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Vaccine Profile

The new ACAM2000™ vaccine and other therapies to control orthopoxvirus outbreaks and bioterror attacks

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Pages 841-850 | Published online: 09 Jan 2014

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Ana Paula Guimarães, Teodorico Castro Ramalho & Tanos Celmar Costa França. (2014) Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus. Journal of Biomolecular Structure and Dynamics 32:10, pages 1601-1612.
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Joseph W Golden & Jay W Hooper. (2011) The strategic use of novel smallpox vaccines in the post-eradication world. Expert Review of Vaccines 10:7, pages 1021-1035.
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Aysegul Nalca & Elizabeth E Zumbrun. (2010) ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile. Drug Design, Development and Therapy 4, pages 71-79.
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Articles from other publishers (25)

Kevin Chiem, Aitor Nogales, Maria Lorenzo, Desarey Morales Vasquez, Yan Xiang, Yogesh K. Gupta, Rafael Blasco, Juan Carlos de la Torre & Luis Martínez-Sobrido. (2023) Identification of In Vitro Inhibitors of Monkeypox Replication . Microbiology Spectrum 11:4.
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Mohamed J. Saadh, Tahmineh Ghadimkhani, Narges Soltani, Arian Abbassioun, Renzon Daniel Cosme Pecho, Ali taha, Tareq Jwad Kazem, Saman Yasamineh & Omid Gholizadeh. (2023) Progress and prospects on vaccine development against monkeypox infection. Microbial Pathogenesis 180, pages 106156.
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Deepak Chandran, V.G. Nandanagopal, Malu Gopan, K. Megha, C.R. Hari Sankar, M.K. Muhammad Aslam, V. Vishnu Savanth, M. Pran, Firzan Nainu, Mohd. Iqbal Yatoo, Mohammad Ebad Ur Rehman, Hitesh Chopra, Talha Bin Emran, Abhijit Dey, Anil K. Sharma, AbdulRahman A. Saied & Kuldeep Dhama. (2022) Major Advances in Monkeypox Vaccine Research and Development – An Update. Journal of Pure and Applied Microbiology 16:suppl 1, pages 3083-3095.
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Sameer Elsayed, Lise Bondy & William P. Hanage. (2022) Monkeypox Virus Infections in Humans. Clinical Microbiology Reviews 35:4.
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Ramadan Abdelmoez Farahat, Abhigan Babu Shrestha, Mohamed Elsayed & Ziad A. Memish. (2022) Monkeypox vaccination: Does it cause neurologic and psychiatric manifestations? – Correspondence. International Journal of Surgery 106, pages 106926.
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Scott Parker, June D'Angelo, R. Mark Buller, Donald F. Smee, Johan Lantto, Henriette Nielsen, Allan Jensen, Mark Prichard & Sarah L. George. (2021) A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge. Antiviral Research 195, pages 105179.
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Jun Ando, Minhtran C. Ngo, Miki Ando, Ann Leen & Cliona M. Rooney. (2020) Identification of protective T-cell antigens for smallpox vaccines. Cytotherapy 22:11, pages 642-652.
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Jean-Marie Lachapelle. 2020. Kanerva’s Occupational Dermatology. Kanerva’s Occupational Dermatology 303 320 .
Kyle Wolf, Tyler Hether, Pavlo Gilchuk, Amrendra Kumar, Ahmad Rajeh, Courtney Schiebout, Julie Maybruck, R. Mark Buller, Tae-Hyuk Ahn, Sebastian Joyce & Richard J. DiPaolo. (2018) Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing. Cell Reports 25:9, pages 2369-2378.e4.
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Jean-Marie Lachapelle. 2018. Kanerva’s Occupational Dermatology. Kanerva’s Occupational Dermatology 1 26 .
Richard B. Kennedy, Gregory A. Poland, Inna G. Ovsyannikova, Ann L. Oberg, Yan W. Asmann, Diane E. Grill, Robert A. Vierkant & Robert M. Jacobson. (2016) Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients. Vaccine 34:28, pages 3283-3290.
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Kavita Singh, Apostolos G. Gittis, Rossitza K. Gitti, Stanley A. Ostazeski, Hua-Poo Su & David N. Garboczi. (2016) The Vaccinia Virus H3 Envelope Protein, a Major Target of Neutralizing Antibodies, Exhibits a Glycosyltransferase Fold and Binds UDP-Glucose. Journal of Virology 90:10, pages 5020-5030.
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Valentina Franceschi, Scott Parker, Sarah Jacca, Ryan W. Crump, Konstantin Doronin, Edguardo Hembrador, Daniela Pompilio, Giulia Tebaldi, Ryan D. Estep, Scott W. Wong, Mark R. Buller & Gaetano Donofrio. (2015) BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge. PLOS Neglected Tropical Diseases 9:6, pages e0003850.
