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Expert Review of Medical Devices Volume 6, 2009 - Issue 5
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Review

Adipose tissue engineering: state of the art, recent advances and innovative approaches

Maria Cristina Tanzi Biomaterials Laboratory, Department of Bioengineering, Politecnico di Milano, 32 Piazza L da Vinci, 20133 Milano, Italy. [email protected]
&
Silvia Farè Biomaterials Laboratory, Department of Bioengineering, Politecnico di Milano, 32 Piazza L da Vinci, 20133 Milano, Italy. [email protected]
Pages 533-551 | Published online: 09 Jan 2014

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K Storck, J Ell, S Regn, B Rittler-Ungetüm, H Mayer, T Schantz, D Müller & M Buchberger. (2015) Optimization of in vitro cultivation strategies for human adipocyte derived stem cells. Adipocyte 4:3, pages 181-187.
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Norbert Pallua, Merdan Serin & Timm P. Wolter. (2014) Characterisation of angiogenetic growth factor production in adipose tissue-derived mesenchymal cells. Journal of Plastic Surgery and Hand Surgery 48:6, pages 412-416.
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Katharina Ladewig. (2011) Drug delivery in soft tissue engineering. Expert Opinion on Drug Delivery 8:9, pages 1175-1188.
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Shelly K McCrady-Spitzer & James A Levine. (2010) Integrated electronic platforms for weight loss. Expert Review of Medical Devices 7:2, pages 201-207.
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Articles from other publishers (71)

Astrid Bülow, Benedikt Schäfer & Justus P. Beier. (2023) Three-Dimensional Bioprinting in Soft Tissue Engineering for Plastic and Reconstructive Surgery. Bioengineering 10:10, pages 1232.
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Arne Peirsman, Huu Tuan Nguyen, Michiel Van Waeyenberge, Carlos Ceballos, Johana Bolivar, Satoru Kawakita, Florian Vanlauwe, Zuzana Tirpáková, Sofie Van Dorpe, Lana Van Damme, Marvin Mecwan, Menekse Ermis, Surjendu Maity, Kalpana Mandal, Rondinelli Herculano, Bernard Depypere, Lore Budiharto, Sandra Van Vlierberghe, Olivier De Wever, Phillip Blondeel, Vadim Jucaud, Mehmet Remzi Dokmeci & Ali Khademhosseini. (2023) Vascularized adipose tissue engineering: moving towards soft tissue reconstruction. Biofabrication 15:3, pages 032003.
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Tao Zhu, Xu Chen & Shenglu Jiang. (2023) Progress and obstacles in transplantation of brown adipose tissue or engineered cells with thermogenic potential for metabolic benefits. Frontiers in Endocrinology 14.
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Ye Li, Xin Bi, Mengfan Wu, Xinyao Chen, Weiqing Zhan, Ziqing Dong & Feng Lu. (2023) Adjusting the stiffness of a cell-free hydrogel system based on tissue-specific extracellular matrix to optimize adipose tissue regeneration. Burns & Trauma 11.
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. (2022) ABSTRACTS (BY NUMBER). Tissue Engineering Part A 28:S1, pages S-1-S-654.
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Zhu Zhu, Zhaoqi Yuan, Linxiumei Guo, Yeltai Nurzat, Heng Xu & Yixin Zhang. (2022) Construction of adipose tissue using a silica expander capsule and cell sheet-assembled of decellularized adipose tissue. Acta Biomaterialia 141, pages 89-101.
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Jiqiao Yang, Chen Zhou, Jingyang Fu, Qianru Yang, Tao He, Qiuwen Tan & Qing Lv. (2021) In situ Adipogenesis in Biomaterials Without Cell Seeds: Current Status and Perspectives. Frontiers in Cell and Developmental Biology 9.
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Eun Young Jeon, Kye Il Joo & Hyung Joon Cha. (2020) Body temperature-activated protein-based injectable adhesive hydrogel incorporated with decellularized adipose extracellular matrix for tissue-specific regenerative stem cell therapy. Acta Biomaterialia 114, pages 244-255.
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P.S. Wiggenhauser, C. Kuhlmann, J. Blum, R.E. Giunta & T. Schenck. (2020) Influence of software parameters on measurements in automatized image-based analysis of fat tissue histology. Acta Histochemica 122:4, pages 151537.
