289
Views
61
CrossRef citations to date
0
Altmetric
Themed article: ADHD - Review

The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder

Pages 1595-1605 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Massimiliano Buoli, Marta Serati & Wiepke Cahn. (2016) Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert Review of Neurotherapeutics 16:2, pages 131-144.
Read now
Xiaonan Li, Xiaolin Sun, Jiayin Chen, Yang Lu, Yongjie Zhang, Chunfeng Wang, Junxiu Li, Qing Zhang, Di Zhao & Xijing Chen. (2015) Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist. Xenobiotica 45:1, pages 88-94.
Read now
Daniel F Connor, Amy FT Arnsten, Geraldine S Pearson & Gabriella F Greco. (2014) Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents. Expert Opinion on Pharmacotherapy 15:11, pages 1601-1610.
Read now
Mark S. Gold, Kenneth Blum, Marlene Oscar–Berman & Eric R. Braverman. (2014) Low Dopamine Function in Attention Deficit/Hyperactivity Disorder: Should Genotyping Signify Early Diagnosis in Children?. Postgraduate Medicine 126:1, pages 153-177.
Read now

Articles from other publishers (57)

Denise Wallace, Nicholas R. Cooper, Alejandra Sel & Riccardo Russo. (2023) Do non-traumatic stressful life events and ageing negatively impact working memory performance and do they interact to further impair working memory performance?. PLOS ONE 18:11, pages e0290635.
Crossref
Marianne Rica Garcia, Iñigo Iribarren, Isabel Rozas & Cristina Trujillo. (2023) Simultaneous Hydrogen Bonds with Different Binding Modes: The Acceptor “Rules” but the Donor “Chooses”. Chemistry – A European Journal 29:21.
Crossref
Iman Idrees, Alessio Bellato, Samuele Cortese & Madeleine J. Groom. (2023) The effects of stimulant and non-stimulant medications on the autonomic nervous system (ANS) functioning in people with ADHD: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 144, pages 104968.
Crossref
Donald R. Smith & Barbara J. Strupp. (2023) Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies. Neurotherapeutics 20:1, pages 3-21.
Crossref
Daniela Vázquez-González, Sonia Carreón-Trujillo, Lourdes Alvarez-Arellano, Daniela Melissa Abarca-Merlin, Pablo Domínguez-López, Marcela Salazar-García & Juan Carlos Corona. 2023. Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders. Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders 327 356 .
Karen Hoang, Hilary Watt, Mara Golemme, Richard J. Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard & Paresh A. Malhotra. (2022) Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer’s Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments. Trials 23:1.
Crossref
Elaine Pinggal, Paul M. Dockree, Redmond G. O'Connell, Mark A. Bellgrove & Thomas Andrillon. (2022) Pharmacological Manipulations of Physiological Arousal and Sleep-Like Slow Waves Modulate Sustained Attention. The Journal of Neuroscience 42:43, pages 8113-8124.
Crossref
Constantin-Cristian Topriceanu, James C. Moon, Gabriella Captur & Bhathika Perera. (2022) The use of attention-deficit hyperactivity disorder medications in cardiac disease. Frontiers in Neuroscience 16.
Crossref
Lélia Lilianna Borges de Sousa Macedo, Flavia Tasmin Techera Antunes, Willyane de Andrade Alvarenga, Mara Cristina Carvalho Batista, Mayara Storel Beserra de Moura, Mariane Nunes Lima Farias, Emanuelle Sistherenn Caminski, Eliane Dallegrave, Ivana Grivicich & Alessandra Hübner de Souza. (2022) Curcumin for attention-deficit–hyperactivity disorder: a systematic review and preliminary behavioral investigation. Naunyn-Schmiedeberg's Archives of Pharmacology 395:7, pages 803-813.
Crossref
Nicholas Cothros & Tamara Pringsheim. 2022. The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics - Part B. The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics - Part B 251 266 .
Benjamin J. MacDougall & Puneet Mishra. 2022. Hospitalized Chronic Pain Patient. Hospitalized Chronic Pain Patient 179 184 .
Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu & Wang-Tso Lee. (2021) Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome. Nutrients 13:11, pages 3698.
