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Review

Updates on the COPD gene list

Pages 607-631 | Published online: 18 Sep 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Marija Stankovic, Aleksandra Nikolic, Ljudmila Nagorni-Obradovic, Natasa Petrovic-Stanojevic & Dragica Radojkovic. (2017) Gene–Gene Interactions Between Glutathione S-Transferase M1 and Matrix Metalloproteinases 1, 9, and 12 in Chronic Obstructive Pulmonary Disease in Serbians. COPD: Journal of Chronic Obstructive Pulmonary Disease 14:6, pages 581-589.
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Anne Orholm Nielsen, Camilla Steen Jensen, Mohamed Simo Arredouani, Ronald Dahl & Morten Dahl. (2017) Variants of the ADRB2 Gene in COPD: Systematic Review and Meta-Analyses of Disease Risk and Treatment Response. COPD: Journal of Chronic Obstructive Pulmonary Disease 14:4, pages 451-460.
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Fadime Mutlu Icduygu, Mujgan Ozdemir Erdogan, Sevinc Sarinc Ulasli, Handan Gonenli Yildiz, Zeynep Sonmez Celik, Mehmet Unlu & Mustafa Solak. (2017) Is There an Association Between NOD2 Gene Polymorphisms and Chronic Obstructive Pulmonary Disease Progression?. International Journal of Human Genetics 17:2, pages 86-96.
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Youcheng Liu, Shuang Yan, Karen Poh, Suyang Liu, Emanehi Iyioriobhe & David A Sterling. (2016) Impact of air quality guidelines on COPD sufferers. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 839-872.
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Elizabeth Córdoba-Lanús, Rebeca Baz-Dávila, Adriana Espinoza-Jiménez, María C. Rodríguez-Pérez, Nerea Varo, Juan P. de-Torres, Delia González-Almeida, Armando Aguirre-Jaime & Ciro Casanova. (2015) IL-8 Gene Variants are Associated with Lung Function Decline and Multidimensional BODE Index in COPD Patients But Not with Disease Susceptibility: A Validation Study. COPD: Journal of Chronic Obstructive Pulmonary Disease 12:1, pages 55-61.
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Gaetano Caramori, Ian M Adcock, Antonino Di Stefano & Kian Fan Chung. (2014) Cytokine inhibition in the treatment of COPD. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 397-412.
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Jose Luis Lopez-Campos, Víctor Bustamante, Xavier Muñoz & Esther Barreiro. (2014) Moving Towards Patient-Centered Medicine for COPD Management: Multidimensional Approaches versus Phenotype-Based Medicine—A Critical View. COPD: Journal of Chronic Obstructive Pulmonary Disease 11:5, pages 591-602.
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Articles from other publishers (46)

Russell A. Wilke & Eric A. Larson. (2021) Air, Land, and Sea: Gene-Environment Interaction in Chronic Disease. The American Journal of Medicine 134:12, pages 1476-1482.
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Emmanuel Minet, Linsey E. Haswell, Sarah Corke, Anisha Banerjee, Andrew Baxter, Ivan Verrastro, Francisco De Abreu e Lima, Tomasz Jaunky, Simone Santopietro, Damien Breheny & Marianna D. Gaça. (2021) Application of text mining to develop AOP-based mucus hypersecretion genesets and confirmation with in vitro and clinical samples. Scientific Reports 11:1.
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Kazushi Matsumura & Shigeaki Ito. (2020) Novel biomarker genes which distinguish between smokers and chronic obstructive pulmonary disease patients with machine learning approach. BMC Pulmonary Medicine 20:1.
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Danni He, Jialin Li, Bo Zhou, Yuanmei Chen, Qin Hui, Fang Ye, Lipeng Zhang, Xuge He, Wenquan Niu & Qi Zhang. (2020) A correlational meta-analytical study of transforming growth factor-β genetic polymorphisms as a risk factor for chronic obstructive pulmonary disease. Gene 744, pages 144633.
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Fabienne Decrue, Olga Gorlanova, Jakob Usemann & Urs Frey. (2020) Lung functional development and asthma trajectories. Seminars in Immunopathology 42:1, pages 17-27.
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Yohan Bossé & Michael H. Cho. 2020. Precision in Pulmonary, Critical Care, and Sleep Medicine. Precision in Pulmonary, Critical Care, and Sleep Medicine 39 55 .
Yangwei Yao, Yangyang Gu, Meng Yang, Dakui Cao & Fengjie Wu. (2019) The Gene Expression Biomarkers for Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease. Frontiers in Genetics 10.
