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Review

Neurotrophins in lung health and disease

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Pages 395-411 | Published online: 09 Jan 2014

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Li Fang, Chun-Hao Li, Qian Zhang, Tian-Jiao Jiang, Yuan Liu, Feng-Po Shi, Peng Yu, Liang Yu, Ai-Ping Chen, Tao Li, Yu-Zhu Wan & Li Shi. (2023) Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis. Journal of Inflammation Research 16, pages 2595-2606.
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Latifa Khalfaoui & Christina M. Pabelick. (2023) Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms. Expert Opinion on Therapeutic Targets 27:1, pages 19-29.
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Ting Wang, Shunjie Bai, Wei Wang, Zhi Chen, Jianjun Chen, Zihong Liang, Xunzhong Qi, Hailan Shen & Peng Xie. (2020) Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways. Drug Design, Development and Therapy 14, pages 1279-1294.
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Lars Lunding, Alexandra Schröder & Michael Wegmann. (2015) Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Review of Respiratory Medicine 9:6, pages 739-750.
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Lynn D O’Hanlon, Sherry M Mabry & Ikechukwu I Ekekezie. (2014) Neurotrophins expression is decreased in lungs of human infants with congenital diaphragmatic hernia. Research and Reports in Neonatology 4, pages 9-15.
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Aleksandra Szczepankiewicz, Paulina Sobkowiak, Marta Rachel, Anna Bręborowicz, Natalia Schoneich, Kimberley Bruce, Zdzisława Kycler, Irena Wojsyk-Banaszak & Monika Dmitrzak-Węglarz. (2012) Multilocus Analysis of Candidate Genes Involved in Neurogenic Inflammation in Pediatric Asthma and Related Phenotypes: A Case–Control Study . Journal of Asthma 49:4, pages 329-335.
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Jinye Shi, Shuang Song, Kaixuan Wu, Gui Liang, Aizhong Wang & Xiaotao Xu. (2023) Role of brain‐derived neurotrophic factor in endotoxaemia‐induced acute lung injury. Experimental Physiology 108:12, pages 1456-1465.
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Cyrille Feybesse, Sylvie Chokron & Sylvie Tordjman. (2023) Melatonin in Neurodevelopmental Disorders: A Critical Literature Review. Antioxidants 12:11, pages 2017.
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Arianna Casini, Giorgio Vivacqua, Rosa Vaccaro, Anastasia Renzi, Stefano Leone, Luigi Pannarale, Antonio Franchitto, Paolo Onori, Romina Mancinelli & Eugenio Gaudio. (2023) Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium. European Journal of Histochemistry 67:4.
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Rodney D. BrittJr.Jr., Anushka Ruwanpathirana, Maria L. Ford & Brandon W. Lewis. (2023) Macrophages Orchestrate Airway Inflammation, Remodeling, and Resolution in Asthma. International Journal of Molecular Sciences 24:13, pages 10451.
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Sara Manti, Federica Xerra, Giulia Spoto, Ambra Butera, Eloisa Gitto, Gabriella Di Rosa & Antonio Gennaro Nicotera. (2023) Neurotrophins: Expression of Brain–Lung Axis Development. International Journal of Molecular Sciences 24:8, pages 7089.
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Armida Miranda-Riestra, Rosa Estrada-Reyes, Erandis D. Torres-Sanchez, Silvia Carreño-García, Genaro Gabriel Ortiz & Gloria Benítez-King. (2022) Melatonin: A Neurotrophic Factor?. Molecules 27:22, pages 7742.
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Alberto Ricci, Claudia Salvucci, Silvia Castelli, Antonella Carraturo, Claudia de Vitis & Michela D’Ascanio. (2022) Adenocarcinomas of the Lung and Neurotrophin System: A Review. Biomedicines 10:10, pages 2531.
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Sandor Haas-Neil, Anna Dvorkin-Gheva & Paul Forsythe. (2022) Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression. PLOS ONE 17:10, pages e0275864.
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Anna Maria Stabile, Alessandra Pistilli, Desirée Bartolini, Eleonora Angelucci, Marco Dell’Omo, Gabriele Di Sante & Mario Rende. (2022) Short-Term Effects of Side-Stream Smoke on Nerve Growth Factor and Its Receptors TrKA and p75NTR in a Group of Non-Smokers. International Journal of Environmental Research and Public Health 19:16, pages 10317.
