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Review

Respiratory syncytial virus vaccine development

Pages 1415-1433 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Gayathri Anandhan, Yogesh B. Narkhede, Manikandan Mohan & Premasudha Paramasivam. (2023) Immunoinformatics aided approach for predicting potent cytotoxic T cell epitopes of respiratory syncytial virus. Journal of Biomolecular Structure and Dynamics 41:21, pages 12093-12105.
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J.A Soto, N.M.S Galvez, D.B Rivera, F.E Díaz, C.A Riedel, S.M Bueno & A.M Kalergis. (2022) From animal studies into clinical trials: the relevance of animal models to develop vaccines and therapies to reduce disease severity and prevent hRSV infection. Expert Opinion on Drug Discovery 17:11, pages 1237-1259.
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Rauf Bhat, Mohamed A. Farrag & Fahad N. Almajhdi. (2020) Double-edged role of natural killer cells during RSV infection. International Reviews of Immunology 39:5, pages 233-244.
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William Flight & Andrew Jones. (2017) The diagnosis and management of respiratory viral infections in cystic fibrosis. Expert Review of Respiratory Medicine 11:3, pages 221-227.
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Susanna Esposito, Elisa Scarselli, Mara Lelii, Alessia Scala, Alessandra Vitelli, Stefania Capone, Marco Fornili, Elia Biganzoli, Annalisa Orenti, Alfredo Nicosia, Riccardo Cortese & Nicola Principi. (2016) Antibody response to respiratory syncytial virus infection in children <18 months old. Human Vaccines & Immunotherapeutics 12:7, pages 1700-1706.
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Charles J. Russell & Julia L. Hurwitz. (2016) Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses. Expert Review of Vaccines 15:2, pages 189-200.
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Hongjing Gu, Tieling Li, Lina Han, Ping Zhu, Peirui Zhang, Shaogeng Zhang, Sujing Sun, Yueqiang Duan, Li Xing, Zhongpeng Zhao, Chengcai Lai, Bohai Wen, Xiliang Wang & PengHui Yang. (2015) Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination . Human Vaccines & Immunotherapeutics 11:4, pages 1057-1064.
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Crystal Passmore, Paul E Makidon, Jessica J O’Konek, Joseph A Zahn, Jessie Pannu, Tarek Hamouda, Vira Bitko, Andrzej Myc, Nicolas W Lukacs, Ali Fattom & James R Baker Jr. (2014) Intranasal immunization with W805EC adjuvanted recombinant RSV rF-ptn enhances clearance of respiratory syncytial virus in a mouse model. Human Vaccines & Immunotherapeutics 10:3, pages 615-622.
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Kerry-Ann F O’Grady, Anne B Chang & Keith Grimwood. (2014) Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations. Expert Review of Respiratory Medicine 8:1, pages 43-55.
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Patricia A Jorquera, Katie E Oakley & Ralph A Tripp. (2013) Advances in and the potential of vaccines for respiratory syncytial virus. Expert Review of Respiratory Medicine 7:4, pages 411-427.
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Patricia Kaaijk, Willem Luytjes & Nynke Y. Rots. (2013) Vaccination against RSV. Human Vaccines & Immunotherapeutics 9:6, pages 1263-1267.
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Articles from other publishers (67)

Alvaro Proaño & Dustin Daniel Flannery. (2023) EBNEO Commentary: Respiratory syncytial virus vaccine in pregnancy for infant protection . Acta Paediatrica 112:11, pages 2449-2450.
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Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Tanya A. Miura, Lisette A. Maddison, Senthil Natesan & Santanu Bose. (2023) Human beta defensin-3 mediated activation of β-catenin during human respiratory syncytial virus infection: interaction of HBD3 with LDL receptor-related protein 5. Frontiers in Microbiology 14.
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Abu Tayab Moin, Md. Asad Ullah, Rajesh B. Patil, Nairita Ahsan Faruqui, Yusha Araf, Sowmen Das, Khaza Md. Kapil Uddin, Md. Shakhawat Hossain, Md. Faruque Miah, Mohammad Ali Moni, Dil Umme Salma Chowdhury & Saiful Islam. (2023) A computational approach to design a polyvalent vaccine against human respiratory syncytial virus. Scientific Reports 13:1.
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Chandrav De, Raymond J. Pickles, Wenbo Yao, Baolin Liao, Allison Boone, Mingyu Choi, Diana M. Battaglia, Frederic B. Askin, Jason K. Whitmire, Guido Silvestri, J. Victor Garcia & Angela Wahl. (2023) Human T cells efficiently control RSV infection. JCI Insight 8:11.