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Milad Dodangeh & Masoud Dodangeh. (2020) Metabolic regulation and the anti-obesity perspectives of brown adipose tissue (BAT); a systematic review. Obesity Medicine 17, pages 100163.
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Marie-Ève Ouellette, Jean-Christophe Bérubé, Jean-Michel Bourget, Maud Vallée, Yohan Bossé & Julie Fradette. (2019) Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue. PLOS ONE 14:10, pages e0224228.
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Liesbeth Tytgat, Lana Van Damme, Jasper Van Hoorick, Heidi Declercq, Hugo Thienpont, Heidi Ottevaere, Phillip Blondeel, Peter Dubruel & Sandra Van Vlierberghe. (2019) Additive manufacturing of photo-crosslinked gelatin scaffolds for adipose tissue engineering. Acta Biomaterialia 94, pages 340-350.
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N. Contessi Negrini, P. Tarsini, M. C. Tanzi & S. Farè. (2018) Chemically crosslinked gelatin hydrogels as scaffolding materials for adipose tissue engineering. Journal of Applied Polymer Science 136:8, pages 47104.
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Stefania Carobbio, Anne-Claire Guénantin, Isabella Samuelson, Myriam Bahri & Antonio Vidal-Puig. (2019) Brown and beige fat: From molecules to physiology and pathophysiology. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864:1, pages 37-50.
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Mina Mohseni, Nathan J. Castro, Hoang Phuc Dang, Tan Dat Nguyen, Hieu Minh Ho, Minh Phuong Nam Tran, Thi Hiep Nguyen & Phong A. Tran. 2019. Biomaterials in Translational Medicine. Biomaterials in Translational Medicine 291 330 .
Maroesjka Spiekman & Marco Conrad Harmsen. 2019. Autologous fat tissue transfer. Autologous fat tissue transfer 5 10 .
Maryse Proulx, Dominique Mayrand, Caroline Vincent, Annie Boisvert, Kim Aubin, Valérie Trottier & Julie Fradette. (2018) Short-term post-implantation dynamics of in vitro engineered human microvascularized adipose tissues . Biomedical Materials 13:6, pages 065013.
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Nida Tanataweethum, Adelyn Zelaya, Feipeng Yang, Ronald N. Cohen, Eric M. Brey & Abhinav Bhushan. (2018) Establishment and characterization of a primary murine adipose tissue-chip. Biotechnology and Bioengineering 115:8, pages 1979-1987.
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Manuela Lago, Lucília da Silva, Catarina Henriques, Andreia Carvalho, Rui Reis & Alexandra Marques. (2018) Generation of Gellan Gum-Based Adipose-Like Microtissues. Bioengineering 5:3, pages 52.
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Xiangpeng Li & Christopher J. Easley. (2017) Microfluidic systems for studying dynamic function of adipocytes and adipose tissue. Analytical and Bioanalytical Chemistry 410:3, pages 791-800.
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Janna Nawroth, Julia Rogal, Martin Weiss, Sara Y. Brucker & Peter Loskill. (2018) Organ-on-a-Chip Systems for Women's Health Applications. Advanced Healthcare Materials 7:2, pages 1700550.
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Paul A. Turner, Bhuvaneswari Gurumurthy, Jennifer L. Bailey, Carrie M. Elks & Amol V. Janorkar. (2017) Adipogenic differentiation of human adipose-derived stem cells grown as spheroids. Process Biochemistry 59, pages 312-320.
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Peter Loskill, Thiagarajan Sezhian, Kevin M. Tharp, Felipe T. Lee-Montiel, Shaheen Jeeawoody, Willie Mae Reese, Peter-James H. Zushin, Andreas Stahl & Kevin E. Healy. (2017) WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue. Lab on a Chip 17:9, pages 1645-1654.
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Abid Hussain, Khalid Mahmood Zia, Shazia Tabasum, Aqdas Noreen, Muhammad Ali, Rehana Iqbal & Mohammad Zuber. (2017) Blends and composites of exopolysaccharides; properties and applications: A review. International Journal of Biological Macromolecules 94, pages 10-27.
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Jinlin Wan, Ziqing Dong, Chen Lei & Feng Lu. (2016) Generating an Engineered Adipose Tissue Flap Using an External Suspension Device. Plastic & Reconstructive Surgery 138:1, pages 109-120.
