Advanced search
Publication Cover
Expert Review of Neurotherapeutics Volume 11, 2011 - Issue 9
Submit an article Journal homepage
123
Views
35
CrossRef citations to date
0
Altmetric
Theme: Demyelinating diseases - Review

Harnessing the therapeutic potential of mesenchymal stem cells in multiple sclerosis

Peter J Darlington Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Neuroimmunology Unit, Room 111, 3801 University Street, Montréal, QC, H3A 2B4, Canada; Current address: Department of Exercise Science, PERFORM Centre, Concordia University, Montréal, QC, Canada; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Neuroimmunology Unit, Room 111, 3801 University Street, Montréal, QC, H3A 2B4, Canada; Current address: Department of Exercise Science, PERFORM Centre, Concordia University, Montréal, QC, Canada
,
Marie-Noëlle Boivin Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Neuroimmunology Unit, Room 111, 3801 University Street, Montréal, QC, H3A 2B4, Canada; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Neuroimmunology Unit, Room 111, 3801 University Street, Montréal, QC, H3A 2B4, Canada
&
Amit Bar-Or Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Neuroimmunology Unit, Room 111, 3801 University Street, Montréal, QC, H3A 2B4, Canada; Experimental Therapeutics Program, Montreal Neurological Institute, McGill University, Montréal, QC, Canada;[email protected]
Pages 1295-1303 | Published online: 09 Jan 2014

Citations (35)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Javier Caballero-Villarraso, Jamil Sawas, Begoña M. Escribano, Francisco A. Martín-Hersog, Andrea Valverde-Martínez & Isaac Túnez. (2021) Gene and cell therapy and nanomedicine for the treatment of multiple sclerosis: bibliometric analysis and systematic review of clinical outcomes. Expert Review of Neurotherapeutics 21:4, pages 431-441.
Read now
Yara Dadalti Fragoso, Tarso Adoni, Andrea Anacleto, Joseph Bruno Bidin Brooks, Margarete de Jesus Carvalho, Rinaldo Claudino, Alfredo Damasceno, Maria Lucia Brito Ferreira, Paulo Diniz da Gama, Marcus Vinicus Magno Goncalves, Anderson Kuntz Grzesiuk, Andre Palma da Cunha Matta & Monica Fiuza Koncke Parolin. (2014) How do we manage and treat a patient with multiple sclerosis at risk of tuberculosis?. Expert Review of Neurotherapeutics 14:11, pages 1251-1260.
Read now

Articles from other publishers (33)