Crossref
Amy F. T. Arnsten, Dibyadeep Datta & Min Wang. (2020) The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex. Molecular Psychiatry 26:8, pages 3684-3700.
Crossref
Dong-oh Seo, Eric T. Zhang, Sean C. Piantadosi, David J. Marcus, Laura E. Motard, Bryce K. Kan, Adrian M. Gomez, Tammy K. Nguyen, Li Xia & Michael R. Bruchas. (2021) A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing. Neuron 109:13, pages 2116-2130.e6.
Crossref
Rachel E. Teneralli, David M. Kern, M. Soledad Cepeda, James P. Gilbert & Wayne C. Drevets. (2021) Exploring real-world evidence to uncover unknown drug benefits and support the discovery of new treatment targets for depressive and bipolar disorders. Journal of Affective Disorders 290, pages 324-333.
Crossref
Rahul Nachnani, Wesley M. Raup-Konsavage & Kent E. Vrana. (2021) The Pharmacological Case for Cannabigerol. Journal of Pharmacology and Experimental Therapeutics 376:2, pages 204-212.
Crossref
Garima Sharma, Naveen Sharma, Bao Trong Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Yukio Yoneda, Eun-Joo Shin & Hyoung-Chun Kim. (2020) Protective Potential of Ginkgo biloba Against an ADHD-like Condition. Current Molecular Pharmacology 14:2, pages 200-209.
Crossref
J. L. Lukkes, H. P. Drozd, S. D. Fitz, A. I. Molosh, D. W. Clapp & A. Shekhar. (2020) Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model. Journal of Neurodevelopmental Disorders 12:1.
Crossref
Sara K. BlaineStephanie WemmNia FogelmanCheryl LacadieDongju SeoDustin ScheinostRajita Sinha. (2020) Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal of Psychiatry 177:11, pages 1048-1059.
Crossref
Sharon B. Wigal, Seth C. Hopkins, Kenneth S. Koblan, Ann Childress, Justine M. Kent, Joyce Tsai, Jay Hsu, Antony Loebel & Robert Goldman. (2019) Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study. Journal of Attention Disorders 24:2, pages 192-204.
Crossref
Andresa Heemann Betti, Camila Boque Antonio, Vivian Herzfeldt, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Jean-Luc do Rego, Jean-Claude do Rego, David Vaudry & Stela Maris Kuze Rates. (2019) PT-31, a putative α2-adrenoceptor agonist, is effective in schizophrenia cognitive symptoms in mice. Behavioural Pharmacology 30:7, pages 574-587.
Crossref
Juhee Agrawal, Birgit Ludwig, Bhaskar Roy & Yogesh Dwivedi. (2018) Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain. Molecular Neurobiology 56:6, pages 4061-4071.
Crossref
Arthur Caye, James M. Swanson, David Coghill & Luis Augusto Rohde. (2018) Treatment strategies for ADHD: an evidence-based guide to select optimal treatment. Molecular Psychiatry 24:3, pages 390-408.
Crossref
Todd M. Preuss. (2019) Critique of Pure Marmoset. Brain, Behavior and Evolution 93:2-3, pages 92-107.
Crossref
Larry W. HawkJrJr, Whitney D. Fosco, Craig R. Colder, James G. Waxmonsky, William E. PelhamJrJr & Keri S. Rosch. (2018) How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition. Journal of Child Psychology and Psychiatry 59:12, pages 1271-1281.
Crossref
Hui-Ching Huang, Lawrence Shih-Hsin Wu, Shun-Chieh Yu, Bo-Jian Wu, Ahai Chang Lua, Shin-Min Lee & Chao-Zong Liu. (2018) The Alpha-2A Adrenergic Receptor Gene -1291C/G Single Nucleotide Polymorphism is Associated with the Efficacy of Methylphenidate in Treating Taiwanese Children and Adolescents with Attention-Deficit Hyperactivity Disorder. Psychiatry Investigation 15:3, pages 306-312.
Crossref
Vladimir S. Naumenko & Evgeni Ponimaskin. (2018) Palmitoylation as a Functional Regulator of Neurotransmitter Receptors. Neural Plasticity 2018, pages 1-18.
