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Editorial

TLR-7 and -8 agonists as vaccine adjuvants

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Pages 405-407 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

John P Vasilakos & Mark A Tomai. (2013) The use of Toll-like receptor 7/8 agonists as vaccine adjuvants. Expert Review of Vaccines 12:7, pages 809-819.
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Thomas Meyer, Christian Surber, Lars E French & Eggert Stockfleth. (2013) Resiquimod, a topical drug for viral skin lesions and skin cancer. Expert Opinion on Investigational Drugs 22:1, pages 149-159.
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Joseph U Igietseme, Francis O Eko & Carolyn M Black. (2011) Chlamydia vaccines: recent developments and the role of adjuvants in future formulations. Expert Review of Vaccines 10:11, pages 1585-1596.
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Nathalie Garçon & Martin Friede. 2023. Plotkin's Vaccines. Plotkin's Vaccines 77 90.e4 .
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Alexander K. Andrianov & Thomas R. Fuerst. (2021) Immunopotentiating and Delivery Systems for HCV Vaccines. Viruses 13:6, pages 981.
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Alexander K. Andrianov & Robert Langer. (2021) Polyphosphazene immunoadjuvants: Historical perspective and recent advances. Journal of Controlled Release 329, pages 299-315.
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Kathryn M. Moore, Cole J. Batty, Rebeca T. Stiepel, Christopher J. Genito, Eric M. Bachelder & Kristy M. Ainslie. (2020) Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications. ACS Applied Materials & Interfaces 12:35, pages 38950-38961.
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Alexander K. Andrianov, Alexander Marin, Ruixue Wang, Hatice Karauzum, Ananda Chowdhury, Pragati Agnihotri, Abdul S. Yunus, Roy A. Mariuzza & Thomas R. Fuerst. (2020) Supramolecular Assembly of Toll-like Receptor 7/8 Agonist into Multimeric Water-Soluble Constructs Enables Superior Immune Stimulation In Vitro and In Vivo . ACS Applied Bio Materials 3:5, pages 3187-3195.
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Cindy Patinote, Nour Bou Karroum, Georges Moarbess, Natalina Cirnat, Issam Kassab, Pierre-Antoine Bonnet & Carine Deleuze-Masquéfa. (2020) Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. European Journal of Medicinal Chemistry 193, pages 112238.
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Stefanie R. Mullins, John P. Vasilakos, Katharina Deschler, Iwen Grigsby, Pete Gillis, Julius John, Matthew J. Elder, John Swales, Elina Timosenko, Zachary Cooper, Simon J. Dovedi, Andrew J. Leishman, Nadia Luheshi, James Elvecrog, Ashenafi Tilahun, Richard Goodwin, Ronald Herbst, Mark A. Tomai & Robert W. Wilkinson. (2019) Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies. Journal for ImmunoTherapy of Cancer 7:1.
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Qian Wang, Meagan A. Barry, Christopher A. Seid, Elissa M. Hudspeth, C. Patrick McAtee & Michael J. Heffernan. (2018) 3M-052 as an adjuvant for a PLGA microparticle-based Leishmania donovani recombinant protein vaccine . Journal of Biomedical Materials Research Part B: Applied Biomaterials 106:4, pages 1587-1594.
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Nathalie Garçon & Martin Friede. 2018. Plotkin's Vaccines. Plotkin's Vaccines 61 74.e4 .
Genada Sinani, Melike Sessevmez, M. Koray Gök, Saadet Özgümüş, Alper Okyar, H. Oya Alpar & Erdal Cevher. (2017) Nasal vaccination with poly(β-amino ester)-poly( d , l -lactide- co -glycolide) hybrid nanoparticles. International Journal of Pharmaceutics 529:1-2, pages 1-14.
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S. De Koker, L. Van Hoecke, A. De Beuckelaer, K. Roose, K. Deswarte, M. A. Willart, P. Bogaert, T. Naessens, B. G. De Geest, X. Saelens, B. N. Lambrecht & J. Grooten. (2017) Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. Scientific Reports 7:1.
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Ji-Kun Li, Jesse J. Balic, Liang Yu & Brendan Jenkins. 2017. Regulation of Inflammatory Signaling in Health and Disease. Regulation of Inflammatory Signaling in Health and Disease 195 212 .
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Agnese Donadei, Cristiana Balocchi, Francesca Mancini, Daniela Proietti, Simona Gallorini, Derek T. O’Hagan, Ugo D’Oro, Francesco Berti, Barbara C. Baudner & Roberto Adamo. (2016) The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine. European Journal of Pharmaceutics and Biopharmaceutics 107, pages 110-119.
