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Review

Nutrient supplementation approaches in the treatment of ADHD

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Pages 461-476 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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John C. Perham, Nida I. Shaikh, Anna Lee, Kathryn A. Darling & Julia J. Rucklidge. (2022) Toward ‘element balance’ in ADHD: an exploratory case control study employing hair analysis. Nutritional Neuroscience 25:1, pages 11-21.
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Julia J. Rucklidge, Jeanette M. Johnstone & Bonnie J. Kaplan. (2021) Nutrition Provides the Essential Foundation for Optimizing Mental Health. Evidence-Based Practice in Child and Adolescent Mental Health 6:1, pages 131-154.
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Julia J Rucklidge & Bonnie J Kaplan. (2013) Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: a systematic review. Expert Review of Neurotherapeutics 13:1, pages 49-73.
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Samuele Cortese, Marco Angriman, Michel Lecendreux & Eric Konofal. (2012) Iron and attention deficit/hyperactivity disorder: what is the empirical evidence so far? A systematic review of the literature. Expert Review of Neurotherapeutics 12:10, pages 1227-1240.
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Francis M Crinella. (2012) Does soy-based infant formula cause ADHD? Update and public policy considerations. Expert Review of Neurotherapeutics 12:4, pages 395-407.
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William B Brinkman & Jeffery N Epstein. (2011) Treatment planning for children with attention-deficit/hyperactivity disorder: treatment utilization and family preferences. Patient Preference and Adherence 5, pages 45-56.
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Gisela Irmisch, Johannes Thome, Olaf Reis, Frank Häßler & Steffen Weirich. (2011) Modified magnesium and lipoproteins in children with attention deficite hyperactivity disorder (ADHD). The World Journal of Biological Psychiatry 12:sup1, pages 63-65.
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William B Brinkman & Jeffery N Epstein. (2011) Promoting productive interactions between parents and physicians in the treatment of children with attention-deficit/hyperactivity disorder. Expert Review of Neurotherapeutics 11:4, pages 579-588.
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Larisa M. Dinu, Samriddhi N. Singh, Neo S. Baker, Alexandra L. Georgescu, Paul G. Overton & Eleanor J. Dommett. (2023) The effects of tryptophan loading on Attention Deficit Hyperactivity in adults: A remote double blind randomised controlled trial. PLOS ONE 18:11, pages e0294911.
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Courtney A. Zulauf-McCurdy, Patrick A. LaCount, Christopher R. Shelton, Anne S. Morrow, Xin A. Zhao, Douglas Russell, Margaret H. Sibley & L. Eugene Arnold. (2023) Systematic Review and Meta-Analyses: Safety and Efficacy of Complementary and Alternative Treatments for Pediatric Attention-Deficit/Hyperactivity Disorder. Journal of Developmental & Behavioral Pediatrics 44:4, pages e322-e332.
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Melika Darzi, Khadijeh Abbasi, Reza Ghiasvand, Mohsen Akhavan Tabib & Mohammad Hossein Rouhani. (2022) The association between dietary polyphenol intake and attention-deficit hyperactivity disorder: a case-control study. BMC Pediatrics 22:1.
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Majid Davidson, Niloufar Rashidi, Kulmira Nurgali & Vasso Apostolopoulos. (2022) The Role of Tryptophan Metabolites in Neuropsychiatric Disorders. International Journal of Molecular Sciences 23:17, pages 9968.
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Tusheema Dutta, Uttpal Anand, Shreya Sikdar Mitra, Mimosa Ghorai, Niraj Kumar Jha, Nusratbanu K. Shaikh, Mahipal S Shekhawat, Devendra Kumar Pandey, Jarosław Proćków & Abhijit Dey. (2022) Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis. Frontiers in Pharmacology 13.
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Larisa Maria Dinu, Nachaphol Phattharakulnij & Eleanor Jane Dommett. (2022) Tryptophan modulation in individuals with attention deficit hyperactivity disorder: a systematic review. Journal of Neural Transmission 129:4, pages 361-377.
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Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam & Anupom Borah. 2022. Proteins Associated with Neurodevelopmental Disorders. Proteins Associated with Neurodevelopmental Disorders 239 255 .
Roser Granero, Alfred Pardo-Garrido, Ivonne Lorena Carpio-Toro, Andrés Alexis Ramírez-Coronel, Pedro Carlos Martínez-Suárez & Geovanny Genaro Reivan-Ortiz. (2021) The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials. Nutrients 13:11, pages 4059.
