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Review

Therapy-resistant depression

Pages 77-86 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Amna Majeed, Jiaqi Xiong, Kayla M. Teopiz, Jason Ng, Roger Ho, Joshua D. Rosenblat, Lee Phan, Bing Cao & Roger S. McIntyre. (2021) Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials. Expert Opinion on Emerging Drugs 26:1, pages 63-74.
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Krzysztof Kucia, Wojciech Merk, Krzysztof Zapalowicz & Tomasz Medrala. (2019) Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up. Neuropsychiatric Disease and Treatment 15, pages 3247-3254.
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Tom Bschor & Laura L. Kilarski. (2016) Are antidepressants effective? A debate on their efficacy for the treatment of major depression in adults. Expert Review of Neurotherapeutics 16:4, pages 367-374.
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Articles from other publishers (26)

Shiau-Shian Huang, Yi-Ting Chen, Mei-Hsin Su, Shih-Jen Tsai, Hsi-Han Chen, Albert C. Yang, Yu-Li Liu & Po-Hsiu Kuo. (2023) Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population. The Pharmacogenomics Journal 23:2-3, pages 50-59.
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Nervana Elbakary, Sami Ouanes, Sadaf Riaz, Oraib Abdallah, Islam Mahran, Noriya Al-Khuzaei & Yassin Eltorki. (2021) Prevalence, median time, and associated factors with the likelihood of initial antidepressant change: a cross-sectional study in Qatar. BMC Psychiatry 21:1.
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Shiau-Shian Huang, Hsi-Han Chen, Jui Wang, Wei J. Chen, Hsi-Chung Chen & Po-Hsiu Kuo. (2020) Investigation of early and lifetime clinical features and comorbidities for the risk of developing treatment-resistant depression in a 13-year nationwide cohort study. BMC Psychiatry 20:1.
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Sebastian Moeller, Ruihao Wang, Merve Aydin, Alexandra P. Lam, Aileen Sitter, Jonas Grüter, Alexandra Philipsen & Helge H.O. Müller. (2020) Rapid titration protocol – Experiences with a dynamic novel titration regime for vagus nerve stimulation in a group of depressive patients. Journal of Clinical Neuroscience 74, pages 262-264.
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Silvia Hoirisch-Clapauch & Antonio E. Nardi. (2019) Antidepressants: bleeding or thrombosis?. Thrombosis Research 181, pages S23-S28.
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Yen-Chin Wang, Hai-Ti Lin, Mong-Liang Lu, Ming-Chyi Huang, Chun-Hsin Chen, Tzu-Hua Wu, Sabrina Wang, Wei-Chung Mao, Po-Hsiu Kuo & Hsi-Chung Chen. (2019) The Association Between the Sedative Loads and Clinical Severity Indicators in the First-Onset Major Depressive Disorder. Frontiers in Psychiatry 10.
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. 2019. Therapie psychischer Erkrankungen. Therapie psychischer Erkrankungen 1 119 .
Helge H. O. Müller, Sebastian Moeller, Caroline Lücke, Alexandra P. Lam, Niclas Braun & Alexandra Philipsen. (2018) Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use. Frontiers in Neuroscience 12.
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Cora Schefft, Laura L. Kilarski, Tom Bschor & Stephan Köhler. (2017) Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis. European Neuropsychopharmacology 27:11, pages 1090-1109.
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Julia Kleeblatt, Felix Betzler, Laura L. Kilarski, Tom Bschor & Stephan Köhler. (2017) Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence. European Neuropsychopharmacology 27:5, pages 423-441.
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Marlene Busche & Tom Bschor. (2017) Leitliniengerechte Pharmakotherapie der therapieresistenten Depression. DNP - Der Neurologe & Psychiater 18:5, pages 36-43.
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T. Bschor. (2015) Trizyklische Antidepressiva zur Initialbehandlung einer depressiven Episode? ProTricyclic antidepressants for initial treatment of depressive episodes? Pro. Der Nervenarzt 87:5, pages 558-560.
