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Theme: Mood Disorders - Review

Therapeutic use of omega-3 fatty acids in bipolar disorder

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Pages 1029-1047 | Published online: 09 Jan 2014

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Anjali Jadhav, Amrita Khaire & Sadhana Joshi. (2020) Exploring the role of oxidative stress, fatty acids and neurotrophins in gestational diabetes mellitus. Growth Factors 38:3-4, pages 226-234.
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Juen-Haur Hwang, Shu-Jing Wu, Po-Long Wu, Yong-Yao Shih & Yin-Ching Chan. (2019) Neuroprotective effect of tempeh against lipopolysaccharide-induced damage in BV-2 microglial cells. Nutritional Neuroscience 22:12, pages 840-849.
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Sahar M. Abdel-Maksoud, Sally I. Hassanein, Neveen A. Gohar, Saad M. M. Attia & Mohamed Z. Gad. (2017) Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids. Nutritional Neuroscience 20:8, pages 443-448.
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George Konstantakopoulos, Stefanos Dimitrakopoulos & Panayiota G Michalopoulou. (2015) Drugs under early investigation for the treatment of bipolar disorder. Expert Opinion on Investigational Drugs 24:4, pages 477-490.
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Bianca Pfaffenseller, Gabriel R Fries, Bianca Wollenhaupt-Aguiar, Gabriela D Colpo, Laura Stertz, Bruna Panizzutti, Pedro VS Magalhães & Flávio Kapczinski. (2013) Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder. Expert Review of Neurotherapeutics 13:7, pages 827-842.
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Murtada Alsaif, Frieder Haenisch, Paul C Guest, Hassan Rahmoune & Sabine Bahn. (2013) Challenges in drug target discovery in bipolar disorder. Expert Opinion on Therapeutic Targets 17:5, pages 565-577.
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Articles from other publishers (64)