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Jiaqiao Li, Yameng Fan, Yan Zhang, Yamei Liu, Yan Yu & Mao Ma. (2022) Resveratrol Induces Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Cells by Activating the NGFR-AMPK-mTOR Pathway. Nutrients 14:12, pages 2413.
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Géssica Luana Antunes, Josiane Silva Silveira, Carolina Luft, Samuel Greggio, Gianina Teribele Venturin, Felipe Schmitz, Helena Biasibetti-Brendler, Francieli Vuolo, Felipe Dal-Pizzol, Jaderson Costa da Costa, Angela T. S. Wyse, Paulo Márcio Pitrez & Aline Andrea da Cunha. (2022) Airway inflammation induces anxiety-like behavior through neuroinflammatory, neurochemical, and neurometabolic changes in an allergic asthma model. Metabolic Brain Disease 37:4, pages 911-926.
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E. M. Andreeva, N. S. Goncharova, E. N. Mikhailov & O. M. Moiseeva. (2022) Neurotrophins in the pathogenesis of pulmonary hypertension and right ventricular dysfunction. Russian Journal of Cardiology 27:2, pages 4840.
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Caiqin Yang, Xin Guo, Jianjie Li, Jingwan Han, Lei Jia, Hong-Ling Wen, Chengxi Sun, Xiaolin Wang, Bohan Zhang, Jingyun Li, Yujia Chi, Tongtong An, Yuyan Wang, Ziping Wang, Hanping Li & Lin Li. (2022) Significant Upregulation of HERV-K (HML-2) Transcription Levels in Human Lung Cancer and Cancer Cells. Frontiers in Microbiology 13.
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Sangeeta Bhallamudi, Benjamin B. Roos, Jacob J. Teske, Sarah A. Wicher, Andrea McConico, Christina M. Pabelick, Venkatachalem Sathish & Y. S. Prakash. (2021) Glial‐derived neurotrophic factor in human airway smooth muscle. Journal of Cellular Physiology 236:12, pages 8184-8196.
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Piaoyang Liu, Shun Li & Liling Tang. (2021) Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases. International Journal of Molecular Sciences 22:17, pages 9112.
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Daniel Ribeiro, Luca Petrigna, Frederico C. Pereira, Antonella Muscella, Antonino Bianco & Paula Tavares. (2021) The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review. International Journal of Molecular Sciences 22:16, pages 8814.
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Zhengli Guo, Lei Liu, Shasha Li, Bingqing Xu, Yihui Xu & Huiping Li. (2021) Effect of BDNF on airway inflammation in a rat model of COPD. Experimental and Therapeutic Medicine 22:4.
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Raquel Laza‐Briviesca, Alberto Cruz‐Bermúdez, Ernest Nadal, Amelia Insa, María del Rosario García‐Campelo, Gerardo Huidobro, Manuel Dómine, Margarita Majem, Delvys Rodríguez‐Abreu, Alex Martínez‐Martí, Javier De Castro Carpeño, Manuel Cobo, Guillermo López Vivanco, Edel Del Barco, Reyes Bernabé Caro, Nuria Viñolas, Isidoro Barneto Aranda, Santiago Viteri, Bartomeu Massuti, Marta Casarrubios, Belén Sierra‐Rodero, Carlos Tarín, Aránzazu García‐Grande, Cara Haymaker, Ignacio I. Wistuba, Atocha Romero, Fernando Franco & Mariano Provencio. (2021) Blood biomarkers associated to complete pathological response on NSCLC patients treated with neoadjuvant chemoimmunotherapy included in NADIM clinical trial. Clinical and Translational Medicine 11:7.
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O. Yu. Kytikova, T. P. Novgorodtseva, M. V. Antonyuk & T. A. Gvozdenko. (2021) The role of neurotrophic growth factors in the pathophysiology of bronchial asthma associated with obesity. Bulletin of Siberian Medicine 20:1, pages 158-167.
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Benjamin B. Roos, Jacob J. Teske, Sangeeta Bhallamudi, Christina M. Pabelick, Venkatachalem Sathish & Y. S. Prakash. 2021. Lung Inflammation in Health and Disease, Volume II. Lung Inflammation in Health and Disease, Volume II 109 121 .
Pien A. Goldsteen, Amalia M. Dolga & Reinoud Gosens. (2020) Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity. Physiology 35:5, pages 348-357.
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Shie Yin Ng, Anyanee Kamkaew, Nanyan Fu, Chin Siang Kue, Lip Yong Chung, Lik Voon Kiew, Jatuporn Wittayakun, Kevin Burgess & Hong Boon Lee. (2020) Active targeted ligand-aza-BODIPY conjugate for near-infrared photodynamic therapy in melanoma. International Journal of Pharmaceutics 579, pages 119189.