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Byeong-Ju Kwon, Mi Hee Lee, Min-Ah Koo, Min Sung Kim, Gyeung Mi Seon, Jae-Jin Han & Jong-Chul Park. (2016) Ethyl-2, 5-dihydroxybenzoate displays dual activity by promoting osteoblast differentiation and inhibiting osteoclast differentiation. Biochemical and Biophysical Research Communications 471:3, pages 335-341.
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Yo-Shen Chen, Yen-Yu Chen, Yu-Sheng Hsueh, Hao-Chih Tai & Feng-Huei Lin. (2016) Modifying alginate with early embryonic extracellular matrix, laminin, and hyaluronic acid for adipose tissue engineering. Journal of Biomedical Materials Research Part A 104:3, pages 669-677.
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Maryse Proulx, Meryem Safoine, Dominique Mayrand, Kim Aubin, Amandine Maux & Julie Fradette. (2016) Impact of TNF and IL-1β on capillary networks within engineered human adipose tissues. Journal of Materials Chemistry B 4:20, pages 3608-3619.
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Andrea M. Unser, Bridget Mooney, David T. Corr, Yu-Hua Tseng & Yubing Xie. (2016) 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”. Biomaterials 75, pages 123-134.
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M. Spiekman & M. C. Harmsen. 2016. Autologe Fettgewebstransplantation. Autologe Fettgewebstransplantation 7 13 .
Charlotte Lequeux, Jonathan Rodriguez, Fabien Boucher, Ondine Rouyer, Odile Damour, Ali Mojallal & Céline Auxenfans. (2015) In vitro and in vivo biocompatibility, bioavailability and tolerance of an injectable vehicle for adipose-derived stem/stromal cells for plastic surgery indications. Journal of Plastic, Reconstructive & Aesthetic Surgery 68:11, pages 1491-1497.
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Andrea M. Unser, Yangzi Tian & Yubing Xie. (2015) Opportunities and challenges in three-dimensional brown adipogenesis of stem cells. Biotechnology Advances 33:6, pages 962-979.
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Maryse ProulxKim AubinJean LagueuxPierre AudetMichèle AugerMarc-André FortinJulie Fradette. (2015) Magnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes. Tissue Engineering Part C: Methods 21:7, pages 693-704.
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Paul A. TurnerYi TangStephen J. WeissAmol V. Janorkar. (2015) Three-Dimensional Spheroid Cell Model of In Vitro Adipocyte Inflammation . Tissue Engineering Part A 21:11-12, pages 1837-1847.
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Sabiniano Roman, Ahmad Agil, Macarena Peran, Eduardo Alvaro-Galue, Francisco J. Ruiz-Ojeda, Gumersindo Fernández-Vázquez & Juan A. Marchal. (2015) Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders. Translational Research 165:4, pages 464-479.
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Valentin Haug, Nestor Torio-Padron, G. Bjoern Stark, Guenter Finkenzeller & Sandra Strassburg. (2015) Comparison between endothelial progenitor cells and human umbilical vein endothelial cells on neovascularization in an adipogenesis mouse model. Microvascular Research 97, pages 159-166.
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Kim Aubin, Caroline Vincent, Maryse Proulx, Dominique Mayrand & Julie Fradette. (2015) Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products. Acta Biomaterialia 11, pages 333-345.
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Paolo Persichetti, Barbara Cagli, Tiziano Pallara, Donata Vaccaro, Carlo Mallio & Bruno Zobel. 2014. Imaging for Plastic Surgery. Imaging for Plastic Surgery 431 448 .
Cecilia Brännmark, Alexandra Paul, Diana Ribeiro, Björn Magnusson, Gabriella Brolén, Annika Enejder & Anna Forslöw. (2014) Increased Adipogenesis of Human Adipose-Derived Stem Cells on Polycaprolactone Fiber Matrices. PLoS ONE 9:11, pages e113620.
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Greta Minonzio, Mattia Corazza, Luca Mariotta, Mauro Gola, Michele Zanzi, Eugenio Gandolfi, Domenico De Fazio & Gianni Soldati. (2014) Frozen adipose-derived mesenchymal stem cells maintain high capability to grow and differentiate. Cryobiology 69:2, pages 211-216.
Crossref
Richard J. Ross, Ramin Shayan, Keith L. Mutimer & Mark W. Ashton. (2014) Autologous Fat Grafting. Annals of Plastic Surgery 73:3, pages 352-357.
