Advanced search
Publication Cover
Expert Review of Vaccines Volume 10, 2011 - Issue 8
Submit an article Journal homepage
926
Views
54
CrossRef citations to date
0
Altmetric
Review

The future of cell culture-based influenza vaccine production

Michael L Perdue Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA;[email protected]
,
Frank Arnold Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
,
Sheng Li Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
,
Armen Donabedian Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
,
Vittoria Cioce Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
,
Thomas Warf Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
&
Robert Huebner Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA; Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA
 show all
Pages 1183-1194 | Published online: 09 Jan 2014

Citations (54)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Xiaofeng Dai, Xuanhao Zhang, Kostya Ostrikov & Levon Abrahamyan. (2020) Host receptors: the key to establishing cells with broad viral tropism for vaccine production. Critical Reviews in Microbiology 46:2, pages 147-168.
Read now
Cristina Galli, Andrea Orsi, Elena Pariani, Piero Luigi Lai, Giulia Guarona, Laura Pellegrinelli, Erika Ebranati, Giancarlo Icardi & Donatella Panatto. (2020) In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains. Expert Review of Vaccines 19:1, pages 115-122.
Read now
Claudia Maria Trombetta, Serena Marchi, Ilaria Manini, Giacomo Lazzeri & Emanuele Montomoli. (2019) Challenges in the development of egg-independent vaccines for influenza. Expert Review of Vaccines 18:7, pages 737-750.
Read now
Zhichao Zheng, Diana Diaz-Arévalo, Hongbing Guan & Mingtao Zeng. (2018) Noninvasive vaccination against infectious diseases. Human Vaccines & Immunotherapeutics 14:7, pages 1717-1733.
Read now
Woo-Jin Shin & Baik Lin Seong. (2017) Type II transmembrane serine proteases as potential target for anti-influenza drug discovery. Expert Opinion on Drug Discovery 12:11, pages 1139-1152.
Read now
Patricio Oyarzún & Bostjan Kobe. (2016) Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines & Immunotherapeutics 12:3, pages 763-767.
Read now
P Noel Barrett, Daniel Portsmouth & Hartmut J Ehrlich. (2013) Vero cell culture-derived pandemic influenza vaccines: preclinical and clinical development. Expert Review of Vaccines 12:4, pages 395-413.
Read now

Articles from other publishers (47)

Feng Yang, Shouwei Wang, Yingying Li, Shilei Li, Wenting Liu, Yushuang Li & Haijuan Hu. (2022) Physical optimization of cell proliferation and differentiation using spinner flask and microcarriers. AMB Express 12:1.
Crossref
Jiayou Zhang, Xuanxuan Nian, Xuedan Li, Shihe Huang, Kai Duan, Xinguo Li & Xiaoming Yang. (2022) The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review. Vaccines 10:11, pages 1873.
Crossref
Aitor Nogales, Marta L. DeDiego & Luis Martínez-Sobrido. (2022) Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Eleanor R. Gaunt & Paul Digard. (2021) Compositional biases in RNA viruses: Causes, consequences and applications . WIREs RNA 13:2.
Crossref
Peiyu Han, Xuanhao Zhang, Siming Yang, Xiaofeng Dai, Qing Lv & Dong Hua. (2021) Expanding virus susceptibility spectrum of MDBK cells by expressing host receptors nectin 4 and TfR. Journal of Virological Methods 289, pages 114038.
Crossref
Sabine Pech, Markus Rehberg, Robert Janke, Dirk Benndorf, Yvonne Genzel, Thilo Muth, Albert Sickmann, Erdmann Rapp & Udo Reichl. (2021) Tracking changes in adaptation to suspension growth for MDCK cells: cell growth correlates with levels of metabolites, enzymes and proteins. Applied Microbiology and Biotechnology 105:5, pages 1861-1874.