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Farshid Rahimibashar, Masoum Khosh Fetrat, Keivan Gohari-Moghadam, Tannaz Jamialahmadi & Amirhossein Sahebkar. 2021. Natural Products and Human Diseases. Natural Products and Human Diseases 243 253 .
Garima Sharma, Naveen Sharma, Bao Trong Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Yukio Yoneda, Eun-Joo Shin & Hyoung-Chun Kim. (2020) Protective Potential of Ginkgo biloba Against an ADHD-like Condition. Current Molecular Pharmacology 14:2, pages 200-209.
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Jeanette M. Johnstone, Andrew Hughes, Joshua Z. Goldenberg, Amy R. Romijn & Julia J. Rucklidge. (2020) Multinutrients for the Treatment of Psychiatric Symptoms in Clinical Samples: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 12:11, pages 3394.
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Harry Robberecht, Annelies A. J. Verlaet, Annelies Breynaert, Tess De Bruyne & Nina Hermans. (2020) Magnesium, Iron, Zinc, Copper and Selenium Status in Attention-Deficit/Hyperactivity Disorder (ADHD). Molecules 25:19, pages 4440.
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Jeanette M. Johnstone, Brenda Leung, Barbara Gracious, Leanna Perez, Gabriella Tost, Andrew Savoy, Irene Hatsu, Andrew Hughes, Alisha Bruton & L. Eugene Arnold. (2019) Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: The Micronutrients for ADHD in Youth (MADDY) study. Contemporary Clinical Trials Communications 16, pages 100478.
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Jing GanPeter GalerDan MaChao ChenTao Xiong. (2019) The Effect of Vitamin D Supplementation on Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Child and Adolescent Psychopharmacology 29:9, pages 670-687.
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Amirmansour Alavi Naeini, Forough Fasihi, Mostafa Najafi, Mohammad Reza Ghazvini & Akbar Hasanzadeh. (2019) The effects of vitamin D supplementation on ADHD (Attention Deficit Hyperactivity Disorder) in 6–13 year-old students: A randomized, double-blind, placebo-controlled study. European Journal of Integrative Medicine 25, pages 28-33.
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Marzieh Rahimi Niyyat, Mohammad Azizzadeh & Javad Khoshnegah. (2018) Effect of Supplementation With Omega-3 Fatty Acids, Magnesium, and Zinc on Canine Behavioral Disorders: Results of a Pilot Study. Topics in Companion Animal Medicine 33:4, pages 150-155.
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G.K. Beela & V.R. Raji. (2018) Elimination of sugar rich confectioneries in children with ADHD symptomatology. FOOD SCIENCE RESEARCH JOURNAL 9:1, pages 143-149.
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Annelies Verlaet, Carlijn Maasakkers, Nina Hermans & Huub Savelkoul. (2018) Rationale for Dietary Antioxidant Treatment of ADHD. Nutrients 10:4, pages 405.
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Julia J. Rucklidge, Matthew J.F. Eggleston, Jeanette M. Johnstone, Kathryn Darling & Chris M. Frampton. (2017) Vitamin‐mineral treatment improves aggression and emotional regulation in children with ADHD : a fully blinded, randomized, placebo‐controlled trial . Journal of Child Psychology and Psychiatry 59:3, pages 232-246.
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Farida Elbaz, Sally Zahra & Hussien Hanafy. (2017) Magnesium, zinc and copper estimation in children with attention deficit hyperactivity disorder (ADHD). Egyptian Journal of Medical Human Genetics 18:2, pages 153-163.
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Eduardo Barragán, Dieter Breuer & Manfred Döpfner. (2016) Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD. Journal of Attention Disorders 21:5, pages 433-441.
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Alejandra Ríos-Hernández, José A. Alda, Andreu Farran-Codina, Estrella Ferreira-GarcíaMaria Izquierdo-Pulido. (2017) The Mediterranean Diet and ADHD in Children and Adolescents. Pediatrics 139:2.
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Yan Wang, Lan Huang, Li Zhang, Yi Qu & Dezhi Mu. (2017) Iron Status in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis. PLOS ONE 12:1, pages e0169145.
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Mahboubeh Firouzkouhi Moghaddam, Tayebeh Rakhshani & Mohsen Khosravi. (2016) Effectiveness of Methylphenidate Supplemented by Zinc, Calcium, and Magnesium for Treatment of ADHD Patients in the City of Zahedan. Shiraz E-Medical Journal 17:9.
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Jana Trebatická & Igor Škodáček. (2016) ADHD - ADHD and the possibility of alternative therapies. Psychiatrie pro praxi 17:E-verze 2/16, pages e11-e17.
