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Drug Design, Development and Therapy Volume 11, 2017 - Issue
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Original Research

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Wei-Wei Zhang1 Department of Physiology, Shanxi Medical University;2 Department of Anesthesiology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China
,
Feng Bai1 Department of Physiology, Shanxi Medical University
,
Jin Wang1 Department of Physiology, Shanxi Medical University
,
Rong-Hua Zheng1 Department of Physiology, Shanxi Medical University
,
Li-Wang Yang1 Department of Physiology, Shanxi Medical University
,
Erskine A James3 Department of Internal Medicine, Navicent Health, Macon
&
Zhi-Qing Zhao1 Department of Physiology, Shanxi Medical University;4 Department of Basic Biomedical Sciences, Mercer University School of Medicine, Savannah, GA, USACorrespondence[email protected]
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Pages 3019-3033 | Published online: 16 Oct 2017

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Rong-Hua Zheng, Xiao-Jie Bai, Wei-Wei Zhang, Jing Wang, Feng Bai, Cai-Ping Yan, Erskine A James, Himangshu S Bose, Ning-Ping Wang & Zhi-Qing Zhao. (2019) Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats. Drug Design, Development and Therapy 13, pages 2745-2757.
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Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg & Xin-Fu Zhou. (2018) Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement. Drug Design, Development and Therapy 12, pages 2051-2069.
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Articles from other publishers (21)

Ping Yuan, Jiangang Liu, Shuang Xiong, Lin Yang, Jie Guan, Guoju Dong & Dazhuo Shi. (2023) Effects and mechanism of Compound Qidan Formula on rats with HFpEF induced by hypertension and diabetes mellitus based on Ang Ⅱ/TGF-β1/Smads signaling pathway. Journal of Ethnopharmacology 313, pages 116558.
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Dongke Yu, Yu Xiang, Tingting Gou, Rongsheng Tong, Chuan Xu, Lu Chen, Ling Zhong & Jianyou Shi. (2023) New therapeutic approaches against pulmonary fibrosis. Bioorganic Chemistry 138, pages 106592.
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Rongrong Zhao, Huajun Zhao, Quanjuan Guo, Yongliang Mu, Jian Zhang, Yuhang Su & Qiuju Han. (2022) Edaravone protects against liver fibrosis progression via decreasing the IL-1β secretion of macrophages. Chemico-Biological Interactions 368, pages 110251.
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Yanina V. Burgart, Galina F. Makhaeva, Olga P. Krasnykh, Sophia S. Borisevich, Natalia A. Agafonova, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Evgeny V. Shchegolkov, Galina A. Triandafilova, Denis A. Gazizov, Olga G. Serebryakova, Maria V. Ulitko, Sergey L. Khursan, Victor I. Saloutin & Rudy J. Richardson. (2022) Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity. Molecules 27:22, pages 7722.
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Dongxu Lin, Mengyang Zhang, Changcheng Luo, Pengyu Wei, Kai Cui & Zhong Chen. (2022) Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis. Journal of Immunology Research 2022, pages 1-12.
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Hisashi Kai, Mamiko Kai, Hiroshi Niiyama, Norihito Okina, Motoki Sasaki, Takanobu Maeda & Atsushi Katoh. (2021) Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies. Hypertension Research 44:8, pages 955-968.
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Miyuki Kobara, Nessa Naseratun, Hiroe Toba & Tetsuo Nakata. (2021) Preconditioning with Short-Term Dietary Restriction Attenuates Cardiac Oxidative Stress and Hypertrophy Induced by Chronic Pressure Overload. Nutrients 13:3, pages 737.
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Hai-Hui Xie, Hong-Yan Ma, Shu Zhang, Jian-Wen Li, Qi Han, Hui-Qun Chen, Bo-Qin Su & Jian-Ping Zhou. (2021) Impact of edaravone on serum CXC chemokine ligand-13 levels and perioperative neurocognitive disorders in elderly patients with hip replacement. Chinese Medical Journal 134:13, pages 1610-1615.
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Yu Li, Jing‑Zhu Duan, Qian He & Chong‑Quan Wang. (2020) miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway. Molecular Medicine Reports.
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Jae Gyun Oh, Philyoung Lee, Ronald E. Gordon, Susmita Sahoo, Changwon Kho & Dongtak Jeong. (2020) Analysis of extracellular vesicle miRNA profiles in heart failure. Journal of Cellular and Molecular Medicine 24:13, pages 7214-7227.
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Lucienne Juillerat-Jeanneret. (2020) The Other Angiotensin II Receptor: AT 2 R as a Therapeutic Target . Journal of Medicinal Chemistry 63:5, pages 1978-1995.
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Wei-Wei Zhang, Rong-Hua Zheng, Feng Bai, Katelyn Sturdivant, Ning-Ping Wang, Erskine A. James, Himangshu S. Bose & Zhi-Qing Zhao. (2019) Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy. Molecular Biology Reports 47:2, pages 1207-1222.
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Yuejia Ding, Yuan Wang, Qiujin Jia, Xiaoling Wang, Yanmin Lu, Ao Zhang, Shichao Lv & Junping Zhang. (2020) Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload. International Journal of Hypertension 2020, pages 1-14.
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Christian Bailly. (2019) Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. International Immunopharmacology 77, pages 105967.
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Man Zhang, Chen‑Huai Teng, Fang‑Fang Wu, Li‑Yun Ge, Jian Xiao, Hong‑Yu Zhang & Da‑Qing Chen. (2019) Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation. Experimental and Therapeutic Medicine.
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Zhoujiang Chen, Weiping Liu, Xin Wang, Yuan Liu & Xiaohong Li. (2019) Sequential Drug Release to Modulate Collagen Synthesis and Promote Micelle Penetration in Tumors. ACS Biomaterials Science & Engineering 5:3, pages 1343-1353.
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Simei Sun, Hae Jin Kee, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Hyung-Seok Kim, Seung-Jung Kee & Myung Ho Jeong. (2019) Gentisic acid prevents the transition from pressure overload-induced cardiac hypertrophy to heart failure. Scientific Reports 9:1.
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Daniele Gabriel-Costa. (2018) The pathophysiology of myocardial infarction-induced heart failure. Pathophysiology 25:4, pages 277-284.
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Ligia Akemi Kiyuna, Rudá Prestes e Albuquerque, Che-Hong Chen, Daria Mochly-Rosen & Julio Cesar Batista Ferreira. (2018) Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine 129, pages 155-168.
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Lucienne Juillerat-Jeanneret, John-David Aubert, Josip Mikulic & Dela Golshayan. (2018) Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. Journal of Medicinal Chemistry 61:22, pages 9811-9840.
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Li Jin, Simei Sun, Yuhee Ryu, Zhe Hao Piao, Bin Liu, Sin Young Choi, Gwi Ran Kim, Hyung-Seok Kim, Hae Jin Kee & Myung Ho Jeong. (2018) Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure. Scientific Reports 8:1.
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