Crossref
Sweety Samal, Tripti Shrivastava, Praveen Sonkusre, Zaigham Abbas Rizvi, Rajesh Kumar, Shubbir Ahmed, Preeti Vishwakarma, Naveen Yadav, Manish Bansal, Kanchana Chauhan, Sebanta Pokhrel, Supratik Das, Padmakar Tambare & Amit Awasthi. (2020) Tetramerizing tGCN4 domain facilitates production of Influenza A H1N1 M2e higher order soluble oligomers that show enhanced immunogenicity in vivo. Journal of Biological Chemistry 295:42, pages 14352-14366.
Crossref
Felipe Tapia, Daniel Wohlfarth, Volker Sandig, Ingo Jordan, Yvonne Genzel & Udo Reichl. (2019) Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”. PLOS ONE 14:11, pages e0224317.
Crossref
Thomas Bissinger, Johannes Fritsch, Adrian Mihut, Yixiao Wu, Xuping Liu, Yvonne Genzel, Wen-Song Tan & Udo Reichl. (2019) Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus production. Vaccine 37:47, pages 7003-7010.
Crossref
A. Raquel Fortuna, Sebastian van Teeffelen, Adrian Ley, Laura M. Fischer, Florian Taft, Yvonne Genzel, Louis Villain, Michael W. Wolff & Udo Reichl. (2019) Use of sulfated cellulose membrane adsorbers for chromatographic purification of cell cultured-derived influenza A and B viruses. Separation and Purification Technology 226, pages 350-358.
Crossref
Chia-Chun Lai, Tsai-Chuan Weng, Yu-Fen Tseng, Jen-Ron Chiang, Min-Shi Lee & Alan Yung-Chih Hu. (2019) Evaluation of novel disposable bioreactors on pandemic influenza virus production. PLOS ONE 14:8, pages e0220803.
Crossref
Pilar Blanco-Lobo, Aitor Nogales, Laura Rodríguez & Luis Martínez-Sobrido. (2019) Novel Approaches for The Development of Live Attenuated Influenza Vaccines. Viruses 11:2, pages 190.
Crossref
Husni Elbahesh, Giulietta Saletti, Thomas Gerlach & Guus F Rimmelzwaan. (2019) Broadly protective influenza vaccines: design and production platforms. Current Opinion in Virology 34, pages 1-9.
Crossref
Mohsen Keshavarz, Hamed Mirzaei, Maryam Salemi, Fatemeh Momeni, Mohammad Javad Mousavi, Mona Sadeghalvad, Yaser Arjeini, Farid Solaymani-Mohammadi, Javid Sadri Nahand, Haideh Namdari, Talat Mokhtari-Azad & Farhad Rezaei. (2019) Influenza vaccine: Where are we and where do we go?. Reviews in Medical Virology 29:1, pages e2014.
Crossref
Urai Chaisri & Wanpen Chaicumpa. (2018) Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy. BioMed Research International 2018, pages 1-23.
Crossref
Kristin Mohn & Fan Zhou. (2018) Clinical Expectations for Better Influenza Virus Vaccines—Perspectives from the Young Investigators’ Point of View. Vaccines 6:2, pages 32.
Crossref
Arun Kumar, Trine Sundebo Meldgaard & Sylvie Bertholet. (2018) Novel Platforms for the Development of a Universal Influenza Vaccine. Frontiers in Immunology 9.
Crossref
Ane Marie Anderson, Marta Baranowska-Hustad, Ranveig Braathen, Gunnveig Grodeland & Bjarne Bogen. (2018) Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza. The Journal of Immunology 200:6, pages 2057-2066.
Crossref
Milena A. Wasik, Luca Eichwald, Yvonne Genzel & Udo Reichl. (2017) Cell culture-based production of defective interfering particles for influenza antiviral therapy. Applied Microbiology and Biotechnology 102:3, pages 1167-1177.
Crossref
Joshua Powell & Timothy Straub. (2018) Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture. Challenges 9:1, pages 2.
Crossref
Feng Wen, Lei Li, Nan Zhao, Meng-Jung Chiang, Hang Xie, Jim Cooley, Richard Webby, Peng George Wang & Xiu-Feng Wan. (2018) A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells. Journal of Virology 92:2.
