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Review

Management of ventilator-associated pneumonia: epidemiology, diagnosis and antimicrobial therapy

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Pages 585-596 | Published online: 10 Jan 2014

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Kathleen Speck, Nishi Rawat, Noah C. Weiner, Haddis G. Tujuba, Donna Farley & Sean Berenholtz. (2016) A systematic approach for developing a ventilator-associated pneumonia prevention bundle. American Journal of Infection Control 44:6, pages 652-656.
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George Dimopoulos & Dimitrios K. Matthaiou. (2016) Duration of therapy of ventilator-associated pneumonia. Current Opinion in Infectious Diseases 29:2, pages 218-222.
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Darren P. Mareiniss, Tim Xu, Julius Cuong Pham, Yu-Hsiang Hsieh, Jiawei Zhao, Christopher Nguyen, Michael Nguyen & Bradford Winters. (2016) Predicting Which Patients will Likely Benefit from Subglottic Secretion Drainage Endotracheal Tubes: A Retrospective Study. The Journal of Emergency Medicine 50:3, pages 385-393.
Crossref
Soman Sen, Charles Johnston, David Greenhalgh & Tina Palmieri. (2016) Ventilator-Associated Pneumonia Prevention Bundle Significantly Reduces the Risk of Ventilator-Associated Pneumonia in Critically Ill Burn Patients. Journal of Burn Care & Research 37:3, pages 166-171.
Crossref
S.U. Picoli & A.L.S. Gonçalves. 2016. The Microbiology of Respiratory System Infections. The Microbiology of Respiratory System Infections 143 152 .
Ignacio Martin-Loeches, Lieuwe D. Bos, Pedro Povoa, Paula Ramirez, Marcus J. Schultz, Antoni Torres & Antonio Artigas. (2015) Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis. Intensive Care Medicine Experimental 3:1.
Crossref
Andrew F. Shorr, Marya D. Zilberberg, Scott T. Micek & Marin H. Kollef. (2015) Outcomes associated with bacteremia in the setting of methicillin-resistant Staphylococcus aureus pneumonia: a retrospective cohort study. Critical Care 19:1.
Crossref
Peggy White, Elizabeth Mahanna, Peggy R. Guin, Vaibhav Bora & Brenda G. Fahy. (2015) Ventilator-Associated Events. Anesthesia & Analgesia 121:5, pages 1240-1248.
Crossref
Doug Elliott, Rosalind Elliott, Anthony Burrell, Peter Harrigan, Margherita Murgo, Kaye Rolls & David Sibbritt. (2015) Incidence of ventilator-associated pneumonia in Australasian intensive care units: use of a consensus-developed clinical surveillance checklist in a multisite prospective audit. BMJ Open 5:10, pages e008924.
Crossref
David P. Nicolau, Leonard Siew, Jon Armstrong, James Li, Timi Edeki, Maria Learoyd & Shampa Das. (2015) Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens. Journal of Antimicrobial Chemotherapy 70:10, pages 2862-2869.
Crossref
J.A. Mora-Arteaga, O.J. Bernal-Ramírez & S.J. Rodríguez. (2015) The effects of prone position ventilation in patients with acute respiratory distress syndrome. A systematic review and metaanalysis. Medicina Intensiva (English Edition) 39:6, pages 359-372.
Crossref
J.A. Mora-Arteaga, O.J. Bernal-Ramírez & S.J. Rodríguez. (2015) Efecto de la ventilación mecánica en posición prona en pacientes con síndrome de dificultad respiratoria aguda. Una revisión sistemática y metanálisis. Medicina Intensiva 39:6, pages 352-365.
Crossref
Raymonde E. Jean, Charlisa D. Gibson, Raymond A. Jean & Pius Ochieng. (2015) Obstructive sleep apnea and acute respiratory failure: An analysis of mortality risk in patients with pneumonia requiring invasive mechanical ventilation. Journal of Critical Care 30:4, pages 778-783.
