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Review

Bacterial ghosts as carriers of protein subunit and DNA-encoded antigens for vaccine applications

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Pages 97-116 | Published online: 09 Jan 2014

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Read on this site (7)

Fars K. Alanazi, Abdulaziz A. Alsuwyeh, Nazrul Haq, Mounir M. Salem-Bekhit, Abdullah Al-Dhfyan & Faiyaz Shakeel. (2020) Vision of bacterial ghosts as drug carriers mandates accepting the effect of cell membrane on drug loading. Drug Development and Industrial Pharmacy 46:10, pages 1716-1725.
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Siamak Alizadeh, Abolghasem Esmaeili, Abolfazl Barzegari, Mohammad A. Rafi & Yadollah Omidi. (2020) Bioengineered smart bacterial carriers for combinational targeted therapy of solid tumours. Journal of Drug Targeting 28:7-8, pages 700-713.
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Diana Groza, Sebastian Gehrig, Pavol Kudela, Martin Holcmann, Christine Pirker, Carina Dinhof, Hemma H. Schueffl, Marek Sramko, Julia Hoebart, Fatih Alioglu, Michael Grusch, Manfred Ogris, Werner Lubitz, Bernhard K. Keppler, Irena Pashkunova-Martic, Christian R. Kowol, Maria Sibilia, Walter Berger & Petra Heffeter. (2018) Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis. OncoImmunology 7:5.
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William S. Bowen, Abhishek K. Svrivastava, Lalit Batra, Hampartsoum Barsoumian & Haval Shirwan. (2018) Current challenges for cancer vaccine adjuvant development. Expert Review of Vaccines 17:3, pages 207-215.
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Nasrin Mirzaei, Farkhondeh Poursina, Sharareh Moghim, Niloufar Rashidi & Hajieh Ghasemian Safaei. (2017) The study of H. pylori putative candidate factors for single- and multi-component vaccine development. Critical Reviews in Microbiology 43:5, pages 631-650.
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Jacqueline Montanaro, Aleksandra Inic-Kanada, Angela Ladurner, Elisabeth Stein, Sandra Belij, Nora Bintner, Simone Schlacher, Nadine Schuerer, Ulrike Beate Mayr, Werner Lubitz, Nikolaus Leisch & Talin Barisani-Asenbauer. (2015) Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface. Drug Design, Development and Therapy 9, pages 3741-3754.
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Ana Isabel Camacho, Juan Manuel Irache & Carlos Gamazo. (2013) Recent progress towards development of a Shigella vaccine. Expert Review of Vaccines 12:1, pages 43-55.
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Chayanika Saha, James Bojdo, Nicholas J. Dunne, Raj Kumar Duary, Niamh Buckley & Helen O. McCarthy. (2022) Nucleic acid vaccination strategies for ovarian cancer. Frontiers in Bioengineering and Biotechnology 10.
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Yi Ma, Qiying Liu, Aihua Hu, Shoujin Jiang, Sijia Wang, Ran Liu, Kun Han & Jufang Wang. (2022) Construction and In Vitro Evaluation of a Tumor Acidic pH-Targeting Drug Delivery System Based on Escherichia coli Nissle 1917 Bacterial Ghosts. Bioengineering 9:9, pages 433.
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Nazrul Haq, Fars K. Alanazi, Mounir M. Salem-Bekhit, Sameh Rabea, Prawez Alam, Ibrahim A. Alsarra & Faiyaz Shakeel. (2022) Greenness estimation of chromatographic assay for the determination of anthracycline-based antitumor drug in bacterial ghost matrix of Salmonella typhimurium. Sustainable Chemistry and Pharmacy 26, pages 100642.
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Stavros A. Maurakis & Cynthia Nau Cornelissen. (2022) Recent Progress Towards a Gonococcal Vaccine. Frontiers in Cellular and Infection Microbiology 12.
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Young-Min Kim, Kwang-Su Lee, Won-Mun Kim, Min Kim, Han-Oh Park, Chang Won Choi, Joong-Soo Han, Shin-Young Park & Ki-Sung Lee. (2022) Hydrochloric acid-treated Bacillus subtilis ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage. Molecular & Cellular Toxicology 18:2, pages 267-276.
