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Expert Review of Neurotherapeutics Volume 12, 2012 - Issue 3
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Theme: Migraine & Headache - Review

Pharmacological targeting of spreading depression in migraine

Katharina Eikermann-Haerter Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA. [email protected]; Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA. [email protected]
,
Anil Can Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA; Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA
&
Cenk Ayata Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA; Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 835, Boston, MA 02114-3117, USA; Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA; Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 835, Boston, MA 02114-3117, USA
Pages 297-306 | Published online: 09 Jan 2014

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Piet Borgdorff. (2018) Arguments against the role of cortical spreading depression in migraine. Neurological Research 40:3, pages 173-181.
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Levente Knapp, Bence Szita, Kitti Kocsis, László Vécsei & József Toldi. (2017) Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues. Drug Design, Development and Therapy 11, pages 27-34.
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Articles from other publishers (25)

Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo & Alfons Macaya. (2023) Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization. Cephalalgia 43:2, pages 033310242211463.
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Elisabetta Indelicato & Sylvia Boesch. 2023. Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease. Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease 227 248 .
Renán Sánchez-Porras, Modar Kentar, Roland Zerelles, Martina Geyer, Carlos Trenado, Jed A. Hartings, Johannes Woitzik, Jens P. Dreier & Edgar Santos. (2022) Eighteen-hour inhibitory effect of s-ketamine on potassium- and ischemia-induced spreading depolarizations in the gyrencephalic swine brain. Neuropharmacology 216, pages 109176.
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Carmen M. Galvez-Sánchez & Casandra I. Montoro Aguilar. (2022) Migraine and Neuroticism: A Scoping Review. Behavioral Sciences 12:2, pages 30.
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Paolo Bazzigaluppi, James Mester, Illsung L Joo, Iliya Weisspapir, Adrienne Dorr, Margaret M Koletar, Tina L Beckett, Houman Khosravani, Peter Carlen & Bojana Stefanovic. (2021) Frequency selective neuronal modulation triggers spreading depolarizations in the rat endothelin-1 model of stroke. Journal of Cerebral Blood Flow & Metabolism 41:10, pages 2756-2768.
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Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung & Shih-Pin Chen. (2019) Spreading depression as a preclinical model of migraine. The Journal of Headache and Pain 20:1.
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David Y Chung, Homa Sadeghian, Tao Qin, Sevda Lule, Hang Lee, Fahri Karakaya, Stacy Goins, Fumiaki Oka, Mohammad A Yaseen, Thijs Houben, Else A Tolner, Arn M J M van den Maagdenberg, Michael J Whalen, Sava Sakadžić & Cenk Ayata. (2019) Determinants of Optogenetic Cortical Spreading Depolarizations. Cerebral Cortex 29:3, pages 1150-1161.
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Sufang Liu, Yuanyuan Tang, Ying Xing, Phillip Kramer, Larry Bellinger & Feng Tao. (2019) Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies. Brain Sciences 9:2, pages 26.
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Yelena Y. Grinberg, Lois A. Zitzow & Richard P. Kraig. (2017) Intranasally administered IGF-1 inhibits spreading depression in vivo. Brain Research 1677, pages 47-57.
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Yuki Kurauchi, Koichi Mokudai, Masahiko Morita, Ayako Kamimura, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara & Kunio Ishii. (2017) l -Citrulline improves cerebral blood flow in migraine model rats. Journal of Functional Foods 38, pages 540-544.
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Shih-Pin Chen & Cenk Ayata. (2017) Novel Therapeutic Targets Against Spreading Depression. Headache: The Journal of Head and Face Pain 57:9, pages 1340-1358.
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Shih-Pin Chen, Tao Qin, Jessica L. Seidel, Yi Zheng, Matthias Eikermann, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Michael A. Moskowitz, Cenk Ayata & Katharina Eikermann-Haerter. (2017) Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain 140:6, pages 1643-1656.
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Shih-Pin Chen & Cenk Ayata. (2016) Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports 20:7.
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Shih-Pin Chen, Else A Tolner & Katharina Eikermann-Haerter. (2016) Animal models of monogenic migraine. Cephalalgia 36:7, pages 704-721.
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Andrew Charles & Amynah A. Pradhan. (2016) Delta-opioid receptors as targets for migraine therapy. Current Opinion in Neurology 29:3, pages 314-319.
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Shih-Pin Chen, Ilknur Ay, Andreia Lopes de Morais, Tao Qin, Yi Zheng, Homa Sadeghian, Fumiaki Oka, Bruce Simon, Katharina Eikermann-Haerter & Cenk Ayata. (2016) Vagus nerve stimulation inhibits cortical spreading depression. Pain 157:4, pages 797-805.
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Frederick R. Taylor, Wade M. Cooper & Robert G. Kaniecki. (2015) Abstracts and Citations. Headache: The Journal of Head and Face Pain 55:5, pages 718-729.
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Else A. Tolner, Thijs Houben, Gisela M. Terwindt, Boukje de Vries, Michel D. Ferrari & Arn M.J.M. van den Maagdenberg. (2015) From migraine genes to mechanisms. Pain 156:Supplement 1, pages S64-S74.
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Raffaele PalmirottaPiero BarbantiCristiano IalongoMaria Laura De MarchisJhessica AlessandroniGabriella EgeoCinzia AuriliaLuisa FofiMaria Giovanna ValentePatrizia FerroniDavid Della-MorteFiorella Guadagni. (2015) Progesterone Receptor Gene (PROGINS) Polymorphism Correlates with Late Onset of Migraine. DNA and Cell Biology 34:3, pages 208-212.
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Renán Sánchez-Porras, Zelong Zheng & Oliver W. Sakowitz. 2015. Neurovascular Events After Subarachnoid Hemorrhage. Neurovascular Events After Subarachnoid Hemorrhage 153 157 .
Dennis A. Turner. (2014) Neurovascular regulation is critical for metabolic recovery from spreading depression. Brain 137:11, pages 2877-2878.
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Katharina Eikermann-Haerter. (2014) Spreading Depolarization May Link Migraine and Stroke. Headache: The Journal of Head and Face Pain 54:7, pages 1146-1157.
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Cinzia Costa, Alessandro Tozzi, Innocenzo Rainero, Letizia Maria Cupini, Paolo Calabresi, Cenk Ayata & Paola Sarchielli. (2013) Cortical spreading depression as a target for anti-migraine agents. The Journal of Headache and Pain 14:1.
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Cenk Ayata. (2013) Pearls and pitfalls in experimental models of spreading depression. Cephalalgia 33:8, pages 604-613.
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Brett Theeler, Sylvia Lucas, Ronald G RiechersIIII & Robert L Ruff. (2013) Post-Traumatic Headaches in Civilians and Military Personnel: A Comparative, Clinical Review. Headache: The Journal of Head and Face Pain 53:6, pages 881-900.
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