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Marina Zaitseva, Kevin Tyler McCullough, Stephanie Cruz, Antonia Thomas, Claudia G. Diaz, Laurie Keilholz, Irma M. Grossi, Lawrence C. Trost & Hana Golding. (2015) Postchallenge Administration of Brincidofovir Protects Healthy and Immune-Deficient Mice Reconstituted with Limited Numbers of T Cells from Lethal Challenge with IHD-J-Luc Vaccinia Virus. Journal of Virology 89:6, pages 3295-3307.
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Ana P. Guimarães, Felipe R. de Souza, Aline A. Oliveira, Arlan S. Gonçalves, Ricardo B. de Alencastro, Teodorico C. Ramalho & Tanos C.C. França. (2015) Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox. European Journal of Medicinal Chemistry 91, pages 72-90.
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Scott Parker, Ryan Crump, Scott Foster, Hollyce Hartzler, Ed Hembrador, E. Randall Lanier, George Painter, Jill Schriewer, Lawrence C. Trost & R. Mark Buller. (2014) Co-administration of the broad-spectrum antiviral, brincidofovir (CMX001), with smallpox vaccine does not compromise vaccine protection in mice challenged with ectromelia virus. Antiviral Research 111, pages 42-52.
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Massimiliano Bissa, Sole Maria Pacchioni, Carlo Zanotto, Carlo De Giuli Morghen, Elena Illiano, Francesca Granucci, Ivan Zanoni, Achille Broggi & Antonia Radaelli. (2013) Systemically administered DNA and fowlpox recombinants expressing four vaccinia virus genes although immunogenic do not protect mice against the highly pathogenic IHD-J vaccinia strain. Virus Research 178:2, pages 374-382.
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M. B. Townsend, M. S. Keckler, N. Patel, D. H. Davies, P. Felgner, I. K. Damon & K. L. Karem. (2013) Humoral Immunity to Smallpox Vaccines and Monkeypox Virus Challenge: Proteomic Assessment and Clinical Correlations. Journal of Virology 87:2, pages 900-911.
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Gary Hermanson, Sookhee Chun, Jiin Felgner, Xiaolin Tan, Jozelyn Pablo, Rie Nakajima-Sasaki, Douglas M. Molina, Philip L. Felgner, Xiaowu Liang & D. Huw Davies. (2012) Measurement of antibody responses to Modified Vaccinia virus Ankara (MVA) and Dryvax® using proteome microarrays and development of recombinant protein ELISAs. Vaccine 30:3, pages 614-625.
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Jean-Marie Lachapelle. 2012. Kanerva's Occupational Dermatology. Kanerva's Occupational Dermatology 231 245 .
M. S. Keckler, D. S. Carroll, N. F. Gallardo-Romero, R. R. Lash, J. S. Salzer, S. L. Weiss, N. Patel, C. J. Clemmons, S. K. Smith, C. L. Hutson, K. L. Karem & I. K. Damon. (2011) Establishment of the Black-Tailed Prairie Dog (Cynomys ludovicianus) as a Novel Animal Model for Comparing Smallpox Vaccines Administered Preexposure in both High- and Low-Dose Monkeypox Virus Challenges. Journal of Virology 85:15, pages 7683-7698.
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Shari N. Gordon, Valentina Cecchinato, Vibeke Andresen, Jean-Michel Heraud, Anna Hryniewicz, Robyn Washington Parks, David Venzon, Hye-kyung Chung, Tatiana Karpova, James McNally, Peter Silvera, Keith A. Reimann, Hajime Matsui, Tomomi Kanehara, Yasuhiko Shinmura, Hiroyuki Yokote & Genoveffa Franchini. (2011) Smallpox Vaccine Safety Is Dependent on T Cells and Not B Cells. The Journal of Infectious Diseases 203:8, pages 1043-1053.
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Nanhai Chen, Clifford J. Bellone, Jill Schriewer, Gelita Owens, Torgny Fredrickson, Scott Parker & R. Mark L. Buller. (2011) Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy. Virology 409:2, pages 328-337.
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José Maria Marcelino, Pedro Borrego, Cheila Rocha, Helena Barroso, Alexandre Quintas, Carlos Novo & Nuno Taveira. (2010) Potent and Broadly Reactive HIV-2 Neutralizing Antibodies Elicited by a Vaccinia Virus Vector Prime-C2V3C3 Polypeptide Boost Immunization Strategy. Journal of Virology 84:23, pages 12429-12436.
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Aysegul Nalca, Virginia A. Livingston, Nicole L. Garza, Elizabeth E. Zumbrun, Ondraya M. Frick, Jennifer L. Chapman & Justin M. Hartings. (2010) Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Aerosolized Monkeypox Virus. PLoS ONE 5:9, pages e12880.
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