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Seongmi Ji, Eun Sun Moon, Han Byul Noh, Hyun Jung Park, Seongdae Kim, Sung Oh, Nagarajan Vinod, Chang Won Choi & Kilhan Kwak. (2022) Protective Immunity against Listeria monocytogenes in Rats, Provided by HCl- and NaOH-Induced Listeria monocytogenes Bacterial Ghosts (LMGs) as Vaccine Candidates. International Journal of Molecular Sciences 23:4, pages 1946.
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Wenxing Zhu, Yali Wei, Zengmei Li, Guoxiang Lin, Feifei Han, Lujiang Hao, Jiaqiang Wu, Xinli Liu & Yuyu Zhang. (2022) Research progress on bacterial ghosts as novel fishery vaccines. Aquaculture 548, pages 737526.
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Sae-Ryung Kang, Dinh-Huy Nguyen, Su Woong Yoo & Jung-Joon Min. (2022) Bacteria and bacterial derivatives as delivery carriers for immunotherapy. Advanced Drug Delivery Reviews 181, pages 114085.
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Jenci Hawthorne, Haval Shirwan & Esma Yolcu. 2022. Cancer Vaccines as Immunotherapy of Cancer. Cancer Vaccines as Immunotherapy of Cancer 209 226 .
Mounir M. Salem-Bekhit, Abdullah M. E. Youssof, Fars K. Alanazi, Fadilah Sfouq Aleanizy, Alsuwyeh Abdulaziz, Ehab I. Taha & Amro Abd Al Fattah Amara. (2021) Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems. Pharmaceutics 13:12, pages 1984.
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Haojie Chen, Hao Ji, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin & Da Sun. (2021) Bacterial Ghosts-Based Vaccine and Drug Delivery Systems. Pharmaceutics 13:11, pages 1892.
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H. Jiao, H. Yang, W. Zheng, Q. Zhang, D. Zhao & G. Li. (2020) Enhancement of immune responses by co‐administration of bacterial ghosts‐mediated Neisseria gonorrhoeae DNA vaccines . Journal of Applied Microbiology 130:5, pages 1770-1777.
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Safoura Soleymani, Amin Tavassoli, Gholamreza Hashemi Tabar, Gholam Ali Kalidari & Hesam Dehghani. (2020) Design, development, and evaluation of the efficacy of a nucleic acid-free version of a bacterial ghost candidate vaccine against avian pathogenic E. coli (APEC) O78:K80 serotype. Veterinary Research 51:1.
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Shengle Ji, Qiyang Gong, Wenwen Zhang, Jun Zheng, Bo Peng & Menghua Yang. (2020) Recombinant Vibrio parahaemolyticus ghosts protect zebrafish against infection by Vibrio species. Fish & Shellfish Immunology 107, pages 64-72.
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Yaxi Li, Chen Zhang, Tianliang Min, Yuan Ping & Kai Li. 2020. New Nanomaterials and Techniques for Tumor-targeted Systems. New Nanomaterials and Techniques for Tumor-targeted Systems 293 336 .
Zheng Jin, Shuang Gao, Xianlan Cui, Dejun Sun & Kai Zhao. (2019) Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines. International Journal of Pharmaceutics 572, pages 118731.
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Peng Zhou, Haiying Wu, Shenghua Chen, Qinqin Bai, Xi Chen, Li Chen, Xindian Zeng, Luyao Liu & Lili Chen. (2019) MOMP and MIP DNA-loaded bacterial ghosts reduce the severity of lung lesions in mice after Chlamydia psittaci respiratory tract infection. Immunobiology 224:6, pages 739-746.
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Abbas Muhammad, Johannes Kassmannhuber, Mascha Rauscher, Alaric A. Falcon, David W. Wheeler, Alan A. Zhang, Petra Lubitz & Werner Lubitz. (2019) Subcutaneous Immunization of Dogs With Bordetella bronchiseptica Bacterial Ghost Vaccine. Frontiers in Immunology 10.