A. S. Fedulov, M. M. Zafranskaya, A. V. Borisov, D. B. Nizhegorodova, N. A. Volkova, S. I. Krivenko & T. A. Shalukho. (2023) Impact of the therapy that changes the clinical course of multiple sclerosis using allogeneic mesenchymal stem cell transplantation on the immunological parameters of patients. Proceedings of the National Academy of Sciences of Belarus, Medical series 20:4, pages 299-307.
Crossref
Reza ArefNezhad & Hossein Motedayyen. 2023. Possibilities and Limitations in Current Translational Stem Cell Research. Possibilities and Limitations in Current Translational Stem Cell Research.
Susan L. Lindsay, Aleksandra M. Molęda, Lindsay M. MacLellan, Siew Min Keh, Daniel E. McElroy, Christopher Linington, Carl S. Goodyear & Susan C. Barnett. (2022) Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination. Acta Neuropathologica Communications 10:1.
Crossref
Yang Jingli, Wang Jing & Yasmeen Saeed. (2022) Ischemic Brain Stroke and Mesenchymal Stem Cells: An Overview of Molecular Mechanisms and Therapeutic Potential. Stem Cells International 2022, pages 1-15.
Crossref
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi & Jafar Ai. (2021) A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis. Stem Cell Research & Therapy 12:1.
Crossref
Reza ArefNezhad, Hossein Motedayyen & Ali Mohammadi. (2021) Therapeutic Aspects of Mesenchymal Stem Cell-Based Cell Therapy with a Focus on Human Amniotic Epithelial Cells in Multiple Sclerosis: A Mechanistic Review. International Journal of Stem Cells 14:3, pages 241-251.
Crossref
Narjes Shahsavani, Hardeep Kataria & Soheila Karimi-Abdolrezaee. (2021) Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:6, pages 166117.
Crossref
Dong Yeol Kim, Sung Hyun Choi, Jee Sun Lee, Hyoung Jun Kim, Ha Na Kim, Ji Eun Lee, Jin Young Shin & Phil Hyu Lee. (2020) Feasibility and Efficacy of Intra-Arterial Administration of Embryonic Stem Cell Derived-Mesenchymal Stem Cells in Animal Model of Alzheimer’s Disease. Journal of Alzheimer's Disease 76:4, pages 1281-1296.
Crossref
Ahmed H.K. El-Hashash. 2020. Mesenchymal Stem Cells in Human Health and Diseases. Mesenchymal Stem Cells in Human Health and Diseases 179 199 .
Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin & Olle Ringdén. (2019) Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells. Frontiers in Immunology 10.
Crossref
Christopher Duma, Oleg Kopyov, Alex Kopyov, Mark Berman, Elliot Lander, Michael Elam, Michael Arata, David Weiland, Ruslana Cannell, Chad Caraway, Sean Berman, Kristin Scord, Lian Stemler, Karlyssa Chung, Samuel Khoudari, Rory McRory, Chace Duma, Sawyer Farmer, Anthony Bravo, Christian Yassa, Ami Sanathara, Elisa Singh & Benjamin Rapaport. (2019) Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients. Molecular Biology Reports 46:5, pages 5257-5272.
Crossref
Xiaoming Zhang, Fei Hua, Ziying Yang, Yueqiu Chen, Xiaomei Teng, Haoyue Huang, Yunfeng Zhao & Zhenya Shen. (2018) Enhancement of Immunoregulatory Function of Modified Bone Marrow Mesenchymal Stem Cells by Targeting SOCS1. BioMed Research International 2018, pages 1-10.
Crossref
Andreas Nicodemou & Lubos Danisovic. (2017) Mesenchymal stromal/stem cell separation methods: concise review. Cell and Tissue Banking 18:4, pages 443-460.
Crossref
Daniel J. Kota, Karthik S. Prabhakara, Naama Toledano-Furman, Deepa Bhattarai, Qingzheng Chen, Bryan DiCarlo, Philippa Smith, Fabio Triolo, Pamela L. Wenzel, Charles S. CoxJr.Jr. & Scott D. Olson. (2017) Prostaglandin E2 Indicates Therapeutic Efficacy of Mesenchymal Stem Cells in Experimental Traumatic Brain Injury. Stem Cells 35:5, pages 1416-1430.
Crossref
C Marin-Ba?asco, K Benabdellah, C Melero-Jerez, B Oliver, M J Pinto-Medel, I Hurtado-Guerrero, F de Castro, D Clemente, O Fern?ndez, F Martin, L Leyva & M Suard?az. (2017) Gene therapy with mesenchymal stem cells expressing IFN-? ameliorates neuroinflammation in experimental models of multiple sclerosis. British Journal of Pharmacology 174:3, pages 238-253.
Crossref
Annie C. Bowles, Amy L. Strong, Rachel M. Wise, Robert C. Thomas, Brittany Y. Gerstein, Maria F. Dutreil, Ryan S. Hunter, Jeffrey M. Gimble & Bruce A. Bunnell. (2017) Adipose Stromal Vascular Fraction-Mediated Improvements at Late-Stage Disease in a Murine Model of Multiple Sclerosis. Stem Cells 35:2, pages 532-544.
