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Review

Influenza vaccines: T-cell responses deserve more attention

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Pages 949-962 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Yuan Yin, BeiBei Li, Linting Zhou, Jian Luo, Xueying Liu, Shilei Wang, Qun Lu, Wensong Tan & Ze Chen. (2020) Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice. Emerging Microbes & Infections 9:1, pages 1933-1942.
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Braeden Donaldson, Zabeen Lateef, Greg F. Walker, Sarah L. Young & Vernon K. Ward. (2018) Virus-like particle vaccines: immunology and formulation for clinical translation. Expert Review of Vaccines 17:9, pages 833-849.
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Adrian Reber & Jacqueline Katz. (2013) Immunological assessment of influenza vaccines and immune correlates of protection. Expert Review of Vaccines 12:5, pages 519-536.
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Suryaprakash Sambhara & Rino Rappuoli. (2012) Improving influenza vaccines. Expert Review of Vaccines 11:8, pages 871-872.
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Alexander J. Badten, Aaron Ramirez, Jenny E. Hernandez-Davies, Tyler J. Albin, Aarti Jain, Rie Nakajima, Jiin Felgner, D. Huw Davies & Szu-Wen Wang. (2023) Protein Nanoparticle-Mediated Delivery of Recombinant Influenza Hemagglutinin Enhances Immunogenicity and Breadth of the Antibody Response. ACS Infectious Diseases 9:2, pages 239-252.
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Walid F. Elkhatib, Shereen S. Abdelkareem, Wafaa S. Khalaf, Mona I. Shahin, Dounia Elfadil, Alaa Alhazmi, Ahmed I. El-Batal & Gharieb S. El-Sayyad. (2022) Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting. Virology Journal 19:1.
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Yorick Janssens, Jasper Joye, Gwenn Waerlop, Frédéric Clement, Geert Leroux-Roels & Isabel Leroux-Roels. (2022) The role of cell-mediated immunity against influenza and its implications for vaccine evaluation. Frontiers in Immunology 13.
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Isabel Leroux-Roels, Gwenn Waerlop, Jessika Tourneur, Fien De Boever, Catherine Maes, Jacques Bruhwyler, Delphine Guyon-Gellin, Philippe Moris, Judith Del Campo, Paul Willems, Geert Leroux-Roels, Alexandre Le Vert & Florence Nicolas. (2022) Randomized, Double-Blind, Reference-Controlled, Phase 2a Study Evaluating the Immunogenicity and Safety of OVX836, A Nucleoprotein-Based Influenza Vaccine. Frontiers in Immunology 13.
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Abdalla Sheikh, Jennie Jackson, Hanjoo Brian Shim, Clement Yau, Jung Hee Seo & Ninan Abraham. (2022) Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection. Scientific Reports 12:1.
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Lucas dos Santos Dias, Hannah E. Dobson, Brock Kingstad Bakke, Gregory C. Kujoth, Junfeng Huang, Elaine M. Kohn, Cleison Ledesma Taira, Huafeng Wang, Nitin T. Supekar, J. Scott Fites, Daisy Gates, Christina L. Gomez, Charles A. Specht, Stuart M. Levitz, Parastoo Azadi, Lingjun Li, Marulasiddappa Suresh, Bruce S. Klein & Marcel Wüthrich. (2021) Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity. PLOS Pathogens 17:3, pages e1009324.
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Elisabeth M. S. Beijnen & Simon D. van Haren. (2020) Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation. Frontiers in Immunology 11.
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Salman M. Toor, Varun Sasidharan Nair & Eyad Elkord. (2020) Editorial of Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine. Vaccines 8:3, pages 376.
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Tres Cookenham, Kathleen G. Lanzer, Emily Gage, Erica C. Lorenzo, Darrick Carter, Rhea N. Coler, Susan L. Baldwin, Laura Haynes, William W. Reiley & Marcia A. Blackman. (2020) Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. Vaccine 38:33, pages 5256-5267.
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David A. G. Skibinski, Leigh Ann Jones, Yuan O. Zhu, Lin Wu Xue, Bijin Au, Bernett Lee, Ahmad Nazri Mohamed Naim, Audrey Lee, Nivashini Kaliaperumal, Jenny G. H. Low, Lawrence S. Lee, Michael Poidinger, Philippe Saudan, Martin Bachmann, Eng Eong Ooi, Brendon J. Hanson, Veronica Novotny-Diermayr, Alex Matter, Anna-Marie Fairhurst, Martin L. Hibberd & John E. Connolly. (2018) Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. Scientific Reports 8:1.