Crossref
Meng-Yuan ZhangShi-Li DingSong-Jia TangHu YangHai-Fei ShiXiao Z. ShenWei-Qiang Tan. (2014) Effect of Chitosan Nanospheres Loaded with VEGF on Adipose Tissue Transplantation: A Preliminary Report. Tissue Engineering Part A 20:17-18, pages 2273-2282.
Crossref
Marcella Vaicik, Ronald Cohen & Eric Brey. 2014. Vascularization. Vascularization 325 342 .
Alfred Gugerell, Johanna Kober, Thorsten Laube, Torsten Walter, Sylvia Nürnberger, Elke Grönniger, Simone Brönneke, Ralf Wyrwa, Matthias Schnabelrauch & Maike Keck. (2014) Electrospun Poly(ester-Urethane)- and Poly(ester-Urethane-Urea) Fleeces as Promising Tissue Engineering Scaffolds for Adipose-Derived Stem Cells. PLoS ONE 9:3, pages e90676.
Crossref
Sebastian Gehmert, Silvan Klein, Sanga Gehmert, Xiaowen Bai & Lukas Prantl. (2014) Real-Time Tracking of Fusion Between Adipose-Tissue Derived Stem Cells and Myocyctes Using A Dual Fluorescent Protein Reporter Vector (pLVX-Puro-HS-GR). Materials and Methods 4.
Crossref
Paul A. Turner, Lacey M. Harris, Christine A. Purser, Rodney C. Baker & Amol V. Janorkar. (2014) A surface-tethered spheroid model for functional evaluation of 3T3-L1 adipocytes. Biotechnology and Bioengineering 111:1, pages 174-183.
Crossref
Kun-Hung Chang, Han-Tsung Liao & Jyh-Ping Chen. (2013) Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies. Acta Biomaterialia 9:11, pages 9012-9026.
Crossref
Heather A. Zimmerman, Kristine C. Olson, Gang Chen & Christopher J. Lynch. (2013) Adipose transplant for inborn errors of branched chain amino acid metabolism in mice. Molecular Genetics and Metabolism 109:4, pages 345-353.
Crossref
Dmitriy Sheyn, Gadi Pelled, Wafa Tawackoli, Susan Su, Shiran Ben-David, Dan Gazit & Zulma Gazit. (2013) Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation. Regenerative Medicine 8:3, pages 295-308.
Crossref
C M Hwang, B Ay, D L Kaplan, J P Rubin, K G Marra, A Atala, J J Yoo & S J Lee. (2013) Assessments of injectable alginate particle-embedded fibrin hydrogels for soft tissue reconstruction. Biomedical Materials 8:1, pages 014105.
Crossref
Sorina Dinescu, Bianca Galateanu, Madalina Albu, Anisoara Cimpean, Anca Dinischiotu & Marieta Costache. (2013) Sericin Enhances the Bioperformance of Collagen-Based Matrices Preseeded with Human-Adipose Derived Stem Cells (hADSCs). International Journal of Molecular Sciences 14:1, pages 1870-1889.
Crossref
Mohit P. Chhaya, Ferry P.W. Melchels, Paul S. Wiggenhauser, Jan T. Schantz & Dietmar W. Hutmacher. 2013. Biofabrication. Biofabrication 183 216 .
Paul Severin Wiggenhauser & Jan-Thorsten Schantz. 2013. Angiogenesis in Adipose Tissue. Angiogenesis in Adipose Tissue 351 370 .
Pedro P. Carvalho, Manuela E. Gomes, Rui L. Reis & Jeffrey M. Gimble. 2013. Mesenchymal Stromal Cells. Mesenchymal Stromal Cells 663 681 .
Changhyun Roh, Min-Kyoung Park, Hee-June Shin, Insub Kim, Jin Kyu Kim & Uhee Jung. (2012) Anti-Obesity Effect of Nepetae spica Extract in High-Fat Mice. Agriculture 2:3, pages 204-210.
Crossref
Qiang Chang & Feng Lu. (2012) A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold. Medical Hypotheses 79:2, pages 267-270.
Crossref
Changhyun Roh, Min-Kyoung Park, Hee-June Shin, Uhee Jung & Jin-Kyu Kim. (2012) Buddleja officinalis Maximowicz Extract Inhibits Lipid Accumulation on Adipocyte Differentiation in 3T3-L1 Cells and High-Fat Mice. Molecules 17:7, pages 8687-8695.
Crossref
A. Peterbauer-Scherb, M. Danzer, C. Gabriel, M. van Griensven, H. Redl & S. Wolbank. (2012) In vitro adipogenesis of adipose-derived stem cells in 3D fibrin matrix of low component concentration. Journal of Tissue Engineering and Regenerative Medicine 6:6, pages 434-442.
