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Drug Profile

Donepezil in the treatment of patients with Alzheimer’s disease

Pages 591-598 | Published online: 09 Jan 2014

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Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh & João Batista Teixeria Rocha. (2023) Phytochemicals from African eggplants (Solanum macrocarpon L) and Black nightshade (Solanum nigrum L) leaves as acetylcholinesterase inhibitors: an in-silico study. Journal of Biomolecular Structure and Dynamics 41:16, pages 7725-7734.
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Anas Shamsi, Moyad Al Shahwan, Shahzaib Ahamad, Md. Imtaiyaz Hassan, Faizan Ahmad & Asimul Islam. (2020) Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug donepezil with human transferrin: implications of Alzheimer’s drug. Journal of Biomolecular Structure and Dynamics 38:4, pages 1094-1102.
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Lu Liu, Ming-Xu Tang, Xia-Nan Sang, Shao-Fei Chen, Xiao-Jie Lu, Yu-Bo Wang, Ying-Ying Si, Hai-Feng Wang, Gang Chen & Yue-Hu Pei. (2019) Three new tetralol analogs from soil-derived fungus Myrothecium verrucaria with anti-inflammatory activity. Journal of Asian Natural Products Research 21:1, pages 33-42.
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Weiwei Zhu, Zhanchou Zhang, Jingfeng Qi, Fang Liu, Jindong Chen, Jingping Zhao & Xiaofeng Guo. (2014) Adjunctive treatment for cognitive impairment in patients with chronic schizophrenia: a double-blind, placebo-controlled study. Neuropsychiatric Disease and Treatment 10, pages 1317-1323.
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Arif Nisha Syad & Kasi Pandima Devi. (2014) Botanics: a potential source of new therapies for Alzheimer's disease?. Botanics: Targets and Therapy 4, pages 11-26.
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Filip Zemek, Lucie Drtinova, Eugenie Nepovimova, Vendula Sepsova, Jan Korabecny, Jiri Klimes & Kamil Kuca. (2014) Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. Expert Opinion on Drug Safety 13:6, pages 759-774.
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K.V. Dileep, C. Remya, I. Tintu & C. Sadasivan. (2013) Designing of multi-target-directed ligands against the enzymes associated with neuroinflammation: an in silico approach. Frontiers in Life Science 7:3-4, pages 174-185.
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Alicja Skrzypek, Joanna Matysiak, Monika M. Karpińska & Andrzej Niewiadomy. (2013) Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds. Journal of Enzyme Inhibition and Medicinal Chemistry 28:4, pages 816-823.
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Gonzalo Emiliano Aranda-Abreu, María Elena Hernández-Aguilar, Jorge Manzo Denes, Luis Isauro García Hernández & Marisol Herrera Rivero. (2011) Rehabilitating a brain with Alzheimer’s: a proposal. Clinical Interventions in Aging 6, pages 53-59.
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Wafaa A. Helmy, Tamer I.M. Ragab, Bassem M. Salama, Mona Basha, Rehab Shamma, Sahar S. Abd El-Rahman & Heba Shawky. (2023) Novel naringin tablet formulations of agro-resides based nano/micro crystalline cellulose with neuroprotective and Alzheimer ameliorative potentials. International Journal of Biological Macromolecules 231, pages 123060.
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Jun-Rui Pang, Sher-Wei How, Kah-Hui Wong, Siew-Huah Lim, Siew-Moi Phang & Yoon-Yen Yow. (2022) Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis. Fisheries and Aquatic Sciences 25:2, pages 49-63.
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Olalekan Olanrewaju Bakare, Adewale Oluwaseun Fadaka, Musa Oyebowale Akanbi, Kolajo Adedamola Akinyede, Ashwil Klein & Marshall Keyster. (2021) Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for ‘Alzheimer’s disease: an in silico approach. BMC Molecular and Cell Biology 22:1.
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Hiroshi Todaka, Mikihiko Arikawa, Tatsuya Noguchi, Atsushi Ichikawa & Takayuki Sato. (2021) Donepezil, an anti-Alzheimer's disease drug, promotes differentiation and regeneration in injured skeletal muscle through the elevation of the expression of myogenic regulatory factors. European Journal of Pharmacology 911, pages 174528.
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Mingoo Bae, Seung Yon Han, Eun-Sun Kim, Byung Hoon You, Young-Mi Kim, Jungsook Cho, Young-Won Chin & Young Hee Choi. (2021) Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 26:17, pages 5246.
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Kana Okada, Kayo Nishizawa, Tomoko Kobayashi, Shogo Sakata, Kouichi Hashimoto & Kazuto Kobayashi. (2021) Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory. Scientific Reports 11:1.
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Giovanni Ribaudo, Maurizio Memo & Alessandra Gianoncelli. (2021) Multi-target Natural and Nature-Inspired Compounds against Neurodegeneration: A Focus on Dual Cholinesterase and Phosphodiesterase Inhibitors. Applied Sciences 11:11, pages 5044.
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Koula Doukani, Ammar Sidi Mohammed Selles & Hasna Bouhenni. 2021. Naturally Occurring Chemicals Against Alzheimer's Disease. Naturally Occurring Chemicals Against Alzheimer's Disease 225 241 .
Monica A. Silva, Alessandra S. Kiametis & Werner Treptow. (2020) Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of Chemical Information and Modeling 60:7, pages 3463-3471.