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Nina Salabert, Biliana Todorova, Frédéric Martinon, Raphaël Boisgard, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre-Bosquet, Antonio Cosma, Thierry Kortulewski, Jacques Banchereau, Yves Levy, Roger Le Grand & Catherine Chapon. (2016) Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo. European Journal of Immunology 46:3, pages 689-700.
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Anthony D. Duong, Michael A. Collier, Eric M. Bachelder, Barbra E. Wyslouzil & Kristy M. Ainslie. (2015) One Step Encapsulation of Small Molecule Drugs in Liposomes via Electrospray-Remote Loading. Molecular Pharmaceutics 13:1, pages 92-99.
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Sunita Minz, Monika Kaurav, Kantrol Kumar Sahu, Vivekananda Mandal & Ravi Shankar Pandey. (2015) Development and validation of TLC-densitometric method for determination of lipid A adjuvant as a bulk and in solid fat nanoemulsions. Biomedical Chromatography 29:10, pages 1473-1479.
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Derek T O'Hagan. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 7 .
Chun-Xue Zhou, Dong Li, Ying-Li Chen, Zeng-Jun Lu, Pu Sun, Yi-Mei Cao, Hui-Fang Bao, Yuan-Fang Fu, Ping-Hua Li, Xing-Wen Bai, Bao-Xia Xie & Zai-Xin Liu. (2014) Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine. BMC Veterinary Research 10:1.
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Robert Schwenk, Margot DeBot, Michael Porter, Jennifer Nikki, Lisa Rein, Roberta Spaccapelo, Andrea Crisanti, Paul D. Wightman, Christian F. Ockenhouse & Sheetij Dutta. (2014) IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice. PLoS ONE 9:10, pages e111020.
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S. Vecchi, S. Bufali, T. Uno, T. Wu, L. Arcidiacono, S. Filippini, F. Rigat & D. O’Hagan. (2014) Conjugation of a TLR7 agonist and antigen enhances protection in the S. pneumoniae murine infection model. European Journal of Pharmaceutics and Biopharmaceutics 87:2, pages 310-317.
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Petr O. Ilyinskii, Christopher J. Roy, Conlin P. O’Neil, Erica A. Browning, Lynnelle A. Pittet, David H. Altreuter, Frank Alexis, Elena Tonti, Jinjun Shi, Pamela A. Basto, Matteo Iannacone, Aleksandar F. Radovic-Moreno, Robert S. Langer, Omid C. Farokhzad, Ulrich H. von Andrian, Lloyd P.M. Johnston & Takashi Kei Kishimoto. (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine 32:24, pages 2882-2895.
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Marie-Ève Lebel, Jean-François Daudelin, Karine Chartrand, Esther Tarrab, Ulrich Kalinke, Pierre Savard, Nathalie Labrecque, Denis Leclerc & Alain Lamarre. (2014) Nanoparticle Adjuvant Sensing by TLR7 Enhances CD8+ T Cell–Mediated Protection from Listeria Monocytogenes Infection . The Journal of Immunology 192:3, pages 1071-1078.
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Charlotte Primard, Johanna Poecheim, Simon Heuking, Emmanuelle Sublet, Farnaz Esmaeili & Gerrit Borchard. (2013) Multifunctional PLGA-Based Nanoparticles Encapsulating Simultaneously Hydrophilic Antigen and Hydrophobic Immunomodulator for Mucosal Immunization. Molecular Pharmaceutics 10:8, pages 2996-3004.
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David J. Dowling, Zhen Tan, Zofia M. Prokopowicz, Christine D. Palmer, Maura-Ann H. Matthews, Gregory N. Dietsch, Robert M. Hershberg & Ofer Levy. (2013) The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes. PLoS ONE 8:3, pages e58164.
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Peter Michael Moyle & Istvan Toth. (2013) Modern Subunit Vaccines: Development, Components, and Research Opportunities. ChemMedChem 8:3, pages 360-376.
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Nathalie. Garçon, Stanley. Hem & Martin. Friede. 2013. Vaccines. Vaccines 58 70 .
Victoria J. Philbin, David J. Dowling, Leighanne C. Gallington, Guadalupe Cortés, Zhen Tan, Eugénie E. Suter, Kevin W. Chi, Ariel Shuckett, Liat Stoler-Barak, Mark Tomai, Richard L. Miller, Keith Mansfield & Ofer Levy. (2012) Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways. Journal of Allergy and Clinical Immunology 130:1, pages 195-204.e9.
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Carl R Alving, Kristina K Peachman, Mangala Rao & Steven G Reed. (2012) Adjuvants for human vaccines. Current Opinion in Immunology 24:3, pages 310-315.
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Marcin Kwissa, Helder I. Nakaya, Herold Oluoch & Bali Pulendran. (2012) Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Blood 119:9, pages 2044-2055.
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Myron M. Levine. (2011) “IDEAL” vaccines for resource poor settings. Vaccine 29, pages D116-D125.
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