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Original Research

Efficacy and safety of once-daily inhaled umeclidinium/vilanterol in Asian patients with COPD: results from a randomized, placebo-controlled study

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Pages 1753-1767 | Published online: 02 Sep 2015

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Rongchang Chen, Nanshan Zhong, Hao-Yan Wang, Li Zhao, Xiaodong Mei, Zhiqiang Qin, Juan Huang, Pryseley N Assam, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin & Colin Reisner. (2020) Efficacy And Safety Of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler (GFF MDI) Formulated Using Co-Suspension Delivery Technology In Chinese Patients With COPD. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 43-56.
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Nanshan Zhong, Jinping Zheng, Sang Haak Lee, David A Lipson, Xin Du & Shunquan Wu. (2020) Efficacy and Safety of Once-Daily Inhaled Umeclidinium in Asian Patients with COPD: Results from a Randomized, Placebo-Controlled Study. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 809-819.
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Chenxi Li, Wenke Cheng, Jin Guo & Wei Guan. (2019) Relationship of inhaled long-acting bronchodilators with cardiovascular outcomes among patients with stable COPD: a meta-analysis and systematic review of 43 randomized trials. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 799-808.
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Timothy E Albertson, Willis S Bowman, Richart W Harper, Regina M Godbout & Susan Murin. (2019) Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1251-1265.
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Paola Rogliani, Luigino Calzetta, Maria Gabriella Matera, Nicola di Daniele, Andrea Girolami, Mario Cazzola & Josuel Ora. (2019) Inhaled therapies and cardiovascular risk in patients with chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 20:6, pages 737-750.
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Antonio Molino, Giovanna Calabrese & Mauro Maniscalco. (2018) Patient considerations in the treatment of COPD: focus on the new combination inhaler fluticasone furoate/umeclidinium/vilanterol. Patient Preference and Adherence 12, pages 993-1001.
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Jinping Zheng, Nanshan Zhong, Changzheng Wang, Yijiang Huang, Ping Chen, Limin Wang, Fuxin Hui, Li Zhao, Haoyan Wang, Linda Luo, Xin Du, Aik Han Goh & David A. Lipson. (2018) The Efficacy and Safety of Once-daily Fluticasone Furoate/Umeclidinium/Vilanterol Versus Twice-daily Budesonide/Formoterol in a Subgroup of Patients from China with Symptomatic COPD at Risk of Exacerbations (FULFIL Trial). COPD: Journal of Chronic Obstructive Pulmonary Disease 15:4, pages 334-340.
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Mohamed Ismail Abdul Aziz, Ling Eng Tan, David Bin-Chia Wu, Fiona Pearce, Gerald Seng Wee Chua, Liang Lin, Ping-Tee Tan & Kwong Ng. (2018) Comparative efficacy of inhaled medications (ICS/LABA, LAMA, LAMA/LABA and SAMA) for COPD: a systematic review and network meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3203-3231.
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Amnon Ariel, Alan Altraja, Andrey Belevskiy, Piotr W Boros, Edvardas Danila, Matjaz Fležar, Vladimir Koblizek, Zvi G Fridlender, Kosta Kostov, Alvils Krams, Branislava Milenkovic, Attila Somfay, Ruzena Tkacova, Neven Tudoric, Ruxandra Ulmeanu & Arschang Valipour. (2018) Inhaled therapies in patients with moderate COPD in clinical practice: current thinking. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 45-56.
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Paola Rogliani, Maria Gabriella Matera, Josuel Ora, Mario Cazzola & Luigino Calzetta. (2017) The impact of dual bronchodilation on cardiovascular serious adverse events and mortality in COPD: a quantitative synthesis. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3469-3485.
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Jadwiga A Wedzicha, Nanshan Zhong, Masakazu Ichinose, Michael Humphries, Robert Fogel, Chau Thach, Francesco Patalano & Donald Banerji. (2017) Indacaterol/glycopyrronium versus salmeterol/fluticasone in Asian patients with COPD at a high risk of exacerbations: results from the FLAME study. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 339-349.
