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Editorial

Genotype–phenotype map and molecular networks: a promising solution in overcoming colorectal cancer resistance to targeted treatment

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Pages 541-545 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Demosthenes E. Ziogas, Georgios Glantzounis, Theodore Liakakos & Dimitrios H. Roukos. (2016) Targeting dynamics of subclones of GI, liver and pancreatic cancers. Expert Review of Gastroenterology & Hepatology 10:7, pages 773-776.
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Dimitrios Roukos, Charalambos Batsis & George Baltogiannis. (2012) Assessing tumor heterogeneity and emergence mutations using next-generation sequencing for overcoming cancer drugs resistance. Expert Review of Anticancer Therapy 12:10, pages 1245-1248.
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Chee-Seng Ku & Dimitrios H Roukos. (2012) De novo mutations, protein–protein interactions and functional regulatory networks toward novel diagnostics in autism. Expert Review of Proteomics 9:5, pages 473-476.
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Christos Katsios, Costas Papaloukas, Margaret Tzaphlidou & Dimitrios H Roukos. (2012) Next-generation sequencing-based testing for cancer mutational landscape diversity: clinical implications?. Expert Review of Molecular Diagnostics 12:7, pages 667-670.
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Dimitrios H Roukos. (2012) Dynamics of genome ‘iPOP’: predicting disease or ‘narciss-ome’?. Expert Review of Molecular Diagnostics 12:6, pages 545-548.
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Demosthenes E Ziogas, Christos S Katsios, Margaret Tzaphlidou & Dimitrios H Roukos. (2012) Targeted therapy: overcoming drug resistance with clinical cancer genome. Expert Review of Anticancer Therapy 12:7, pages 861-864.
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Dimitrios H Roukos. (2011) Innovation versus evidence: to trust direct-to-consumer personal genomic tests?. Expert Review of Molecular Diagnostics 11:1, pages 1-4.
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Christos Katsios, Dimosthenis E Ziogas & Dimitrios H Roukos. (2011) New molecular oncology-changing era: prospects and challenges of cancer genome and integrative systems biology. Expert Review of Anticancer Therapy 11:1, pages 5-8.
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Dimitrios H Roukos. (2010) Next-generation sequencing and epigenome technologies: potential medical applications. Expert Review of Medical Devices 7:6, pages 723-726.
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Sarah Kraus, Ajay Goel & Nadir Arber. (2010) Blood-based peptide, genetic, and epigenetic biomarkers for diagnosing gastrointestinal cancers. Expert Opinion on Medical Diagnostics 4:6, pages 459-471.
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Christos Katsios, Dimosthenis E Ziogas & Dimitrios H Roukos. (2010) Colorectal cancer: cetuximab, KRAS, BRAF, PIK3CA mutations and beyond. Expert Review of Gastroenterology & Hepatology 4:5, pages 525-529.
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Dimitrios H Roukos, Dimosthenis E Ziogas & Christos Katsios. (2010) Multigene assays and isolated tumor cells for early breast cancer treatment: time for bionetworks. Expert Review of Anticancer Therapy 10:8, pages 1187-1195.
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Articles from other publishers (64)

Syed Nazreen, Serag Eldin I. Elbehairi, Azizah M. Malebari, Nuha Alghamdi, Reem F. Alshehri, Ali A. Shati, Nada M. Ali, Mohammad Y. Alfaifi, Ahmed A. Elhenawy & Mohammad Mahboob Alam. (2023) New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies. ACS Omega 8:21, pages 18811-18822.
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Abdulraheem SA Almalki, Syed Nazreen, Serag Eldin I. Elbehairi, Mohammad Asad, Ali A. Shati, Mohammad Y. Alfaifi, Abdulrahman Alhadhrami, Ahmed A. Elhenawy, Ali Q. Alorabi, Abdullah M. Asiri & Mohammad Mahboob Alam. (2022) Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors. New Journal of Chemistry 46:31, pages 14967-14978.
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Alisa P Olkinuora, Päivi T Peltomäki, Lauri A Aaltonen & Kristiina Rajamäki. (2021) From APC to the genetics of hereditary and familial colon cancer syndromes . Human Molecular Genetics 30:R2, pages R206-R224.
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Khaled R.A. Abdellatif, Amany Belal, Mohamed T. El-Saadi, Noha H. Amin, Eman G. Said & Loah R. Hemeda. (2020) Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorganic Chemistry 101, pages 103976.
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Dimitrios H. Roukos. (2017) Spatiotemporal diversification of intrapatient genomic clones and early drug development concepts realize the roadmap of precision cancer medicine. Drug Discovery Today 22:8, pages 1148-1164.
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Sarah J. Leung, Photini S. Rice & Jennifer K. Barton. (2015) In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. Lasers in Surgery and Medicine 47:1, pages 40-49.
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Ganji Purnachandra Nagaraju, Olatunji B. Alese, Jerome Landry, Roberto Diaz & Bassel F. El-Rayes. (2014) HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy. Oncotarget 5:20, pages 9980-9991.
