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Expert Review of Vaccines Volume 10, 2011 - Issue 4
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Review

IFN-α as a vaccine adjuvant: recent insights into the mechanisms and perspectives for its clinical use

Paola Rizza Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
,
Imerio Capone Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
,
Franca Moretti Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
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Enrico Proietti Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
&
Filippo Belardelli Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy;[email protected]
Pages 487-498 | Published online: 09 Jan 2014

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Pouria Mosaddeghi, Farbod Shahabinezhad, Mohammadreza Dorvash, Mojtaba Goodarzi & Manica Negahdaripour. (2021) Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19. Human Vaccines & Immunotherapeutics 17:6, pages 1650-1661.
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Articles from other publishers (26)

Olga N. Kaplina, Svetlana G. Gamaley, Olga S. Ivanova & Elena D. Danilenko. (2023) Double-stranded RNAs are promising adjuvants for enhancing immunogenicity of vaccines. Journal of microbiology, epidemiology and immunobiology 99:6, pages 661-668.
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Xiaochen Gong, Yuan Gao, Jianhong Shu, Chunjing Zhang & Kai Zhao. (2022) Chitosan-Based Nanomaterial as Immune Adjuvant and Delivery Carrier for Vaccines. Vaccines 10:11, pages 1906.
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Jingyi Fan, Shengbin Jin, Lachlan Gilmartin, Istvan Toth, Waleed M. Hussein & Rachel J. Stephenson. (2022) Advances in Infectious Disease Vaccine Adjuvants. Vaccines 10:7, pages 1120.
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Amber Blaauboer, Peter Van Koetsveld, Dana Mustafa, Jasper Dumas, Fadime Dogan, Suzanne Van Zwienen, Casper Van Eijck & Leo Hofland. (2022) Immunomodulatory antitumor effect of interferon‑beta combined with gemcitabine in pancreatic cancer. International Journal of Oncology 61:2.
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Brandi T. Johnson-Weaver, Soman N. Abraham & Herman F. Staats. 2020. Mucosal Vaccines. Mucosal Vaccines 167 183 .
Luca D. Bertzbach, Olof Harlin, Sonja Härtle, Frank Fehler, Tereza Vychodil, Benedikt B. Kaufer & Bernd Kaspers. (2019) IFNα and IFNγ Impede Marek’s Disease Progression. Viruses 11:12, pages 1103.
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Shi‐Fang Li, Fu‐Rong Zhao, Mei‐Jiao Gong, Jun‐Jun Shao, Yin‐Li Xie, Hui‐Yun Chang & Yong‐Guang Zhang. (2018) Antiviral activity of porcine interferon omega 7 against foot‐and‐mouth disease virus in vitro. Journal of Medical Virology 91:2, pages 208-214.
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Mahsa Keshavarz-Fathi & Nima Rezaei. 2019. Vaccines for Cancer Immunotherapy. Vaccines for Cancer Immunotherapy 161 170 .
Matthew P. Rausch & Karen Taraszka Hastings. 2019. Fundamentals of Cancer Prevention. Fundamentals of Cancer Prevention 111 159 .
Annett Ziegler, Claudia Soldner, Stefan Lienenklaus, Julia Spanier, Stephanie Trittel, Peggy Riese, Thomas Kramps, Siegfried Weiss, Regina Heidenreich, Edith Jasny, Carlos A. Guzmán, Karl-Josef Kallen, Mariola Fotin-Mleczek & Ulrich Kalinke. (2017) A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects. The Journal of Immunology 198:4, pages 1595-1605.
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Shengbin Zhang, Yongsheng Zhou, Lifu Su, Xiaodong Zhang, Hao Wang & Baoqin Liu. (2016) In vivo evaluation of the efficacy of combined albedazole-IFN-α treatment for cystic echinococcosis in mice. Parasitology Research 116:2, pages 735-742.
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Leo Swadling, John Halliday, Christabel Kelly, Anthony Brown, Stefania Capone, M. Ansari, David Bonsall, Rachel Richardson, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Annette Von Delft, Cinzia Traboni, Adrian Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman, Antonella Folgori & Eleanor Barnes. (2016) Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection. Vaccines 4:3, pages 27.