Crossref
Luca Melnychuk, Lara Ajamian, Patrick Jean-Pierre, Jiaming Liang, Romina Gheorghe, Mark A. Wainberg & Gerasimos J. Zaharatos. (2017) Development of a DNA vaccine expressing a secreted HIV-1 gp41 ectodomain that includes the membrane-proximal external region. Vaccine 35:20, pages 2736-2744.
Crossref
Ilseob Lee, Jin Il Kim, Sehee Park, Joon-Yong Bae, Kirim Yoo, Soo-Hyeon Yun, Joo-Yeon Lee, Kisoon Kim, Chun Kang & Man-Seong Park. (2017) Single PA mutation as a high yield determinant of avian influenza vaccines. Scientific Reports 7:1.
Crossref
Hung-Wei Yang, Ling Ye, Xin Dong Guo, Chinglai Yang, Richard W. Compans & Mark R. Prausnitz. (2017) Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch. Advanced Healthcare Materials 6:1, pages 1600750.
Crossref
Lauren Parker, Stephen A. Wharton, Stephen R. Martin, Karen Cross, Yipu Lin, Yan Liu, Ten Feizi, Rodney S. Daniels & John W. McCauley. (2016) Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses. Journal of General Virology 97:6, pages 1333-1344.
Crossref
Aitor Nogales, Steven F. Baker, William Domm & Luis Martínez-Sobrido. (2016) Development and applications of single-cycle infectious influenza A virus (sciIAV). Virus Research 216, pages 26-40.
Crossref
Kyuri KangSeunghoon HanTaegon HongSangil JeonJeongki PaekJin Han KangDong-Seok Yim. (2016) Immunogenicity and Safety of Trivalent Split Influenza Vaccine in Healthy Korean Adults with Low Pre-Existing Antibody Levels: An Open Phase I Trial. Yonsei Medical Journal 57:6, pages 1354.
Crossref
Jihui Ping, Tiago J.S. Lopes, Chairul A. Nidom, Elodie Ghedin, Catherine A. Macken, Adam Fitch, Masaki Imai, Eileen A. Maher, Gabriele Neumann & Yoshihiro Kawaoka. (2015) Development of high-yield influenza A virus vaccine viruses. Nature Communications 6:1.
Crossref
Anne Schuind, Nathan Segall, Mamadou Drame & Bruce L. Innis. (2015) Immunogenicity and Safety of an EB66 Cell-Culture-Derived Influenza A/Indonesia/5/2005(H5N1) AS03-Adjuvanted Vaccine: A Phase 1 Randomized Trial. Journal of Infectious Diseases 212:4, pages 531-541.
Crossref
Peter C. Soema, Ronald Kompier, Jean-Pierre Amorij & Gideon F.A. Kersten. (2015) Current and next generation influenza vaccines: Formulation and production strategies. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 251-263.
Crossref
Steven F Baker, Aitor Nogales & Luis Martínez-Sobrido. (2015) Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines. Future Virology 10:6, pages 715-730.
Crossref
Florian Krammer. (2015) Emerging influenza viruses and the prospect of a universal influenza virus vaccine. Biotechnology Journal 10:5, pages 690-701.
Crossref
Belete Teferedegne, Juliete Macauley, Gideon Foseh, Eugenia Dragunsky, Konstantin Chumakov, Haruhiko Murata, Keith Peden & Andrew M. LewisJr.Jr.. (2014) MicroRNAs as potential biomarkers for VERO cell tumorigenicity. Vaccine 32:37, pages 4799-4805.
Crossref
Manfred Reiter, Daniel Portsmouth & P. Noel Barrett. 2014. Industrial Scale Suspension Culture of Living Cells. Industrial Scale Suspension Culture of Living Cells 390 409 .
