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Special Report

Issues and challenges in the development of pneumococcal protein vaccines

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Pages 279-285 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Nicola Principi & Susanna Esposito. (2020) Unsolved problems and new medical approaches to otitis media. Expert Opinion on Biological Therapy 20:7, pages 741-749.
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Nicola Principi & Susanna Esposito. (2018) Development of pneumococcal vaccines over the last 10 years. Expert Opinion on Biological Therapy 18:1, pages 7-17.
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Robert Cohen, Jérémie François Cohen, Martin Chalumeau & Corinne Levy. (2017) Impact of pneumococcal conjugate vaccines for children in high- and non–high-income countries. Expert Review of Vaccines 16:6, pages 625-640.
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Kristin Moffitt & Richard Malley. (2016) Rationale and prospects for novel pneumococcal vaccines. Human Vaccines & Immunotherapeutics 12:2, pages 383-392.
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Articles from other publishers (36)

Keith P. Klugman, Richard Malley & Cynthia G. Whitney. 2023. Plotkin's Vaccines. Plotkin's Vaccines 826 868.e18 .
Jessica R. Lane, Muralidhar Tata, David E. Briles & Carlos J. Orihuela. (2022) A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology 12.
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Andrzej Pawlowski, Jonas Lannergård, Majela Gonzalez-Miro, Duojia Cao, Sara Larsson, Jenny J. Persson, Geoff Kitson, Michael Darsley, Ane Lilleøre Rom, Morten Hedegaard, Per B. Fischer & Bengt Johansson-Lindbom. (2022) A group B Streptococcus alpha-like protein subunit vaccine induces functionally active antibodies in humans targeting homotypic and heterotypic strains. Cell Reports Medicine 3:2, pages 100511.
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Aaron D. Gingerich & Jarrod J. Mousa. (2022) Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies. Frontiers in Cellular and Infection Microbiology 12.
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Edmund Bedeley, Andrea Gori, Dorothy Yeboah-Manu & Kanny Diallo. (2021) Control of Streptococcal Infections: Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniae. Frontiers in Microbiology 12.
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Julio Sempere, Mirella Llamosí, Idoia del Río Menéndez, Beatriz López Ruiz, Mirian Domenech & Fernando González-Camacho. (2021) Pneumococcal Choline-Binding Proteins Involved in Virulence as Vaccine Candidates. Vaccines 9:2, pages 181.
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Jennifer N. Luck, Hervé Tettelin & Carlos J. Orihuela. (2020) Sugar-Coated Killer: Serotype 3 Pneumococcal Disease. Frontiers in Cellular and Infection Microbiology 10.
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Mamta Singh, Hema Sori, Rahul Ahuja, Jairam Meena, Devinder Sehgal & Amulya Kumar Panda. (2020) Effect of N-terminal poly histidine-tag on immunogenicity of Streptococcus pneumoniae surface protein SP0845. International Journal of Biological Macromolecules 163, pages 1240-1248.
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Malihe Masomian, Zuleeza Ahmad, Lai Ti Gew & Chit Laa Poh. (2020) Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection. Vaccines 8:1, pages 132.
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Aderonke Odutola, Martin O.C. Ota, Martin Antonio, Ezra O. Ogundare, Yauba Saidu, Patrick K. Owiafe, Archibald Worwui, Olubukola T. Idoko, Olumuyiwa Owolabi, Beate Kampmann, Brian M. Greenwood, Mark Alderson, Magali Traskine, Kristien Swinnen, Vincent Verlant, Kurt Dobbelaere & Dorota Borys. (2019) Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines – A phase II, randomised, observer-blind study in Gambian infants. Vaccine 37:19, pages 2586-2599.