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Mythili Dileepan, Xiao Na Ge, Idil Bastan, Yana G. Greenberg, Yuying Liang, P. Sriramarao & Savita P. Rao. (2020) Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A. The Journal of Immunology 204:3, pages 682-693.
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Oxana Yu. Kytikova, Tatyana P. Novgorodtseva, Marina V. Antonyuk & Tatyana A. Gvozdenko. (2019) The role of regulatory neuropeptides and neurotrophic factors in asthma pathophysiology. Russian Open Medical Journal 8:4.
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Sina Webering, Lars Peter Lunding, Christina Vock, Alexandra Schröder, Karoline I. Gaede, Christian Herzmann, Heinz Fehrenbach & Michael Wegmann. (2019) The alpha‐melanocyte‐stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clinical & Experimental Allergy 49:7, pages 1026-1039.
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Rodney D. BrittJr.Jr., Michael A. Thompson, Sarah A. Wicher, Logan J. Manlove, Anne Roesler, Yun-Hua Fang, Carolyn Roos, Leslie Smith, Jordan D. Miller, Christina M. Pabelick & Y. S. Prakash. (2018) Smooth muscle brain‐derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. The FASEB Journal 33:2, pages 3024-3034.
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Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy & Vadim Bernard-Gauthier. (2019) Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging. Pharmaceuticals 12:1, pages 7.
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A.M. Stabile, L. Marinucci, S. Balloni, A. Giuliani, A. Pistilli, M. Bodo & M. Rende. (2018) Long term effects of cigarette smoke extract or nicotine on nerve growth factor and its receptors in a bronchial epithelial cell line. Toxicology in Vitro 53, pages 29-36.
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Kristen Kurtzeborn, Cristina Cebrian & Satu Kuure. (2018) Regulation of Renal Differentiation by Trophic Factors. Frontiers in Physiology 9.
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Su-Jin Baek, Jin Chun, Tae-Wook Kang, Yun-Soo Seo, Sung-Bae Kim, Boseok Seong, Yunji Jang, Ga-Hee Shin & Chul Kim. (2018) Identification of Epigenetic Mechanisms Involved in the Anti-Asthmatic Effects of Descurainia sophia Seed Extract Based on a Multi-Omics Approach. Molecules 23:11, pages 2879.
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Yan Zhou, Galina V. Shurin, Hua Zhong, Yuri L. Bunimovich, Baohui Han & Michael R. Shurin. (2018) Schwann Cells Augment Cell Spreading and Metastasis of Lung Cancer. Cancer Research 78:20, pages 5927-5939.
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Marwa M. Sherkawy, Amira M. Abo-youssef, Abeer A.A. Salama & Ismaiel E. Ismaiel. (2018) Fluoxetine protects against OVA induced bronchial asthma and depression in rats. European Journal of Pharmacology 837, pages 25-32.
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Raymond S. Oh, Andrew J. Haak, Karry M. J. Smith, Giovanni Ligresti, Kyoung Moo Choi, Tiao Xie, Shaohua Wang, Paula R. Walters, Michael A. Thompson, Michelle R. Freeman, Logan J. Manlove, Vivian M. Chu, Carol Feghali-Bostwick, Anja C. Roden, Jürgen Schymeinsky, Christina M. Pabelick, Y. S. Prakash, Robert Vassallo & Daniel J. Tschumperlin. (2018) RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation. Journal of Cell Science 131:10.
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Pauline Dravet-Gounot, Cécile Morin, Sébastien Jacques, Florent Dumont, Fabiola Ely-Marius, Daniel Vaiman, Pierre-Henri Jarreau, Céline Méhats & Elodie Zana-Taïeb. (2017) Lung microRNA deregulation associated with impaired alveolarization in rats after intrauterine growth restriction. PLOS ONE 12:12, pages e0190445.
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Emanuela Cherubini, Salvatore Mariotta, Davide Scozzi, Rita Mancini, Giorgia Osman, Michela D’Ascanio, Pierdonato Bruno, Giuseppe Cardillo & Alberto Ricci. (2017) BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis. Journal of Translational Medicine 15:1.
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Min Oh, Jaegyoon Ahn, Taekeon Lee, Giup Jang, Chihyun Park & Youngmi Yoon. (2017) Drug voyager: a computational platform for exploring unintended drug action. BMC Bioinformatics 18:1.
