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Expert Review of Vaccines Volume 9, 2010 - Issue 10
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Review

Potency testing for the experimental Na-GST-1 hookworm vaccine

Amar R Jariwala Albert B. Sabin Vaccine Institute, Washington DC, USA; Albert B. Sabin Vaccine Institute, Washington DC, USA
,
Luciana M Oliveira Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
,
David J Diemert Albert B. Sabin Vaccine Institute, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Albert B. Sabin Vaccine Institute, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
,
Brian Keegan Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
,
Jordan L Plieskatt Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
,
Maria V Periago Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
,
Maria E Bottazzi Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
,
Peter J Hotez Albert B. Sabin Vaccine Institute, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA; Albert B. Sabin Vaccine Institute, Washington DC, USA; Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
&
Jeffrey M Bethony Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA;[email protected]
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Pages 1219-1230 | Published online: 09 Jan 2014

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Attapol Titapun, Vor Luvira, Tharatip Srisuk, Apiwat Jareanrat, Vasin Thanasukarn, Malinee Thanee, Prakasit Sa-Ngiamwibool, Sureerat Padthaisong, Kassaporn Duangkumpha, Manida Suksawat, Watcharin Loilome, Paiboon Sithithaworn, Anchalee Techasen, Bandit Thinkhamrop, Alexa Dzienny, Ayse Caglayan, David Park, Simran Mahmud & Narong Khuntikeo. (2021) High Levels of Serum IgG for Opisthorchis viverrini and CD44 Expression Predict Worse Prognosis for Cholangiocarcinoma Patients after Curative Resection. International Journal of General Medicine 14, pages 2191-2204.
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Attapol Titapun, Anchalee Techasen, Prakasit Sa-Ngiamwibool, Paiboon Sithithaworn, Vor Luvira, Tharatip Srisuk, Apiwat Jareanrat, Hasaya Dokduang, Watcharin Loilome, Bandit Thinkhamrop & Narong Khuntikeo. (2020) Serum IgG as a Marker for Opisthorchis viverrini-Associated Cholangiocarcinoma Correlated with HER2 Overexpression. International Journal of General Medicine 13, pages 1271-1283.
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Mark S Pearson, Amar R Jariwala, Giovanni Abbenante, Jordan Plieskatt, David Wilson, Maria Elena Bottazzi, Peter J Hotez, Brian Keegan, Jeffrey M Bethony & Alex Loukas. (2015) New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74. Human Vaccines & Immunotherapeutics 11:5, pages 1251-1257.
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Paul E.M. Fine, Kim Mulholland, J. Anthony Scott & W. John Edmunds. 2023. Plotkin's Vaccines. Plotkin's Vaccines 1603 1624.e8 .
Phongsaran Kimawaha, Raynoo Thanan, Apinya Jusakul, Wassana Jamnongkan, Atit Silsirivanit, Prakasit Sa-Ngaimwibool, Attapol Titapun, Narong Khuntikeo, Paiboon Sithithaworn, Chanika Worasith, Sutthiwan Janthamala, Carlito B. Lebrilla & Anchalee Techasen. (2022) Serum α2,6-sialylated glycoform of serotransferrin as a glycobiomarker for diagnosis and prediction of clinical severity in cholangiocarcinoma. Clinica Chimica Acta 536, pages 142-154.
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David J. Diemert, Maria Zumer, Doreen Campbell, Shannon Grahek, Guangzhao Li, Jin Peng, Maria Elena Bottazzi, Peter Hotez & Jeffrey Bethony. (2022) Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults. Vaccine 40:42, pages 6084-6092.
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Ahmed O. Shalash, Waleed M. Hussein, Mariusz Skwarczynski & Istvan Toth. (2021) Hookworm infection: Toward development of safe and effective peptide vaccines. Journal of Allergy and Clinical Immunology 148:6, pages 1394-1419.e6.
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Yoanne D. Mouwenda, Madeleine E. Betouke Ongwe, Friederike Sonnet, Koen A. Stam, Lucja A. Labuda, Sophie De Vries, Martin P. Grobusch, Frejus J. Zinsou, Yabo J. Honkpehedji, Jean-Claude Dejon Agobe, David J. Diemert, Remko van Leeuwen, Maria E. Bottazzi, Peter J. Hotez, Peter G. Kremsner, Jeffrey M. Bethony, Simon P. Jochems, Ayola A. Adegnika, Marguerite Massinga Loembe & Maria Yazdanbakhsh. (2021) Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon. PLOS Neglected Tropical Diseases 15:10, pages e0009732.
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Guangzhao Li, Lara Hoeweler, Brian Keegan, Jin Peng, Larissa Scholte, Peter Hotez, Maria Elena Bottazzi, David Diemert & Jeffrey Bethony. (2021) Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine. Vaccine: X 8, pages 100100.