Crossref
Madeleine Monique Uys, Mohammed Shahid & Brian Herbert Harvey. (2017) Therapeutic Potential of Selectively Targeting the α2C-Adrenoceptor in Cognition, Depression, and Schizophrenia—New Developments and Future Perspective. Frontiers in Psychiatry 8.
Crossref
Sara Loureiro‐Vieira, Vera Marisa Costa, Maria Lourdes Bastos, Félix Carvalho & João Paulo Capela. (2017) Methylphenidate effects in the young brain: friend or foe?. International Journal of Developmental Neuroscience 60:1, pages 34-47.
Crossref
Stephane A. Beaudin, Barbara J. Strupp, Walter Uribe, Lauren Ysais, Myla Strawderman & Donald R. Smith. (2017) Methylphenidate alleviates manganese-induced impulsivity but not distractibility. Neurotoxicology and Teratology 61, pages 17-28.
Crossref
Stephane A. Beaudin, Barbara J. Strupp, Myla Strawderman & Donald R. Smith. (2017) Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats. Environmental Health Perspectives 125:2, pages 230-237.
Crossref
Akiko Sumitomo, Ayumi Saka, Keisho Ueta, Kouta Horike, Kazuko Hirai, Nao J. Gamo, Takatoshi Hikida, Keiichi I. Nakayama, Akira Sawa, Takeshi Sakurai & Toshifumi Tomoda. (2017) Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <b><i>Fez1</i></b>-Deficient Mice. Complex Psychiatry 3:4, pages 223-233.
Crossref
Denis G. Sukhodolsky, Theresa R. Gladstone, Shivani A. Kaushal, Justyna B. Piasecka & James F. Leckman. 2017. Handbook of Childhood Psychopathology and Developmental Disabilities Treatment. Handbook of Childhood Psychopathology and Developmental Disabilities Treatment 241 256 .
F. M. Grisales-Franco, J. M. Medina-Salcedo, D. M. Ovalle-Martínez, J. D. Martínez-Vargas, D. G. García-Murillo & G. Castellanos-Dominguez. 2017. Natural and Artificial Computation for Biomedicine and Neuroscience. Natural and Artificial Computation for Biomedicine and Neuroscience 416 425 .
Craig W. Berridge & Robert C. Spencer. (2016) Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex. Brain Research 1641, pages 189-196.
Crossref
Toni-Lee Sterley, Fleur M. Howells & Vivienne A. Russell. (2016) Genetically determined differences in noradrenergic function: The spontaneously hypertensive rat model. Brain Research 1641, pages 291-305.
Crossref
Amy F.T. ArnstenMin Wang. (2016) Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders. Annual Review of Pharmacology and Toxicology 56:1, pages 339-360.
Crossref
Gabriel J. Aranovich, Samuel M. McClure, Susanna Fryer & Daniel H. Mathalon. (2016) The effect of cognitive challenge on delay discounting. NeuroImage 124, pages 733-739.
Crossref
Mariana Gongora, Caroline Peressuti, Bruna Velasques, Juliana Bittencourt, Silmar Teixeira, Oscar Arias-Carrión, Mauricio Cagy & Pedro Ribeiro. (2014) Absolute Theta Power in the Frontal Cortex During a Visuomotor Task. Clinical EEG and Neuroscience 46:4, pages 292-298.
Crossref
James F. Leckman & Michael H. Bloch. 2015. Rutter's Child and Adolescent Psychiatry. Rutter's Child and Adolescent Psychiatry 757 773 .
Robert C. Spencer, David M. Devilbiss & Craig W. Berridge. (2015) The Cognition-Enhancing Effects of Psychostimulants Involve Direct Action in the Prefrontal Cortex. Biological Psychiatry 77:11, pages 940-950.
Crossref
Ida Fredriksson, Nitya Jayaram-Lindström, Malin Wirf, Erik Nylander, Erica Nyström, Kent Jardemark & Pia Steensland. (2014) Evaluation of Guanfacine as a Potential Medication for Alcohol Use Disorder in Long-Term Drinking Rats: Behavioral and Electrophysiological Findings. Neuropsychopharmacology 40:5, pages 1130-1140.