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Claudia Montagnoli, Roberto Tiribuzi, Lucia Crispoltoni, Alessandra Pistilli, Anna Maria Stabile, Francesco Manfreda, Giacomo Placella, Mario Rende & Giuliano G. Cerulli. (2017) β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis. Biological Chemistry 398:9, pages 1045-1054.
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Michelle R. FreemanVenkatachalem Sathish, Logan ManloveShengyu Wang, Rodney D. BrittJr.Jr., Michael A. ThompsonChristina M. Pabelick & Y. S. Prakash. (2017) Brain-derived neurotrophic factor and airway fibrosis in asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology 313:2, pages L360-L370.
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Yao-Zhong Liu, Lei Zhang, Astrid M Roy-Engel, Shigeki Saito, Joseph A Lasky, Guangdi Wang & He Wang. (2017) Carcinogenic effects of oil dispersants: A KEGG pathway-based RNA-seq study of human airway epithelial cells. Gene 602, pages 16-23.
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S. Manti, P. Brown, M.K. Perez & G. Piedimonte. 2017. Neurotrophins. Neurotrophins 313 341 .
Michael Thompson, Rodney D. BrittJr.Jr., Christina M. Pabelick & Y. S. Prakash. 2017. Pulmonary Vasculature Redox Signaling in Health and Disease. Pulmonary Vasculature Redox Signaling in Health and Disease 325 334 .
Takamitsu Kawazu, Takeshi Nakamura, Takashi Moriki, Yoshi‐ichiro Kamijo, Yukihide Nishimura, Tokio Kinoshita & Fumihiro Tajima. (2016) Aerobic Exercise Combined With Noninvasive Positive Pressure Ventilation Increases Serum Brain‐Derived Neurotrophic Factor in Healthy Males. PM&R 8:12, pages 1136-1141.
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Sheng-Yu Wang, Michelle R. Freeman, Venkatachalem Sathish, Michael A. Thompson, Christina M. Pabelick & Y. S. Prakash. (2016) Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion From Human Airway Smooth Muscle Cells. Journal of Cellular Physiology 231:7, pages 1586-1592.
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Ronaldo P. Panganiban, Yanli Wang, Judie Howrylak, Vernon M. Chinchilli, Timothy J. Craig, Avery August & Faoud T. Ishmael. (2016) Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma. Journal of Allergy and Clinical Immunology 137:5, pages 1423-1432.
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Anna Stabile, Alessandra Pistilli, Lucia Crispoltoni, Claudia Montagnoli, Roberto Tiribuzi, Lucio Casali & Mario Rende. (2016) A role for NGF and its receptors TrKA and p75NTR in the progression of COPD. Biological Chemistry 397:2.
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Kelly J. Brunst & Rosalind J. Wright. 2016. Health Disparities in Respiratory Medicine. Health Disparities in Respiratory Medicine 147 171 .
Michael A. Thompson, Rodney D. BrittJr.Jr., Ine Kuipers, Alecia Stewart, James Thu, Hitesh C. Pandya, Peter MacFarlane, Christina M. Pabelick, Richard J. Martin & Y.S. Prakash. (2015) cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:10, pages 2506-2514.
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Vinicio A. de Jesus Perez. (2015) First among Equals: Nerve Growth Factor in the Pathogenesis of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine 192:3, pages 274-275.
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M. Al‐Qudah, R. Alkahtani, H. I. Akbarali, K. S. Murthy & J. R. Grider. (2015) Stimulation of synthesis and release of brain‐derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase‐activating peptide. Neurogastroenterology & Motility 27:8, pages 1162-1174.
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William Hartman, Martin Helan, Dan Smelter, Venkatachalem Sathish, Michael Thompson, Christina M. Pabelick, Bruce Johnson & Y. S. Prakash. (2015) Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle. PLOS ONE 10:7, pages e0129489.
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Krithika Lingappan, Chandra Srinivasan, Weiwu Jiang, Lihua Wang, Xanthi I. Couroucli & Bhagavatula Moorthy. (2014) Analysis of the Transcriptome in Hyperoxic Lung Injury and Sex-Specific Alterations in Gene Expression. PLoS ONE 9:7, pages e101581.
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Y.S. Prakash & Richard J. Martin. (2014) Brain-derived neurotrophic factor in the airways. Pharmacology & Therapeutics 143:1, pages 74-86.
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Roberto Castano, Melanie Welman, Carole Trudeau, Lucero Castellanos & Karim Maghni. (2014) Effect of inhalation exposure to wheat flour on sputum levels of brain-derived neurotrophic factor. Annals of Allergy, Asthma & Immunology 112:4, pages 389-390.e1.