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Christof Hottenrott. (2012) Colorectal cancer liver metastases: advances in minimally invasive surgery and genome sequencing-based discoveries. Surgical Endoscopy 27:5, pages 1848-1850.
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Christof Hottenrott. (2012) GIST: advances in tyrosine kinase inhibitors enhance laparoscopic resection even in advanced disease. Surgical Endoscopy 27:4, pages 1446-1447.
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Christof Hottenrott. (2012) Next-generation, genome- and mutational landscape heterogeneity-based novel biomarkers for personalized neoadjuvant treatment and laparoscopic rectal cancer resection. Surgical Endoscopy 27:4, pages 1441-1443.
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Christof Hottenrott. (2012) Dynamic imaging in medicine and network biology. Surgical Endoscopy 27:2, pages 689-690.
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Christof Hottenrott. (2012) Predictive medicine and esophageal cancer response to preoperative chemotherapy. Surgical Endoscopy 27:1, pages 347-348.
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Christof Hottenrott. (2012) Expanding laparoscopic gastrectomy for gastric cancer outside Korea and Japan. Surgical Endoscopy 26:12, pages 3700-3701.
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Christof Hottenrott. (2012) The long-term efficacy of laparoscopic surgery in early and advanced gastric cancer. Surgical Endoscopy 26:12, pages 3695-3696.
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Christof Hottenrott. (2012) Personalized medicine for laparoscopic gastrectomy in gastric cancer. Surgical Endoscopy 26:11, pages 3352-3353.
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Demosthenes E Ziogas, George Baltogiannis, John Spiliotis, Margaret Tzaphlidou & Dimitrios H Roukos. (2012) Genome-based diagnostics and predictive tools: a new epoch for breast cancer management. Future Oncology 8:10, pages 1211-1214.
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Christof Hottenrott. (2012) Histology classification challenges for the endoscopic treatment of early gastric cancer. Surgical Endoscopy 26:7, pages 2092-2093.
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William Cho, Demosthenes E Ziogas, Christos Katsios & Dimitrios H Roukos. (2012) Emerging personalized oncology: sequencing and systems strategies. Future Oncology 8:6, pages 637-641.
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Christos Katsios, Dimosthenis E. Ziogas, Theodore Liakakos, Odysseas Zoras & Dimitrios H. Roukos. (2012) Translating Cancer Genomes Sequencing Revolution into Surgical Oncology Practice. Journal of Surgical Research 173:2, pages 365-369.
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Christof Hottenrott. (2011) Timing of laparoscopic surgery in the neoadjuvant treatment of rectal cancer. Surgical Endoscopy 26:3, pages 884-885.
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Christof Hottenrott. (2011) Robotic surgery and limitations. Surgical Endoscopy 26:2, pages 580-581.
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Christof Hottenrott. (2011) Laparoscopic low anterior resection with total mesorectal excision for rectal cancer. Surgical Endoscopy 26:2, pages 578-579.
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Christof Hottenrott. (2011) Endoscopic and laparoscopic ultrasonography used to predict tumor staging and improve therapeutic decisions for upper gastrointestinal tract cancer. Surgical Endoscopy 26:1, pages 280-281.
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Haralabos Demetriades. (2011) HER2-Positive Gastric Cancer. Annals of Surgical Oncology 18:S3, pages 190-191.
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Charalambos Batsis. (2011) Strategy for Nonresponder Breast Cancer Patients to Neoadjuvant Treatment. Annals of Surgical Oncology 18:S3, pages 286-287.
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Christof Hottenrott. (2011) Preventive and Therapeutic Implications of Positive CDH1 Testing in Diffuse Gastric Cancer. Annals of Surgical Oncology 18:S3, pages 192-193.
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Christof Hottenrott. (2011) BRCA Testing Changes Decision on Breast Cancer Surgery but Evidence for Benefit Is Still Scarce. Annals of Surgical Oncology 18:S3, pages 284-285.
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Theodore Liakakos. (2011) High Ligation of Inferior Mesenteric Artery: A Standard Procedure for Colorectal Cancer?. Annals of Surgical Oncology 18:S3, pages 240-241.
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John Spiliotis & Eugenia Halkia. (2011) Slow Progress in Predicting and Preventing Fatal Gastric Cancer Peritoneal Recurrence. Annals of Surgical Oncology 18:S3, pages 200-201.
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Christof Hottenrott. (2011) Robotic versus laparoscopic surgery for rectal cancer and cost-effectiveness analysis. Surgical Endoscopy 25:12, pages 3954-3956.
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Theodore Liakakos. (2011) Totally laparoscopic total gastrectomy and the challenge of esophagojejunostomy. Surgical Endoscopy 25:10, pages 3468-3469.
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Theodore Liakakos. (2011) Thoracolaparoscopic esophagectomy: further improvement in the multimodal treatment of esophageal cancer. Surgical Endoscopy 25:10, pages 3466-3467.