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Xiu-Xiong Li, Tao Peng, Jing Gao, Jia-Gang Feng, Dan-Dan Wu, Ting Yang, Li Zhong, Wei-Ping Fu & Chang Sun. (2019) Allele-specific expression identified rs2509956 as a novel long-distance cis -regulatory SNP for SCGB1A1 , an important gene for multiple pulmonary diseases . American Journal of Physiology-Lung Cellular and Molecular Physiology 317:4, pages L456-L463.
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Yohan Bossé, Maxime Lamontagne, Nathalie Gaudreault, Christine Racine, Marie-Hélène Levesque, Benjamin M Smith, Dominique Auger, Alisson Clemenceau, Marie-Ève Paré, Louis Laviolette, Victor Tremblay, Bruno Maranda, Mathieu C Morissette & François Maltais. (2019) Early-onset emphysema in a large French-Canadian family: a genetic investigation. The Lancet Respiratory Medicine 7:5, pages 427-436.
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Jisoo Park, Benjamin J. Hescott & Donna K. Slonim. (2019) Pathway centrality in protein interaction networks identifies putative functional mediating pathways in pulmonary disease. Scientific Reports 9:1.
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Xiang Zeng, Judith M. Vonk, Diana A. van der Plaat, Alen Faiz, Peter D. Paré, Philippe Joubert, David Nickle, Corry-Anke Brandsma, Hans Kromhout, Roel Vermeulen, Xijin Xu, Xia Huo, Kim de Jong & H. Marike Boezen. (2019) Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms. Environment International 122, pages 263-269.
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Maaike de Vries, Diana A van der Plaat, Ivana Nedeljkovic, Rikst Nynke Verkaik-Schakel, Wierd Kooistra, Najaf Amin, Cornelia M van Duijn, Corry-Anke Brandsma, Cleo C van Diemen, Judith M Vonk & H Marike Boezen. (2018) From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function. Respiratory Research 19:1.
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Jiyoun Yeo, Diego A. Morales, Tian Chen, Erin L. Crawford, Xiaolu Zhang, Thomas M. Blomquist, Albert M. Levin, Pierre P. Massion, Douglas A. Arenberg, David E. Midthun, Peter J. Mazzone, Steven D. Nathan, Ronald J. Wainz, Patrick Nana-Sinkam, Paige F. S. Willey, Taylor J. Arend, Karanbir Padda, Shuhao Qiu, Alexei Federov, Dawn-Alita R. Hernandez, Jeffrey R. Hammersley, Youngsook Yoon, Fadi Safi, Sadik A. Khuder & James C. Willey. (2018) RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs. BMC Pulmonary Medicine 18:1.
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Maor Sauler, Maxime Lamontagne, Eric Finnemore, Jose D. Herazo-Maya, John Tedrow, Xuchen Zhang, Julia E. Morneau, Frank Sciurba, Wim Timens, Peter D. Paré, Patty J. Lee, Naftali Kaminski, Yohan Bossé & Jose L. Gomez. (2018) The DNA repair transcriptome in severe COPD. European Respiratory Journal 52:4, pages 1701994.
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Maxime Lamontagne, Jean-Christophe Bérubé, Ma’en Obeidat, Michael H Cho, Brian D Hobbs, Phuwanat Sakornsakolpat, Kim de Jong, H Marike Boezen, David Nickle, Ke Hao, Wim Timens, Maarten van den Berge, Philippe Joubert, Michel Laviolette, Don D Sin, Peter D Paré & Yohan Bossé. (2018) Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations. Human Molecular Genetics 27:10, pages 1819-1829.
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Ivana Nedeljkovic, Elena Carnero-Montoro, Lies Lahousse, Diana A. van der Plaat, Kim de Jong, Judith M. Vonk, Cleo C. van Diemen, Alen Faiz, Maarten van den Berge, Ma’en Obeidat, Yohan Bossé, David C. Nickle, BIOS Consortium, Andre G. Uitterlinden, Joyce J. B. van Meurs, Bruno C. H. Stricker, Guy G. Brusselle, Dirkje S. Postma, H. Marike Boezen, Cornelia M. van Duijn & Najaf Amin. (2018) Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics. European Journal of Human Genetics 26:5, pages 709-722.
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Nobuyuki Horita. 2018. Clinical Relevance of Genetic Factors in Pulmonary Diseases. Clinical Relevance of Genetic Factors in Pulmonary Diseases 57 75 .