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Rana Ahmed, Kirsten J McCaffery & Parisa Aslani. (2016) Development and validation of a question prompt list for parents of children with attention-deficit/hyperactivity disorder: a Delphi study. Health Expectations 19:2, pages 234-252.
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So-Young Park, Soyoung Irene Lee & Moon-Soo Lee. (2016) Review on the Efficacy of Omega-3 in the Treatment of Attention-Deficit Hyperactivity Disorder. Journal of the Korean Academy of Child and Adolescent Psychiatry 27:1, pages 31-38.
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James Ahn, Hyung Seok Ahn, Jae Hoon Cheong & Ike dela Peña. (2016) Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy. Neural Plasticity 2016, pages 1-18.
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James Kean, Jordy Kaufman, Justine Lomas, Antionette Goh, David White, David Simpson, Andrew Scholey, Hemant Singh, Jerome Sarris, Andrea Zangara & Con Stough. (2015) A Randomized Controlled Trial Investigating the Effects of a Special Extract of Bacopa monnieri (CDRI 08) on Hyperactivity and Inattention in Male Children and Adolescents: BACHI Study Protocol (ANZCTRN12612000827831). Nutrients 7:12, pages 9931-9945.
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Heather A GordonJulia J RucklidgeNeville M BlampiedJeanette M Johnstone. (2015) Clinically Significant Symptom Reduction in Children with Attention-Deficit/Hyperactivity Disorder Treated with Micronutrients: An Open-Label Reversal Design Study. Journal of Child and Adolescent Psychopharmacology 25:10, pages 783-798.
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Jana Trebatická & Zdeňka Ďuračková. (2015) Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?. Oxidative Medicine and Cellular Longevity 2015, pages 1-16.
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Kevin M. Antshel. (2015) Psychosocial Interventions in Attention-Deficit/Hyperactivity Disorder. Child and Adolescent Psychiatric Clinics of North America 24:1, pages 79-97.
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Joel T. Nigg & Kathleen Holton. (2014) Restriction and Elimination Diets in ADHD Treatment. Child and Adolescent Psychiatric Clinics of North America 23:4, pages 937-953.
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Michael H. Bloch & Jilian Mulqueen. (2014) Nutritional Supplements for the Treatment of ADHD. Child and Adolescent Psychiatric Clinics of North America 23:4, pages 883-897.
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Julia J. Rucklidge & Bonnie J. Kaplan. (2014) Broad-Spectrum Micronutrient Treatment for Attention-Deficit/Hyperactivity Disorder: Rationale and Evidence to Date. CNS Drugs 28:9, pages 775-785.
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Omer KabilVictor VitvitskyRuma Banerjee. (2014) Sulfur as a Signaling Nutrient Through Hydrogen Sulfide. Annual Review of Nutrition 34:1, pages 171-205.
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Charles W. Popper. (2014) Single-Micronutrient and Broad-Spectrum Micronutrient Approaches for Treating Mood Disorders in Youth and Adults. Child and Adolescent Psychiatric Clinics of North America 23:3, pages 591-672.
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Julia J. Rucklidge, Chris M. Frampton, Brigette Gorman & Anna Boggis. (2018) Vitamin–mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised placebo-controlled trial. British Journal of Psychiatry 204:4, pages 306-315.
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Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang & Hyoung-Chun Kim. (2014) YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and Chemical Toxicology 65, pages 280-292.
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James D Kean, David Camfield, Jerome Sarris, Marni Kras, Richard Silberstein, Andrew Scholey & Con Stough. (2013) A randomized controlled trial investigating the effects of PCSO-524®, a patented oil extract of the New Zealand green lipped mussel (Perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and adolescents (aged 6–14 years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study protocol ACTRN12610000978066. Nutrition Journal 12:1.
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Julia J Rucklidge, Rebecca Andridge, Brigette Gorman, Neville Blampied, Heather Gordon & Anna Boggis. (2012) Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Human Psychopharmacology: Clinical and Experimental 27:5, pages 440-454.
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Julia J. RucklidgeRachel HarrisonJeanette Johnstone. (2011) Can Micronutrients Improve Neurocognitive Functioning in Adults with ADHD and Severe Mood Dysregulation? A Pilot Study. The Journal of Alternative and Complementary Medicine 17:12, pages 1125-1131.
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Julia Rucklidge, Jeanette Johnstone, Rachel Harrison & Anna Boggis. (2011) Micronutrients reduce stress and anxiety in adults with Attention-Deficit/Hyperactivity Disorder following a 7.1 earthquake. Psychiatry Research 189:2, pages 281-287.
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