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Alfonso Carmona Martinez, Roman Prymula, Mariano Miranda Valdivieso, Maria del Carmen Otero Reigada, Jose Manuel Merino Arribas, Jerzy Brzostek, Leszek Szenborn, Renata Ruzkova, Michael R. Horn, Teresa Jackowska, Fernando Centeno-Malfaz, Magali Traskine, Kurt Dobbelaere & Dorota Borys. (2019) Immunogenicity and safety of 11- and 12-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccines (11vPHiD-CV, 12vPHiD-CV) in infants: Results from a phase II, randomised, multicentre study. Vaccine 37:1, pages 176-186.
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Sara Eve Crager. (2018) Mejorar el acceso mundial a las nuevas vacunas: propiedad intelectual, transferencia de tecnología y vías de reglamentación. American Journal of Public Health 108:S6, pages S421-S429.
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Sara Eve Crager. (2018) Improving Global Access to New Vaccines: Intellectual Property, Technology Transfer, and Regulatory Pathways. American Journal of Public Health 108:S6, pages S414-S420.
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E. S. Petukhova, D. S. Vorobyev & I. B. Semenova. (2018) THE ROLE OF PROTEINS OF STREPTOCOCCUS PNEUMONIAE IN THE DEVELOPMENT OF SEROTYPE-INDEPENDENT PNEUMOCOCCAL VACCINES. Journal of microbiology, epidemiology and immunobiology 95:3, pages 74-80.
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Lavida R. K. Brooks & George I. Mias. (2018) Streptococcus pneumoniae’s Virulence and Host Immunity: Aging, Diagnostics, and Prevention. Frontiers in Immunology 9.
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Keith P. Klugman, Ron Dagan, Richard Malley & Cynthia G. Whitney. 2018. Plotkin's Vaccines. Plotkin's Vaccines 773 815.e18 .
Seija Keskitalo-Foley & Päivi Naskali. (2017) Intersectionality in Finnish adult education research: insights from the journal Aikuiskasvatus 2010–2016. European Journal for Research on the Education and Learning of Adults 9:1, pages 13-27.
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Roman Prymula, Leszek Szenborn, Sven-Arne Silfverdal, Jacek Wysocki, Piotr Albrecht, Magali Traskine, Asparuh Gardev, Yue Song & Dorota Borys. (2017) Safety, reactogenicity and immunogenicity of two investigational pneumococcal protein-based vaccines: Results from a randomized phase II study in infants. Vaccine 35:35, pages 4603-4611.
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Kosuke Kataoka, Yoshiko Fukuyama, David E. Briles, Tatsuro Miyake & Kohtaro Fujihashi. (2017) Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae . Microbiology and Immunology 61:6, pages 195-205.
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Xiaoyu Sun, Jichao Wang, Jie Zhou, Hong Wang, Xiaofang Wang, Jingwen Wu, Yujuan He, Yibing Yin, Xuemei Zhang & Wenchun Xu. (2017) Subcutaneous immunization with Streptococcus pneumoniae GAPDH confers effective protection in mice via TLR2 and TLR4. Molecular Immunology 83, pages 1-12.
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Ruth B. Thornton, Lea-Ann S. Kirkham, Karli J. Corscadden, Harvey L. Coates, Shyan Vijayasekaran, Jessica Hillwood, Sophie Toster, Phillipa Edminston, Guicheng Zhang, Anthony Keil & Peter C. Richmond. (2017) No evidence for impaired humoral immunity to pneumococcal proteins in Australian Aboriginal children with otitis media. International Journal of Pediatric Otorhinolaryngology 92, pages 119-125.
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Richard J. Anderson, Siradanahalli Guru, Risini Weeratna, Shawn Makinen, Derek J. Falconer, Neil C. Sheppard, Susanne Lang, Bingsheng Chang, Anne-Laure Goenaga, Bruce A. Green, James R. Merson, Stephen J. Gracheck & Jim E. Eyles. (2016) In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity. Vaccine 34:50, pages 6292-6300.