Nagendra R. Hegde, Deepak Kumar, P. Panduranga Rao, P. Krishna Kumari, Yashpal Kaushik, R. Ravikrishnan, Sai D. Prasad & Krishna M. Ella. (2014) Development and preclinical testing of HNVAC, a cell culture-based H1N1 pandemic influenza vaccine from India. Vaccine 32:29, pages 3636-3643.
Crossref
Irina Isakova-Sivak, Li-Mei Chen, Melissa Bourgeois, Yumiko Matsuoka, J. Theo M. Voeten, Jacco G. M. Heldens, Han van den Bosch, Alexander Klimov, Larisa Rudenko, Nancy J. Cox & Ruben O. Donis. (2014) Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model. Clinical and Vaccine Immunology 21:5, pages 722-731.
Crossref
John M. Hickey, Kathleen M. Holtz, Prakash Manikwar, Sangeeta B. Joshi, Clifton E. Mcpherson, Barry Buckland, Indresh K. Srivastava, C. Russell Middaugh & David B. Volkin. (2014) Mechanism of a Decrease in Potency for the Recombinant Influenza A Virus Hemagglutinin H3 Antigen During Storage. Journal of Pharmaceutical Sciences 103:3, pages 821-827.
Crossref
Yvonne Genzel, Jana Rödig, Erdmann Rapp & Udo Reichl. 2014. Animal Cell Biotechnology. Animal Cell Biotechnology 371 393 .
Zheng Teng, Xiaozhou Kuang, Jiayu Wang & Xi Zhang. (2013) Real-time cell analysis – A new method for dynamic, quantitative measurement of infectious viruses and antiserum neutralizing activity. Journal of Virological Methods 193:2, pages 364-370.
Crossref
Klaus Stöhr. 2013. Textbook of Influenza. Textbook of Influenza 352 370 .
Gunnveig Grodeland, Siri Mjaaland, Kenneth H. Roux, Agnete Brunsvik Fredriksen & Bjarne Bogen. (2013) DNA Vaccine that Targets Hemagglutinin to MHC Class II Molecules Rapidly Induces Antibody-Mediated Protection against Influenza. The Journal of Immunology 191:6, pages 3221-3231.
Crossref
Sonia Pagliusi, Luciana C.C. Leite, Mahima Datla, Morena Makhoana, Yongzhong Gao, Mahendra Suhardono, Suresh Jadhav, Gutla V.J.A. Harshavardhan & Akira Homma. (2013) Developing Countries Vaccine Manufacturers Network: Doing good by making high-quality vaccines affordable for all. Vaccine 31, pages B176-B183.
Crossref
Yvonne Genzel, Timo Frensing & Udo Reichl. (2012) Herstellung moderner Grippeimpfstoffe. Chemie in unserer Zeit 47:1, pages 12-22.
Crossref
Mansoureh Sameni, Stefanie R. Mullins, Kamiar Moin, Bonnie F. Sloane & Kingsley Osuala. 2013. Breast Cancer Metastasis and Drug Resistance. Breast Cancer Metastasis and Drug Resistance 177 188 .
Hartmut J. Ehrlich, Gregory Berezuk, Sandor Fritsch, Gerald Aichinger, Julia Singer, Daniel Portsmouth, Mary Kate Hart, Wael El-Amin, Otfried Kistner & P. Noel Barrett. (2012) Clinical development of a Vero cell culture-derived seasonal influenza vaccine. Vaccine 30:29, pages 4377-4386.
Crossref
Yeu-Chun Kim, Jae-Min Song, Aleksandr S. Lipatov, Seong-O Choi, Jeong Woo Lee, Ruben O. Donis, Richard W. Compans, Sang-Moo Kang & Mark R. Prausnitz. (2012) Increased immunogenicity of avian influenza DNA vaccine delivered to the skin using a microneedle patch. European Journal of Pharmaceutics and Biopharmaceutics 81:2, pages 239-247.
Crossref
Min-Shi Lee & Alan Yung-Chih Hu. (2012) A cell-based backup to speed up pandemic influenza vaccine production. Trends in Microbiology 20:3, pages 103-105.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.