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Chen Zhang, Zhao Zhao, Jian Li, Kai-Ge Song, Kai Hao, Jin Wang, Gao-Xue Wang & Bin Zhu. (2019) Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus. Aquaculture 504, pages 361-368.
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Dan-Dan Chen, Yuan-Yuan Yao, Zheng-Wei Cui, Xiang-Yang Zhang, Xia Guo, Yuan-Yuan Zhou & Yong-An Zhang. (2019) Comparative study of the immunoprotective effect of two grass carp-sourced Bacillus subtilis spore-based vaccines against grass carp reovirus. Aquaculture 504, pages 88-95.
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Rui Hou, Muzi Li, Tingting Tang, Ruichong Wang, Yijing Li, Yigang Xu, Lijie Tang, Li Wang, Min Liu, Yanping Jiang, Wen Cui & Xinyuan Qiao. (2018) Construction of Lactobacillus casei ghosts by Holin-mediated inactivation and the potential as a safe and effective vehicle for the delivery of DNA vaccines. BMC Microbiology 18:1.
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Fatemeh Farjadian, Mohsen Moghoofei, Soroush Mirkiani, Amir Ghasemi, Navid Rabiee, Shima Hadifar, Ali Beyzavi, Mahdi Karimi & Michael R. Hamblin. (2018) Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: Set the bugs to work?. Biotechnology Advances 36:4, pages 968-985.
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Si-yang LIU, Ren-yong JIA, Qing-qing LI, Dai-shen FENG, Hao-yue SHEN, Cui YANG, Ming-shu WANG, De-kang ZHU, Shun CHEN, Ma-feng LIU, Xin-xin ZHAO, Zhong-qiong YIN, Bo JING & An-chun CHENG. (2018) Immunogenicity and protective efficacy of DHBV DNA vaccines expressing envelope and capsid fusion proteins in ducks delivered by attenuated Salmonella typhimurium. Journal of Integrative Agriculture 17:4, pages 928-939.
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Wei Si, Shenye Yu, Henggui Liu, Chunlai Wang, Liping Chen, Gaoling Wang, Jianan Wu & Siguo Liu. (2017) A bacterial ghost improves the immunological efficacy of a Newcastle disease virus inactivated vaccine. Veterinary Microbiology 203, pages 189-195.
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Kai Hao, Xiao-Hui Chen, Xiao-Zhou Qi, Xiao-Bo Yu, En-Qi Du, Fei Ling, Bin Zhu & Gao-Xue Wang. (2017) Protective immunity of grass carp induced by DNA vaccine encoding capsid protein gene (vp7) of grass carp reovirus using bacterial ghost as delivery vehicles. Fish & Shellfish Immunology 64, pages 414-425.
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Jaroslav Michalek, Renata Hezova, Pavlina Turanek-Knötigova, Jana Gabkova, Marius Strioga, Werner Lubitz & Pavol Kudela. (2016) Oncolysate-loaded Escherichia coli bacterial ghosts enhance the stimulatory capacity of human dendritic cells. Cancer Immunology, Immunotherapy 66:2, pages 149-159.
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Jan Aleksander Kraśko, Karolina Žilionytė, Adas Darinskas, Marius Strioga, Svetlana Rjabceva, Iosif Zalutsky, Marina Derevyanko, Vladimir Kulchitsky, Werner Lubitz, Pavol Kudela, Edita Miseikyte-Kaubriene, Olha Karaman, Hennadii Didenko, Hryhorii Potebnya, Vasyl Chekhun & Vita Pašukonienė. (2017) Bacterial ghosts as adjuvants in syngeneic tumour cell lysate-based anticancer vaccination in a murine lung carcinoma model. Oncology Reports 37:1, pages 171-178.
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M.M. Strioga & N.T. Dobrovolskiene. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 43 64 .
Hyun Park, Sung Oh, Nagarajan Vinod, Seongmi Ji, Han Noh, Jung Koo, Su Lee, Sei Kim, Ki-Sung Lee & Chang Choi. (2016) Characterization of Chemically-Induced Bacterial Ghosts (BGs) Using Sodium Hydroxide-Induced Vibrio parahaemolyticus Ghosts (VPGs). International Journal of Molecular Sciences 17:11, pages 1904.