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Yannic C. Bartsch, Deniz Cizmeci, Jaewon Kang, Tomer Zohar, Sivakumar Periasamy, Nickita Mehta, Jeroen Tolboom, Leslie Van der Fits, Jerry Sadoff, Christy Comeaux, Benoit Callendret, Alexander Bukreyev, Douglas A. Lauffenburger, Arangassery Rosemary Bastian & Galit Alter. (2022) Antibody effector functions are associated with protection from respiratory syncytial virus. Cell 185:26, pages 4873-4886.e10.
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Rahul Ahuja, Asha Shelly, Jairam Meena & Amulya K. Panda. (2022) Microparticles entrapping pneumococcal protein SP0845 show improved immunogenicity and temperature stability. International Journal of Biological Macromolecules 203, pages 661-670.
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Anna A. Shtro, Galina D. Petukhova & Aleksandra S. Romanova. (2022) Protein and Peptide Substances in the Treatment of Respiratory Syncytial Infection: Current State. Molecules 27:7, pages 2263.
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Emanuele Andreano, Ida Paciello, Monia Bardelli, Simona Tavarini, Chiara Sammicheli, Elisabetta Frigimelica, Silvia Guidotti, Giulia Torricelli, Marco Biancucci, Ugo D’Oro, Sumana Chandramouli, Matthew J Bottomley, Rino Rappuoli, Oretta Finco & Francesca Buricchi. (2021) The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors. EMBO Molecular Medicine 13:6.
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Fabián E. Díaz, Mariana Guerra-Maupome, Paiton O. McDonald, Daniela Rivera-Pérez, Alexis M. Kalergis & Jodi L. McGill. (2021) A Recombinant BCG Vaccine Is Safe and Immunogenic in Neonatal Calves and Reduces the Clinical Disease Caused by the Respiratory Syncytial Virus. Frontiers in Immunology 12.
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Abu Hamza, Zoya Shafat, Zahoor Ahmad Parray, Malik Hisamuddin, Wajihul Hasan Khan, Anwar Ahmed, Fahad N. Almajhdi, Mohamed A. Farrag, Arif Ahmed Mohammed, Asimul Islam & Shama Parveen. (2021) Structural Characterization and Binding Studies of the Ectodomain G Protein of Respiratory Syncytial Virus Reveal the Crucial Role of pH with Possible Implications in Host–Pathogen Interactions. ACS Omega 6:15, pages 10403-10414.
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Jerald Sadoff, Els De Paepe, Wouter Haazen, Edmund Omoruyi, Arangassery R Bastian, Christy Comeaux, Esther Heijnen, Cynthia Strout, Hanneke Schuitemaker & Benoit Callendret. (2021) Safety and Immunogenicity of the Ad26.RSV.preF Investigational Vaccine Coadministered With an Influenza Vaccine in Older Adults. The Journal of Infectious Diseases 223:4, pages 699-708.
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Roshan Goswami, Derek T. O’Hagan, Roberto Adamo & Barbara C. Baudner. (2021) Conjugation of Mannans to Enhance the Potency of Liposome Nanoparticles for the Delivery of RNA Vaccines. Pharmaceutics 13:2, pages 240.
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Thomas J. Brouwers & Bernard A.M. Van der Zeijst. 2021. Encyclopedia of Virology. Encyclopedia of Virology 281 288 .
Salman Ahmad Mustfa, Eleonora Maurizi, John McGrath & Ciro Chiappini. (2020) Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery. Advanced Therapeutics 4:1, pages 2000160.
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Wayne Harshbarger, Sai Tian, Newton Wahome, Ankita Balsaraf, Deep Bhattacharya, Desheng Jiang, Ratnesh Pandey, Kunal Tungare, Kristian Friedrich, Nurjahan Mehzabeen, Marco Biancucci, Diana Chinchilla-Olszar, Corey P. Mallett, Ying Huang, Zihao Wang, Matthew James Bottomley, Enrico Malito & Sumana Chandramouli. (2020) Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. PLOS Pathogens 16:11, pages e1008943.
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MengJie Hu, Marie A. Bogoyevitch & David A. Jans. (2020) Impact of Respiratory Syncytial Virus Infection on Host Functions: Implications for Antiviral Strategies. Physiological Reviews 100:4, pages 1527-1594.
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Lori Bedient, Swechha Mainali Pokharel, Kim R. Chiok, Indira Mohanty, Sierra S. Beach, Tanya A. Miura & Santanu Bose. (2020) Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis. Viruses 12:9, pages 932.
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Ismail Sebina & Simon Phipps. (2020) The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis. Viruses 12:8, pages 808.