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Nicola A Hanania, Suzanne C. Lareau & Barbara P. Yawn. (2017) Safety of inhaled long-acting anti-muscarinic agents in COPD. Postgraduate Medicine 129:5, pages 500-512.
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Mingjin Yang, Yishi Li, Youfan Jiang, Shuliang Guo, Jian-Qing He & Don D. Sin. (2023) Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review and meta-analysis. European Respiratory Journal 61:2, pages 2200302.
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Yiwen Gong, Yinghua Lv, Hongxia Liu, Qingshan Zheng & Lujin Li. (2022) Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD. Therapeutic Advances in Respiratory Disease 16, pages 175346662110660.
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Paola Rogliani, Maria Gabriella Matera, Beatrice Ludovica Ritondo, Ilaria De Guido, Ermanno Puxeddu, Mario Cazzola & Luigino Calzetta. (2019) Efficacy and cardiovascular safety profile of dual bronchodilation therapy in chronic obstructive pulmonary disease: A bidimensional comparative analysis across fixed-dose combinations. Pulmonary Pharmacology & Therapeutics 59, pages 101841.
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Jinchun Wu, Yi Ye, Chenxi Li, Wenqin Zhou & Rong Chang. (2019) Correlation of Inhaled Long-Acting Bronchodilators With Adverse Cardiovascular Outcomes in Patients With Stable COPD. Journal of Cardiovascular Pharmacology 74:3, pages 255-265.
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François Maltais, Gary T. Ferguson, Gregory J. Feldman, Gaëtan Deslee, Arnaud Bourdin, Harald Fjällbrant, Agnieszka Siwek-Posłuszna, Martin A. Jenkins & Ubaldo J. Martin. (2019) A Randomized, Double-Blind, Double-Dummy Study of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Relative to Umeclidinium/Vilanterol Dry Powder Inhaler in COPD. Advances in Therapy 36:9, pages 2434-2449.
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Usman Maqsood, Terence N Ho, Karen Palmer, Fiona JR Eccles, Mohammed Munavvar, Ran Wang, Iain Crossingham & David JW Evans. (2019) Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2019:3.
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Chin Kook Rhee, Hajime Yoshisue & Rahul Lad. (2019) Fixed-Dose Combinations of Long-Acting Bronchodilators for the Management of COPD: Global and Asian Perspectives. Advances in Therapy 36:3, pages 495-519.
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Mohd Kashif Siddiqui, Pragya Shukla, Martin Jenkins, Mario Ouwens, Deniz Guranlioglu, Patrick Darken & Mousumi Biswas. (2019) Systematic review and network meta-analysis of the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler in comparison with other long-acting muscarinic antagonist/long-acting β 2 -agonist fixed-dose combinations in COPD . Therapeutic Advances in Respiratory Disease 13, pages 175346661989450.
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Yuji Oba, Edna Keeney, Namratta Ghatehorde & Sofia Dias. (2018) Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2018:12.
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Marc Miravitlles, Seungjae BaekVatsal VithlaniRahul Lad. (2018) Optimal Bronchodilation for COPD Patients: Are All Long-Acting β 2 -Agonist/Long-Acting Muscarinic Antagonists the Same? . Tuberculosis and Respiratory Diseases 81:3, pages 198.
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Koichi ANDO, Akihiko TANAKA, Sojiro KUSUMOTO, Toshimitsu YAMAOKA, Tohru OHMORI, Tsukasa OHNISHI, Shin INOUE & Hironori SAGARA. (2018) Efficacy and Safety of Long-acting Beta-2 Agonist and Long-acting Muscarinic Antagonist Combinations in Patients with Chronic Obstructive Pulmonary Disease: Meta-analysis of Phase 3 Randomized Trials. The Showa University Journal of Medical Sciences 30:2, pages 159-174.
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Cheng-Liang Qian & Rong Fan. (2017) Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial. Experimental and Therapeutic Medicine 14:4, pages 3915-3925.
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Han Ni, Aung Htet & Soe Moe. (2017) Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD). Cochrane Database of Systematic Reviews 2017:6.
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