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Bingming Ou, Ying Yang, Wai Liang Tham, Lin Chen, Jitao Guo & Guoqiang Zhu. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. Applied Microbiology and Biotechnology 100:20, pages 8693-8699.
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Sharan Bobbala & Sarah Hook. (2016) Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?. Pharmaceutical Research 33:9, pages 2078-2097.
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Milad Lagzian, Mohammad Reza Bassami & Hesam Dehghani. (2016) In vitro responses of chicken macrophage-like monocytes following exposure to pathogenic and non-pathogenic E. coli ghosts loaded with a rational design of conserved genetic materials of influenza and Newcastle disease viruses. Veterinary Immunology and Immunopathology 176, pages 5-17.
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Lili Fan, Yan Wang, Min Zhao, Jinzhu Song, Jueyu Wang & Zijing Jin. (2016) Magnetic Ganoderma lucidum spore microspheres: A novel material to immobilize CotA multicopper oxidase for dye decolorization. Journal of Hazardous Materials 313, pages 122-129.
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Rongxian Guo, Shizhong Geng, Hongmei Jiao, Zhiming Pan, Xiang Chen & Xinan Jiao. (2016) Evaluation of protective efficacy of a novel inactivated Salmonella Pullorum ghost vaccine against virulent challenge in chickens. Veterinary Immunology and Immunopathology 173, pages 27-33.
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Andrea Meitz, Patrick Sagmeister, Werner Lubitz, Christoph Herwig & Timo Langemann. (2016) Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control. Microorganisms 4:2, pages 18.
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Aleksandra Inic-Kanada, Marijana Stojanovic, Simone Schlacher, Elisabeth Stein, Sandra Belij-Rammerstorfer, Emilija Marinkovic, Ivana Lukic, Jacqueline Montanaro, Nadine Schuerer, Nora Bintner, Vesna Kovacevic-Jovanovic, Ognjen Krnjaja, Ulrike Beate Mayr, Werner Lubitz & Talin Barisani-Asenbauer. (2015) Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers. PLOS ONE 10:12, pages e0144380.
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Jiansen Chen, Neng Li & Feifei She. (2014) Helicobacter pylori outer inflammatory protein DNA vaccine-loaded bacterial ghost enhances immune protective efficacy in C57BL/6 mice. Vaccine 32:46, pages 6054-6060.
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Jimei Ma, Jinmei Xu, Lingyu Guan, Tianjian Hu, Qin Liu, Jingfan Xiao & Yuanxing Zhang. (2014) Cell-penetrating peptides mediated protein cross-membrane delivery and its use in bacterial vector vaccine. Fish & Shellfish Immunology 39:1, pages 8-16.
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Virgil Schijns, Eric Tartour, Jaroslav Michalek, Apostolos Stathopoulos, Neringa T. Dobrovolskienė & Marius M. Strioga. (2014) Immune adjuvants as critical guides directing immunity triggered by therapeutic cancer vaccines. Cytotherapy 16:4, pages 427-439.
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Amara A. Amro, Ahmed J. Neama, Ahmed Hussein, Emad A. Hashish & Salah A. Sheweita. (2014) Evaluation the Surface Antigen of the Salmonella typhimurium ATCC 14028 Ghosts Prepared by “SLRP” . The Scientific World Journal 2014, pages 1-6.
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Amro A. Amara, Mounir M. Salem-Bekh & Fars K. Alanazi. (2013) Preparation of Bacterial Ghosts for E. coli JM109 Using “Sponge-like Reduced Protocol”. Asian Journal of Biological Sciences 6:8, pages 363-369.
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Verena J. Koller, Verena M. Dirsch, Hortenzia Beres, Oliver Donath, Gottfried Reznicek, Werner Lubitz & Pavol Kudela. (2013) Modulation of bacterial ghosts – induced nitric oxide production in macrophages by bacterial ghost‐delivered resveratrol. The FEBS Journal 280:5, pages 1214-1225.
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