Jushan Zhang, Shouneng Peng, Haoxiang Cheng, Yoko Nomura, Antonio Fabio Di Narzo & Ke Hao. (2017) Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes. Scientific Reports 7:1.
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Julie Weidner, Linnea Jarenbäck, Kim de Jong, Judith M. Vonk, Maarten van den Berge, Corry-Anke Brandsma, H. Marike Boezen, Don Sin, Yohan Bossé, David Nickle, Jaro Ankerst, Leif Bjermer, Dirkje S. Postma, Alen Faiz & Ellen Tufvesson. (2017) Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease. Respiratory Research 18:1.
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Eitan Halper-Stromberg, Michael H. Cho, Carla Wilson, Dipti Nevrekar, James D. Crapo, George Washko, Raúl San José Estépar, David A. Lynch, Edwin K. Silverman, Sonia Leach & Peter J. Castaldi. (2017) Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society 14:1, pages 33-40.
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Takeo Ishii & Koichi Hagiwara. 2017. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 31 55 .
Hans Matsson, Cilla Söderhäll, Elisabet Einarsdottir, Maxime Lamontagne, Sanna Gudmundsson, Helena Backman, Anne Lindberg, Eva Rönmark, Juha Kere, Don Sin, Dirkje S. Postma, Yohan Bossé, Bo Lundbäck & Joakim Klar. (2016) Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease. BMC Pulmonary Medicine 16:1.
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Micol Marchetti-Bowick, Junming Yin, Judie A. Howrylak & Eric P. Xing. (2016) A time-varying group sparse additive model for genome-wide association studies of dynamic complex traits. Bioinformatics 32:19, pages 2903-2910.
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Tarek F. El-Gazzar, Samy S. El-dahdouh, Ibrahim I. El-Mahalawy, Hisham E. Abd El-aty & Safaa I. Tayel. (2016) Role of glutathione S-transferase P-1 (GSTP-1) gene polymorphism in COPD patients. Egyptian Journal of Chest Diseases and Tuberculosis 65:4, pages 739-744.
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Zhichao Pan, Haishan Yu & Jie-Lou Liao. (2016) Probing Cellular and Molecular Mechanisms of Cigarette Smoke-Induced Immune Response in the Progression of Chronic Obstructive Pulmonary Disease Using Multiscale Network Modeling. PLOS ONE 11:9, pages e0163192.
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Emanuela Cherubini, Maria Cristina Esposito, Davide Scozzi, Fabrizio Terzo, Giorgia Amira Osman, Salvatore Mariotta, Rita Mancini, Pierdonato Bruno & Alberto Ricci. (2016) Genetic Polymorphism of CHRM2 in COPD: Clinical Significance and Therapeutic Implications. Journal of Cellular Physiology 231:8, pages 1745-1751.
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Jonathan Fallica, Lidenys Varela, Laura Johnston, Bo Kim, Leonid Serebreni, Lan Wang, Mahendra Damarla, Todd M. Kolb, Paul M. Hassoun & Rachel Damico. (2016) Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1–p38–Xanthine Oxidoreductase–Dependent Cigarette Smoke–Induced Apoptosis. American Journal of Respiratory Cell and Molecular Biology 54:4, pages 504-514.
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Andrew J. Sandford. (2016) The BuMPy Road to COPD Gene Discovery. EBioMedicine 5, pages 18-19.
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YIPENG DING, HUAN NIU, YIZHOU LI, PING HE, QUANNI LI, YANHONG OUYANG, MIN LI, ZHIGAO HU, YOUQING ZHONG, PEI SUN & TIANBO JIN. (2016) Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province. Journal of Genetics 95:1, pages 151-156.
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Jean-Christophe Bérubé, Nathalie Gaudreault, Emilie Lavoie-Charland, Laura Sbarra, Cyndi Henry, Anne-Marie Madore, Peter D. Paré, Maarten van den Berge, David Nickle, Michel Laviolette, Catherine Laprise, Louis-Philippe Boulet & Yohan Bossé. (2016) Identification of Susceptibility Genes of Adult Asthma in French Canadian Women. Canadian Respiratory Journal 2016, pages 1-12.
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Zhe Liu, Wan Li, Junjie Lv, Ruiqiang Xie, Hao Huang, Yiran Li, Yuehan He, Jing Jiang, Binbin Chen, Shanshan Guo & Lina Chen. (2016) Identification of potential COPD genes based on multi-omics data at the functional level. Molecular BioSystems 12:1, pages 191-204.