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Magda S. Jonczyk, Michelle Simon, Saumya Kumar, Vitor E. Fernandes, Nicolas Sylvius, Ann-Marie Mallon, Paul Denny & Peter W. Andrew. (2014) Genetic Factors Regulating Lung Vasculature and Immune Cell Functions Associate with Resistance to Pneumococcal Infection. PLoS ONE 9:3, pages e89831.
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Martin Helan, Bharathi Aravamudan, William R. Hartman, Michael A. Thompson, Bruce D. Johnson, Christina M. Pabelick & Y.S. Prakash. (2014) BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. Journal of Molecular and Cellular Cardiology 68, pages 89-97.
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Yueh-Hsiu Mathilda Chiu, Brent A. Coull, Michelle J. Sternthal, Itai Kloog, Joel Schwartz, Sheldon Cohen & Rosalind J. Wright. (2014) Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population. Journal of Allergy and Clinical Immunology 133:3, pages 713-722.e4.
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M. Al-Qudah, C. D. AndersonS. MahavadiZ. L. BradleyH. I. Akbarali, K. S. MurthyJ. R. Grider. (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. American Journal of Physiology-Gastrointestinal and Liver Physiology 306:4, pages G328-G337.
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Y. S. Prakash. (2013) Airway smooth muscle in airway reactivity and remodeling: what have we learned?. American Journal of Physiology-Lung Cellular and Molecular Physiology 305:12, pages L912-L933.
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Aleksandra Szczepankiewicz, Peter M Lackie & John W Holloway. (2013) Altered microRNA expression profile during epithelial wound repair in bronchial epithelial cells. BMC Pulmonary Medicine 13:1.
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Pawan K. Vohra, Michael A. Thompson, Venkatachalem Sathish, Alexander Kiel, Calvin Jerde, Christina M. Pabelick, Brij B. Singh & Y.S. Prakash. (2013) TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:12, pages 2953-2960.
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Céline Caravagna, Jorge Soliz & Tommy Seaborn. (2013) Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration. European Journal of Neuroscience 38:9, pages 3261-3269.
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Venkatachalem Sathish, Sarah Kay VanOosten, Brent S. Miller, Bharathi Aravamudan, Michael A. Thompson, Christina M. Pabelick, Robert Vassallo & Y. S. Prakash. (2013) Brain-Derived Neurotrophic Factor in Cigarette Smoke–Induced Airway Hyperreactivity. American Journal of Respiratory Cell and Molecular Biology 48:4, pages 431-438.
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Rosalind J. Wright & Kelly J. Brunst. (2013) Programming of respiratory health in childhood. Current Opinion in Pediatrics 25:2, pages 232-239.
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Bharathi Aravamudan, Michael Thompson, Christina Pabelick & Y. S. Prakash. (2012) Brain‐derived neurotrophic factor induces proliferation of human airway smooth muscle cells. Journal of Cellular and Molecular Medicine 16:4, pages 812-823.
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Hiromi Hiruma, Shiori Hikawa & Tadashi Kawakami. (2012) Immunocytochemical Colocalization of Fibroblast Growth Factor-1 with Neurotrophin-3 in Mouse Alveolar Macrophages. Acta Histochemica et Cytochemica ACTA HISTOCHEMICA ET CYTOCHEMICA 45:2, pages 131-137.
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Lucas W. Meuchel, Michael A. Thompson, Steven D. Cassivi, Christina M. Pabelick & Y.S. Prakash. (2011) Neurotrophins induce nitric oxide generation in human pulmonary artery endothelial cells. Cardiovascular Research 91:4, pages 668-676.
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Lucas W. Meuchel, Alecia Stewart, Dan F. Smelter, Amard J. Abcejo, Michael A. Thompson, Syed I. A. Zaidi, Richard J. Martin & Y. S. Prakash. (2011) Neurokinin-neurotrophin interactions in airway smooth muscle. American Journal of Physiology-Lung Cellular and Molecular Physiology 301:1, pages L91-L98.
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BERNARD C. DUYSINX, ASTRID PAULUS, VINCENT HEINEN, DELPHINE NGUYEN, MONIQUE HENKET, JEAN-LOUIS CORHAY & RENAUD LOUIS. (2011) Diagnostic value of neurotrophin expression in malignant pleural effusions. Experimental and Therapeutic Medicine 2:5, pages 941-946.
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