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Jasdave S. ChahalOmar F. KhanChristopher L. CooperJustine S. McPartlanJonathan K. TsosieLucas D. TilleySaima M. SidikSebastian Lourido, Robert Langer, Sina BavariHidde L. PloeghDaniel G. Anderson. (2016) Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose . Proceedings of the National Academy of Sciences 113:29.
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Paola Rizza, Franca Moretti, Imerio Capone & Filippo Belardelli. (2015) Role of type I interferon in inducing a protective immune response: Perspectives for clinical applications. Cytokine & Growth Factor Reviews 26:2, pages 195-201.
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Sandra Gessani, Lucia Conti, Manuela Del Cornò & Filippo Belardelli. (2014) Type I Interferons as Regulators of Human Antigen Presenting Cell Functions. Toxins 6:6, pages 1696-1723.
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Michael Frese, Eva Lee, Maximilian Larena, Pek Siew Lim, Sudha Rao, Klaus I. Matthaei, Alexander Khromykh, Ian Ramshaw & Mario Lobigs. (2014) Internal Ribosome Entry Site-Based Attenuation of a Flavivirus Candidate Vaccine and Evaluation of the Effect of Beta Interferon Coexpression on Vaccine Properties. Journal of Virology 88:4, pages 2056-2070.
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Karen Taraszka Hastings & Matthew P. Rausch. 2014. Fundamentals of Cancer Prevention. Fundamentals of Cancer Prevention 81 121 .
Abhisake Kole, JianPing He, Aymeric Rivollier, Danielle D. Silveira, Kazuya Kitamura, Kevin J. Maloy & Brian L. Kelsall. (2013) Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell–Mediated Colitis. The Journal of Immunology 191:5, pages 2771-2779.
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Luping Du, Bin Li, Kongwang He, Haibin Zhang, Kehe Huang & Shaobo Xiao. (2013) Construction and Immunogenicity of DNA Vaccines Encoding Fusion Protein of Porcine IFN- 1 and GP5 Gene of Porcine Reproductive and Respiratory Syndrome Virus . BioMed Research International 2013, pages 1-9.
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Luis Martínez-Gil, Juan Ayllon, Mila Brum Ortigoza, Adolfo García-Sastre, Megan L. Shaw & Peter Palese. (2012) Identification of Small Molecules with Type I Interferon Inducing Properties by High-Throughput Screening. PLoS ONE 7:11, pages e49049.
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Yun Zhou, Ying Zhang, Zhiqiang Yao, Jonathan Patrick Moorman & Zhansheng Jia. (2012) Dendritic cell‐based immunity and vaccination against hepatitis C virus infection. Immunology 136:4, pages 385-396.
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Lei L. Chen, Xinjian Chen, Haesun Choi, Hongxun Sang, Leo C. Chen, Hongbo Zhang, Launce Gouw, Robert H. Andtbacka, Benjamin K. Chan, Christopher K. Rodesch, Arnie Jimenez, Pedro Cano, Kimberly A. Jones, Caroline O. Oyedeji, Tom Martins, Harry R. Hill, Jonathan Schumacher, Carlynn Willmore, Courtney L. Scaife, John H. Ward, Kathryn Morton, R. Lor Randall, Alexander J. Lazar, Shreyaskumar Patel, Jonathan C. Trent, Marsha L. Frazier, Patrick Lin, Peter Jensen & Robert S. Benjamin. (2011) Exploiting antitumor immunity to overcome relapse and improve remission duration. Cancer Immunology, Immunotherapy 61:7, pages 1113-1124.
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Eleonora AricòFilippo Belardelli. (2012) Interferon-α as Antiviral and Antitumor Vaccine Adjuvants: Mechanisms of Action and Response Signature. Journal of Interferon & Cytokine Research 32:6, pages 235-247.
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Enrico Proietti, Federica Moschella, Imerio Capone & Filippo Belardelli. (2012) Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy. Molecular Oncology 6:1, pages 1-14.
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Tanja D. de Gruijl & Rieneke van de Ven. 2012. Applications of viruses for cancer therapy. Applications of viruses for cancer therapy 147 220 .
F. Pandolfi, R. Cianci, D. Pagliari, F. Casciano, C. Bagalà, A. Astone, R. Landolfi & C. Barone. (2011) The Immune Response to Tumors as a Tool toward Immunotherapy. Clinical and Developmental Immunology 2011, pages 1-12.
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