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Kai Zhang & Kenji Hashimoto. (2019) An update on ketamine and its two enantiomers as rapid-acting antidepressants. Expert Review of Neurotherapeutics 19:1, pages 83-92.
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Ceren Sahin, Serdar Dursun, Mesut Cetin & Feyza Aricioglu. (2016) The Neuroinflammation Perspective of Depression: Reuniting the Outstanding Mechanisms of the Pathophysiology. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 26:2, pages 196-206.
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Beata Karolewicz, Mesut Cetin & Feyza Aricioglu. (2011) Beyond The Glutamate N-methyl D-aspartate Receptor in Major Depressive Disorder: The mTOR Signaling Pathway. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 21:1, pages 1-6.
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Articles from other publishers (36)
Marlene Santos, Luis Lima, Serafim Carvalho, Jorge Mota-Pereira, Paulo Pimentel, Dulce Maia, Diana Correia, M. Fátima Barroso, Sofia Gomes, Agostinho Cruz & Rui Medeiros. (2023) The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes. International Journal of Molecular Sciences 24:7, pages 6758.
Crossref
Crossref
Taro Kato. (2023) Role of mTOR1 signaling in the antidepressant effects of ketamine and the potential of mTORC1 activators as novel antidepressants. Neuropharmacology 223, pages 109325.
Crossref
Crossref
Ya-Ting Wang, Xiao-Le Wang, Si-Tong Feng, Nai-Hong Chen, Zhen-Zhen Wang & Yi Zhang. (2021) Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression. Pharmacological Research 171, pages 105761.
Crossref
Crossref
Nan Zhang, Lihua Yao, Peilin Wang & Zhongchun Liu. (2021) Immunoregulation and antidepressant effect of ketamine. Translational Neuroscience 12:1, pages 218-236.
Crossref
Crossref
Esmé Jansen van Vuren, Stephan F. Steyn, Christiaan B. Brink, Marisa Möller, Francois P. Viljoen & Brian H. Harvey. (2021) The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment. Biomedicine & Pharmacotherapy 135, pages 111200.
Crossref
Crossref
Amanda J. Sales, Izaque S. Maciel, Angélica C. D. R. Suavinha & Sâmia R. L. Joca. (2020) Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology 58:2, pages 777-794.
Crossref
Crossref
Motohiro Okada, Yasuhiro Kawano, Kouji Fukuyama, Eishi Motomura & Takashi Shiroyama. (2020) Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions. International Journal of Molecular Sciences 21:21, pages 7951.
Crossref
Crossref
Athira K V, Arathy S Mohan & Sumana Chakravarty. (2020) Rapid acting antidepressants in the mTOR pathway: Current evidence. Brain Research Bulletin 163, pages 170-177.
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Crossref
Albert Adell. (2020) Brain NMDA Receptors in Schizophrenia and Depression. Biomolecules 10:6, pages 947.
Crossref
Crossref
Ana Paula Vargas Visentin, Rafael Colombo, Ellen Scotton, Débora Soligo Fracasso, Adriane Ribeiro da Rosa, Catia Santos Branco & Mirian Salvador. (2020) Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges. Oxidative Medicine and Cellular Longevity 2020, pages 1-20.
Crossref
Crossref
Kenji Hashimoto. (2019) Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective. Psychiatry and Clinical Neurosciences 73:10, pages 613-627.
Crossref
Crossref
Dong Xiao, Li Liu, Yuanjie Li, Jie Ruan & Hanqing Wang. (2019) Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors. Neurochemical Research 44:9, pages 2044-2056.
Crossref
Crossref
Meysam Amidfar, Marie Woelfer, Gislaine Z. Réus, João Quevedo, Martin Walter & Yong-Ku Kim. (2019) The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research. Progress in Neuro-Psychopharmacology and Biological Psychiatry 94, pages 109668.
Crossref
Crossref
Zhonghua Wu, Zhengchen You, Peng Chen, Cheng Chen, Fei Chen, Jianhong Shen & Hui Xu. (2018) Matrine Exerts Antidepressant-Like Effects on Mice: Role of the Hippocampal PI3K/Akt/mTOR Signaling. International Journal of Neuropsychopharmacology 21:8, pages 764-776.
Crossref
Crossref
León Jesús German-Ponciano, Gilberto Uriel Rosas-Sánchez, Eduardo Rivadeneyra-Domínguez & Juan Francisco Rodríguez-Landa. (2018) Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents. Scientifica 2018, pages 1-14.
Crossref
Crossref
Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui & Bo Jiang. (2018) Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology 128, pages 181-195.
Crossref
Crossref
Isabel Vieira de Assis Lima, Ana Flávia Almeida-Santos, Talita Hélen Ferreira-Vieira, Daniele Cristina Aguiar, Fabíola Mara Ribeiro, Alline Cristina Campos & Antônio Carlos Pinheiro de Oliveira. (2017) Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway. Behavioural Brain Research 329, pages 166-171.
Crossref
Crossref
Larisa Ryskalin, Gloria Lazzeri, Marina Flaibani, Francesca Biagioni, Stefano Gambardella, Alessandro Frati & Francesco Fornai. (2017) mTOR-Dependent Cell Proliferation in the Brain. BioMed Research International 2017, pages 1-14.