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Jonathan Henssler, Tom Bschor & Christopher Baethge. (2016) Combining Antidepressants in Acute Treatment of Depression: A Meta-Analysis of 38 Studies Including 4511 Patients. The Canadian Journal of Psychiatry 61:1, pages 29-43.
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Y.Q. Zhang, D. Zhu, X.Y. Zhou, Y.Y. Liu, B. Qin, G.P. Ren & P. Xie. (2015) Bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis of randomized controlled trials. Brazilian Journal of Medical and Biological Research 48:3, pages 198-206.
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Tom Bschor. (2014) Lithium in the Treatment of Major Depressive Disorder. Drugs 74:8, pages 855-862.
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Cheng-Ta Li, Ya-Mei Bai, Ying-Chiao Lee, Wei-Chung Mao, Mu-Hong Chen, Pei-Chi Tu, Ying-Sheue Chen, Tzeng-Ji Chen, Wen-Hang Chang & Tung-Ping Su. (2014) High Dosage of Hypnotics Predicts Subsequent Sleep-Related Breathing Disorders and Is Associated with Worse Outcomes for Depression. Sleep 37:4, pages 803-809.
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Alexander Bystritsky, Jessica Danial & David Kronemyer. (2014) Interactions Between Diabetes and Anxiety and Depression. Endocrinology and Metabolism Clinics of North America 43:1, pages 269-283.
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Wenbin Guo, Feng Liu, Zhimin Xue, Keming Gao, Zhening Liu, Changqing Xiao, Huafu Chen & Jingping Zhao. (2013) Decreased Interhemispheric Coordination in Treatment-Resistant Depression: A Resting-State fMRI Study. PLoS ONE 8:8, pages e71368.
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Wen-bin Guo, Feng Liu, Jin-dong Chen, Keming Gao, Zhi-min Xue, Xi-jia Xu, Ren-rong Wu, Chang-lian Tan, Xue-li Sun, Zhe-ning Liu, Hua-fu Chen & Jing-ping Zhao. (2012) Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: A resting-state fMRI study. Journal of Psychiatric Research 46:10, pages 1366-1373.
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Wen-bin Guo, Feng Liu, Jin-dong Chen, Xi-jia Xu, Ren-rong Wu, Chao-qiong Ma, Keming Gao, Chang-lian Tan, Xue-li Sun, Chang-qing Xiao, Hua-fu Chen & Jing-ping Zhao. (2012) Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics. Progress in Neuro-Psychopharmacology and Biological Psychiatry 38:2, pages 201-206.
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Wen-bin Guo, Feng Liu, Zhi-min Xue, Xi-jia Xu, Ren-rong Wu, Chao-qiong Ma, Sarah C. Wooderson, Chang-lian Tan, Xue-li Sun, Jin-dong Chen, Zhe-ning Liu, Chang-qing Xiao, Hua-fu Chen & Jing-ping Zhao. (2012) Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 37:1, pages 153-160.
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Cheng-Ta Li, Ya-Mei Bai, Yu-Lin Huang, Ying-Sheue Chen, Tzeng-Ji Chen, Ju-Yin Cheng & Tung-Ping Su. (2018) Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study. British Journal of Psychiatry 200:1, pages 45-51.
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Tom Bschor, Marcus Ising, Sebastian Erbe, Patricia Winkelmann, Dirk Ritter, Manfred Uhr & Ute Lewitzka. (2012) Impact of citalopram on the HPA system. A study of the combined DEX/CRH test in 30 unipolar depressed patients. Journal of Psychiatric Research 46:1, pages 111-117.
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Yan Zhou, Ling-di Qin, Jun Chen, Li-jun Qian, Jing Tao, Yi-ru Fang & Jian-rong Xu. (2011) Brain microstructural abnormalities revealed by diffusion tensor images in patients with treatment-resistant depression compared with major depressive disorder before treatment. European Journal of Radiology 80:2, pages 450-454.
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Annette Beatrix Brühl, Lutz Jäncke & Uwe Herwig. (2011) Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants. Psychopharmacology 216:3, pages 389-399.
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Wen-bin Guo, Xue-li Sun, Ling Liu, Qiang Xu, Ren-rong Wu, Zhe-ning Liu, Chang-lian Tan, Hua-fu Chen & Jing-Ping Zhao. (2011) Disrupted regional homogeneity in treatment-resistant depression: A resting-state fMRI study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:5, pages 1297-1302.
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