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Cell culture-derived influenza vaccines from Vero cells: a new horizon for vaccine production

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Pages 587-594 | Published online: 09 Jan 2014

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Xiaofeng Dai, Xuanhao Zhang, Kostya Ostrikov & Levon Abrahamyan. (2020) Host receptors: the key to establishing cells with broad viral tropism for vaccine production. Critical Reviews in Microbiology 46:2, pages 147-168.
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Sai V Vemula, Ekramy E Sayedahmed, Suryaprakash Sambhara & Suresh K Mittal. (2017) Vaccine approaches conferring cross-protection against influenza viruses. Expert Review of Vaccines 16:11, pages 1141-1154.
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Ilaria Manini, Alexander Domnich, Daniela Amicizia, Stefania Rossi, Teresa Pozzi, Roberto Gasparini, Donatella Panatto & Emanuele Montomoli. (2015) Flucelvax (Optaflu) for seasonal influenza. Expert Review of Vaccines 14:6, pages 789-804.
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Zeyu Yang, Barbara Cristina Martins Fernandes Paes, Julia Puppin Chaves Fulber, Michelle Yen Tran, Omar Farnós & Amine A. Kamen. (2023) Development of an Integrated Continuous Manufacturing Process for the rVSV-Vectored SARS-CoV-2 Candidate Vaccine. Vaccines 11:4, pages 841.
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Shashank Bhangde, Rushit N. Lodaya & Mansoor M. Amiji. 2023. Nanomedicines for the Prevention and Treatment of Infectious Diseases. Nanomedicines for the Prevention and Treatment of Infectious Diseases 331 347 .
Yuao Zhu, Joe Binder, Irina Yurgelonis, Devendra K. Rai, Sarah Lazarro, Chester Costales, Keith Kobylarz, Patricia McMonagle, Claire M. Steppan, Lisa Aschenbrenner, Annaliesa S. Anderson & Rhonda D. Cardin. (2022) Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study. Antiviral Research 208, pages 105429.
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Pan Tang, En-hui Cui, Wen-chi Chang, Chen Yu, Hao Wang, En-qi Du & Jing-yu Wang. (2022) Nanoparticle-Based Bivalent Swine Influenza Virus Vaccine Induces Enhanced Immunity and Effective Protection against Drifted H1N1 and H3N2 Viruses in Mice. Viruses 14:11, pages 2443.
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Shouzhi Yu, Junyu Yan, Zhaona Yang, Yuxiu Zhao, Hui Wang & Xiaoming Yang. (2022) Metabolic Responses and Pathway Changes of Vero Cells under High-Vitamin B Medium. Vaccines 10:11, pages 1787.
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Georges Bastin, Véronique Chotteau & Alain Vande Wouwer. (2021) Metabolic Flux Analysis of VERO Cells under Various Culture Conditions. Processes 9:12, pages 2097.
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Thomas Bissinger, Yixiao Wu, Pavel Marichal‐Gallardo, Dietmar Riedel, Xuping Liu, Yvonne Genzel, Wen‐Song Tan & Udo Reichl. (2021) Towards integrated production of an influenza A vaccine candidate with MDCK suspension cells. Biotechnology and Bioengineering 118:10, pages 3996-4013.
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Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan & Albert D M E Osterhaus. (2021) Influenza Vaccines: Successes and Continuing Challenges. The Journal of Infectious Diseases 224:Supplement_4, pages S405-S419.
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Yuko Okemoto-Nakamura, Kenji Someya, Toshiyuki Yamaji, Kyoko Saito, Makoto Takeda & Kentaro Hanada. (2021) Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan. Scientific Reports 11:1.
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Peiyu Han, Xuanhao Zhang, Siming Yang, Xiaofeng Dai, Qing Lv & Dong Hua. (2021) Expanding virus susceptibility spectrum of MDBK cells by expressing host receptors nectin 4 and TfR. Journal of Virological Methods 289, pages 114038.
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Alberto A. Amarilla, Naphak Modhiran, Yin Xiang Setoh, Nias Y. G. Peng, Julian D. J. Sng, Benjamin Liang, Christopher L. D. McMillan, Morgan E. Freney, Stacey T. M. Cheung, Keith J. Chappell, Alexander A. Khromykh, Paul R. Young & Daniel Watterson. (2021) An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2. Frontiers in Microbiology 12.
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K. A. Richards, S. Moritzky, I. Shannon, T. Fitzgerald, H. Yang, A. Branche, D. J. Topham, J. J. Treanor, J. Nayak & Andrea J. Sant. (2020) Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans. npj Vaccines 5:1.
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Mohammed A. Rohaim & Muhammad Munir. (2020) A Scalable Topical Vectored Vaccine Candidate against SARS-CoV-2. Vaccines 8:3, pages 472.
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Thirumeni Nagarajan & Charles E. Rupprecht. 2020. Rabies and Rabies Vaccines. Rabies and Rabies Vaccines 11 43 .