Crossref
Crossref
Gislaine Z. Réus, Meagan R. Pitcher, Camila O. Arent & João Quevedo. 2016. Molecules to Medicine with mTOR. Molecules to Medicine with mTOR
205
214
.
Yael Yuhas, Shai Ashkenazi, Eva Berent & Abraham Weizman. (2015) Immunomodulatory activity of ketamine in human astroglial A172 cells: Possible relevance to its rapid antidepressant activity. Journal of Neuroimmunology 282, pages 33-38.
Crossref
Crossref
Kenji Hashimoto. (2015) Inflammatory Biomarkers as Differential Predictors of Antidepressant Response. International Journal of Molecular Sciences 16:12, pages 7796-7801.
Crossref
Crossref
Jennifer Romine, Xiang Gao, Xiao-Ming Xu, Kwok Fai So & Jinhui Chen. (2015) The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation. Neurobiology of Aging 36:4, pages 1716-1726.
Crossref
Crossref
Rodrigo Machado-Vieira, Marcus V. Zanetti, Antonio L. Teixeira, Miyuki Uno, Leandro L. Valiengo, Marcio G. Soeiro-de-Souza, Sueli M. Oba-Shinjo, Rafael T. de Sousa, Carlos. A. ZarateJr.Jr., Wagner F. Gattaz & Suely K.N. Marie. (2015) Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder. European Neuropsychopharmacology 25:4, pages 468-473.
Crossref
Crossref
Ji-chun Zhang, Jin Wu, Yuko Fujita, Wei Yao, Qian Ren, Chun Yang, Su-xia Li, Yukihiko Shirayama & Kenji Hashimoto. (2015) Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation. International Journal of Neuropsychopharmacology 18:4.
Crossref
Crossref
Shangli Cai, Shucai Huang & Wei Hao. (2015) New hypothesis and treatment targets of depression: an integrated view of key findings. Neuroscience Bulletin 31:1, pages 61-74.
Crossref
Crossref
Li-Ming Zhang, Wen-Wen Zhou, Ya-Jun Ji, Ying Li, Nan Zhao, Hong-Xia Chen, Rui Xue, Xin-Guo Mei, You-Zhi Zhang, Heng-Lin Wang & Yun-Feng Li. (2014) Anxiolytic effects of ketamine in animal models of posttraumatic stress disorder. Psychopharmacology 232:4, pages 663-672.
Crossref
Crossref
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol & Young Hoon Kim. (2014) Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. The International Journal of Neuropsychopharmacology 17:11, pages 1831-1846.
Crossref
Crossref
David-Marian Otte, Maria Luisa Barcena de Arellano, Andras Bilkei-Gorzo, Önder Albayram, Sophie Imbeault, Haang Jeung, Judith Alferink & Andreas Zimmer. (2013) Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. PLoS ONE 8:6, pages e67131.
Crossref
Crossref
Xian-Cang Ma, Yong-Hui Dang, Min Jia, Rui Ma, Fen Wang, Jin Wu, Cheng-Ge Gao & Kenji Hashimoto. (2013) Long-Lasting Antidepressant Action of Ketamine, but Not Glycogen Synthase Kinase-3 Inhibitor SB216763, in the Chronic Mild Stress Model of Mice. PLoS ONE 8:2, pages e56053.
Crossref
Crossref
Agata Chandran, Abiye H. Iyo, Courtney S. Jernigan, Beata Legutko, Mark C. Austin & Beata Karolewicz. (2013) Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress. Progress in Neuro-Psychopharmacology and Biological Psychiatry 40, pages 240-245.
Crossref
Crossref
Kenji Hashimoto. (2013) Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression. Progress in Neurobiology 100, pages 15-29.
Crossref
Crossref
Kenichi Tokita, Takayuki Yamaji & Kenji Hashimoto. (2012) Roles of glutamate signaling in preclinical and/or mechanistic models of depression. Pharmacology Biochemistry and Behavior 100:4, pages 688-704.
Crossref
Crossref
Chun Yang, Wen-Yuan Li, Hai-Yin Yu, Zhi-Qin Gao, Xiang-Liu Liu, Zhi-Qiang Zhou & Jian-Jun Yang. (2012) Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. Journal of Biomedicine and Biotechnology 2012, pages 1-6.
Crossref
Crossref
Rami Bou Khalil. (2012) Is there any place for macrolides in mood disorders?. Medical Hypotheses 78:1, pages 86-87.
Crossref
Crossref
Courtney S. Jernigan, Dharmendra B. Goswami, Mark C. Austin, Abiye H. Iyo, Agata Chandran, Craig A. Stockmeier & Beata Karolewicz. (2011) The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:7, pages 1774-1779.
Crossref
Crossref
Xian-cang Ma, Dong Jiang, Wen-hui Jiang, Fen Wang, Min Jia, Jin Wu, Kenji Hashimoto, Yong-hui Dang & Cheng-ge Gao. (2011) Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress. PLoS ONE 6:6, pages e20955.
Crossref
Crossref