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Ayola A Adegnika, Sophia G de Vries, Frejus J Zinsou, Yabo J Honkepehedji, Jean-Claude Dejon Agobé, Kafui G Vodonou, Rodrigue Bikangui, Aurore Bouyoukou Hounkpatin, Emmanuel B Bache, Marguerite Massinga Loembe, Remko van Leeuwen, Marjan Molemans, Peter G Kremsner, Maria Yazdanbakhsh, Peter J Hotez, Maria Elena Bottazzi, Guangzhao Li, Jeffrey M Bethony, David J Diemert, Martin P Grobusch, Yoanne D Mouwenda, Eunice Betouke Ongwe, Anne-Marie Nkoma Mouima, Odilon P Nouatin, Jean R Edoa, Prince G Manouana, Susana Pinto de Jesus, Vera Kühne, Benjamin Mordmueller, Bertrand Lell, Selidji T Agnandji & Carsten Koehler. (2021) Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. The Lancet Infectious Diseases 21:2, pages 275-285.
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W.A. Keitel, G.E. Potter, D. Diemert, J. Bethony, H.M. El Sahly, J.K. Kennedy, S.M. Patel, J.L. Plieskatt, W. Jones, G. Deye, M.E. Bottazzi, P.J. Hotez & R.L. Atmar. (2019) A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area. Vaccine 37:43, pages 6500-6509.
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David J. Diemert, Maria Elena Bottazzi, Jordan Plieskatt, Peter J. Hotez & Jeffrey M. Bethony. (2018) Lessons along the Critical Path: Developing Vaccines against Human Helminths. Trends in Parasitology 34:9, pages 747-758.
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Paul E.M. Fine, Kim Mulholland, J. Anthony Scott & W. John Edmunds. 2018. Plotkin's Vaccines. Plotkin's Vaccines 1512 1531.e5 .
Ying Sun, Yu Wang, Xing Huang, Xiaobing Gu, Weimin Lai, Xuerong Peng & Guangyou Yang. (2017) Characterization of glutathione S-transferase and its immunodiagnostic potential for detecting Taenia multiceps. Veterinary Parasitology 242, pages 31-37.
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David J. Diemert, Janaína Freire, Vanderson Valente, Carlos Geraldo Fraga, Frederico Talles, Shannon Grahek, Doreen Campbell, Amar Jariwala, Maria Victoria Periago, Martin Enk, Maria Flávia Gazzinelli, Maria Elena Bottazzi, Robert Hamilton, Jill Brelsford, Anna Yakovleva, Guangzhao Li, Jin Peng, Rodrigo Correa-Oliveira, Peter Hotez & Jeffrey Bethony. (2017) Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLOS Neglected Tropical Diseases 11:5, pages e0005574.
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Jill B. Brelsford, Jordan L. Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P. Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert & Jeffrey M. Bethony. (2017) Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine. PLOS Neglected Tropical Diseases 11:2, pages e0005385.
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David L. Sacks, Nathan C. Peters & Jeffrey M. Bethony. 2016. The Vaccine Book. The Vaccine Book 331 360 .
M.E. Bottazzi. (2015) The human hookworm vaccine: recent updates and prospects for success. Journal of Helminthology 89:5, pages 540-544.
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Prasert Saichua, Paiboon Sithithaworn, Amar R. Jariwala, David J. Deimert, Jiraporn Sithithaworn, Banchob Sripa, Thewarach Laha, Eimorn Mairiang, Chawalit Pairojkul, Maria Victoria Periago, Narong Khuntikeo, Jason Mulvenna & Jeffrey M. Bethony. (2013) Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis. PLoS Neglected Tropical Diseases 7:5, pages e2228.
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Paul E.M. Fine & Kim Mulholland. 2013. Vaccines. Vaccines 1395 1412 .
Hesham M. Al-Mekhlafi, Yvonne A. L. Lim, Norhayati Moktar & Romano Ngui. 2013. Parasites and their vectors. Parasites and their vectors 205 232 .
Sara Lustigman. 2012. Immunity to Parasitic Infection. Immunity to Parasitic Infection 459 470 .
Jeffrey M. Bethony, Maria Victoria Periago & Amar R. Jariwala. 2012. Parasitic Helminths. Parasitic Helminths 341 356 .
Prajak Sawangsoda, Jiraporn Sithithaworn, Smarn Tesana, Somchai Pinlaor, Thidarut Boonmars, Eimorn Mairiang, Puangrat Yongvanit, Kunyarat Duenngai & Paiboon Sithithaworn. (2012) Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. Parasitology International 61:1, pages 196-202.
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Jeffrey M. Bethony, Rhea N. Cole, Xiaoti Guo, Shaden Kamhawi, Marshall W. Lightowlers, Alex Loukas, William Petri, Steven Reed, Jesus G. Valenzuela & Peter J. Hotez. (2011) Vaccines to combat the neglected tropical diseases. Immunological Reviews 239:1, pages 237-270.
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