Crossref
Sherry A McKee, Marc N Potenza, Hedy Kober, Mehmet Sofuoglu, Amy FT Arnsten, Marina R Picciotto, Andrea H Weinberger, Rebecca Ashare & Rajita Sinha. (2014) A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal of Psychopharmacology 29:3, pages 300-311.
Crossref
Alvin V. TerryJr.Jr., Patrick M. Callahan, Rosann Schade, Nancy J. Kille & Marc Plagenhoef. (2014) Alpha 2A adrenergic receptor agonist, guanfacine, attenuates cocaine-related impairments of inhibitory response control and working memory in animal models. Pharmacology Biochemistry and Behavior 126, pages 63-72.
Crossref
Toni-Lee Sterley, Fleur M. Howells & Vivienne A. Russell. (2014) Nicotine-stimulated release of [3H]norepinephrine is reduced in the hippocampus of an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat. Brain Research 1572, pages 1-10.
Crossref
Amy F.T. Arnsten & Lu E. Jin. 2014. Molecular Basis of Memory. Molecular Basis of Memory 211 231 .
Jose Martinez-Raga, Carlos Knecht, Raquel de Alvaro, Nestor Szerman & Pedro Ruiz. (2013) Addressing Dual Diagnosis Patients Suffering from Attention-Deficit Hyperactivity Disorders and Comorbid Substance Use Disorders. Addictive Disorders & Their Treatment 12:4, pages 213-230.
Crossref
Shen-Chieh Chang & Winston W. Shen. (2013) Stimulants, Wakefulness-promoting Agents, and Nonstimulant Attention Deficit Hyperactivity Disorder Medications. Journal of Experimental & Clinical Medicine 5:6, pages 210-216.
Crossref
Xiaonan Li, Ning Li, Xiaolin Sun, Wei Yang, Yu Dai, Jie Xu, Wei Zhang, Chunfeng Wang, Suilou Wang & Xijing Chen. (2013) Development and validation of a simple, sensitive and accurate LC‐MS/MS method for the determination of guanfacine, a selective α 2A ‐adrenergicreceptor agonist, in plasma and its application to a pharmacokinetic study . Biomedical Chromatography 27:12, pages 1708-1713.
Crossref
Hannah Weisman, Imraan A. Qureshi, James F. Leckman, Lawrence Scahill & Michael H. Bloch. (2013) Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neuroscience & Biobehavioral Reviews 37:6, pages 1162-1171.
Crossref
Crystal Thomas. (2013) Extended Release Alpha-2 Agonists for ADHD. Child and Adolescent Psychopharmacology News 18:2, pages 7-9.
Crossref
Andreas Hartmann. 2013. Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome. Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome 351 372 .
Amy F.T. Arnsten, Min J. Wang & Constantinos D. Paspalas. (2012) Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses. Neuron 76:1, pages 223-239.
Crossref
Helen C Fox, Dongju Seo, Keri Tuit, Julie Hansen, Anne Kimmerling, Peter T Morgan & Rajita Sinha. (2012) Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. Journal of Psychopharmacology 26:7, pages 958-972.
Crossref
Craig W. Berridge, Jed S. Shumsky, Matt E. Andrzejewski, Jill A. McGaughy, Robert C. Spencer, David M. Devilbiss & Barry D. Waterhouse. (2012) Differential Sensitivity to Psychostimulants Across Prefrontal Cognitive Tasks: Differential Involvement of Noradrenergic α1- and α2-Receptors. Biological Psychiatry 71:5, pages 467-473.
Crossref
Soyoun Kim, Irina Bobeica, Nao J. Gamo, Amy F. T. Arnsten & Daeyeol Lee. (2011) Effects of α-2A adrenergic receptor agonist on time and risk preference in primates. Psychopharmacology 219:2, pages 363-375.
Crossref
Hans‐Willi Clement & Eberhard Schulz. (2011) α 2 ‐Agonisten und adrenerge Pharmaka bei ADHS . Pharmazie in unserer Zeit 40:6, pages 503-509.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.