Crossref
Paul S. Wiggenhauser, Daniel F. Müller, Ferry P. W. Melchels, José T. Egaña, Katharina Storck, Helena Mayer, Peter Leuthner, Daniel Skodacek, Ursula Hopfner, Hans G. Machens, Rainer Staudenmaier & Jan T. Schantz. (2011) Engineering of vascularized adipose constructs. Cell and Tissue Research 347:3, pages 747-757.
Crossref
Changhyun Roh & Uhee Jung. (2012) Screening of Crude Plant Extracts with Anti-Obesity Activity. International Journal of Molecular Sciences 13:2, pages 1710-1719.
Crossref
Fabiola Munarin, Paola Petrini, Sabrina Bozzini & Maria Cristina Tanzi. (2018) New Perspectives in Cell Delivery Systems for Tissue Regeneration: Natural-derived Injectable Hydrogels. Journal of Applied Biomaterials & Functional Materials 10:2, pages 67-81.
Crossref
Ali Mojallal, Charlotte Lequeux, Christo Shipkov, Antoine Duclos, Fabienne Braye, Rod Rohrich, Spencer Brown & Odile Damour. (2011) Influence of Age and Body Mass Index on the Yield and Proliferation Capacity of Adipose-Derived Stem Cells. Aesthetic Plastic Surgery 35:6, pages 1097-1105.
Crossref
Ali Mojallal, Charlotte Lequeux, Christo Shipkov, Lucas Rifkin, Rod Rohrich, Antoine Duclos, Spencer Brown & Odile Damour. (2011) Stem Cells, Mature Adipocytes, and Extracellular Scaffold: What Does Each Contribute to Fat Graft Survival?. Aesthetic Plastic Surgery 35:6, pages 1061-1072.
Crossref
Jennifer Chwalek & Alexander L. Berlin. 2011. Disorders of Fat and Cellulite: Advances in Diagnosis and Treatment. Disorders of Fat and Cellulite: Advances in Diagnosis and Treatment 202 209 .
Joep C. N. Willemsen, Karlijn M. Mulder & Hieronymus P. J. D. Stevens. (2011) Lipofilling With Minimal Access Cranial Suspension Lifting for Enhanced Rejuvenation. Aesthetic Surgery Journal 31:7, pages 759-769.
Crossref
Ferry Melchels, Paul Severin Wiggenhauser, David Warne, Mark Barry, Fook Rhu Ong, Woon Shin Chong, Dietmar Werner Hutmacher & Jan-Thorsten Schantz. (2011) CAD/CAM-assisted breast reconstruction. Biofabrication 3:3, pages 034114.
Crossref
Sarah B. Anderson, Chien-Chi Lin, Donna V. Kuntzler & Kristi S. Anseth. (2011) The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 32:14, pages 3564-3574.
Crossref
Kedong Song, Mo Qiao, Tianqing Liu, Bo Jiang, Hugo M. Macedo, Xuehu Ma & Zhanfeng Cui. (2010) Preparation, fabrication and biocompatibility of novel injectable temperature-sensitive chitosan/glycerophosphate/collagen hydrogels. Journal of Materials Science: Materials in Medicine 21:10, pages 2835-2842.
Crossref
Xiuli Wang, Michaela R. Reagan & David L. Kaplan. (2010) Synthetic Adipose Tissue Models for Studying Mammary Gland Development and Breast Tissue Engineering. Journal of Mammary Gland Biology and Neoplasia 15:3, pages 365-376.
Crossref
Elisabetta Rosellini, Caterina Cristallini, Giulio D Guerra, Niccoletta Barbani & Paolo Giusti. (2010) Synthesis and characterization of a novel PNIPAAm-based copolymer with hydrolysis-dependent thermosensitivity. Biomedical Materials 5:3, pages 035012.
Crossref
Sylvia Nürnberger, Susanne Wolbank, Anja Peterbauer-Scherb, Tatjana J. Morton, Georg A. Feichtinger, Alfred Gugerell, Alexandra Meinl, Krystyna Labuda, Michaela Bittner, Waltraud Pasteiner, Lila Nikkola, Christian Gabriel, Martijn van Griensven & Heinz Redl. 2010. Biological Adhesive Systems. Biological Adhesive Systems 237 259 .

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