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Dohyun Kim, Tae Hee Han, Seong-Chul Hong, Sun Jae Park, Yong Hak Lee, Hyeongmin Kim, Minwoo Park & Jaehwi Lee. (2020) PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride. Pharmaceutics 12:4, pages 311.
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Saida Haider, Laraib Liaquat, Saara Ahmad, Zehra Batool, Rafat Ali Siddiqui, Saiqa Tabassum, Sidrah Shahzad, Sahar Rafiq & Narjis Naz. (2020) Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress. PLOS ONE 15:1, pages e0227631.
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Muhammad Saeed Jan, Sajjad Ahmad, Fida Hussain, Ashfaq Ahmad, Fawad Mahmood, Umer Rashid, Obaid-ur-Rahman Abid, Farhat Ullah, Muhammad Ayaz & Abdul Sadiq. (2020) Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. European Journal of Medicinal Chemistry 186, pages 111863.
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Norifumi Tsuno, Takahiro Mori, Ichiro Ishikawa, Nobuyasu Bando, Haeyoung Park, Yoshito Matsumoto, Itsuko Mori, Mariko Tanaka, Takayuki Hirano & Yu Nakamura. (2019) Efficacy of rivastigmine transdermal therapy on low food intake in patients with Alzheimer's disease: The Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with Rivastigmine Effects study. Geriatrics & Gerontology International 19:7, pages 571-576.
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James T. BrewsterIIII, Simone Dell’Acqua, Danny Q. Thach & Jonathan L. Sessler. (2018) Classics in Chemical Neuroscience: Donepezil. ACS Chemical Neuroscience 10:1, pages 155-167.
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Weenawan Somphon, Anittha Prasertsabw & Nongpanga Jarussophon. (2019) Novel cogrinding of donepezil with neurotransmitters and coumarins: characterization, physical properties and in vitro drug release study. Materials Today: Proceedings 17, pages 1887-1897.
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Katrine Skovgård, Claus Agerskov, Kristi A. Kohlmeier & Kjartan F. Herrik. (2018) The 5-HT3 receptor antagonist ondansetron potentiates the effects of the acetylcholinesterase inhibitor donepezil on neuronal network oscillations in the rat dorsal hippocampus. Neuropharmacology 143, pages 130-142.
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Odunayo Michael Agunloye & Ganiyu Oboh. (2018) Modulatory effect of caffeic acid on cholinesterases inhibitory properties of donepezil. Journal of Complementary and Integrative Medicine 15:1.
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Kinga Gawel, Ewa Gibula-Bruzda, Marcin Dziedzic, Malgorzata Jenda-Wojtanowska, Marta Marszalek-Grabska, Jerzy Silberring & Jolanta H. Kotlinska. (2017) Cholinergic activation affects the acute and chronic antinociceptive effects of morphine. Physiology & Behavior 169, pages 22-32.
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Mikihiko Arikawa, Yoshihiko Kakinuma, Tatsuya Noguchi, Hiroshi Todaka & Takayuki Sato. (2016) Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation. European Journal of Pharmacology 789, pages 17-26.
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Minsook Ye, Hwan-Suck Chung, Yong Ho An, Su-jin Lim, Won Choi, A. Ram Yu, Jin Su Kim, Manho Kang, Seunghun Cho, Insop Shim & Hyunsu Bae. (2015) Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer?s Disease. Molecular Neurobiology 53:8, pages 5401-5412.
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Olivier Beauchet, John Barden, Teresa Liu-Ambrose, Victoria L. Chester, Cedric Annweiler, Tony Szturm, Sébastien Grenier, Guillaume Léonard, Louis Bherer & Gilles Allali. (2016) Anti-Dementia Drugs, Gait Performance and Mental Imagery of Gait: A Non-Randomized Open-Label Trial. Drugs & Aging 33:9, pages 665-673.
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Kjartan F. Herrik, Arne Mørk, Nelly Richard, Christoffer Bundgaard, Jesper F. Bastlund & Inge E.M. de Jong. (2016) The 5-HT 6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus. Neuropharmacology 107, pages 351-363.
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Hazem Eimar, Sharifa Alebrahim, Garthiga Manickam, Ahmed Al-Subaie, Lina Abu-Nada, Monzur Murshed & Faleh Tamimi. (2016) Donepezil regulates energy metabolism and favors bone mass accrual. Bone 84, pages 131-138.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 215 225 .
Takashi Kudo, Kenneth L. Davis, Rafael Blesa Gonzalez & David George WilkinsonTakashi Kudo. 2016. Practical Pharmacology for Alzheimer’s Disease. Practical Pharmacology for Alzheimer’s Disease 119 135 .
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Omar M. E. Abdel-Salam, Eman R. Youness, Fatma A. Morsy, Marwa M. Mahfouz & Sanaa A. Kenawy. (2014) Study of the effect of antidepressant drugs and donepezil on aluminum-induced memory impairment and biochemical alterations in rats. Comparative Clinical Pathology 24:4, pages 847-860.
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Maviye Galipoğlu, Meryem Sedef Erdal & Sevgi Güngör. (2014) Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment. AAPS PharmSciTech 16:2, pages 284-292.
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Olivier Beauchet, Cyrille P. Launay, Gilles Allali, François R. Herrmann & Cedric Annweiler. (2014) Gait Changes with Anti-Dementia Drugs: A Prospective, Open-Label Study Combining Single and Dual Task Assessments in Patients with Alzheimer’s Disease. Drugs & Aging 31:5, pages 363-372.
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Vageesh Revadigar, Raza Murad Ghalib, Vikneswaran Murugaiyah, Mohamed A. Embaby, Ali Jawad, Sayed Hasan Mehdi, Rokiah Hashim & Othman Sulaiman. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 142 198 .
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