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Song Gao, Lingbin Zeng, Xuemei Zhang, Yingying Wu, Jingjing Cui, Zhixin Song, Xiaoyu Sun, Hong Wang, Yibing Yin & Wenchun Xu. (2016) Attenuated Streptococcus pneumoniae vaccine candidate SPY1 promotes dendritic cell activation and drives a Th1/Th17 response. Immunology Letters 179, pages 47-55.
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I. B. Semenova & N. A. Mikhailova. (2016) SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION. Journal of microbiology, epidemiology and immunobiology 93:4, pages 76-85.
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Nitesh K. Kunda, Iman M. Alfagih, Eliane N. Miyaji, Douglas B. Figueiredo, Viviane M. Gonçalves, Daniela M. Ferreira, Sarah R. Dennison, Satyanarayana Somavarapu, Gillian A. Hutcheon & Imran Y. Saleem. (2015) Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles. International Journal of Pharmaceutics 495:2, pages 903-912.
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Marco Tamborrini, Nina Geib, Aniebrys Marrero-Nodarse, Maja Jud, Julia Hauser, Celestine Aho, Araceli Lamelas, Armando Zuniga, Gerd Pluschke, Arin Ghasparian & John Robinson. (2015) A Synthetic Virus-Like Particle Streptococcal Vaccine Candidate Using B-Cell Epitopes from the Proline-Rich Region of Pneumococcal Surface Protein A. Vaccines 3:4, pages 850-874.
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Mohit Vashishta, Naeem Khan, Subhash Mehto, Devinder Sehgal & Krishnamurthy Natarajan. (2015) Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner. PLOS ONE 10:7, pages e0133601.
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J.-H. Xu, W.-J. Dai, B. Chen & X.-Y. Fan. (2015) Mucosal Immunization with PsaA Protein, Using Chitosan as a Delivery System, Increases Protection Against Acute Otitis Media and Invasive Infection by Streptococcus pneumoniae . Scandinavian Journal of Immunology 81:3, pages 177-185.
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Sara Eve Crager. (2014) Improving Global Access to New Vaccines: Intellectual Property, Technology Transfer, and Regulatory Pathways. American Journal of Public Health 104:11, pages e85-e91.
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Charles Feldman & Ronald Anderson. (2014) Review: Current and new generation pneumococcal vaccines. Journal of Infection 69:4, pages 309-325.
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Roman Prymula, Petr Pazdiora, Magali Traskine, Jens U. Rüggeberg & Dorota Borys. (2014) Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial. Vaccine 32:25, pages 3025-3034.
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Yusi Liu, Hong Wang, Shuai Zhang, Lingbin Zeng, Xiuyu Xu, Kaifeng Wu, Wei Wang, Nanlin Yin, Zhixin Song, Xuemei Zhang & Yibing Yin. (2014) Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A. Infection and Immunity 82:4, pages 1666-1675.
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Shifeng Wang & Roy Curtiss III. (2014) Development of Streptococcus pneumoniae Vaccines Using Live Vectors. Vaccines 2:1, pages 49-88.
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Shannon L. Haughney, Latrisha K. Petersen, Amy D. Schoofs, Amanda E. Ramer-Tait, Janice D. King, David E. Briles, Michael J. Wannemuehler & Balaji Narasimhan. (2013) Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles. Acta Biomaterialia 9:9, pages 8262-8271.
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Ju Cao, Xiaojiao Zhang, Yi Gong, Yuhong Zhang, Yali Cui, Xiaofei Lai, Yibing Yin, Meijuan Li, Dairong Li & Liping Zhang. (2013) Protection against pneumococcal infection elicited by immunization with multiple pneumococcal heat shock proteins. Vaccine 31:35, pages 3564-3571.
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Peter B McIntyre, Katherine L O'Brien, Brian Greenwood & Diederik van de Beek. (2012) Effect of vaccines on bacterial meningitis worldwide. The Lancet 380:9854, pages 1703-1711.
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