Crossref
Xiang Liu, Yanhu Wu, Yihu Tang, Zhi Geng, Yaping Han & Dongyue Zhang. (2014) The Development of Early-Onset Ventilator-Associated Pneumonia after Cardiac Surgery with Cardiopulmonary Bypass is Associated with Toll-like Receptor 4 Signal Transduction Pathways. Inflammation 38:1, pages 187-194.
Crossref
Teiji Sawa, Masaru Shimizu, Kiyoshi Moriyama & Jeanine P Wiener-Kronish. (2014) Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review. Critical Care 18:6.
Crossref
Lukas Stulik, Stefan Malafa, Jana Hudcova, Harald Rouha, Bence Z. Henics, Donald E. Craven, Agnes M. Sonnevend & Eszter Nagy. (2014) α-Hemolysin Activity of Methicillin-Susceptible Staphylococcus aureus Predicts Ventilator-associated Pneumonia . American Journal of Respiratory and Critical Care Medicine 190:10, pages 1139-1148.
Crossref
Nishi Rawat, Ting Yang, Kathleen Speck, Jennifer Helzer, Cathleen Barenski & Sean Berenholtz. (2013) An Evaluation of Ventilator-Associated Pneumonia Process Measure Sampling Strategies in a Surgical ICU. American Journal of Medical Quality 29:5, pages 397-402.
Crossref
Virve I. Enne, Yoann Personne, Ljuban Grgic, Vanya Gant & Alimuddin Zumla. (2014) Aetiology of hospital-acquired pneumonia and trends in antimicrobial resistance. Current Opinion in Pulmonary Medicine 20:3, pages 252-258.
Crossref
J. Chastre, F. Blasi, R.G. Masterton, J. Relio, A. Torres & T. Welte. (2014) European perspective and update on the management of nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid. Clinical Microbiology and Infection 20, pages 19-36.
Crossref
Paula Regina De Souza, Denise De Andrade, Danielle Bezerra Cabral & Evandro Watanabe. (2014) Endotracheal tube biofilm and ventilator-associated pneumonia with mechanical ventilation. Microscopy Research and Technique 77:4, pages 305-312.
Crossref
Shawn H. MacVane, Joseph L. Kuti & David P. Nicolau. (2014) Clinical Pharmacodynamics of Antipseudomonal Cephalosporins in Patients with Ventilator-Associated Pneumonia. Antimicrobial Agents and Chemotherapy 58:3, pages 1359-1364.
Crossref
R. Manji, M. Bythrow, J. A. Branda, C.-A. D. Burnham, M. J. Ferraro, O. B. Garner, R. Jennemann, M. A. Lewinski, A. B. Mochon, G. W. Procop, S. S. Richter, J. A. Rychert, L. Sercia, L. F. Westblade & C. C. Ginocchio. (2013) Multi-center evaluation of the VITEK® MS system for mass spectrometric identification of non-Enterobacteriaceae Gram-negative bacilli. European Journal of Clinical Microbiology & Infectious Diseases 33:3, pages 337-346.
Crossref
George Dimopoulos, Garyphallia Poulakou, Ioannis A. Pneumatikos, Apostolos Armaganidis, Marin H. Kollef & Dimitrios K. Matthaiou. (2013) Short- vs Long-Duration Antibiotic Regimens for Ventilator-Associated Pneumonia. Chest 144:6, pages 1759-1767.
Crossref
HUI XIAO, XIONG YE, QINGZHONG LIU & LI LI. (2013) Antibiotic susceptibility and genotype patterns of Pseudomonas aeruginosa from mechanical ventilation-associated pneumonia in intensive care units. Biomedical Reports 1:4, pages 589-593.
Crossref
Patrick Scheiermann & Soeren E Pischke. (2013) Lipid peroxidation in multidrug-resistant Gram-negative sepsis: translating science to the septic patient?. Critical Care 17:2.
Crossref
Maryam Habibzay, Gudrun Weiss & Tracy Hussell. (2013) Bacterial superinfection following lung inflammatory disorders. Future Microbiology 8:2, pages 247-256.
Crossref

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