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Kim de Jong, Judith M. Vonk, Wim Timens, Yohan Bossé, Don D. Sin, Ke Hao, Hans Kromhout, Roel Vermeulen, Dirkje S. Postma & H. Marike Boezen. (2015) Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels. Journal of Allergy and Clinical Immunology 136:6, pages 1664-1672.e14.
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Lela Lackey, Evonne McArthur & Alain Laederach. (2015) Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease. PLOS ONE 10:10, pages e0140885.
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Wei Chen, John M. Brehm, Ani Manichaikul, Michael H. Cho, Nadia Boutaoui, Qi Yan, Kristin M. Burkart, Paul L. Enright, Jerome I. Rotter, Hans Petersen, Shuguang Leng, Ma’en Obeidat, Yohan Bossé, Corry-Anke Brandsma, Ke Hao, Stephen S. Rich, Rhea Powell, Lydiana Avila, Manuel Soto-Quiros, Edwin K. Silverman, Yohannes Tesfaigzi, R. Graham Barr & Juan C. Celedón. (2015) A Genome-Wide Association Study of Chronic Obstructive Pulmonary Disease in Hispanics. Annals of the American Thoracic Society 12:3, pages 340-348.
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Nobuyuki Horita, Naoki Miyazawa, Koji Tomaru, Miyo Inoue, Yoshiaki Ishigatsubo & Takeshi Kaneko. (2015) Vitamin D binding protein genotype variants and risk of chronic obstructive pulmonary disease: A meta-analysis. Respirology 20:2, pages 219-225.
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Seungyeul Yoo, Sachiko Takikawa, Patrick Geraghty, Carmen Argmann, Joshua Campbell, Luan Lin, Tao Huang, Zhidong Tu, Robert Feronjy, Avrum Spira, Eric E. Schadt, Charles A. Powell & Jun Zhu. (2015) Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD. PLoS Genetics 11:1, pages e1004898.
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Kazutetsu Aoshiba, Takao Tsuji, Masayuki Itoh, Kazuhiro Yamaguchi & Hiroyuki Nakamura. (2015) An Evolutionary Medicine Approach to Understanding Factors That Contribute to Chronic Obstructive Pulmonary Disease. Respiration 89:3, pages 243-252.
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Maxime Lamontagne, Wim Timens, Ke Hao, Yohan Bossé, Michel Laviolette, Katrina Steiling, Joshua D Campbell, Christian Couture, Massimo Conti, Karen Sherwood, James C Hogg, Corry-Anke Brandsma, Maarten van den Berge, Andrew Sandford, Stephen Lam, Marc E Lenburg, Avrum Spira, Peter D Paré, David Nickle, Don D Sin & Dirkje S Postma. (2014) Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction . Thorax 69:11, pages 997-1004.
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Zi-Kang Xie, Qiu-Pin Huang, Jian Huang & Zheng-Fu Xie. (2014) Association between the IL1B, IL1RN polymorphisms and COPD risk: A meta-analysis. Scientific Reports 4:1.
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Aabida Saferali, Jee Lee, Don D. Sin, Farshid N. Rouhani, Mark L. Brantly & Andrew J. Sandford. (2014) Longer Telomere Length in COPD Patients with α1-Antitrypsin Deficiency Independent of Lung Function. PLoS ONE 9:4, pages e95600.
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Enrique Diaz-Guzman & David M. Mannino. (2014) Epidemiology and Prevalence of Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 35:1, pages 7-16.
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Dirkje S. Postma, Helen K. Reddel, Nick H.T. ten Hacken & Maarten van den Berge. (2014) Asthma and Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 35:1, pages 143-156.
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Nicola A. Hanania, Peter M.A. Calverley, Mark T. Dransfield, Jill P. Karpel, Manja Brose, Haiyuan Zhu, Udo-Michael Goehring & Paul Rowe. (2014) Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD. Respiratory Medicine 108:2, pages 366-375.
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Qin Wei, Youbao Sha, Abhisek Bhattacharya, Elmoataz Abdel Fattah, Diana Bonilla, Soma S. S. K. Jyothula, Lavannya Pandit, Gurjit K. Khurana Hershey & N. Tony Eissa. (2014) Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 189:1, pages 16-29.
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Maxime Lamontagne, Christian Couture, Dirkje S. Postma, Wim Timens, Don D. Sin, Peter D. Paré, James C. Hogg, David Nickle, Michel Laviolette & Yohan Bossé. (2013) Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls. PLoS ONE 8:7, pages e70220.
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Yohan Bossé. (2013) Research Highlights: Highlights from the latest articles in chronic obstructive pulmonary disease genetics. Personalized Medicine 10:2, pages 123-125.
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