Crossref
J. Liang, D. Wang, D. Farge & L. Sun. (2016) Mesenchymal stem cells for treating autoimmune diseases: The Chinese experience from lab to clinics. Current Research in Translational Medicine 64:2, pages 115-120.
Crossref
Daniel J. Kota, Karthik S. Prabhakara, Alexandra J. van Brummen, Supinder Bedi, Hasen Xue, Bryan DiCarlo, Charles S. CoxJr.Jr. & Scott D. Olson. (2016) Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury. Stem Cells Translational Medicine 5:1, pages 33-44.
Crossref
Fatmagül İlayda AYDINLI, Eşref ÇELİK, Burcu Kurt VATANDAŞLAR & Bilal E. KERMAN. (2016) Myelin disorders and stem cells: as therapies and models. TURKISH JOURNAL OF BIOLOGY 40, pages 1068-1080.
Crossref
Mingjun Cao, Qingjie Pan, Huansheng Dong, Xinxu Yuan, Yang Li, Zhen Sun, Xiao Dong & Hongjun Wang. (2015) Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice. Stem Cell Research & Therapy 6:1.
Crossref
M. V. Kovalchuk, O. G. Deryabina, L. D. Pichkur, S. A. Verbovskaya, N. S. Shuvalova, O. L. Pichkur & V. A. Kordium. (2015) Distribution of transplanted human mesenchymal stem cells from Wharton?s Jelly in the central nervous systems of the EAE rats. Biopolymers and Cell 31:5, pages 371-378.
Crossref
Krisztian Nemeth & Eva Mezey. (2015) Bone marrow stromal cells as immunomodulators. A primer for dermatologists. Journal of Dermatological Science 77:1, pages 11-20.
Crossref
Michelle B. Locke & Vaughan J. Feisst. 2015. Regenerative Medicine. Regenerative Medicine 135 149 .
Fred D. Lublin, James D. Bowen, John Huddlestone, Marcelo Kremenchutzky, Adam Carpenter, John R. Corboy, Mark S. Freedman, Lauren Krupp, Corri Paulo, Robert J. Hariri & Steven A. Fischkoff. (2014) Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: A randomized, placebo-controlled, multiple-dose study. Multiple Sclerosis and Related Disorders 3:6, pages 696-704.
Crossref
Simon A. Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, Helmut Butzkueven, Robert Heard, Suzanne Hodgkinson, Allan G. Kermode, Jeannette Lechner-Scott, Richard A.L. Macdonell, Mark Marriott, Deborah F. Mason, John Parratt, Stephen W. Reddel, Cameron P. Shaw, Mark Slee, Judith Spies, Bruce V. Taylor, William M. Carroll, Trevor J. Kilpatrick, John King, Pamela A. McCombe, John D. Pollard & Ernest Willoughby. (2014) Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy. Journal of Clinical Neuroscience 21:11, pages 1847-1856.
Crossref
Daniel J. Kota, Karthik S. Prabhakara, Charles S. Cox & Scott D. Olson. (2014) MSCs and hyaluronan: Sticking together for new therapeutic potential?. The International Journal of Biochemistry & Cell Biology 55, pages 1-10.
Crossref
Daniel J. Kota, Bryan DiCarlo, Robert A. Hetz, Philippa Smith, Charles S. Cox & Scott D. Olson. (2014) Differential MSC activation leads to distinct mononuclear leukocyte binding mechanisms. Scientific Reports 4:1.
Crossref
Sarah E Lutz, Justin Lengfeld & Dritan Agalliu. (2014) Stem cell-based therapies for multiple sclerosis: recent advances in animal models and human clinical trials. Regenerative Medicine 9:2, pages 129-132.
Crossref
M. Zafranskaya, D. Nizheharodava, M. Yurkevich, G. Ivanchik, Y. Demidchik, H. Kozhukh & A. Fedulov. (2013) PGE 2 Contributes to In vitro MSC-Mediated Inhibition of Non-Specific and Antigen-Specific T Cell Proliferation in MS Patients . Scandinavian Journal of Immunology 78:5, pages 455-462.
Crossref
G Li, L Yuan, X Ren, H Nian, L Zhang, Z C Han, X Li & X Zhang. (2013) The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis. Clinical and Experimental Immunology 173:1, pages 28-37.
Crossref
Ossama Allam, Suzanne Samarani & Ali Ahmad. (2013) Mesenchymal stem cell therapy in HIV-infected HAART-treated nonimmune responders restores immune competence. AIDS 27:8, pages 1349-1352.
Crossref
Marina M. Zafranskaya, Darya B. Nizheharodova, Mariya Yu. Yurkevich, Natallia V. Lamouskaya, Yana M. Motuzova, Svetlana S. Bagatka, Halina I. Ivanchik & Alexander S. Fedulov. (2013) In vitro assessment of mesenchymal stem cells immunosuppressive potential in multiple sclerosis patients. Immunology Letters 149:1-2, pages 9-18.
Crossref
Hakan Orbay, Morikuni Tobita & Hiroshi Mizuno. (2012) Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications. Stem Cells International 2012, pages 1-9.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.