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Angela M. Jaramillo-Ospina, Gabriel T. Roman, Danitsa M. Rodrigues, Sachin Patel, Irina Pokhvisneva, Valentina G. Chakr, Robert D. Levitan, Michael J. Meaney & Patricia P. Silveira. (2023) Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children. Pediatric Research.
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Giselli Scaini, Taylor Andrews, Camila N.C. Lima, Deborah Benevenuto, Emilio L. Streck & João Quevedo. (2021) Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder. Mitochondrion 57, pages 23-36.
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Klaus W. Lange. (2020) Omega-3 fatty acids and mental health. Global Health Journal 4:1, pages 18-30.
Crossref
Klaus W. Lange. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products 1 20 .
Dragan PavlovićM.M., Aleksandra PavlovićM.M. & Jelena Đordević. (2020) Omega 3 fatty acids in psychiatry: Myth and reality. Engrami 42:1, pages 44-57.
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Hana Kotolová & Tomáš Hammer. (2019) Inflammation as a part of the pathophysiology of depression and the possibility of its influence by polyunsaturated fatty acids. Psychiatrie pro praxi 20:2, pages 60-63.
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Lili Zhang, Zesheng Zhang, Mehrdad Negahban & Antoine Jérusalem. (2019) Molecular dynamics simulation of cell membrane pore sealing. Extreme Mechanics Letters 27, pages 83-93.
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Danitsa Marcos Rodrigues, Gisele Gus Manfro & Patrícia Pelufo Silveira. 2019. Omega Fatty Acids in Brain and Neurological Health. Omega Fatty Acids in Brain and Neurological Health 295 309 .
Danitsa Marcos Rodrigues, Gisele Gus Manfro, Robert Daniel Levitan, Meir Steiner, Michael Joseph Meaney & Patrícia Pelufo Silveira. (2018) Moderating effect of PLIN4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age. Prostaglandins, Leukotrienes and Essential Fatty Acids 137, pages 19-25.
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Fanqianhui Yu, Zhaojie Li, Tao Zhang, Yinong Wei, Yong Xue & Changhu Xue. (2017) Influence of encapsulation techniques on the structure, physical properties, and thermal stability of fish oil microcapsules by spray drying. Journal of Food Process Engineering 40:6, pages e12576.
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Hiroko Noguchi, Daisuke Nishi, Kenta Matsumura, Kei Hamazaki, Tomohito Hamazaki & Yutaka J. Matsuoka. (2017) Limited effect of omega-3 fatty acids on the quality of life in survivors of traumatic injury: A randomized, placebo-controlled trial. Prostaglandins, Leukotrienes and Essential Fatty Acids 127, pages 1-5.
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Lili Zhang, Zesheng Zhang, John Jasa, Dongli Li, Robin O. Cleveland, Mehrdad Negahban & Antoine Jérusalem. (2017) Molecular dynamics simulations of heterogeneous cell membranes in response to uniaxial membrane stretches at high loading rates. Scientific Reports 7:1.
Crossref
Kizzy Cancelier, Lara M. Gomes, Milena Carvalho-Silva, Letícia J. Teixeira, Joyce Rebelo, Isabella T. Mota, Camila O. Arent, Edemilson Mariot, Luiza W. Kist, Maurício R. Bogo, João Quevedo, Giselli Scaini & Emilio L. Streck. (2016) Omega-3 Fatty Acids and Mood Stabilizers Alter Behavioural and Energy Metabolism Parameters in Animals Subjected to an Animal Model of Mania Induced by Fenproporex. Molecular Neurobiology 54:6, pages 3935-3947.
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Gloria Terrats Ruiz. (2017) Los nutracéuticos como coadyuvantes de las terapias farmacológicas en el trastorno bipolar: revisión sistemática. Anuario de Psicología 47:2, pages 70-79.
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Maurizio Pompili, Lucia Longo, Giovanni Dominici, Gianluca Serafini, Dorian A. Lamis, Jerome Sarris, Mario Amore & Paolo Girardi. (2017) Polyunsaturated fatty acids and suicide risk in mood disorders: A systematic review. Progress in Neuro-Psychopharmacology and Biological Psychiatry 74, pages 43-56.
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Francesco Russo, Guglielmina Chimienti, Caterina Clemente, Carla Ferreri, Antonella Orlando & Giuseppe Riezzo. (2015) A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet. European Journal of Nutrition 56:2, pages 807-818.
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Muhammad Zahid Khan & Ling He. (2017) The role of polyunsaturated fatty acids and GPR40 receptor in brain. Neuropharmacology 113, pages 639-651.
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Kiran V. Sandhu, Eoin Sherwin, Harriët Schellekens, Catherine Stanton, Timothy G. Dinan & John F. Cryan. (2017) Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry. Translational Research 179, pages 223-244.
Crossref
Adrianne Rahde Bischoff, Roberta DalleMolle & Patrícia Pelufo Silveira. 2017. Diet, Nutrition, and Fetal Programming. Diet, Nutrition, and Fetal Programming 453 470 .
Richa Rathod, Anvita Kale & Sadhana Joshi. (2016) Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function. Journal of Biomedical Science 23:1.
Crossref
Giselli Scaini, Gislaine T. Rezin, Andre F. Carvalho, Emilio L. Streck, Michael Berk & João Quevedo. (2016) Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications. Neuroscience & Biobehavioral Reviews 68, pages 694-713.
Crossref
Adrian L. LoprestiFelice N. Jacka. (2015) Diet and Bipolar Disorder: A Review of Its Relationship and Potential Therapeutic Mechanisms of Action. The Journal of Alternative and Complementary Medicine 21:12, pages 733-739.
Crossref
Derek F. Keenan, Virginia C. Resconi, Thomas J. Smyth, Cristina Botinestean, Célio Lefranc, Joseph P. Kerry & Ruth M. Hamill. (2015) The effect of partial-fat substitutions with encapsulated and unencapsulated fish oils on the technological and eating quality of beef burgers over storage. Meat Science 107, pages 75-85.
Crossref