Jackelyn Murray, Kyle V. Todd, Abhijeet Bakre, Nichole Orr-Burks, Les Jones, Weilin Wu & Ralph A. Tripp. (2017) A universal mammalian vaccine cell line substrate. PLOS ONE 12:11, pages e0188333.
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Muhammad Asif Zahoor, Mohsin Khurshid, Rabia Qureshi, Aneeqa Naz & Muhammad Shahid. (2016) Cell culture-based viral vaccines: current status and future prospects. Future Virology 11:7, pages 549-562.
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Hitomi Fukumoto, Tsunekazu Hishima, Hideki Hasegawa, Hidehisa Saeki, Makoto Kuroda & Harutaka Katano. (2016) Evaluation of Vero-cell-derived simian endogenous retrovirus infection in humans by detection of viral genome in clinicopathological samples and commercialized vaccines and by serology of Japanese general population. Vaccine 34:24, pages 2700-2706.
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Shin-ichi Tamura, Akira Ainai, Tadaki Suzuki, Takeshi Kurata & Hideki Hasegawa. (2016) Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?. Japanese Journal of Infectious Diseases 69:3, pages 165-179.
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Matthias GieseMatthias Giese. 2016. Introduction to Molecular Vaccinology. Introduction to Molecular Vaccinology 259 291 .
Daniel Steil, Catherine-Louise Schepers, Gottfried Pohlentz, Nadine Legros, Jana Runde, Hans-Ulrich Humpf, Helge Karch & Johannes Müthing. (2015) Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment. Journal of Lipid Research 56:12, pages 2322-2336.
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Aziza P. Manceur & Amine A. Kamen. (2015) Critical review of current and emerging quantification methods for the development of influenza vaccine candidates. Vaccine 33:44, pages 5913-5919.
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Françoise Aubrit, Fabien Perugi, Arnaud Léon, Fabienne Guéhenneux, Patrick Champion-Arnaud, Mehdi Lahmar & Klaus Schwamborn. (2015) Cell substrates for the production of viral vaccines. Vaccine 33:44, pages 5905-5912.
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Anne Schuind, Nathan Segall, Mamadou Drame & Bruce L. Innis. (2015) Immunogenicity and Safety of an EB66 Cell-Culture-Derived Influenza A/Indonesia/5/2005(H5N1) AS03-Adjuvanted Vaccine: A Phase 1 Randomized Trial. Journal of Infectious Diseases 212:4, pages 531-541.
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Hong Zhang, Qinglin Han, Xianqiang Ping, Li Li, Chong Chang, Ze Chen, Yuelong Shu, Ke Xu & Bing Sun. (2015) A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells. Virology 482, pages 32-40.
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Naoki Osada, Arihiro Kohara, Toshiyuki Yamaji, Noriko Hirayama, Fumio Kasai, Tsuyoshi Sekizuka, Makoto Kuroda & Kentaro Hanada. (2014) The Genome Landscape of the African Green Monkey Kidney-Derived Vero Cell Line. DNA Research 21:6, pages 673-683.
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Belete Teferedegne, Juliete Macauley, Gideon Foseh, Eugenia Dragunsky, Konstantin Chumakov, Haruhiko Murata, Keith Peden & Andrew M. LewisJr.Jr.. (2014) MicroRNAs as potential biomarkers for VERO cell tumorigenicity. Vaccine 32:37, pages 4799-4805.
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Anne N. Nafziger & David S. Pratt. (2014) Seasonal influenza vaccination and technologies. The Journal of Clinical Pharmacology 54:7, pages 719-731.
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Irina Isakova-Sivak, Li-Mei Chen, Melissa Bourgeois, Yumiko Matsuoka, J. Theo M. Voeten, Jacco G. M. Heldens, Han van den Bosch, Alexander Klimov, Larisa Rudenko, Nancy J. Cox & Ruben O. Donis. (2014) Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model. Clinical and Vaccine Immunology 21:5, pages 722-731.
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B. Peschel, S. Frentzel, T. Laske, Y. Genzel & U. Reichl. (2013) Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31:48, pages 5693-5699.
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Yanming An, Joseph A. Rininger, Donald L. Jarvis, Xianghong Jing, Zhiping Ye, Jared J. Aumiller, Maryna Eichelberger & John F. Cipollo. (2013) Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms. Journal of Proteome Research 12:8, pages 3707-3720.
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Mustafeez Mujtaba Babar, Muhammad Suleman Riaz, Najam-us-Sahar Sadaf Zaidi, Farhan Afzal & Muhammad Sabir Farooq. (2013) Production of avian influenza virus vaccine using primary cell cultures generated from host organs. Journal of Industrial Microbiology and Biotechnology 40:6, pages 625-632.
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Anne-Cécile V. Bayne, David Boltz, Carole Owen, Yelena Betz, Goncalo Maia, Parastoo Azadi, Stephanie Archer-Hartmann, Ross Zirkle & J. Casey Lippmeier. (2013) Vaccination against Influenza with Recombinant Hemagglutinin Expressed by Schizochytrium sp. Confers Protective Immunity. PLoS ONE 8:4, pages e61790.
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