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Ernst Hanisch & Charalabos Batsis. (2011) Pancreatic Cancer: The Challenge of the Future in Tumorigenesis-based Prevention. World Journal of Surgery 35:9, pages 2182-2183.
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Eugenia Halkia & Nikolaos Kalinoglou. (2011) Challenges with identification of angiogenesis biomarkers in cancer. Surgical Endoscopy 25:8, pages 2769-2770.
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John Spiliotis & Odysseas Zoras. (2011) Linking epidermal growth factor plasma levels with the prognosis and treatment response of colorectal cancer patients treated with a minimally invasive approach: does it have clinical utility?. Surgical Endoscopy 25:8, pages 2766-2767.
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Christof Hottenrott. (2011) Single-incision laparoscopic surgery for colorectal cancer. Surgical Endoscopy 25:8, pages 2764-2765.
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Charalambos Batsis. (2011) Proximal gastric cancer: advances of laparoscopic surgery. Surgical Endoscopy 25:8, pages 2761-2763.
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Charalambos Batsis. (2011) Mediastinal lymphadenopathy: assessing clinical utility of EUS-FNA. Surgical Endoscopy 25:8, pages 2756-2757.
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John Spiliotis. (2011) Genotyping Gastric Cancer. World Journal of Surgery 35:8, pages 1933-1934.
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Christof Hottenrott. (2011) Laparoscopic and robotic-assisted D2 surgery for gastric cancer: a reality in Europe?. Surgical Endoscopy 25:7, pages 2414-2416.
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Odysseas Zoras & John Spiliotis. (2010) Nonepithelial, submucosal gastric tumors: is laparoscopic wedge resection the optimal treatment?. Surgical Endoscopy 25:6, pages 2052-2053.
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Ernst Hanisch & Dimosthenis E. Ziogas. (2010) Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis and impact of anti-tumor necrosis factor on postoperative outcomes. Surgical Endoscopy 25:6, pages 2057-2058.
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Christof Hottenrott. (2010) Optimizing Preoperative Management of Rectal Cancer. World Journal of Surgery 35:6, pages 1416-1417.
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John Spiliotis. (2010) Exploring indications for laparoscopic primary tumor resection in metastatic colorectal cancer. Surgical Endoscopy 25:5, pages 1706-1707.
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John Spiliotis & Odysseas Zoras. (2010) Histological and Immediate Postoperative Outcome after Preoperative Cetuximab: Case-matched Control Study. World Journal of Surgery 35:5, pages 1153-1154.
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Georgios Glantzounis & Christos S. Katsios. (2010) Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases. World Journal of Surgery 35:4, pages 926-927.
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Christof Hottenrott. (2010) Cost-effectiveness analyses of laparoscopic versus open surgery. Surgical Endoscopy 25:3, pages 990-992.
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Ernst Hanisch & Dimosthenis E. Ziogas. (2010) From evidence to a day-to-day laparoscopic colectomy. Surgical Endoscopy 25:3, pages 985-987.
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Theodore Liakakos. (2010) Minimally invasive esophagectomy. Surgical Endoscopy 25:3, pages 981-982.
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Ernst Hanisch & Charalambos Batsis. (2010) Clinicopathologic Characteristics of Colorectal Cancer Patients with Synchronous and Metachronous Gastric Cancer. World Journal of Surgery 35:3, pages 700-701.
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Charalabos Batsis. (2010) Two-Stage Breast Cancer Screening in the Developing World. World Journal of Surgery 35:3, pages 698-699.
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George C Zografos & Dimitrios H Roukos. (2011) Innovative biomarker development for personalized medicine in breast cancer care. Biomarkers in Medicine 5:1, pages 73-78.
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John Spiliotis & Odysseas Zoras. (2010) Adjuvant S-1 Chemotherapy for Gastric Cancer and Peritoneal Wash. World Journal of Surgery 35:2, pages 468-469.
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Christos S. Katsios. (2010) Metachronous Cancer in the Stomach Remnant. World Journal of Surgery 35:2, pages 465-466.
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Christof Hottenrott. (2010) Remnant Gastric Cancer: Can the Risk Be Predicted When Planning Initial Surgery?. World Journal of Surgery 35:2, pages 462-463.
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Kyriakos Kalogerakos. (2010) Managing BRCA Mutation Carriers in China. World Journal of Surgery 35:2, pages 458-459.
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Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha & Arielle Cantor. (2011) The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells. Journal of Biomedicine and Biotechnology 2011, pages 1-12.
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Christof Hottenrott. (2010) Predicting and Preventing Anastomotic Leakage after Low Anterior Resection for Rectal Cancer. World Journal of Surgery 35:1, pages 239-240.
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Christos Katsios, Odysseas Zoras & Dimitrios H Roukos. (2010) Cancer genome sequencing and potential application in oncology. Future Oncology 6:10, pages 1527-1531.
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Dimitrios H Roukos. (2010) Complete genome sequencing and network modeling to overcome trastuzumab resistance. Pharmacogenomics 11:8, pages 1039-1043.
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