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Stéphane Pillet, Éric Aubin, Sonia Trépanier, Jean-François Poulin, Bader Yassine-Diab, Jan ter Meulen, Brian J. Ward & Nathalie Landry. (2018) Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial. npj Vaccines 3:1.
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Zahra F. Olson, Matthew R. Sandbulte, Carine Kunzler Souza, Daniel R. Perez, Amy L. Vincent & Crystal L. Loving. (2017) Factors affecting induction of peripheral IFN-γ recall response to influenza A virus vaccination in pigs. Veterinary Immunology and Immunopathology 185, pages 57-65.
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David J. Gasper, Brandon Neldner, Erin H. Plisch, Hani Rustom, Emily Carrow, Hirotaka Imai, Yoshihiro Kawaoka & M. Suresh. (2016) Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines. PLOS Pathogens 12:12, pages e1006064.
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Rahul Subramanian, Andrea L. Graham, Bryan T. Grenfell & Nimalan Arinaminpathy. (2016) Universal or Specific? A Modeling-Based Comparison of Broad-Spectrum Influenza Vaccines against Conventional, Strain-Matched Vaccines. PLOS Computational Biology 12:12, pages e1005204.
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Stéphane Pillet, Éric Aubin, Sonia Trépanier, Diane Bussière, Michèle Dargis, Jean-François Poulin, Bader Yassine-Diab, Brian J. Ward & Nathalie Landry. (2016) A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults. Clinical Immunology 168, pages 72-87.
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S. Pillet, T. Racine.C. Nfon, T.Z. Di Lenardo, S. Babiuk, B.J. Ward, G.P. Kobinger & N. Landry. (2015) Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets. Vaccine 33:46, pages 6282-6289.
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Weifeng Zhang, Lianyan Wang, Tingyuan Yang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia & Guanghui Ma. (2015) Immunopotentiator-Loaded Polymeric Microparticles as Robust Adjuvant to Improve Vaccine Efficacy. Pharmaceutical Research 32:9, pages 2837-2850.
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Mehran Dabaghian, Ali Mohammad Latifi, Majid Tebianian, Fariba Dabaghian & Seyyed Mahmoud Ebrahimi. (2015) A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice. Antiviral Research 120, pages 23-31.
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YanChun Peng, Beibei Wang, Kawsar Talaat, Ruth Karron, Timothy J. Powell, Hui Zeng, Danning Dong, Catherine J. Luke, Andrew McMichael, Kanta Subbarao & Tao Dong. (2015) Boosted Influenza-Specific T Cell Responses after H5N1 Pandemic Live Attenuated Influenza Virus Vaccination. Frontiers in Immunology 6.
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Peter C. Soema, Sietske K. Rosendahl Huber, Geert-Jan Willems, Wim Jiskoot, Gideon F. A. Kersten & Jean-Pierre Amorij. (2014) Influenza T-cell Epitope-Loaded Virosomes Adjuvanted with CpG as a Potential Influenza Vaccine. Pharmaceutical Research 32:4, pages 1505-1515.
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James N. Francis, Campbell J. Bunce, Claire Horlock, Jeannette M. Watson, Steven J. Warrington, Bertrand Georges & Carlton B. Brown. (2015) A novel peptide-based pan-influenza A vaccine: A double blind, randomised clinical trial of immunogenicity and safety. Vaccine 33:2, pages 396-402.
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Michael Schotsaert & Adolfo García-Sastre. (2014) Influenza Vaccines: A Moving Interdisciplinary Field. Viruses 6:10, pages 3809-3826.
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Nathalie Landry, Stéphane Pillet, David Favre, Jean-François Poulin, Sonia Trépanier, Bader Yassine-Diab & Brian J. Ward. (2014) Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens. Clinical Immunology 154:2, pages 164-177.
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Maria Victoria Sanchez, Thomas Ebensen, Kai Schulze, Diego Cargnelutti, Paulina Blazejewska, Eduardo A. Scodeller & Carlos A. Guzmán. (2014) Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge. PLoS ONE 9:8, pages e104824.
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K. Kai McKinstry, Richard W. Dutton, Susan L. Swain & Tara M. Strutt. (2013) Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful. Archivum Immunologiae et Therapiae Experimentalis 61:5, pages 341-353.
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Marian Wiegand, Gianni Gori-Savellini, Barbara Martorelli, Sascha Bossow, Wolfgang J. Neubert & Maria Grazia Cusi. (2013) Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector. Vaccine 31:37, pages 3888-3893.
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Teresa Lambe, John B. Carey, Yuanyuan Li, Alexandra J. Spencer, Arjan van Laarhoven, Caitlin E. Mullarkey, Anto Vrdoljak, Anne C. Moore & Sarah C. Gilbert. (2013) Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1. Scientific Reports 3:1.
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