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Rhiannon R. PenkertJane S. HankinsNeal S. YoungJulia L. Hurwitz. (2020) Vaccine Design Informed by Virus-Induced Immunity. Viral Immunology 33:4, pages 342-350.
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MengJie Hu, Marie A. Bogoyevitch & David A. Jans. (2019) Subversion of Host Cell Mitochondria by RSV to Favor Virus Production is Dependent on Inhibition of Mitochondrial Complex I and ROS Generation. Cells 8:11, pages 1417.
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Kirsten Schneider-Ohrum, Angie Snell Bennett, Gaurav Manohar Rajani, Leigh Hostetler, Sean K. Maynard, Michelle Lazzaro, Lily I. Cheng, Terrence O’Day & Corinne Cayatte. (2019) CD4 + T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model . Journal of Virology 93:15.
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AKSHAY ASHOK .MANJUSHA GOEL .BHARTI CHAUBEY .RAJESH PATIL .. (2019) VITAMIN D LEVEL IN CRITICALLY ILL CHILDREN 6 MONTHS–5 YEARS AGE ADMITTED TO INTENSIVE CARE UNIT IN TERTIARY CARE HOSPITAL OF CENTRAL INDIA. Indian Journal of Child Health 06:04, pages 413-415.
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MengJie MengJie Hu, Keith E Schulze, Reena Ghildyal, Darren C Henstridge, Jacek L Kolanowski, Elizabeth J New, Yuning Hong, Alan C Hsu, Philip M Hansbro, Peter AB Wark, Marie A Bogoyevitch & David Andrew Jans. (2019) Respiratory Syncytial Virus co-opts host mitochondrial function to favour infectious virus production. eLife 8.
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Xueting Qiu, Venkata R. Duvvuri & Justin Bahl. (2019) Computational Approaches and Challenges to Developing Universal Influenza Vaccines. Vaccines 7:2, pages 45.
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María José Altamirano-Lagos, Fabián E. Díaz, Miguel Andrés Mansilla, Daniela Rivera-Pérez, Daniel Soto, Jodi L. McGill, Abel E. Vasquez & Alexis M. Kalergis. (2019) Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus. Frontiers in Microbiology 10.
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Mariana Guerra-Maupome, Mitchell V. Palmer, Jodi L. McGill & Randy E. Sacco. (2019) Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection. Vaccines 7:1, pages 7.
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Inam Ullah Khan, Jiansheng Huang, Xue Li, Jun Xie & Naishuo Zhu. (2018) Nasal immunization with RSV F and G protein fragments conjugated to an M cell-targeting ligand induces an enhanced immune response and protection against RSV infection. Antiviral Research 159, pages 95-103.
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Kedir N. Turi, Lindsey Romick-Rosendale, Tebeb Gebretsadik, Miki Watanabe, Steven Brunwasser, Larry J. Anderson, Martin L. Moore, Emma K. Larkin, Ray Stokes PeeblesJr.Jr. & Tina V. Hartert. (2018) Using urine metabolomics to understand the pathogenesis of infant respiratory syncytial virus (RSV) infection and its role in childhood wheezing. Metabolomics 14:10.
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Tiago Fazolo, Rodrigo Benedetti Gassen, Deise Nascimento de Freitas, Thiago J. Borges, Maurício Menegatti Rigo, Rodrigo Dornelles da Silva, Fábio Maito, Aline Cunha, Daniel Augusto Gasparin Bueno Mendes, André Báfica, José Eduardo Vargas, Ana Paula Duarte de Souza & Cristina Bonorino. (2018) Vaccination with RSV M 209-223 peptide promotes a protective immune response associated with reduced pulmonary inflammation. Antiviral Research 157, pages 102-110.
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Aleisha J. Anderson, Tom L. Snelling, Hannah C. Moore & Christopher C. Blyth. (2017) Advances in Vaccines to Prevent Viral Respiratory Illnesses in Children. Pediatric Drugs 19:6, pages 523-531.
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Lars Radke, Grit Sandig, Annika Lubitz, Ulrike Schließer, Hans von Horsten, Veronique Blanchard, Karolin Keil, Volker Sandig, Christoph Giese, Michael Hummel, Stephan Hinderlich & Marcus Frohme. (2017) In Vitro Evaluation of Glycoengineered RSV-F in the Human Artificial Lymph Node Reactor. Bioengineering 4:4, pages 70.
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Elisa C. Martinez, Ravendra Garg, Pratima Shrivastava, Susantha Gomis & Sylvia van Drunen Littel-van den Hurk. (2016) Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice. Antiviral Research 135, pages 108-119.
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