ALEXANDRA I. ZUGNO, LARA CANEVER, GUSTAVO MASTELLA, ALEXANDRA S. HEYLMANN, MARIANA B. OLIVEIRA, AMANDA V. STECKERT, ADALBERTO A. CASTRO, FELIPE DAL PIZZOL, JOÃO QUEVEDO & CLARISSA S. GAMA. (2015) Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia. Anais da Academia Brasileira de Ciências 87:2 suppl, pages 1475-1486.
Crossref
Pablo V. Escribá, Xavier Busquets, Jin-ichi Inokuchi, Gábor Balogh, Zsolt Török, Ibolya Horváth, John L. Harwood & László Vígh. (2015) Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Progress in Lipid Research 59, pages 38-53.
Crossref
Roberta Sena Reis, Juliana Rombaldi Bernardi, Meir Steiner, Michael J. Meaney, Robert D. Levitan & Patrícia Pelufo Silveira. (2015) Poor infant inhibitory control predicts food fussiness in childhood – A possible protective role of n-3 PUFAs for vulnerable children. Prostaglandins, Leukotrienes and Essential Fatty Acids 97, pages 21-25.
Crossref
Ziada Ayorech, Derek K. Tracy, David Baumeister & Giovanni Giaroli. (2015) Taking the fuel out of the fire: Evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders. Journal of Affective Disorders 174, pages 467-478.
Crossref
Laura G. Hermida & Gabriela Gallardo. 2015. Microencapsulation and Microspheres for Food Applications. Microencapsulation and Microspheres for Food Applications 271 299 .
Winnie-Pui-Pui Liew, Jia-Sin Ong, Chee-Yuan Gan, Sawibah Yahaya, Boon-Yin Khoo & Min-Tze Liong. 2015. Beneficial Microorganisms in Medical and Health Applications. Beneficial Microorganisms in Medical and Health Applications 223 255 .
Anilkumar Pillai & Jeffrey K. Yao. 2015. Studies on Psychiatric Disorders. Studies on Psychiatric Disorders 505 520 .
Alan C Logan & Felice N Jacka. (2014) Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch. Journal of Physiological Anthropology 33:1.
Crossref
Charles Francisco Ferreira, Juliana Rombaldi Bernardi, Vera Lúcia Bosa, Ilaine Schuch, Marcelo Zubaran Goldani, Flávio Kapczinski, Giovanni Abrahão Salum, Carla Dalmaz, Gisele Gus Manfro & Patrícia Pelufo Silveira. (2014) Correlation between n-3 polyunsaturated fatty acids consumption and BDNF peripheral levels in adolescents. Lipids in Health and Disease 13:1.
Crossref
Simon J. Evans, Rachel N. Ringrose, Gloria J. Harrington, Peter Mancuso, Charles F. Burant & Melvin G. McInnis. (2014) Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. Journal of Psychiatric Research 57, pages 58-64.
Crossref
Akiko Harauma, Junpei Saito, Yoshitake Watanabe & Toru Moriguchi. (2014) Potential for daily supplementation of n-3 fatty acids to reverse symptoms of dry eye in mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 90:6, pages 207-213.
Crossref
Borislav Angelov, Angelina Angelova, Sergey K. Filippov, Markus Drechsler, Petr Štěpánek & Sylviane Lesieur. (2014) Multicompartment Lipid Cubic Nanoparticles with High Protein Upload: Millisecond Dynamics of Formation. ACS Nano 8:5, pages 5216-5226.
Crossref
Giuseppe Grosso, Andrzej Pajak, Stefano Marventano, Sabrina Castellano, Fabio Galvano, Claudio Bucolo, Filippo Drago & Filippo Caraci. (2014) Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials. PLoS ONE 9:5, pages e96905.
Crossref
Camila S. Model, Lara M. Gomes, Giselli Scaini, Gabriela K. Ferreira, Cinara L. Gonçalves, Gislaine T. Rezin, Amanda V. Steckert, Samira S. Valvassori, Roger B. Varela, João Quevedo & Emilio L. Streck. (2014) Omega-3 fatty acids alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration. Metabolic Brain Disease 29:1, pages 185-192.
Crossref
Grace E Giles, Caroline R Mahoney & Robin B Kanarek. (2013) Omega-3 fatty acids influence mood in healthy and depressed individuals. Nutrition Reviews 71:11, pages 727-741.
Crossref
Sarah K. Orr, Sara Palumbo, Francesca Bosetti, Howard T. Mount, Jing X. Kang, Carol E. Greenwood, David W. L. Ma, Charles N. Serhan & Richard P. Bazinet. (2013) Unesterified docosahexaenoic acid is protective in neuroinflammation. Journal of Neurochemistry 127:3, pages 378-393.
Crossref
Francis E. Lotrich, Barry Sears & Robert K. McNamara. (2013) Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. Journal of Psychosomatic Research 75:5, pages 475-483.
Crossref
Chirayu D. Pandya, Kristy R. Howell & Anilkumar Pillai. (2013) Antioxidants as potential therapeutics for neuropsychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 46, pages 214-223.
Crossref
Gabriela Gallardo, Leticia Guida, Vanina Martinez, María C. López, Dana Bernhardt, Ramiro Blasco, Ruth Pedroza-Islas & Laura G. Hermida. (2013) Microencapsulation of linseed oil by spray drying for functional food application. Food Research International 52:2, pages 473-482.
Crossref
Charles Francisco Ferreira, Juliana Rombaldi Bernardi, Rachel Krolow, Danusa Mar Arcego, Gabriel Rodrigo Fries, Bianca Wollenhaupt de Aguiar, Gabrielle Senter, Flávio Pereira Kapczinski, Patrícia Pelufo Silveira & Carla Dalmaz. (2013) Vulnerability to dietary n-3 polyunsaturated fatty acid deficiency after exposure to early stress in rats. Pharmacology Biochemistry and Behavior 107, pages 11-19.
Crossref
Marianne A. Yon, Suzanna L. Mauger & Lucy C. Pickavance. (2013) Relationships between dietary macronutrients and adult neurogenesis in the regulation of energy metabolism. British Journal of Nutrition 109:9, pages 1573-1589.
Crossref
Fred Lühder, Ralf Gold, Alexander Flügel & Ralf A. Linker. (2013) Brain-Derived Neurotrophic Factor in Neuroimmunology: Lessons Learned from Multiple Sclerosis Patients and Experimental Autoimmune Encephalomyelitis Models. Archivum Immunologiae et Therapiae Experimentalis 61:2, pages 95-105.
Crossref
Clarissa S. Gama, Lara Canever, Bruna Panizzutti, Carolina Gubert, Laura Stertz, Raffael Massuda, Mariana Pedrini, David F. de Lucena, Renata D. Luca, Daiane B. Fraga, Alexandra S. Heylmann, Pedro F. Deroza & Alexandra I. Zugno. (2012) Effects of omega-3 dietary supplement in prevention of positive, negative and cognitive symptoms: A study in adolescent rats with ketamine-induced model of schizophrenia. Schizophrenia Research 141:2-3, pages 162-167.
Crossref

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