ling, Dongyong Zhu & Qingyun Long. (2018) CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma: a short-term efficacy and safety study. World Journal of Surgical Oncology 16:1.
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Andrew L Lewis, Sean L Willis, Matthew R Dreher, Yiqing Tang, Koorosh Ashrafi, Bradford J Wood, Elliot B Levy, Karun V Sharma, Ayele H Negussie & Andrew S Mikhail. (2018) Bench-to-clinic development of imageable drug-eluting embolization beads: finding the balance. Future Oncology 14:26, pages 2741-2760.
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Antonio Facciorusso. (2018) Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: Current state of the art. World Journal of Gastroenterology 24:2, pages 161-169.
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Marcus Caine, Dario Carugo, Xunli Zhang, Martyn Hill, Matthew R. Dreher & Andrew L. Lewis. (2017) Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab. Advanced Healthcare Materials 6:9, pages 1601291.
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Alice Hagan, Gary J. Phillips, Wendy M. Macfarlane, Andrew W. Lloyd, Peter Czuczman & Andrew L. Lewis. (2017) Preparation and characterisation of vandetanib-eluting radiopaque beads for locoregional treatment of hepatic malignancies. European Journal of Pharmaceutical Sciences 101, pages 22-30.
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Clare L. Heaysman, Gary J. Philips, Andrew W. Lloyd & Andrew L. Lewis. (2017) Unusual behaviour induced by phase separation in hydrogel microspheres. Acta Biomaterialia 53, pages 190-198.
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Koorosh Ashrafi, Yiqing Tang, Hugh Britton, Orianne Domenge, Delphine Blino, Andrew J. Bushby, Kseniya Shuturminska, Mark den Hartog, Alessandro Radaelli, Ayele H. Negussie, Andrew S. Mikhail, David L. Woods, Venkatesh Krishnasamy, Elliot B. Levy, Bradford J. Wood, Sean L. Willis, Matthew R. Dreher & Andrew L. Lewis. (2017) Characterization of a novel intrinsically radiopaque Drug-eluting Bead for image-guided therapy: DC Bead LUMI™. Journal of Controlled Release 250, pages 36-47.
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Iman Sarakbi & Irene Krämer. (2016) Compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media. Journal of Oncology Pharmacy Practice 22:6, pages 749-756.
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Kirsten C Spindeldreier, Judith Thiesen & Irene Krämer. (2015) Loading, release and stability of epirubicin-loaded drug-eluting beads. Journal of Oncology Pharmacy Practice 22:4, pages 591-598.
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Ron C. Gaba, Robert J. Lewandowski, Ryan Hickey, Mark O. Baerlocher, Emil I. Cohen, Sean R. Dariushnia, Bertrand Janne d’Othée, Siddharth A. Padia, Riad Salem, David S. Wang, Boris Nikolic & Daniel B. Brown. (2016) Transcatheter Therapy for Hepatic Malignancy: Standardization of Terminology and Reporting Criteria. Journal of Vascular and Interventional Radiology 27:4, pages 457-473.
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Yujing Wang, Daniël G.M. Molin, Chantal Sevrin, Christian Grandfils, Nynke M.S. van den Akker, Mick Gagliardi, Menno L. Knetsch, Tammo Delhaas & Leo H. Koole. (2016) In vitro and in vivo evaluation of drug-eluting microspheres designed for transarterial chemoembolization therapy. International Journal of Pharmaceutics 503:1-2, pages 150-162.
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Andrew L. Lewis, Matthew R. Dreher, Vincent O’Byrne, David Grey, Marcus Caine, Anthony Dunn, Yiqing Tang, Brenda Hall, Kirk D. Fowers, Carmen Gacchina Johnson, Karun V. Sharma & Bradford J. Wood. (2015) DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy. Journal of Materials Science: Materials in Medicine 27:1.
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Katerina MalagariEmmanouil Emmanouil, Maria Pomoni & Dimitrios Kelekis. (2014) Chemoembolization with DC Bead™ for the treatment of hepatocellular carcinoma: an update. Hepatic Oncology 1:2, pages 205-214.
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Valentin Verret, Julien Namur, Saïda Homayra Ghegediban, Michel Wassef, Laurence Moine, Michel Bonneau, Jean-Pierre Pelage & Alexandre Laurent. (2012) Toxicity of Doxorubicin on Pig Liver After Chemoembolization with Doxorubicin-loaded Microspheres: A Pilot DNA-microarrays and Histology Study. CardioVascular and Interventional Radiology 36:1, pages 204-212.
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Richard E.J. Forster, Yiqing Tang, Cressida Bowyer, Andrew W. Lloyd, Wendy Macfarlane, Gary J. Phillips & Andrew L. Lewis. (2012) Development of a combination drug-eluting bead. Anti-Cancer Drugs 23:4, pages 355-369.
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Matthew R. Dreher, Karun V. Sharma, David L. Woods, Goutham Reddy, Yiqing Tang, William F. Pritchard, Oscar A. Chiesa, John W. Karanian, Juan A. Esparza, Danielle Donahue, Elliot B. Levy, Sean L. Willis, Andrew L. Lewis & Bradford J. Wood. (2012) Radiopaque Drug-Eluting Beads for Transcatheter Embolotherapy: Experimental Study of Drug Penetration and Coverage in Swine. Journal of Vascular and Interventional Radiology 23:2, pages 257-264.e4.
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